Skip to main content

Consuelo Egla Diana Rabinovich

Professor of Pediatrics
Pediatrics, Rheumatology
Box 3212, Durham, NC 27710
2301 Erwin Road, CHC T0909, Durham, NC 27710

Selected Publications


Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale.

Journal Article Arthritis Care Res (Hoboken) · May 2024 OBJECTIVE: Juvenile localized scleroderma (jLS) is a chronic autoimmune disease commonly associated with poor outcomes, including contractures, hemiatrophy, uveitis, and seizures. Despite improvements in treatment, >25% of patients with jLS have functional ... Full text Link to item Cite

Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile-Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature.

Journal Article Arthritis Rheumatol · March 2024 OBJECTIVE: Patients with juvenile-onset systemic lupus erythematosus (JSLE) have increased atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) ... Full text Link to item Cite

Anti-FHL1 autoantibodies in juvenile myositis are associated with anti-Ro52 autoantibodies but not with severe disease features.

Journal Article Rheumatology (Oxford) · February 23, 2023 OBJECTIVES: Four-and-a-half LIM domains 1 (FHL1) is a muscle-specific protein. Autoantibodies against FHL1 were recently discovered in adults with idiopathic inflammatory myopathies (IIMs) and were found to be associated with clinical features and outcomes ... Full text Link to item Cite

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.

Journal Article Arthritis Care Res (Hoboken) · April 2022 OBJECTIVE: To provide recommendations for the management of juvenile idiopathic arthritis (JIA) with a focus on nonpharmacologic therapies, medication monitoring, immunizations, and imaging, irrespective of JIA phenotype. METHODS: We developed clinically r ... Full text Link to item Cite

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.

Journal Article Arthritis Rheumatol · April 2022 OBJECTIVE: To provide updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint (TMJ) arthritis, and systemic JIA with and without macrophage activation syndrome ... Full text Link to item Cite

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.

Journal Article Arthritis Care Res (Hoboken) · April 2022 OBJECTIVE: To provide updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint (TMJ) arthritis, and systemic JIA with and without macrophage activation syndrome ... Full text Link to item Cite

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.

Journal Article Arthritis Rheumatol · April 2022 OBJECTIVE: To provide recommendations for the management of juvenile idiopathic arthritis (JIA) with a focus on nonpharmacologic therapies, medication monitoring, immunizations, and imaging, irrespective of JIA phenotype. METHODS: We developed clinically r ... Full text Link to item Cite

Extracutaneous involvement is common and associated with prolonged disease activity and greater impact in juvenile localized scleroderma.

Journal Article Rheumatology (Oxford) · December 1, 2021 OBJECTIVE: The aim of this study was to evaluate factors associated with extracutaneous involvement (ECI) in juvenile localized scleroderma (jLS). METHODS: A prospective, multicentre, 6-month observational study was performed. The data collected included d ... Full text Link to item Cite

Preliminary evidence on abatacept safety and efficacy in refractory juvenile localized scleroderma.

Journal Article Rheumatology (Oxford) · August 2, 2021 OBJECTIVE: To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study. METHODS: A multicentre cohort study was performed to evaluate jLS subjects treated with abatacept with follo ... Full text Link to item Cite

Pulmonary Manifestations of Rheumatic Diseases in Children.

Journal Article Pediatr Clin North Am · February 2021 Children with rheumatic disease have rare pulmonary manifestations that may cause significant morbidity and mortality. These children are often clinically asymptomatic until disease has significantly progressed, so they should be screened for pulmonary inv ... Full text Link to item Cite

Pulmonary Manifestations of Rheumatic Disease in Children

Chapter · December 2, 2020 Pulmonary Manifestations of Rheumatic Diseases in Children Mary M. Buckley, MD , C. Egla Rabinovich, MD, MPH * KEYWORDS SLE JDMS JIA jSSc Sarcoid PFTs HRCT KEY POINTS Children with rheumatic disease have rare pulmonary manifestations ... ... Full text Cite

Safety and Effectiveness of Adalimumab in Patients With Polyarticular Course of Juvenile Idiopathic Arthritis: STRIVE Registry Seven-Year Interim Results.

