Scholars@Duke
Rajendra H. Mehta

Rajendra H. Mehta

Consulting Professor in the Department of Medicine
Medicine, Cardiology
Duke North, Durham, NC 27710

Selected Publications

Acute Heart Failure: Diagnostic-Therapeutic Pathways and Preventive Strategies-A Real-World Clinician's Guide.

Journal Article J Clin Med · January 20, 2023 Acute heart failure (AHF) is the most frequent cause of unplanned hospital admission in patients of >65 years of age and it is associated with significantly increased morbidity, mortality, and healthcare costs. Different AHF classification criteria have be ... Full text Link to item Cite

Predictors and associated clinical outcomes of low cardiac output syndrome following cardiac surgery: insights from the LEVO-CTS trial.

Journal Article Eur Heart J Acute Cardiovasc Care · November 30, 2022 AIMS: High-risk cardiac surgery is commonly complicated by low cardiac output syndrome (LCOS), which is associated with high mortality. There are limited data derived from multi-centre studies with adjudicated endpoints describing factors associated with L ... Full text Link to item Cite

Evaluating Statin Tolerability in Historically Intolerant Patients After Correcting for Subclinical Hypothyroidism and Vitamin D Insufficiency.

Journal Article High Blood Press Cardiovasc Prev · September 2022 INTRODUCTION: Atherosclerotic cardiovascular disease (ASCVD) is the major cause of morbidity and mortality worldwide. Statins provide primary and secondary ASCVD prevention. Intolerance due to statin-associated myalgias reduces long-term adherence, thus mu ... Full text Link to item Cite

Prophylactic levosimendan in patients with low ejection fraction undergoing coronary artery bypass grafting: A pooled analysis of two multicentre randomised controlled trials.

Journal Article Anaesth Crit Care Pain Med · August 2022 OBJECTIVES: To assess the effect of preoperative levosimendan on mortality at day 90 in patients with left ventricular ejection fraction (LVEF) ≤ 40%, and to investigate a possible differential effect between patients undergoing isolated coronary artery by ... Full text Link to item Cite

Associated factors and clinical outcomes in mechanical circulatory support use in patients undergoing high risk on-pump cardiac surgery: Insights from the LEVO-CTS trial.

Journal Article Am Heart J · June 2022 BACKGROUND: We describe variables and outcomes associated with peri-operative mechanical circulatory support (MCS) utilization among patients enrolled in the Levosimendan in patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Req ... Full text Link to item Cite

Clinical and cardiac magnetic resonance findings in post-COVID patients referred for suspected myocarditis.

Journal Article Clin Res Cardiol · November 2021 OBJECTIVES: We assessed possible myocardial involvement in previously cardiac healthy post-COVID patients referred for persisting symptoms with suspected myocarditis. BACKGROUND: Prior studies suggested myocardial inflammation in patients with coronavirus- ... Full text Link to item Cite

Preoperative Assessment and Management of Cardiovascular Risk in Patients Undergoing Non-Cardiac Surgery: Implementing a Systematic Stepwise Approach during the COVID-19 Pandemic Era.

Journal Article J Cardiovasc Dev Dis · October 3, 2021 Major adverse cardiac events, defined as death or myocardial infarction, are common causes of perioperative mortality and major morbidity in patients undergoing non-cardiac surgery. Reduction of perioperative cardiovascular risk in relation to non-cardiac ... Full text Link to item Cite

Clinical features and outcomes in patients with cardiogenic shock complicating acute myocardial infarction: early vs recent experience with impella.

Journal Article Am Heart J · August 2021 OBJECTIVES: To compare clinical features and outcomes in patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) treated in the early experience with Impella percutaneous ventricular assist device and patients treated recently. B ... Full text Link to item Cite

Cardiogenic Shock Complicating Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention Supported by Impella: Implications of Advanced Age and Refractory Shock on Outcomes.

Journal Article Crit Care Explor · June 2021 UNLABELLED: With percutaneous left ventricular mechanical circulatory support devices becoming increasingly available for patients with cardiogenic shock due to acute myocardial infarction and the lack of a clear mortality benefit to date, identifying opti ... Full text Link to item Cite

Unmasking Severe Tricuspid Valve Regurgitation After Percutaneous Debulking of Large Tricuspid Vegetation.

Journal Article JACC Case Rep · May 2021 A 27-year-old man admitted with tricuspid valve endocarditis with a large vegetation, persistent bacteremia, and pulmonary and systemic septic embolization was deemed not a suitable surgical candidate. He underwent percutaneous vegetation debulking using t ... Full text Link to item Cite

Differences in Baseline Characteristics and Outcomes in Young Caucasians and African Americans with Acute Myocardial Infarction.

Journal Article Am J Med Sci · February 2021 BACKGROUND: The incidence of acute myocardial infarction (AMI) in young patients is increasing. While race-related differences in clinical characteristics and outcomes for older AMI patients have been well-studied, such differences in young patients are un ... Full text Link to item Cite

Association between levosimendan, postoperative AKI, and mortality in cardiac surgery: Insights from the LEVO-CTS trial.

