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Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma.

Publication ,  Journal Article
Li, SC; Torok, KS; Pope, E; Dedeoglu, F; Hong, S; Jacobe, HT; Rabinovich, CE; Laxer, RM; Higgins, GC; Ferguson, PJ; Lasky, A; Baszis, K ...
Published in: Arthritis Care Res (Hoboken)
August 2012

OBJECTIVE: Juvenile localized scleroderma (LS) is a chronic inflammatory skin disorder associated with substantial morbidity and disability. Although a wide range of therapeutic strategies has been reported in the literature, a lack of agreement on treatment specifics and accepted methods for clinical assessment has made it difficult to compare approaches and identify optimal therapy. Our objective was to develop standardized treatment plans, clinical assessments, and response criteria for active, moderate to high severity juvenile LS. METHODS: A core group of pediatric rheumatologists, dermatologists, and a lay advisor was engaged by the Childhood Arthritis and Rheumatology Research Alliance (CARRA) to develop standardized treatment plans and assessment parameters for juvenile LS using consensus methods/nominal group techniques. Recommendations were validated in 2 face-to-face conferences with a larger group of practitioners with expertise in juvenile LS and with the full membership of CARRA, which encompasses the majority of pediatric rheumatologists in the US and Canada. RESULTS: Consensus was achieved on standardized treatment plans that reflect the prevailing treatment practices of CARRA members. Standardized clinical assessment methods and provisional treatment response criteria were also developed. Greater than 90% of pediatric rheumatologists responding to a survey (66% of CARRA membership) affirmed the final recommendations and agreed to utilize these consensus plans to treat patients with juvenile LS. CONCLUSION: Using consensus methodology, we have developed standardized treatment plans and assessment methods for juvenile LS. The high level of support among pediatric rheumatologists will support future comparative effectiveness studies and enable the development of evidence-based guidelines for the treatment of juvenile LS.

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Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

August 2012

Volume

64

Issue

8

Start / End Page

1175 / 1185

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Scleroderma, Systemic
  • Scleroderma, Localized
  • Randomized Controlled Trials as Topic
  • Program Development
  • Practice Guidelines as Topic
  • Methylprednisolone
  • Methotrexate
  • Male
 

Citation

APA
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MLA
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Li, S. C., Torok, K. S., Pope, E., Dedeoglu, F., Hong, S., Jacobe, H. T., … Childhood Arthritis and Rheumatology Research Alliance (CARRA) Localized Scleroderma Workgroup, . (2012). Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res (Hoboken), 64(8), 1175–1185. https://doi.org/10.1002/acr.21687
Li, Suzanne C., Kathryn S. Torok, Elena Pope, Fatma Dedeoglu, Sandy Hong, Heidi T. Jacobe, C Egla Rabinovich, et al. “Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma.Arthritis Care Res (Hoboken) 64, no. 8 (August 2012): 1175–85. https://doi.org/10.1002/acr.21687.
Li SC, Torok KS, Pope E, Dedeoglu F, Hong S, Jacobe HT, et al. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res (Hoboken). 2012 Aug;64(8):1175–85.
Li, Suzanne C., et al. “Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma.Arthritis Care Res (Hoboken), vol. 64, no. 8, Aug. 2012, pp. 1175–85. Pubmed, doi:10.1002/acr.21687.
Li SC, Torok KS, Pope E, Dedeoglu F, Hong S, Jacobe HT, Rabinovich CE, Laxer RM, Higgins GC, Ferguson PJ, Lasky A, Baszis K, Becker M, Campillo S, Cartwright V, Cidon M, Inman CJ, Jerath R, O’Neil KM, Vora S, Zeft A, Wallace CA, Ilowite NT, Fuhlbrigge RC, Childhood Arthritis and Rheumatology Research Alliance (CARRA) Localized Scleroderma Workgroup. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res (Hoboken). 2012 Aug;64(8):1175–1185.
Journal cover image

Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

August 2012

Volume

64

Issue

8

Start / End Page

1175 / 1185

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Scleroderma, Systemic
  • Scleroderma, Localized
  • Randomized Controlled Trials as Topic
  • Program Development
  • Practice Guidelines as Topic
  • Methylprednisolone
  • Methotrexate
  • Male