Journal Article Arthritis Care Res (Hoboken) · October 2020 OBJECTIVE: To evaluate safety and effectiveness of adalimumab (ADA) in polyarticular-course juvenile idiopathic arthritis (JIA) in the STRIVE registry. METHODS: STRIVE enrolled patients with polyarticular-course JIA into 2 arms based on treatment with meth ... Full text Link to item Cite

Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma.

Journal Article J Rheumatol · August 1, 2020 OBJECTIVE: To perform a comparative effectiveness feasibility study in juvenile localized scleroderma (LS), using standardized treatment regimens (consensus treatment plans; CTP). METHODS: A prospective, multicenter 1-year pilot observational cohort study ... Full text Link to item Cite

Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study.

Journal Article Pediatr Rheumatol Online J · July 15, 2019 BACKGROUND: We designed and initiated a pilot comparative effectiveness study for juvenile localized scleroderma (jLS), for which there is limited evidence on best therapy. We evaluated the process we used, in relation to the specific protocol and to the g ... Full text Link to item Cite

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.

Journal Article Arthritis Rheumatol · June 2019 Featured Publication OBJECTIVE: To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS: Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and ... Full text Link to item Cite

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.

Journal Article Arthritis Care Res (Hoboken) · June 2019 Featured Publication OBJECTIVE: To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS: Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and ... Full text Link to item Cite

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis.

Journal Article Arthritis Rheumatol · June 2019 Featured Publication OBJECTIVE: To develop treatment recommendations for children with juvenile idiopathic arthritis manifesting as non-systemic polyarthritis, sacroiliitis, or enthesitis. METHODS: The Patient/Population, Intervention, Comparison, and Outcomes (PICO) questions ... Full text Link to item Cite

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis.

Journal Article Arthritis Care Res (Hoboken) · June 2019 Featured Publication OBJECTIVE: To develop treatment recommendations for children with juvenile idiopathic arthritis manifesting as non-systemic polyarthritis, sacroiliitis, or enthesitis. METHODS: The Patient/Population, Intervention, Comparison, and Outcomes (PICO) questions ... Full text Link to item Cite

Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis.

Journal Article Arthritis Care Res (Hoboken) · April 2019 OBJECTIVE: Systemic immunosuppressive treatment of pediatric chronic anterior uveitis (CAU), both juvenile idiopathic arthritis-associated and idiopathic anterior uveitis, varies, making it difficult to identify best treatments. The Childhood Arthritis and ... Full text Link to item Cite

Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Journal Article ACR Open Rheumatol · April 2019 OBJECTIVE: Localized scleroderma (LS) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile LS (jLS) cohort from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, a multicenter obs ... Full text Link to item Cite

Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale.

Journal Article Arthritis Care Res (Hoboken) · May 2024 OBJECTIVE: Juvenile localized scleroderma (jLS) is a chronic autoimmune disease commonly associated with poor outcomes, including contractures, hemiatrophy, uveitis, and seizures. Despite improvements in treatment, >25% of patients with jLS have functional ... Full text Link to item Cite

Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile-Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature.

Journal Article Arthritis Rheumatol · March 2024 OBJECTIVE: Patients with juvenile-onset systemic lupus erythematosus (JSLE) have increased atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) ... Full text Link to item Cite

Anti-FHL1 autoantibodies in juvenile myositis are associated with anti-Ro52 autoantibodies but not with severe disease features.

Journal Article Rheumatology (Oxford) · February 23, 2023 OBJECTIVES: Four-and-a-half LIM domains 1 (FHL1) is a muscle-specific protein. Autoantibodies against FHL1 were recently discovered in adults with idiopathic inflammatory myopathies (IIMs) and were found to be associated with clinical features and outcomes ... Full text Link to item Cite

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.