Journal Article Am Heart J · January 2021 OBJECTIVES: We aimed to evaluate the association between levosimendan treatment and acute kidney injury (AKI) as well as assess the clinical sequelae of AKI in cardiac surgery patients with depressed left ventricular function (ejection fraction <35%). METH ... Full text Link to item Cite

Treatment of heavily calcified coronary artery stenosis using 3.5 mm peripheral intravascular lithotripsy balloon: case series.

Journal Article Eur Heart J Case Rep · October 2020 BACKGROUND: Prevalence of coronary artery calcification is high among patients with advanced age, chronic kidney disease, and diabetes. Percutaneous coronary intervention of heavily calcified coronary artery remains a significant challenge for intervention ... Full text Link to item Cite

Reply: Treating Chronic Total Occlusions Successfully.

Journal Article JACC Cardiovasc Interv · August 10, 2020 Full text Link to item Cite

Association of Operator and Hospital Experience With Procedural Success Rates and Outcomes in Patients Undergoing Percutaneous Coronary Interventions for Chronic Total Occlusions: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium.

Journal Article Circ Cardiovasc Interv · August 2020 BACKGROUND: An inverse relationship has been described between procedural success and outcomes of all major cardiovascular procedures. However, this relationship has not been studied for percutaneous coronary intervention (PCI) of chronic total occlusion ( ... Full text Link to item Cite

Imaging Cardiovascular Emergencies: Real World Clinical Cases.

Journal Article Heart Fail Clin · July 2020 Cardiovascular emergencies represent life-threatening conditions requiring a high index of clinical suspicion. In an emergency scenario, a simple stepwise biomarker/imaging diagnostic algorithm may help prompt diagnosis and timely treatment along with rela ... Full text Link to item Cite

Percutaneous Coronary Intervention for Chronic Total Occlusion-The Michigan Experience: Insights From the BMC2 Registry.

Journal Article JACC Cardiovasc Interv · June 8, 2020 OBJECTIVES: The aim of this study was to describe the performance and outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in Michigan. BACKGROUND: CTO PCI has been associated with reduction in angina, but previous registry an ... Full text Link to item Cite

Levosimendan in patients with reduced left ventricular function undergoing isolated coronary or valve surgery.

Journal Article J Thorac Cardiovasc Surg · June 2020 OBJECTIVE: In the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial, no differences in clinical outcomes were observed between levosimendan and placebo in a broa ... Full text Link to item Cite

Comparison of nationwide trends in 30-day readmission rates after carotid artery stenting and carotid endarterectomy.

Journal Article J Vasc Surg · April 2020 OBJECTIVE: Carotid revascularization procedures, carotid artery stenting (CAS) and carotid endarterectomy (CEA), are among the most common vascular interventions performed in the United States, with significant resource utilization. Whereas multiple studie ... Full text Link to item Cite

Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease: Insights From the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Trial.

Journal Article JAMA Cardiol · February 1, 2020 IMPORTANCE: Although cardiovascular (CV) disease represents the leading cause of morbidity and mortality that increases with age, the best noninvasive test to identify older patients at risk for CV events remains unknown. OBJECTIVE: To determine whether th ... Full text Link to item Cite

Major bleeding in patients with peripheral artery disease: Insights from the EUCLID trial.

Journal Article Am Heart J · February 2020 BACKGROUND: Rates and predictors of major bleeding in patients with peripheral artery disease (PAD) treated with antiplatelets have not been well studied. This post hoc analysis of EUCLID aimed to determine the incidence of major/minor bleeding, predictors ... Full text Open Access Link to item Cite

Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial.

Journal Article Lancet · September 28, 2019 BACKGROUND: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin ... Full text Link to item Cite

Meta-analysis of fractional flow reserve guided complete revascularization versus infarct related artery only revascularization in patients with ST-elevation myocardial infarction and multivessel coronary artery disease.

Journal Article Coron Artery Dis · September 2019 BACKGROUND: Multivessel coronary artery disease is found in 30-50% of patients with ST-elevation myocardial infarction (MI) and is associated with adverse outcomes. It is not yet clear if outcomes are improved by utilizing fractional flow reserve (FFR) gui ... Full text Link to item Cite

Association of Race with Long-Term Outcomes in Patients Undergoing Popliteal and Infra-Popliteal Percutaneous Peripheral Arterial Interventions.

Journal Article Cardiovasc Revasc Med · August 2019 BACKGROUND: Race-related differences in clinical features, presentation, treatment and outcomes of patients with various cardiovascular diseases have been reported in previous studies. However, the long-term outcomes in black versus white patients with pop ... Full text Link to item Cite

Meta-analysis of drug eluting stents compared with bare metal stents in high bleeding risk patients undergoing percutaneous coronary interventions.

Journal Article Catheter Cardiovasc Interv · July 1, 2019 OBJECTIVES: To determine the efficacy and safety of drug-eluting stents (DESs) and bare metal stents (BMSs) when used with short or tailored dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients. BACKGROUND: DES have been shown to reduce ta ... Full text Link to item Cite

Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials.

Journal Article Circulation · February 12, 2019 BACKGROUND: Modern cardiometabolic clinical trials often include cardiovascular death as a component of a composite primary outcome, requiring central adjudication by a clinical events committee to classify cause of death. However, sometimes the cause of d ... Full text Link to item Cite

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.

