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Rachel Mary Reilly

Assistant Professor of Orthopaedic Surgery
Orthopaedic Surgery

Selected Publications


Skin Antisepsis before Surgical Fixation of Extremity Fractures.

Journal Article N Engl J Med · February 1, 2024 BACKGROUND: Studies evaluating surgical-site infection have had conflicting results with respect to the use of alcohol solutions containing iodine povacrylex or chlorhexidine gluconate as skin antisepsis before surgery to repair a fractured limb (i.e., an ... Full text Link to item Cite

The VANCO Trial Findings Are Generalizable to a North American Trauma Registry.

Journal Article J Orthop Trauma · January 1, 2024 OBJECTIVES: To estimate the generalizability of treatment effects observed in the VANCO trial to a broader population of patients with tibial plateau or pilon fractures. METHODS: Design and Setting: Clinical trial data from 36 United States trauma centers ... Full text Link to item Cite

Do superficial infections increase the risk of deep infections in tibial plateau and plafond fractures?

Journal Article Eur J Orthop Surg Traumatol · October 2023 PURPOSE: Open reduction internal fixation of tibial plateau and pilon fractures may be complicated by deep surgical site infection requiring operative debridement and antibiotic therapy. The management of superficial surgical site infection is controversia ... Full text Link to item Cite

The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes.

Journal Article Injury · March 6, 2023 BACKGROUND: Heterotopic ossification (HO) is a common complication after surgical fixation of acetabular fractures. Numerous strategies have been employed to prevent HO formation, but results are mixed and optimal treatment strategy remains controversial. ... Full text Link to item Cite

Pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study

Journal Article Pilot and Feasibility Studies · December 1, 2021 Background: Preoperative antiseptic skin solutions are used prior to most surgical procedures; however, there is no definitive research comparing infection-related outcomes following use of the various solutions available to orthopedic trauma surgeons. The ... Full text Cite

Outcomes Following Severe Distal Tibial, Ankle, and/or Mid/Hindfoot Trauma: Comparison of Limb Salvage and Transtibial Amputation (OUTLET).

Journal Article J Bone Joint Surg Am · September 1, 2021 BACKGROUND: Selecting the best treatment for patients with severe terminal lower-limb injury remains a challenge. For some injuries, amputation may result in better outcomes than limb salvage. This study compared the outcomes of patients who underwent limb ... Full text Link to item Cite

Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials

Journal Article Contemporary Clinical Trials Communications · June 1, 2021 Introduction: Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may not be ... Full text Cite

Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial.

Journal Article JAMA Surg · May 1, 2021 IMPORTANCE: Despite the widespread use of systemic antibiotics to prevent infections in surgically treated patients with fracture, high rates of surgical site infection persist. OBJECTIVE: To examine the effect of intrawound vancomycin powder in reducing d ... Full text Link to item Cite

Managing work flow in high enrolling trials: The development and implementation of a sampling strategy in the PREPARE trial

Journal Article Contemporary Clinical Trials Communications · March 1, 2021 Introduction: Pragmatic trials in comparative effectiveness research assess the effects of different treatment, therapeutic, or healthcare options in clinical practice. They are characterized by broad eligibility criteria and large sample sizes, which can ... Full text Cite

Risk Factors Associated With Infection in Open Fractures of the Upper and Lower Extremities.

Journal Article J Am Acad Orthop Surg Glob Res Rev · December 8, 2020 INTRODUCTION: Open fractures are associated with a high risk of infection. The prevention of infection is the single most important goal, influencing perioperative care of patients with open fractures. Using data from 2,500 participants with open fracture ... Full text Link to item Cite

Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials.

Journal Article Trials · September 30, 2020 An amendment to this paper has been published and can be accessed via the original article. ... Full text Link to item Cite

Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol.

Journal Article Open Forum Infect Dis · May 2020 Cefiderocol is a novel catechol siderophore cephalosporin antibiotic developed to treat resistant gram-negative infections. We describe its successful use as rescue therapy, combined with surgical debridement, to treat a patient with osteomyelitis due to e ... Full text Link to item Cite

Wound Surface Area as a Risk Factor for Flap Complications among Patients with Open Fractures.

Journal Article Plast Reconstr Surg · July 2018 BACKGROUND: Soft-tissue complications often dictate the success of limb salvage and the overall outcome of open fractures. Based on prior work at the R Adams Cowley Shock Trauma Center, the authors hypothesize that wounds larger than 200 cm are associated ... Full text Link to item Cite

Are large clinical trials in orthopaedic trauma justified?