Journal Article Arthritis Care Res (Hoboken) · April 2022 OBJECTIVE: To provide recommendations for the management of juvenile idiopathic arthritis (JIA) with a focus on nonpharmacologic therapies, medication monitoring, immunizations, and imaging, irrespective of JIA phenotype. METHODS: We developed clinically r ... Full text Link to item Cite

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.

Journal Article Arthritis Rheumatol · April 2022 OBJECTIVE: To provide updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint (TMJ) arthritis, and systemic JIA with and without macrophage activation syndrome ... Full text Link to item Cite

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.

Journal Article Arthritis Care Res (Hoboken) · April 2022 OBJECTIVE: To provide updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint (TMJ) arthritis, and systemic JIA with and without macrophage activation syndrome ... Full text Link to item Cite

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.

Journal Article Arthritis Rheumatol · April 2022 OBJECTIVE: To provide recommendations for the management of juvenile idiopathic arthritis (JIA) with a focus on nonpharmacologic therapies, medication monitoring, immunizations, and imaging, irrespective of JIA phenotype. METHODS: We developed clinically r ... Full text Link to item Cite

Extracutaneous involvement is common and associated with prolonged disease activity and greater impact in juvenile localized scleroderma.

Journal Article Rheumatology (Oxford) · December 1, 2021 OBJECTIVE: The aim of this study was to evaluate factors associated with extracutaneous involvement (ECI) in juvenile localized scleroderma (jLS). METHODS: A prospective, multicentre, 6-month observational study was performed. The data collected included d ... Full text Link to item Cite

Preliminary evidence on abatacept safety and efficacy in refractory juvenile localized scleroderma.

Journal Article Rheumatology (Oxford) · August 2, 2021 OBJECTIVE: To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study. METHODS: A multicentre cohort study was performed to evaluate jLS subjects treated with abatacept with follo ... Full text Link to item Cite

Pulmonary Manifestations of Rheumatic Diseases in Children.

Journal Article Pediatr Clin North Am · February 2021 Children with rheumatic disease have rare pulmonary manifestations that may cause significant morbidity and mortality. These children are often clinically asymptomatic until disease has significantly progressed, so they should be screened for pulmonary inv ... Full text Link to item Cite

Pulmonary Manifestations of Rheumatic Disease in Children

Chapter · December 2, 2020 Pulmonary Manifestations of Rheumatic Diseases in Children Mary M. Buckley, MD , C. Egla Rabinovich, MD, MPH * KEYWORDS SLE JDMS JIA jSSc Sarcoid PFTs HRCT KEY POINTS Children with rheumatic disease have rare pulmonary manifestations ... ... Full text Cite

Safety and Effectiveness of Adalimumab in Patients With Polyarticular Course of Juvenile Idiopathic Arthritis: STRIVE Registry Seven-Year Interim Results.

Journal Article Arthritis Care Res (Hoboken) · October 2020 OBJECTIVE: To evaluate safety and effectiveness of adalimumab (ADA) in polyarticular-course juvenile idiopathic arthritis (JIA) in the STRIVE registry. METHODS: STRIVE enrolled patients with polyarticular-course JIA into 2 arms based on treatment with meth ... Full text Link to item Cite

Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma.

Journal Article J Rheumatol · August 1, 2020 OBJECTIVE: To perform a comparative effectiveness feasibility study in juvenile localized scleroderma (LS), using standardized treatment regimens (consensus treatment plans; CTP). METHODS: A prospective, multicenter 1-year pilot observational cohort study ... Full text Link to item Cite

Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study.

Journal Article Pediatr Rheumatol Online J · July 15, 2019 BACKGROUND: We designed and initiated a pilot comparative effectiveness study for juvenile localized scleroderma (jLS), for which there is limited evidence on best therapy. We evaluated the process we used, in relation to the specific protocol and to the g ... Full text Link to item Cite

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.

Journal Article Arthritis Rheumatol · June 2019 Featured Publication OBJECTIVE: To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS: Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and ... Full text Link to item Cite

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.