Journal Article Lancet · October 27, 2018 BACKGROUND: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine t ... Full text Link to item Cite

Long-term outcomes of patients with diabetes mellitus undergoing percutaneous intervention for popliteal and infrapopliteal peripheral arterial disease.

Journal Article Catheter Cardiovasc Interv · July 2018 OBJECTIVES: To evaluate the association of diabetes mellitus (DM) with clinical and angiographic characteristics and outcomes of patients with popliteal and infrapopliteal peripheral arterial disease (PAD) undergoing peripheral vascular intervention (PVI). ... Full text Link to item Cite

Meta-Analysis of Transcatheter Valve-in-Valve Implantation Versus Redo Aortic Valve Surgery for Bioprosthetic Aortic Valve Dysfunction.

Journal Article Am J Cardiol · June 15, 2018 Transcatheter valve-in-valve implantation (ViV-TAVI) has evolved as an alternative to redo surgical valve replacement (redo-SAVR) for high-risk patients with aortic bioprosthetic valve (BPV) dysfunction. The differences in procedural success and outcomes i ... Full text Link to item Cite

In-hospital outcomes after transcatheter or surgical aortic valve replacement in younger patients less than 75 years old: a propensity-matched comparison.

Journal Article EuroIntervention · May 20, 2018 AIMS: Randomised trials comparing transcatheter aortic valve replacement (TAVR) with surgical aortic valve replacement (SAVR) have included mainly elderly patients >80 years. The authors investigated comparative in-hospital outcomes of younger patients <75 ... Full text Link to item Cite

Early Versus Delayed Use of Ultrasound-Assisted Catheter-Directed Thrombolysis in Patients With Acute Submassive Pulmonary Embolism.

Journal Article J Invasive Cardiol · May 2018 OBJECTIVES: The effect of early vs delayed use of ultrasound-assisted catheter-directed thrombolysis (USAT) on invasive hemodynamics and in-hospital outcomes in patients with acute submassive pulmonary embolism (PE) is not well known. METHODS: We evaluated ... Link to item Cite

Incidence and outcomes of emergent cardiac surgery during transfemoral transcatheter aortic valve implantation (TAVI): insights from the European Registry on Emergent Cardiac Surgery during TAVI (EuRECS-TAVI).

Journal Article Eur Heart J · February 21, 2018 AIMS: Life-threatening complications occur during transcatheter aortic valve implantation (TAVI) which can require emergent cardiac surgery (ECS). Risks and outcomes of patients needing ECS during or immediately after TAVI are still unclear. METHODS AND RE ... Full text Link to item Cite

Association of Anemia With Outcomes in Patients Undergoing Percutaneous Peripheral Vascular Intervention: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2 VIC).

Journal Article J Invasive Cardiol · January 2018 OBJECTIVES: To evaluate the clinical features and outcomes of patients with anemia undergoing percutaneous peripheral vascular intervention (PVI) in a contemporary registry. METHODS: We evaluated the differences in the clinical features and outcomes of pat ... Link to item Cite

The association of race with quality of health in peripheral artery disease following peripheral vascular intervention: The Q-PAD Study.

Journal Article Vasc Med · December 2017 Black patients have a higher prevalence of peripheral artery disease (PAD) than white patients, and also tend to have a greater extent and severity of disease, and poorer outcomes. The association of race with quality of health (QOH) after peripheral vascu ... Full text Link to item Cite

Levosimendan in Cardiac Surgery.

Journal Article N Engl J Med · November 9, 2017 Full text Link to item Cite

Volume-outcome relationship with transfemoral transcatheter aortic valve implantation (TAVI): insights from the compulsory German Quality Assurance Registry on Aortic Valve Replacement (AQUA).

Journal Article EuroIntervention · October 20, 2017 AIMS: Previous studies have shown lower rates of in-hospital complications and mortality for patients undergoing surgical aortic valve replacement (sAVR) in high-volume compared with lower-volume hospitals. It was the aim of our study to analyse whether th ... Full text Link to item Cite

The Association of Gender with Quality of Health in Peripheral Arterial Disease Following Peripheral Vascular Intervention

Journal Article Vascular Disease Management · October 1, 2017 BACKGROUND: Women and men have similar prevalence of peripheral arterial disease (PAD). However, women are reported to have more severe disease and worse claudication symptoms than men. The association of the gender-related differences in PAD-specific heal ... Cite

Distal Cuff Occlusion: A Novel, Simple Approach for Distal Embolic Protection in Peripheral Vascular Intervention.

Journal Article J Invasive Cardiol · September 2017 AIM: To evaluate the feasibility, effectiveness, and safety of the cuff-occlusion method for distal embolic protection in peripheral artery disease. METHODS AND RESULTS: We evaluated 61 patients who underwent peripheral vascular intervention (PVI) for infr ... Link to item Cite

Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery.

Journal Article N Engl J Med · May 25, 2017 BACKGROUND: Levosimendan is an inotropic agent that has been shown in small studies to prevent or treat the low cardiac output syndrome after cardiac surgery. METHODS: In a multicenter, randomized, placebo-controlled, phase 3 trial, we evaluated the effica ... Full text Link to item Cite

Nonsteroidal Anti-Inflammatory Drugs and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Surgery.

