Scholars@Duke
Qin Zhang

Qin Zhang

Research Scientist
Anesthesiology

Selected Publications

Inflammation and Infection in Pain and the Role of GPR37.

Journal Article Int J Mol Sci · November 20, 2022 Inflammation is known to cause pain, and pain is of one of the cardinal signs of inflammation. Mounting evidence suggests that acute inflammation also resolves pain through specialized pro-resolving mediators (SPMs) and macrophage signaling. GPR37 is expre ... Full text Link to item Cite

beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue.

Journal Article J Neuroimmunol · April 2, 2001 Immunocyte-derived beta-endorphin can activate peripheral opioid receptors on sensory neurons to inhibit pain within inflamed tissue. This study examined mu-opioid receptors (MOR) on sensory nerves and beta-endorphin (END) in activated/memory CD4(+) cells ... Full text Link to item Cite

Pain control in inflammation governed by selectins

Journal Article Nature Medicine · December 1998 Full text Cite

aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy.

Journal Article Regul Pept · October 22, 1996 Using immunohistochemistry and in situ hybridization the in vivo effects of acidic and basic fibroblast growth factor (aFGF, bFGF), and of nerve growth factor (NGF) on the expression of galanin, neuropeptide Y (NPY) and substance P in axotomized dorsal roo ... Full text Link to item Cite

Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia.

Journal Article Proceedings of the National Academy of Sciences · June 11, 1996 Immune cell-derived opioid peptides can activate opioid receptors on peripheral sensory nerves to inhibit inflammatory pain. The intrinsic mechanisms triggering this neuroimmune interaction are unknown. This study investigates the involvement of en ... Full text Cite

Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence.

Journal Article Brain Res · December 24, 1995 Pituitary adenylate cyclase-activating polypeptide (PACAP) has recently been demonstrated in sensory neurons. In the present study on rat 17.5% of all neurons, mainly of small size, contained PACAP in normal dorsal root ganglia (DRGs). Transection of the s ... Full text Link to item Cite

Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation.

Journal Article J Neurosci · December 1995 Recently, antisera that recognize unique epitopes of the cloned mu-, delta-, and kappa-opioid, receptors (MOR, DOR, KOR, respectively) have been developed. In the present study MOR-, DOR-, and KOR-like immunoreactivities (LIs) were examined in rat dorsal r ... Full text Link to item Cite

Prominent expression of bFGF in dorsal root ganglia after axotomy.

Journal Article Eur J Neurosci · December 1, 1995 Using quantitative in situ hybridization and immunohistochemistry the expression of acidic and basic fibroblast growth factors (aFGF, bFGF) in dorsal root ganglia (DRGs) was examined. Around 5% of the small neurons expressed bFGF mRNA in normal DRGs. Nerve ... Full text Link to item Cite

Effect of growth factors on substance P mRNA expression in axotomized dorsal root ganglia.

Journal Article Neuroreport · June 19, 1995 The effects of NGF, BDNF, NT-3, BDNF plus NT-3 and LIF on substance P (SP) mRNA levels were analysed in axotomized dorsal root ganglia (DRGs) in vivo by quantitative in situ hybridization. The growth factors were applied on to the transected sciatic nerve. ... Full text Link to item Cite

Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy.

Journal Article Proc Natl Acad Sci U S A · December 20, 1994 Antisense (AS) oligonucleotides (ONs) to galanin (GAL) were applied to the proximal end of a transected sciatic nerve, allowing their cellular uptake and transport into injured axons. GAL expression in dorsal root ganglia and self-mutilation behavior (auto ... Full text Link to item Cite