Journal Article Arthritis Care Res (Hoboken) · June 2019 Featured Publication OBJECTIVE: To develop recommendations for the screening, monitoring, and treatment of uveitis in children with juvenile idiopathic arthritis (JIA). METHODS: Pediatric rheumatologists, ophthalmologists with expertise in uveitis, patient representatives, and ... Full text Link to item Cite

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis.

Journal Article Arthritis Rheumatol · June 2019 Featured Publication OBJECTIVE: To develop treatment recommendations for children with juvenile idiopathic arthritis manifesting as non-systemic polyarthritis, sacroiliitis, or enthesitis. METHODS: The Patient/Population, Intervention, Comparison, and Outcomes (PICO) questions ... Full text Link to item Cite

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis.

Journal Article Arthritis Care Res (Hoboken) · June 2019 Featured Publication OBJECTIVE: To develop treatment recommendations for children with juvenile idiopathic arthritis manifesting as non-systemic polyarthritis, sacroiliitis, or enthesitis. METHODS: The Patient/Population, Intervention, Comparison, and Outcomes (PICO) questions ... Full text Link to item Cite

Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis.

Journal Article Arthritis Care Res (Hoboken) · April 2019 OBJECTIVE: Systemic immunosuppressive treatment of pediatric chronic anterior uveitis (CAU), both juvenile idiopathic arthritis-associated and idiopathic anterior uveitis, varies, making it difficult to identify best treatments. The Childhood Arthritis and ... Full text Link to item Cite

Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Journal Article ACR Open Rheumatol · April 2019 OBJECTIVE: Localized scleroderma (LS) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile LS (jLS) cohort from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, a multicenter obs ... Full text Link to item Cite

Clinical Characteristics and Factors Associated With Disability and Impaired Quality of Life in Children With Juvenile Systemic Sclerosis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Journal Article Arthritis Care Res (Hoboken) · December 2018 OBJECTIVE: To investigate clinical manifestations of juvenile systemic sclerosis (SSc; scleroderma), including disease characteristics and patient quality of life, using the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legac ... Full text Link to item Cite

New Features for Measuring Disease Activity in Pediatric Localized Scleroderma.

Journal Article J Rheumatol · December 2018 OBJECTIVE: To identify clinical features that define disease activity in pediatric localized scleroderma (LS), and determine their specificity and importance. METHODS: We conducted a multicenter prospective study of patients with active and inactive LS ski ... Full text Link to item Cite

Adiposity in Juvenile Psoriatic Arthritis.

Journal Article J Rheumatol · March 2018 OBJECTIVE: Adult patients with psoriatic arthritis are at increased risk for obesity and metabolic syndrome, but data regarding adiposity in children with juvenile psoriatic arthritis (JPsA) are limited. Our study assessed adiposity in children with JPsA i ... Full text Link to item Cite

Delays to Care in Pediatric Lupus Patients: Data From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Journal Article Arthritis Care Res (Hoboken) · March 2018 OBJECTIVE: Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation amon ... Full text Link to item Cite

Association of Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients.

Journal Article Arthritis Care Res (Hoboken) · July 2017 OBJECTIVE: Autoantibodies recognizing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are associated with statin exposure, the HLA allele DRB1*11:01, and necrotizing muscle biopsies in adult myositis patients. The aim of this study was to character ... Full text Link to item Cite

Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus.

Journal Article Lupus · May 2017 Objective Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's ... Full text Link to item Cite

Race, Income, and Disease Outcomes in Juvenile Dermatomyositis.

Journal Article J Pediatr · May 2017 OBJECTIVE: To determine the relationships among race, income, and disease outcomes in children with juvenile dermatomyositis (JDM). STUDY DESIGN: Data from 438 subjects with JDM enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) ... Full text Link to item Cite

Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans.

Journal Article Pediatr Rheumatol Online J · April 11, 2017 OBJECTIVES: To assess the feasibility of studying the comparative effectiveness of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) for systemic Juvenile Idiopathic Arthritis (JIA) using an observational r ... Full text Link to item Cite

The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013.