Journal Article Am J Med · April 2017 BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in perioperative pain management of patients undergoing coronary artery bypass graft surgery. However, the association of periprocedural use of NSAIDs and clinical outcomes after c ... Full text Link to item Cite

Is mortality a useful parameter for public reporting in pacemaker implantation? Results of an obligatory external quality control programme.

Journal Article Europace · April 1, 2017 AIMS: To evaluate if public reporting of pacemaker implantation-associated mortality is meaningful in a large contemporary patient cohort. METHODS AND RESULTS: The database of the obligatory external quality control programme in the Federal State of Hessen ... Full text Link to item Cite

Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial.

Journal Article Am Heart J · December 2016 BACKGROUND: Low cardiac output syndrome is associated with increased mortality and occurs in 3% to 14% of patients undergoing cardiac surgery on cardiopulmonary bypass (CPB). Levosimendan, a novel calcium sensitizer and KATP channel activator with inotropi ... Full text Link to item Cite

Outcomes of transfemoral transcatheter aortic valve implantation at hospitals with and without on-site cardiac surgery department: insights from the prospective German aortic valve replacement quality assurance registry (AQUA) in 17 919 patients.

Journal Article Eur Heart J · July 21, 2016 AIMS: Performing transcatheter aortic valve implantation (TAVI) at hospitals with only cardiology department but no cardiac surgery (CS) on-site is at great odds with current Guidelines. METHODS AND RESULTS: We analysed data from the official, prospective ... Full text Link to item Cite

Relation of Baseline Renal Dysfunction With Outcomes in Patients Undergoing Popliteal and Infrapopliteal Percutaneous Peripheral Arterial Interventions.

Journal Article Am J Cardiol · July 15, 2016 Renal dysfunction is a major risk factor for peripheral arterial disease (PAD). Infrapopliteal PAD is associated with more co-morbid conditions and worse prognosis than suprapopliteal PAD. Long-term outcomes of patients with renal dysfunction and popliteal ... Full text Link to item Cite

Association Of Bleeding Avoidance Strategies with age-related bleeding and In-hospital mortality in patients undergoing percutaneous coronary Interventions.

Journal Article Cardiovasc Revasc Med · June 2016 BACKGROUND: The association of bleeding avoidance strategy (BAS) (consisting of a combination of radial access, bivalirudin [rather than heparin +/- glycoprotein GPIIb/IIIa antagonists], and/or vascular closure devices after femoral access) with bleeding a ... Full text Link to item Cite

Clopidogrel use After Myocardial Revascularization: Prevalence, Predictors, and One-Year Survival Rate.

Journal Article Braz J Cardiovasc Surg · April 2016 INTRODUCTION: Antiplatelet therapy after coronary artery bypass graft (CABG) has been used. Little is known about the predictors and efficacy of clopidogrel in this scenario. OBJECTIVE: Identify predictors of clopidogrel following CABG. METHODS: We evaluat ... Full text Open Access Link to item Cite

Renal failure in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention: Predictors, clinical and angiographic features, and outcomes.

Journal Article Am Heart J · March 2016 BACKGROUND: Among patients presenting with ST-segment elevation myocardial infarction (STEMI) for primary percutaneous coronary intervention (PCI), the associations between clinical outcomes and both baseline renal function and the development of acute kid ... Full text Link to item Cite

Transcatheter aortic valve implantation (TAVI) in Germany 2008-2014: on its way to standard therapy for aortic valve stenosis in the elderly?

Journal Article EuroIntervention · January 22, 2016 AIMS: In Germany, all transcatheter aortic valve implantations (TAVI) and surgical aortic valve replacements (sAVR) are registered within an obligatory quality assurance programme led by the independent AQUA Institute. We have summarised patient and proced ... Full text Link to item Cite

Novel CenterCross and MultiCross devices for the treatment of infrainguinal chronic total occlusions: initial single-centre experience.

Journal Article EuroIntervention · January 22, 2016 AIMS: Our aim was to evaluate the effectiveness and safety of CenterCross/MultiCross devices to facilitate the crossing of chronic total occlusions in peripheral arteries. METHODS AND RESULTS: This was a single-centre study in which 53 consecutive patients ... Full text Link to item Cite

Association of Hospital and Physician Characteristics and Care Processes With Racial Disparities in Procedural Outcomes Among Contemporary Patients Undergoing Coronary Artery Bypass Grafting Surgery.

Journal Article Circulation · January 12, 2016 BACKGROUND: Previous studies have reported that black patients undergoing coronary artery bypass surgery had worse outcomes than white patients, even after accounting for patient factors. The degree to which clinician, hospital, and care factors account fo ... Full text Link to item Cite

Procedural and clinical outcomes after use of the glycoprotein IIb/IIIa inhibitor abciximab for saphenous vein graft interventions.

Conference Cardiovasc Revasc Med · 2016 BACKGROUND: Percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) poses a high-risk for distal coronary thromboembolic events. Glycoprotein IIb/IIIa inhibitors are frequently used in hope of reducing the impact of this, although the safet ... Full text Link to item Cite

TAVI - A true success story

Journal Article EuroIntervention · January 1, 2016 Cite

Laser in infrapopliteal and popliteal stenosis 2 study (LIPS2): Long-term outcomes of laser-assisted balloon angioplasty versus balloon angioplasty for below knee peripheral arterial disease.

