Research Interests
Mechanistic investigation and technology development in shock wave and laser lithotripsy; Ultrasound-elicited mechanotransduction, neuromodulation and sonogenetics; HIFU and immunotherapy for cancer treatment; Acoustic and optical cavitation.
Selected Grants
Assessment of the Optimal Settings of TFL for Laser Lithotripsy and Associated Thermal Injury Risk
ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2025 - 2028Duke KURe Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2013 - 2028U2C/TL1 NC KUH TRIO Administrative Core
ResearchPreceptor · Awarded by University of North Carolina - Chapel Hill · 2023 - 20283D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease
ResearchCo-Principal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2028Development of a near-commercial prototype of multispark lithotripter
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2025 - 2027Title: NRT-FW-HTF: NSF Traineeship in the Advancement of Surgical Technologies
Inst. Training Prgm or CMEParticipants · Awarded by National Science Foundation · 2021 - 2026Innovations in Shock Wave Lithotripsy Technology
ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 1997 - 2026Collaborative Research: Investigating Crack Nucleation and Growth Under Dynamic Fatigue: Application to Nano-Pulse Lithotripsy
ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2021 - 2025Enhancing Laser Lithotripsy via Nanoparticle Fine-Tuned NIR absorption
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025Improving Mechanistic Understanding and Treatment Efficiency of Laser Lithotripsy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2022CAREER: Experimental validation of a new multiphase fluid computational model of cavitation bubble-bubble interaction
ResearchPrincipal Investigator · Awarded by Virginia Tech · 2019 - 2020In Vitro Assessment and Optimization of New Laser Lithotripsy Technologies for Treatment of Kidney Stones
ResearchMentor · Awarded by Urology Care Foundation · 2019 - 2020Probing the Bioeffects of Cavitation at Single-Cell Level
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2017Novel Strategies to Broaden the Impact of HIFU Therapy in Cancer Management
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2011Innovations in Shock Wave Lithotripsy Technology
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 2010Targeted Gene Delivery and Activation by Ultrasound
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2009A Novel Combination of Thermal Ablation and Heat-Induced Gene Therapy
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2006 - 2009Effect of Shockwaves on the Biochemical and Biomechanical Function of Cells (supplement)
ResearchCo Investigator · Awarded by Army Research Office · 2007 - 2009Cavitation and Wound Healing In SWL
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2000 - 2008Ultra High-speed Imaging System
EquipmentPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2008A Novel Ultrasound System for Epo Gene Therapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2007Innovations in Shock Wave Lithotripsy Technology (Supplement)
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 2006Flexible Catheter for the Delivery of Ionizing Radiation
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2001 - 2004Innovations in Shock Wave Lithotripsy Technology
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 2001Shockwave Mediated Gene Transfer and Drug Delivery
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 1999Shockwave-mediated Gene Transfer and Drug Delivery
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 1999Cavitation-Mediated Gene Transfer
ResearchPrincipal Investigator · Awarded by National Science Foundation · 1997 - 1998External Relationships
- Dornier Medtech
- ZSI Technology
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.