Journal Article J Rheumatol · September 2016 OBJECTIVE: We aimed to identify the (1) demographic/clinical characteristics, (2) medication usage trends, (3) variables associated with worse disease activity, and (4) characteristics of patients with persistent chronic arthritis in the Childhood Arthriti ... Full text Link to item Cite

Uveitis in children.

Journal Article Curr Opin Rheumatol · September 2016 PURPOSE OF REVIEW: The review provides updates on novel risk markers for the development of pediatric inflammatory uveitis and a severe disease course, on treatment of refractory disease, and on the measurement of visual outcomes. RECENT FINDINGS: There ar ... Full text Link to item Cite

Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry.

Journal Article Pediatr Rheumatol Online J · March 10, 2016 BACKGROUND: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and j ... Full text Link to item Cite

Medication use in juvenile uveitis patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Pediatr Rheumatol Online J · February 16, 2016 Featured Publication BACKGROUND: There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We sought to assess current practice patterns within a large cohort of children with juven ... Full text Link to item Cite

Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.

Journal Article Pediatr Nephrol · February 2016 BACKGROUND: Primary vesicoureteral reflux (PVUR) is the most common malformation of the kidney and urinary tract, and reflux nephropathy is a major cause of chronic kidney disease in children. Recently, we reported mutations in the tenascin XB gene (TNXB) ... Full text Link to item Cite

Profile of adalimumab and its potential in the treatment of uveitis.

Journal Article Drug Des Devel Ther · 2016 Uveitis refers to the presence of intraocular inflammation, and as a strict definition compromises the iris and ciliary body anteriorly and the choroid posteriorly (the uvea). Untreated, uveitis can lead to visual loss or blindness. The etiology of uveitis ... Full text Link to item Cite

Harms, benefits, and the nature of interventions in pragmatic clinical trials.

Journal Article Clin Trials · October 2015 To produce evidence capable of informing healthcare decision making at all critical levels, pragmatic clinical trials are diverse both in terms of the type of intervention (medical, behavioral, and/or technological) and the target of intervention (patients ... Full text Link to item Cite

The Future Is Now: Biologics for Non-Infectious Pediatric Anterior Uveitis.

Journal Article Paediatr Drugs · August 2015 Featured Publication Anterior uveitis (AU), inflammation of the iris, choroid or ciliary body, can cause significant eye morbidity, including visual loss. In the pediatric age group, the most common underlying diagnosis for AU is juvenile idiopathic associated uveitis and idio ... Full text Open Access Link to item Cite

Novel method to collect medication adverse events in juvenile arthritis: results from the childhood arthritis and rheumatology research alliance enhanced drug safety surveillance project.

Journal Article Arthritis Care Res (Hoboken) · April 2015 OBJECTIVE: Few data are available regarding the rates of serious adverse events (SAEs) and important medical events (IMEs) outside of product-based registries and clinical trials for juvenile idiopathic arthritis (JIA). The Enhanced Drug Safety Surveillanc ... Full text Link to item Cite

Enthesitis-related arthritis: time to re-define?

Journal Article Curr Rheumatol Rep · December 2014 Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. Enthesitis-related arthritis (ERA) is one of the seven JIA subtypes classified by the International League of Associations for Rheumatology (ILAR). Due to inclusion and ... Full text Open Access Link to item Cite

Successful management of refractory pediatric-onset complex aphthosis with lenalidomide.

Journal Article J Clin Rheumatol · June 2014 Clinicians are frequently confronted with patients presenting with oral aphthous ulcers or orogenital aphthae. Patients with complex aphthosis are characterized by the nearly constant presence of more than 3 oral aphthous ulcers or recurrent orogenital aph ... Full text Link to item Cite

Methotrexate: new uses for an old drug.

Journal Article J Pediatr · February 2014 Full text Link to item Cite

Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus: an Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy.