Journal Article Catheter Cardiovasc Interv · December 1, 2015 BACKGROUND: Laser-assisted balloon angioplasty (LABA) has been shown to be more effective in achieving angiographic success for treatment for below knee peripheral artery disease (PAD) compared with balloon angioplasty alone(BA). However, long-term outcome ... Full text Link to item Cite

Comparative Effectiveness of Hybrid Coronary Revascularization vs Coronary Artery Bypass Grafting.

Journal Article J Am Coll Surg · August 2015 BACKGROUND: Hybrid coronary revascularization (HCR) combines minimally invasive left internal mammary artery to left anterior descending bypass with percutaneous coronary intervention of non-left anterior descending vessels. Its safety and effectiveness co ... Full text Link to item Cite

Association between hospital procedure volume and early complications after pacemaker implantation: results from a large, unselected, contemporary cohort of the German nationwide obligatory external quality assurance programme.

Journal Article Europace · May 2015 AIMS: Several studies demonstrated an inverse relationship between cardioverter-defibrillator implantation volume and complication rates, suggesting better outcomes for higher volume centres. However, the association of institutional procedural volume with ... Full text Link to item Cite

Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion.

Journal Article Int J Cardiol · April 1, 2015 In cardiac surgery, postoperative low cardiac output has been shown to correlate with increased rates of organ failure and mortality. Catecholamines have been the standard therapy for many years, although they carry substantial risk for adverse cardiac and ... Full text Link to item Cite

Doing the right things and doing them the right way: association between hospital guideline adherence, dosing safety, and outcomes among patients with acute coronary syndrome.

Journal Article Circulation · March 17, 2015 BACKGROUND: Performance metrics currently focus on the measurement of the application of guideline-indicated medications without considering the appropriate dosing of these drugs. METHODS AND RESULTS: We studied 39 291 patients from the Can Rapid Risk Stra ... Full text Link to item Cite

Emergent cardiac surgery during transcatheter aortic valve implantation (TAVI): insights from the Edwards SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) registry.

Journal Article EuroIntervention · December 2014 AIMS: Transcatheter aortic valve implantation (TAVI) carries the risk of intraprocedural complications that may ultimately require emergent cardiac surgery (ECS). However, few data exist on the incidence, reasons and outcomes of patients needing ECS during ... Full text Link to item Cite

Differences in sex-related bleeding and outcomes after percutaneous coronary intervention: insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) registry.

Journal Article Am Heart J · October 2014 BACKGROUND: Bleeding after percutaneous coronary intervention (PCI) is more common in women than in men. However, the relationship of sex and bleeding with outcomes is less well studied. METHODS: We examined the sex-related differences in the incidence of ... Full text Link to item Cite

Transcatheter aortic valve implantation (TAVI) by centres with and without an on-site cardiac surgery programme: preliminary experience from the German TAVI registry.

Journal Article EuroIntervention · September 2014 AIMS: To analyse patient characteristics, decision-making processes, and outcomes of TAVI performed in hospitals with versus those without on-site cardiac surgery (CS). METHODS AND RESULTS: Current guidelines mandate transcatheter aortic valve implantation ... Full text Link to item Cite

Association of metabolic syndrome and its individual components with outcomes among patients with high-risk non-ST-segment elevation acute coronary syndromes.

Journal Article Am Heart J · August 2014 BACKGROUND: The relationship of metabolic syndrome and its individual components (obesity, hypertension, glucose intolerance, high triglycerides, and low high-density lipoprotein cholesterol) with 1-year mortality in non-ST-segment elevation acute coronary ... Full text Link to item Cite

Race/Ethnic differences in the risk of hemorrhagic complications among patients with ischemic stroke receiving thrombolytic therapy.

Journal Article Stroke · August 2014 BACKGROUND AND PURPOSE: Race/ethnic-related differences in safety of intravenous thrombolytic therapy have been shown in patients with myocardial infarction, but not studied in ischemic stroke. METHODS: Using data from the Get With The Guidelines (GWTG)-St ... Full text Link to item Cite

Reply: To PMID 23673070.

Journal Article Ann Thorac Surg · February 2014 Full text Link to item Cite

Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis.

Journal Article J Cardiothorac Vasc Anesth · December 2013 OBJECTIVE: Left ventricular systolic dysfunction is associated with increased morbidity and mortality in patients undergoing cardiac surgery. The authors performed a meta-analysis investigating the effects of levosimendan in cardiac surgery patients with a ... Full text Link to item Cite

Relationship between postoperative clopidogrel use and subsequent angiographic and clinical outcomes following coronary artery bypass grafting.

Journal Article J Thromb Thrombolysis · November 2013 Dual antiplatelet therapy with both aspirin and clopidogrel is increasingly used after coronary artery bypass grafting (CABG); however, little is known about the safety or efficacy. We sought to determine the relationship between postoperative clopidogrel ... Full text Link to item Cite

Association of gender and lowest hematocrit on cardiopulmonary bypass with acute kidney injury and operative mortality in patients undergoing cardiac surgery.