Journal Article BMC Musculoskelet Disord · April 20, 2018 BACKGROUND: The objective of this analysis is to evaluate the necessity of large clinical trials using FLOW trial data. METHODS: The FLOW pilot study and definitive trial were factorial trials evaluating the effect of different irrigation solutions and pre ... Full text Link to item Cite

Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture.

Journal Article Foot Ankle Int · October 2017 BACKGROUND: The study objective was to examine the effect of time and fracture severity on the undiluted synovial fluid (SF) microenvironment during the acute phase following intra-articular fracture (IAF) of the human ankle. METHODS: Ankle SF from 54 pati ... Full text Link to item Cite

Outcomes After Severe Distal Tibia, Ankle, and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation (OUTLET).

Journal Article J Orthop Trauma · April 2017 Severe foot and ankle injuries are complex and challenging to treat, often requiring multiple operations to salvage the limb contributing to a prolonged healing period. There is some evidence to suggest that early amputation for some patients may result in ... Full text Link to item Cite

Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter, Randomized, Controlled Trial (VANCO Study).

Journal Article J Orthop Trauma · April 2017 A number of clinical studies in the spine literature suggest that the use of local vancomycin powder may substantially reduce surgical site infections (SSIs). These studies are primarily retrospective and observational and few focus on orthopaedic trauma p ... Full text Link to item Cite

Are antibiotic nails effective in the treatment of infected tibial fractures?

Journal Article Injury · December 2016 BACKGROUND: Antibiotic-impregnated cement nails are used to treat postoperative deep infections after primary intramedullary nail insertion for the treatment of tibial fractures. Few data exist regarding the efficacy of this treatment strategy. We hypothes ... Full text Link to item Cite

Skin Antisepsis before Surgical Fixation of Extremity Fractures.

Journal Article N Engl J Med · February 1, 2024 BACKGROUND: Studies evaluating surgical-site infection have had conflicting results with respect to the use of alcohol solutions containing iodine povacrylex or chlorhexidine gluconate as skin antisepsis before surgery to repair a fractured limb (i.e., an ... Full text Link to item Cite

The VANCO Trial Findings Are Generalizable to a North American Trauma Registry.

Journal Article J Orthop Trauma · January 1, 2024 OBJECTIVES: To estimate the generalizability of treatment effects observed in the VANCO trial to a broader population of patients with tibial plateau or pilon fractures. METHODS: Design and Setting: Clinical trial data from 36 United States trauma centers ... Full text Link to item Cite

Do superficial infections increase the risk of deep infections in tibial plateau and plafond fractures?

Journal Article Eur J Orthop Surg Traumatol · October 2023 PURPOSE: Open reduction internal fixation of tibial plateau and pilon fractures may be complicated by deep surgical site infection requiring operative debridement and antibiotic therapy. The management of superficial surgical site infection is controversia ... Full text Link to item Cite

The impact of heterotopic ossification prophylaxis after surgical fixation of acetabular fractures: national treatment patterns and related outcomes.

Journal Article Injury · March 6, 2023 BACKGROUND: Heterotopic ossification (HO) is a common complication after surgical fixation of acetabular fractures. Numerous strategies have been employed to prevent HO formation, but results are mixed and optimal treatment strategy remains controversial. ... Full text Link to item Cite

Pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study

Journal Article Pilot and Feasibility Studies · December 1, 2021 Background: Preoperative antiseptic skin solutions are used prior to most surgical procedures; however, there is no definitive research comparing infection-related outcomes following use of the various solutions available to orthopedic trauma surgeons. The ... Full text Cite

Outcomes Following Severe Distal Tibial, Ankle, and/or Mid/Hindfoot Trauma: Comparison of Limb Salvage and Transtibial Amputation (OUTLET).

Journal Article J Bone Joint Surg Am · September 1, 2021 BACKGROUND: Selecting the best treatment for patients with severe terminal lower-limb injury remains a challenge. For some injuries, amputation may result in better outcomes than limb salvage. This study compared the outcomes of patients who underwent limb ... Full text Link to item Cite

Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials

Journal Article Contemporary Clinical Trials Communications · June 1, 2021 Introduction: Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may not be ... Full text Cite

Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial.