Journal Article Lupus Sci Med · 2014 OBJECTIVE: Epidemiological associations suggest that vitamin D status may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements and other existing data from the Atheroscleros ... Full text Link to item Cite

TNXB mutations can cause vesicoureteral reflux.

Journal Article J Am Soc Nephrol · July 2013 Primary vesicoureteral reflux (VUR) is the most common congenital anomaly of the kidney and the urinary tract, and it is a major risk factor for pyelonephritic scarring and CKD in children. Although twin studies support the heritability of VUR, specific ge ... Full text Link to item Cite

Pulmonary hypertension and other potentially fatal pulmonary complications in systemic juvenile idiopathic arthritis.

Journal Article Arthritis Care Res (Hoboken) · May 2013 OBJECTIVE: Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin-1 (IL-1) and IL-6 inhibitors appear to be effective treatments. Pulmonary arterial hypertension (PAH), interstitial lung disease ... Full text Link to item Cite

Juvenile idiopathic arthritis: Diagnosis and management

Journal Article Journal of Clinical Outcomes Management · January 1, 2013 Objective: To provide an overview of diagnosis and management of juvenile idiopathic arthritis (JIA). Methods: Review of the literature. Results: JIA is the most common rheumatologic disease in children. There are 7 categories of JIA. The diagnosis is made ... Cite

Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis: a consensus effort from the multinational interdisciplinary working group for uveitis in childhood.

Journal Article Arthritis Care Res (Hoboken) · September 2012 OBJECTIVE: To develop a set of core outcome measures for use in randomized controlled trials (RCTs) and longitudinal observational studies in juvenile idiopathic arthritis (JIA)-associated uveitis. METHODS: The literature relating to outcome measures used ... Full text Link to item Cite

Increased sensitivity of the European medicines agency algorithm for classification of childhood granulomatosis with polyangiitis.

Journal Article J Rheumatol · August 2012 OBJECTIVE: Granulomatosis with polyangiitis (Wegener's; GPA) and other antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare in childhood and are sometimes difficult to discriminate. We compared use of adult-derived classificati ... Full text Link to item Cite

Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma.

Journal Article Arthritis Care Res (Hoboken) · August 2012 Featured Publication OBJECTIVE: Juvenile localized scleroderma (LS) is a chronic inflammatory skin disorder associated with substantial morbidity and disability. Although a wide range of therapeutic strategies has been reported in the literature, a lack of agreement on treatme ... Full text Link to item Cite

Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe).

Journal Article J Rheumatol · May 2012 OBJECTIVE: There are no validated tools for measuring disease activity in pediatric vasculitis. The Birmingham Vasculitis Activity Score (BVAS) is a valid disease activity tool in adult vasculitis. Version 3 (BVAS v.3) correlates well with physician's glob ... Full text Link to item Cite

Pulmonary complications of childhood rheumatic disease.

Journal Article Paediatr Respir Rev · March 2012 Featured Publication The array of paediatric pulmonary complications of the various rheumatologic disorders illustrates both the complexities and challenges of the underlying disorders and the continuing lack of detailed knowledge of the pathophysiology and optimal treatment p ... Full text Link to item Cite

Disease activity, proteinuria, and vitamin D status in children with systemic lupus erythematosus and juvenile dermatomyositis.

Journal Article J Pediatr · February 2012 OBJECTIVE: To evaluate relationships among vitamin D, proteinuria, and disease activity in pediatric systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM). STUDY DESIGN: Multiple linear regression was used to associate subject-reported race ... Full text Link to item Cite

Challenges in the diagnosis and treatment of juvenile systemic sclerosis.

Journal Article Nat Rev Rheumatol · October 11, 2011 Featured Publication During the past 10 years, descriptions of large registries of children with juvenile systemic sclerosis (jSSc) have improved our knowledge of this disease. jSSc differs from the adult disease in presentation as well as disease course. Two courses of diseas ... Full text Link to item Cite

Treatment of juvenile idiopathic arthritis-associated uveitis: challenges and update.