Journal Article Ann Thorac Surg · July 2013 BACKGROUND: Nadir hematocrit on cardiopulmonary bypass (CPB) is a known risk factor for worse outcomes after cardiac surgery. Whether women, because of lower nadir hematocrit on CPB, are more prone to worse outcomes than men after cardiac surgery remains u ... Full text Link to item Cite

Short-term outcomes of balloon angioplasty versus stent placement for patients undergoing primary percutaneous coronary intervention: Implications for patients requiring early coronary artery bypass surgery.

Journal Article Am Heart J · June 2013 BACKGROUND: In patients with acute ST-elevation myocardial infarction (STEMI) needing early coronary artery bypass graft (CABG) surgery, it is unknown whether primary percutaneous balloon angioplasty (PTCA)-without stent implantation-allows safe transition ... Full text Link to item Cite

Coronary aneurysm and purulent pericardial effusion: old disease with an unusual cause.

Journal Article Ann Thorac Surg · May 2013 We describe the case of a 60-year-old man with prior rotational atherectomy and drug-eluting stent to the left anterior descending artery (LAD) who presented with shortness of breath and chest pain 8 weeks after stent placement. Further workup revealed a l ... Full text Link to item Cite

Stroke after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction: timing, characteristics, and clinical outcomes.

Journal Article Circ Cardiovasc Interv · April 2013 BACKGROUND: Stroke is a rare but potentially devastating complication of acute myocardial infarction. Little is known about stroke timing, characteristics, and clinical outcomes in patients with ST-segment elevation myocardial infarction treated with prima ... Full text Link to item Cite

Emergent cardiac surgery during transcatheter aortic valve implantation (TAVI): a weighted meta-analysis of 9,251 patients from 46 studies.

Journal Article EuroIntervention · January 22, 2013 AIMS: Transcatheter aortic valve implantation (TAVI) is a novel treatment option for high surgical risk patients with severe symptomatic aortic valve (AV) stenosis. During TAVI, some patients may require emergent cardiac surgery (ECS). However, the inciden ... Full text Link to item Cite

Decreased readmissions and improved quality of care with the use of an inexpensive checklist in heart failure.

Journal Article Congest Heart Fail · 2013 Providing effective discharge instructions, appropriate dose uptitration, education regarding heart failure (HF) monitoring, and strict follow-up have all been shown to decrease readmissions for HF but are all underutilized. The authors developed and evalu ... Full text Link to item Cite

Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.

Journal Article N Engl J Med · October 4, 2012 BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, ... Full text Link to item Cite

Red versus white thrombi in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: clinical and angiographic outcomes.

Journal Article Am Heart J · October 2012 BACKGROUND: Aspiration thrombectomy is used in primary percutaneous coronary interventions, but the importance of thrombus constituency has been scarcely investigated. The objective of this study was to evaluate thrombus constituency and its association wi ... Full text Link to item Cite

Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) 5-year results.

Journal Article Am Heart J · September 2012 BACKGROUND: Edifoligide, an E2F transcription factor decoy, does not prevent vein graft failure or adverse clinical outcomes at 1 year in patients undergoing coronary artery bypass grafting (CABG). We compared the 5-year clinical outcomes of patients in PR ... Full text Link to item Cite

Sustained ventricular tachycardia and ventricular fibrillation complicating non-ST-segment-elevation acute coronary syndromes.

Journal Article Circulation · July 3, 2012 BACKGROUND: Ventricular arrhythmias remain a lethal complication of acute coronary syndromes (ACS). However, the incidence and prognosis of sustained ventricular tachycardia/ventricular fibrillation (VT/VF) in contemporary non-ST-segment-elevation (NSTE) A ... Full text Link to item Cite

Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes.

Journal Article JACC Cardiovasc Interv · July 2012 OBJECTIVES: The aim of this study was to address the knowledge gap using the APEX-AMI (Assessment of Pexelizumab in Acute Myocardial Infarction) trial database. We also assessed the association between serious infections and 90-day death or death/myocardia ... Full text Link to item Cite

Cardiac catheterization within 1 to 3 days of proximal aortic surgery is not associated with increased postoperative acute kidney injury.

Journal Article J Thorac Cardiovasc Surg · June 2012 OBJECTIVE: Cardiac catheterization shortly before coronary artery bypass grafting or valve surgery has been associated with increased postoperative acute kidney injury. The relationship between catheterization timing and acute kidney injury after proximal ... Full text Link to item Cite

Risk of stroke after transcatheter aortic valve implantation (TAVI): a meta-analysis of 10,037 published patients.

Journal Article EuroIntervention · May 15, 2012 AIMS: Transcatheter aortic valve implantation (TAVI) represents a novel treatment option for inoperable or high surgical risk patients with severe symptomatic aortic valve disease. Recent randomised studies have raised major safety concerns because of incr ... Full text Link to item Cite

Variations in practice and outcomes in patients undergoing primary percutaneous coronary intervention in the United States and Canada: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI) trial.

Journal Article Am Heart J · May 2012 BACKGROUND: Information on practice patterns and outcomes in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary interventions (PCIs) in Canada vs United States is limited. METHODS: We evaluated differences in clinical ... Full text Link to item Cite

Association of bleeding and in-hospital mortality in black and white patients with st-segment-elevation myocardial infarction receiving reperfusion.

