Journal ArticleJ Orthop Trauma · February 1, 2025
OBJECTIVES: To determine the association between closed suction drainage and postoperative infection in patients with tibial plateau or pilon fractures. Secondarily, this study assessed whether intrawound vancomycin powder modified the association of close ...
Full textLink to itemCite
Journal ArticleInj Prev · January 21, 2025
INTRODUCTION: Return-to-acute-care metrics, such as early emergency department (ED) visits, are key indicators of healthcare quality, with ED returns following surgery often considered avoidable and costly events. Proactively identifying patients at high r ...
Full textLink to itemCite
Journal ArticleOTA International · November 25, 2024
Objectives:To develop and validate a prediction model for a deep surgical site infection (SSI) after fixation of a tibial plateau or pilon fracture.Design:Pooled data from 2 randomized trials (VANCO and OXYGEN).Setting:Fifty-two US trauma centers.Patients: ...
Full textCite
Journal ArticleInt J Mol Sci · November 9, 2024
Intra-articular ankle fracture (IAF) often leads to post-traumatic osteoarthritis (PTOA), resulting in significant long-term morbidity. While previous research has focused on the inflammatory cytokines and matrix metalloproteinases within the synovial flui ...
Full textLink to itemCite
Journal ArticleJ Orthop Trauma · April 1, 2024
OBJECTIVE: To determine whether intrawound vancomycin changes the bacteriology of surgical site infection pathogens and investigate the emergence of antibiotic-resistant pathogens. DESIGN: Secondary analysis of phase III, prospective, randomized clinical t ...
Full textLink to itemCite
Journal ArticleN Engl J Med · February 1, 2024
BACKGROUND: Studies evaluating surgical-site infection have had conflicting results with respect to the use of alcohol solutions containing iodine povacrylex or chlorhexidine gluconate as skin antisepsis before surgery to repair a fractured limb (i.e., an ...
Full textLink to itemCite
Journal ArticleJ Orthop Trauma · January 1, 2024
OBJECTIVES: To estimate the generalizability of treatment effects observed in the VANCO trial to a broader population of patients with tibial plateau or pilon fractures. METHODS: Design and Setting: Clinical trial data from 36 United States trauma centers ...
Full textLink to itemCite
Journal ArticleEur J Orthop Surg Traumatol · October 2023
PURPOSE: Open reduction internal fixation of tibial plateau and pilon fractures may be complicated by deep surgical site infection requiring operative debridement and antibiotic therapy. The management of superficial surgical site infection is controversia ...
Full textLink to itemCite
Journal ArticleInjury · March 6, 2023
BACKGROUND: Heterotopic ossification (HO) is a common complication after surgical fixation of acetabular fractures. Numerous strategies have been employed to prevent HO formation, but results are mixed and optimal treatment strategy remains controversial. ...
Full textLink to itemCite
Journal ArticlePilot and Feasibility Studies · December 1, 2021
Background: Preoperative antiseptic skin solutions are used prior to most surgical procedures; however, there is no definitive research comparing infection-related outcomes following use of the various solutions available to orthopedic trauma surgeons. The ...
Full textCite
Journal ArticleJ Bone Joint Surg Am · September 1, 2021
BACKGROUND: Selecting the best treatment for patients with severe terminal lower-limb injury remains a challenge. For some injuries, amputation may result in better outcomes than limb salvage. This study compared the outcomes of patients who underwent limb ...
Full textLink to itemCite
Journal ArticleContemporary Clinical Trials Communications · June 1, 2021
Introduction: Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may not be ...
Full textCite
Journal ArticleJAMA Surg · May 1, 2021
IMPORTANCE: Despite the widespread use of systemic antibiotics to prevent infections in surgically treated patients with fracture, high rates of surgical site infection persist. OBJECTIVE: To examine the effect of intrawound vancomycin powder in reducing d ...
Full textLink to itemCite
Journal ArticleContemporary Clinical Trials Communications · March 1, 2021
Introduction: Pragmatic trials in comparative effectiveness research assess the effects of different treatment, therapeutic, or healthcare options in clinical practice. They are characterized by broad eligibility criteria and large sample sizes, which can ...
Full textCite
Journal ArticleJ Am Acad Orthop Surg Glob Res Rev · December 8, 2020
INTRODUCTION: Open fractures are associated with a high risk of infection. The prevention of infection is the single most important goal, influencing perioperative care of patients with open fractures. Using data from 2,500 participants with open fracture ...
Full textLink to itemCite
Journal ArticleTrials · September 30, 2020
An amendment to this paper has been published and can be accessed via the original article. ...
Full textLink to itemCite
Journal ArticleOpen Forum Infect Dis · May 2020
Cefiderocol is a novel catechol siderophore cephalosporin antibiotic developed to treat resistant gram-negative infections. We describe its successful use as rescue therapy, combined with surgical debridement, to treat a patient with osteomyelitis due to e ...
Full textLink to itemCite
Journal ArticlePlast Reconstr Surg · July 2018
BACKGROUND: Soft-tissue complications often dictate the success of limb salvage and the overall outcome of open fractures. Based on prior work at the R Adams Cowley Shock Trauma Center, the authors hypothesize that wounds larger than 200 cm are associated ...
Full textLink to itemCite
Journal ArticleBMC Musculoskelet Disord · April 20, 2018
BACKGROUND: The objective of this analysis is to evaluate the necessity of large clinical trials using FLOW trial data. METHODS: The FLOW pilot study and definitive trial were factorial trials evaluating the effect of different irrigation solutions and pre ...
Full textLink to itemCite
Journal ArticleFoot Ankle Int · October 2017
BACKGROUND: The study objective was to examine the effect of time and fracture severity on the undiluted synovial fluid (SF) microenvironment during the acute phase following intra-articular fracture (IAF) of the human ankle. METHODS: Ankle SF from 54 pati ...
Full textLink to itemCite
Journal ArticleJ Orthop Trauma · April 2017
Severe foot and ankle injuries are complex and challenging to treat, often requiring multiple operations to salvage the limb contributing to a prolonged healing period. There is some evidence to suggest that early amputation for some patients may result in ...
Full textLink to itemCite
Journal ArticleJ Orthop Trauma · April 2017
A number of clinical studies in the spine literature suggest that the use of local vancomycin powder may substantially reduce surgical site infections (SSIs). These studies are primarily retrospective and observational and few focus on orthopaedic trauma p ...
Full textLink to itemCite
Journal ArticleInjury · December 2016
BACKGROUND: Antibiotic-impregnated cement nails are used to treat postoperative deep infections after primary intramedullary nail insertion for the treatment of tibial fractures. Few data exist regarding the efficacy of this treatment strategy. We hypothes ...
Full textLink to itemCite
Journal ArticleArthritis Rheumatol · May 2015
OBJECTIVE: The inflammatory response following an articular fracture is thought to play a role in the development of posttraumatic arthritis (PTA) but has not been well characterized. The objective of this study was to characterize the acute inflammatory r ...
Full textLink to itemCite
Journal ArticleJ Hand Surg Am · September 2005
PURPOSE: To evaluate the progression of Depuytren's nodules with more than 6 years of follow-up study. METHODS: Fifty-nine patients who presented initially with Dupuytren's nodules returned for physical examination at an average follow-up period of 8.7 yea ...
Full textLink to itemCite