Journal Article Curr Opin Rheumatol · September 2011 Featured Publication PURPOSE OF REVIEW: To update the current understanding of the risk factors for poor outcomes in juvenile idiopathic arthritis-related uveitis. In addition, current therapies, both traditional and biological, are reviewed. RECENT FINDINGS: Male sex, indepen ... Full text Link to item Cite

Reply

Journal Article Arthritis Care and Research · September 1, 2011 Full text Cite

2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features.

Journal Article Arthritis Care Res (Hoboken) · April 2011 Featured Publication Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient. The ACR considers adherence to ... Full text Link to item Cite

Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series.

Journal Article Arthritis Rheum · February 2011 Featured Publication OBJECTIVE: To examine the safety and efficacy of the interleukin-1 (IL-1) receptor antagonist anakinra as first-line therapy for systemic juvenile idiopathic arthritis (JIA). METHODS: Patients with systemic JIA receiving anakinra as part of initial disease ... Full text Link to item Cite

Effects of long-term etanercept treatment on growth in children with selected categories of juvenile idiopathic arthritis.

Journal Article Arthritis Rheum · November 2010 Featured Publication OBJECTIVE: To evaluate the effects of long-term etanercept treatment, with or without methotrexate, on growth in children with selected categories of juvenile idiopathic arthritis (JIA). METHODS: We conducted a 3-year, open-label, nonrandomized registry of ... Full text Link to item Cite

Pediatric neuro-Behçet's disease responsive to adalimumab.

Journal Article Pediatr Neurol · October 2010 Neurologic manifestations of Behçet's disease (neuro-Behçet's disease) are uncommon, but may cause patients significant morbidity and mortality. Neuro-Behçet's disease is chronic and may be refractory to treatment. We report on a 12-year-old girl with neur ... Full text Link to item Cite

Avascular necrosis of the metacarpals in juvenile dermatomyositis.

Journal Article J Clin Rheumatol · August 2010 Avascular necrosis (AVN) of the metacarpal heads is uncommon and has been associated with trauma, systemic lupus erythematosus, and corticosteroid usage. There have been no previous reports of metacarpal AVN described in patients with juvenile dermatomyosi ... Full text Link to item Cite

The localized scleroderma skin severity index and physician global assessment of disease activity: a work in progress toward development of localized scleroderma outcome measures.

Journal Article J Rheumatol · December 2009 OBJECTIVE: To develop and evaluate a Localized Scleroderma (LS) Skin Severity Index (LoSSI) and global assessments' clinimetric property and effect on quality of life (QOL). METHODS: A 3-phase study was conducted. The first phase involved 15 patients with ... Full text Link to item Cite

Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood.

Journal Article Arthritis Rheum · November 2009 OBJECTIVE: To compare the criteria for Wegener's granulomatosis (WG) of the American College of Rheumatology (ACR) with those of the European League Against Rheumatism/Pediatric Rheumatology European Society (EULAR/PRES) in a cohort of children with WG and ... Full text Link to item Cite

Long-term safety and effectiveness of etanercept in children with selected categories of juvenile idiopathic arthritis.

Journal Article Arthritis Rheum · September 2009 Featured Publication OBJECTIVE: This study was undertaken to evaluate the long-term safety and effectiveness of etanercept alone or in combination with methotrexate (MTX) in children with selected categories of juvenile idiopathic arthritis (JIA). METHODS: Patients ages 2-18 y ... Full text Link to item Cite

Pulmonary manifestations of rheumatoid diseases

Journal Article Pulmonary Manifestations of Pediatric Diseases · 2009 Featured Publication Full text Cite

Infliximab to treat chronic noninfectious uveitis in children: retrospective case series with long-term follow-up.

Journal Article Am J Ophthalmol · December 2007 Featured Publication PURPOSE: To assess a response to infliximab therapy in childhood uveitis. DESIGN: Retrospective case series. METHODS: We reviewed the course of 16 children with noninfectious uveitis treated with infliximab at an academic medical center. Outcome measures i ... Full text Link to item Cite

Use of tumor necrosis factor inhibitors in uveitis.