Journal Article Circulation · April 10, 2012 BACKGROUND: Prior studies have suggested that blacks with acute ST-segment-elevation myocardial infarction have increased bleeding risks with fibrinolysis relative to whites, yet these data were quite limited. Additionally, it is unknown whether there are ... Full text Link to item Cite

Comparison of bleeding and in-hospital mortality in Asian-Americans versus Caucasian-Americans with ST-elevation myocardial infarction receiving reperfusion therapy.

Journal Article Am J Cardiol · April 1, 2012 Concern has been raised that Asian-Americans may have a higher bleeding risk than Caucasian-Americans when treated with fibrinolytic and antithrombotic agents. To date there is limited evidence to support or refute this hypothesis or evaluate bleeding risk ... Full text Link to item Cite

Prognostic significance of postprocedural sustained ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention (from the HORIZONS-AMI Trial).

Journal Article Am J Cardiol · March 15, 2012 The prognostic significance of postprocedure sustained ventricular tachycardia or ventricular fibrillation (VT/VF) in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) has rarely be ... Full text Link to item Cite

Relationship between vein graft failure and subsequent clinical outcomes after coronary artery bypass surgery.

Journal Article Circulation · February 14, 2012 BACKGROUND: Vein graft failure (VGF) is common after coronary artery bypass graft surgery, but its relationship with long-term clinical outcomes is unknown. In this retrospective analysis, we examined the relationship between VGF, assessed by coronary angi ... Full text Link to item Cite

Comparison of incidence of bleeding and mortality of men versus women with ST-elevation myocardial infarction treated with fibrinolysis.

Journal Article Am J Cardiol · February 1, 2012 Gender-related differences in the incidence of bleeding and its relation to subsequent mortality in patients with ST-segment elevation myocardial infarction (STEMI) treated with fibrinolysis are not well understood. We studied patients with STEMI receiving ... Full text Link to item Cite

International variation in and factors associated with hospital readmission after myocardial infarction.

Journal Article JAMA · January 4, 2012 CONTEXT: ST-segment elevation myocardial infarction (STEMI) treatment has improved outcomes and shortened hospital stay. Recently, 30-day readmission rates have been proposed as a metric for care of patients with STEMI. However, international rates and pre ... Full text Link to item Cite

Differences in clinical features and in-hospital outcomes of older adults with tako-tsubo cardiomyopathy.

Journal Article J Am Geriatr Soc · January 2012 OBJECTIVES: To describe the clinical characteristics and in-hospital outcomes of older adults with tako-tsubo cardiomyopathy (TTC). DESIGN: Partially retrospective, partially prospective observational study. SETTING: Eleven Italian referral cardiac centers ... Full text Link to item Cite

Trends and predictors of length of stay after primary percutaneous coronary intervention: a report from the CathPCI registry.

Journal Article Am Heart J · December 2011 BACKGROUND: Post hoc analyses of clinical trials suggest that certain patients are eligible for early discharge after ST-segment elevation myocardial infarction. The extent to which ST-segment elevation myocardial infarction patients are discharged early a ... Full text Link to item Cite

Valve-in-valve transcatheter aortic valve implantation for degenerated bioprosthetic heart valves.

Journal Article JACC Cardiovasc Interv · November 2011 OBJECTIVES: We sought to analyze outcomes of patients with degenerated surgically implanted bioprosthetic heart valves undergoing valve-in-valve (viv) transcatheter aortic valve implantation (TAVI). BACKGROUND: Redo cardiac surgery for degenerated bioprost ... Full text Link to item Cite

Naproxen as prophylaxis against atrial fibrillation after cardiac surgery: the NAFARM randomized trial.

Journal Article Am J Med · November 2011 PURPOSE: We sought to assess the effect of naproxen versus placebo on prevention of atrial fibrillation after coronary artery bypass graft (CABG) surgery. METHODS: In this randomized, double-blind, placebo-controlled, single-center trial of 161 consecutive ... Full text Link to item Cite

Diagnosing acute myocardial infarction in patients with left bundle branch block.

Journal Article Am J Cardiol · September 15, 2011 We compared the clinical features, laboratory and coronary angiographic findings, treatments, and outcomes among patients with ST-segment elevation myocardial infarction (MI) with and without left bundle branch block (LBBB). We examined 5,742 patients with ... Full text Link to item Cite

Relationship of the time interval between cardiac catheterization and elective coronary artery bypass surgery with postprocedural acute kidney injury.

Journal Article Circulation · September 13, 2011 BACKGROUND: Some prior studies have suggested that the time to cardiac surgery after cardiac catheterization is inversely related to postoperative acute kidney injury (AKI). However, these studies, because of the small number of patients, were unable to ad ... Full text Link to item Cite

Low-dose versus high-dose aspirin after percutaneous coronary intervention: analysis from the guthrie health off-label StenT (GHOST) registry.