Journal Article JAMA Surg · May 1, 2021 IMPORTANCE: Despite the widespread use of systemic antibiotics to prevent infections in surgically treated patients with fracture, high rates of surgical site infection persist. OBJECTIVE: To examine the effect of intrawound vancomycin powder in reducing d ... Full text Link to item Cite

Managing work flow in high enrolling trials: The development and implementation of a sampling strategy in the PREPARE trial

Journal Article Contemporary Clinical Trials Communications · March 1, 2021 Introduction: Pragmatic trials in comparative effectiveness research assess the effects of different treatment, therapeutic, or healthcare options in clinical practice. They are characterized by broad eligibility criteria and large sample sizes, which can ... Full text Cite

Risk Factors Associated With Infection in Open Fractures of the Upper and Lower Extremities.

Journal Article J Am Acad Orthop Surg Glob Res Rev · December 8, 2020 INTRODUCTION: Open fractures are associated with a high risk of infection. The prevention of infection is the single most important goal, influencing perioperative care of patients with open fractures. Using data from 2,500 participants with open fracture ... Full text Link to item Cite

Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials.

Journal Article Trials · September 30, 2020 An amendment to this paper has been published and can be accessed via the original article. ... Full text Link to item Cite

Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol.

Journal Article Open Forum Infect Dis · May 2020 Cefiderocol is a novel catechol siderophore cephalosporin antibiotic developed to treat resistant gram-negative infections. We describe its successful use as rescue therapy, combined with surgical debridement, to treat a patient with osteomyelitis due to e ... Full text Link to item Cite

Wound Surface Area as a Risk Factor for Flap Complications among Patients with Open Fractures.

Journal Article Plast Reconstr Surg · July 2018 BACKGROUND: Soft-tissue complications often dictate the success of limb salvage and the overall outcome of open fractures. Based on prior work at the R Adams Cowley Shock Trauma Center, the authors hypothesize that wounds larger than 200 cm are associated ... Full text Link to item Cite

Are large clinical trials in orthopaedic trauma justified?

Journal Article BMC Musculoskelet Disord · April 20, 2018 BACKGROUND: The objective of this analysis is to evaluate the necessity of large clinical trials using FLOW trial data. METHODS: The FLOW pilot study and definitive trial were factorial trials evaluating the effect of different irrigation solutions and pre ... Full text Link to item Cite

Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture.

Journal Article Foot Ankle Int · October 2017 BACKGROUND: The study objective was to examine the effect of time and fracture severity on the undiluted synovial fluid (SF) microenvironment during the acute phase following intra-articular fracture (IAF) of the human ankle. METHODS: Ankle SF from 54 pati ... Full text Link to item Cite

Outcomes After Severe Distal Tibia, Ankle, and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation (OUTLET).

Journal Article J Orthop Trauma · April 2017 Severe foot and ankle injuries are complex and challenging to treat, often requiring multiple operations to salvage the limb contributing to a prolonged healing period. There is some evidence to suggest that early amputation for some patients may result in ... Full text Link to item Cite

Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter, Randomized, Controlled Trial (VANCO Study).

Journal Article J Orthop Trauma · April 2017 A number of clinical studies in the spine literature suggest that the use of local vancomycin powder may substantially reduce surgical site infections (SSIs). These studies are primarily retrospective and observational and few focus on orthopaedic trauma p ... Full text Link to item Cite

Are antibiotic nails effective in the treatment of infected tibial fractures?

Journal Article Injury · December 2016 BACKGROUND: Antibiotic-impregnated cement nails are used to treat postoperative deep infections after primary intramedullary nail insertion for the treatment of tibial fractures. Few data exist regarding the efficacy of this treatment strategy. We hypothes ... Full text Link to item Cite

Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines.

Journal Article Arthritis Rheumatol · May 2015 OBJECTIVE: The inflammatory response following an articular fracture is thought to play a role in the development of posttraumatic arthritis (PTA) but has not been well characterized. The objective of this study was to characterize the acute inflammatory r ... Full text Link to item Cite

A retrospective review of the management of Dupuytren's nodules.

Journal Article J Hand Surg Am · September 2005 PURPOSE: To evaluate the progression of Depuytren's nodules with more than 6 years of follow-up study. METHODS: Fifty-nine patients who presented initially with Dupuytren's nodules returned for physical examination at an average follow-up period of 8.7 yea ... Full text Link to item Cite