Journal Article Curr Opin Rheumatol · September 2007 Featured Publication PURPOSE OF REVIEW: Use of tumor necrosis factor-alpha blocking agents to treat chronic pediatric uveitis is becoming recognized as an important therapeutic modality. This review summarizes the rationale for this use, highlighting new studies of these agent ... Full text Link to item Cite

A multicenter case-control study on predictive factors distinguishing childhood leukemia from juvenile rheumatoid arthritis.

Journal Article Pediatrics · May 2006 Featured Publication OBJECTIVE: Acute lymphocytic leukemia (ALL) often presents with musculoskeletal concerns such as pain or swelling, even before appearance of blasts in the peripheral blood. Such presentation may lead to misdiagnosis of a child with juvenile rheumatoid arth ... Full text Link to item Cite

Parry-Romberg syndrome with fatal brain stem involvement.

Journal Article J Pediatr · March 2005 We report the case of a 4 year-old boy with Parry-Romberg syndrome who had intractable seizures, progressive cerebral hemisphere atrophy, and fatal brain stem involvement. ... Full text Link to item Cite

Osteoporosis: a pediatric perspective.

Journal Article Arthritis Rheum · April 2004 Featured Publication Full text Link to item Cite

Health status of patients with juvenile rheumatoid arthritis at 1 and 5 years after diagnosis.

Journal Article J Rheumatol · February 2003 Featured Publication OBJECTIVE: To describe the health and functional status of children with juvenile rheumatoid arthritis (JRA) diagnosed in the early 1990s. METHODS: Patients were obtained from the Pediatric Rheumatology Disease Registry, a database of patients seen in pedi ... Link to item Cite

Bone metabolism in childhood rheumatic disease.

Journal Article Rheum Dis Clin North Am · August 2002 Featured Publication There is an increasing appreciation among physicians about the importance of bone health in children as a potential modifiable risk factor for development of osteoporosis later in life. Many unanswered questions about normal pediatric bone health make the ... Full text Link to item Cite

Bone mineral status in juvenile rheumatoid arthritis.

Journal Article J Rheumatol Suppl · April 2000 Featured Publication Osteoporosis can be thought of as a disease of childhood with manifestations in the adult years. One strategy in prevention of osteoporosis is to maximize peak bone mass with interventions focused during the childhood and adolescent years, taking advantage ... Link to item Cite

Chronic recurrent multifocal osteomyelitis associated with chronic inflammatory bowel disease in children.

Journal Article Dig Dis Sci · December 1999 Chronic recurrent multifocal osteomyelitis (CRMO) is a rare disease of children characterized by aseptic inflammation of the long bones and clavicles. No infectious etiology has been identified, and CRMO has been associated with a number of autoimmune dise ... Full text Link to item Cite

The school experience of children with arthritis. Coping in the 1990s and transition into adulthood.

Journal Article Pediatr Clin North Am · October 1995 To the arthritic child and his or her family, the pediatrician is a valuable resource. When school problems first occur in elementary school, the pediatrician can try to solve them with an informal contact with the school teacher, nurse, counselor, or prin ... Full text Link to item Cite

Breast feeding and the development of juvenile rheumatoid arthritis.

Journal Article J Rheumatol · June 1995 OBJECTIVE: To determine if children with juvenile rheumatoid arthritis (JRA) are less likely to have been breast fed than controls. METHODS: Case-control study of data obtained from a survey of mothers 54 children with JRA and 79 playmates regarding breast ... Link to item Cite

Lupus nephritis study--questions.

Journal Article Pediatrics · October 1992 Link to item Cite

Percutaneous transluminal coronary angioplasty as palliation for patients considered poor surgical candidates.

Journal Article Am Heart J · May 1986 Thirty-one patients with angina inadequately controlled by medical therapy, but who were poor surgical candidates because of advanced age and poor general condition, or because of depressed left ventricular function, had percutaneous transluminal coronary ... Full text Link to item Cite