Journal Article J Interv Cardiol · August 2011 BACKGROUND: The optimal dose of aspirin therapy after percutaneous coronary intervention (PCI) remains unclear. We sought to compare the effectiveness and safety of low and high doses of aspirin in preventing adverse outcomes after PCI. METHODS: We studied ... Full text Link to item Cite

Saphenous vein grafts with multiple versus single distal targets in patients undergoing coronary artery bypass surgery: one-year graft failure and five-year outcomes from the Project of Ex-Vivo Vein Graft Engineering via Transfection (PREVENT) IV trial.

Journal Article Circulation · July 19, 2011 BACKGROUND: Limited information exists on the intermediate-term graft patency and 5-year clinical outcomes of patients receiving saphenous vein grafts with multiple (m-SVG) versus single distal targets (s-SVG) during coronary artery bypass graft (CABG) sur ... Full text Link to item Cite

Clinical outcomes in patients with the concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention: an analysis from the Guthrie Health Off-Label Stent (GHOST) investigators.

Journal Article Circ Cardiovasc Interv · April 1, 2011 BACKGROUND: The concomitant use of proton pump inhibitors (PPIs) with clopidogrel is suspected to be associated with an adverse impact on clinical outcomes in patients with coronary artery disease. We sought to evaluate whether the use of PPIs with clopido ... Full text Link to item Cite

Relationship of sustained ventricular tachyarrhythmias to outcomes in patients undergoing primary percutaneous coronary intervention with varying underlying baseline risk.

Journal Article Am Heart J · April 2011 BACKGROUND: The association of sustained ventricular tachycardia/fibrillation (VT/VF) with mortality in patients undergoing primary percutaneous coronary intervention (PCI) may vary with baseline patient risk and may be associated with higher mortality in ... Full text Link to item Cite

Age and outcomes in ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: findings from the APEX-AMI trial.

Journal Article Arch Intern Med · March 28, 2011 BACKGROUND: To understand the influence of age on treatment and outcomes, we analyzed the largest group of patients 75 years or older with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention (PPCI) in a clinic ... Full text Link to item Cite

Identifying patients at risk for premature discontinuation of thienopyridine after coronary stent implantation.

Journal Article Am J Cardiol · March 1, 2011 We sought to identify patients at risk for premature discontinuation of thienopyridines and to develop a risk score for thienopyridine adherence after coronary stent implantation. Patients were prospectively included from December 2007 to March 2008. At 1- ... Full text Link to item Cite

Association of mortality with years of education in patients with ST-segment elevation myocardial infarction treated with fibrinolysis.

Journal Article J Am Coll Cardiol · January 11, 2011 OBJECTIVES: The purpose of this study was to examine the association between lower socioeconomic status (SES), as ascertained by years of education, and outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Previou ... Full text Link to item Cite

Race, Bleeding, and Outcomes in STEMI Patients Treated with Fibrinolytic Therapy.

Journal Article Am J Med · January 2011 BACKGROUND: studies have shown higher bleeding and mortality rates among African Americans who receive fibrinolytic therapy for ST-segment elevation myocardial infarction (STEMI) compared with whites; however, the relationship of bleeding risk to mortality ... Full text Link to item Cite

Antiarrhythmic drug therapy for sustained ventricular arrhythmias complicating acute myocardial infarction.

Journal Article Crit Care Med · January 2011 OBJECTIVE: Few data exist to guide antiarrhythmic drug therapy for sustained ventricular tachycardia/ventricular fibrillation after acute myocardial infarction. The objective of this analysis was to describe the survival of patients with sustained ventricu ... Full text Link to item Cite

Impact of recovery of renal function on long-term mortality after coronary artery bypass grafting.

Journal Article Am J Cardiol · December 15, 2010 Whether prognosis differs in acute renal failure (ARF) after coronary artery bypass grafting (CABG) in patients with and without recovery of renal function is not known. We studied patients who had CABG at Duke University Medical Center (1995 to 2008). ARF ... Full text Link to item Cite

A model for predicting mortality in acute ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: results from the Assessment of Pexelizumab in Acute Myocardial Infarction Trial.

Journal Article Circ Cardiovasc Interv · October 2010 BACKGROUND: Accurate models to predict mortality are needed for risk stratification in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS AND RESULTS: We examined 5745 patie ... Full text Link to item Cite

Influence of transfer-in rates on quality of care and outcomes at receiving hospitals in patients with non-ST-segment elevation myocardial infarction.

Journal Article Am Heart J · September 2010 BACKGROUND: Patients with non-ST-segment elevation myocardial infarction (NSTEMI) are frequently transferred to tertiary hospitals for angiography and/or revascularization from hospitals lacking such capabilities. Given that patients who undergo invasive c ... Full text Link to item Cite

Triage after hospitalization with advanced heart failure: the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) risk model and discharge score.

Journal Article J Am Coll Cardiol · March 2, 2010 OBJECTIVES: Identifying high-risk heart failure (HF) patients at hospital discharge may allow more effective triage to management strategies. BACKGROUND: Heart failure severity at presentation predicts outcomes, but the prognostic importance of clinical st ... Full text Link to item Cite

N-terminal pro-brain natriuretic peptide and outcomes in patients undergoing surgical ventricular restoration.

Journal Article Am J Cardiol · March 1, 2010 N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels have been shown to be increased at baseline in patients undergoing surgical ventricular restoration (SVR) of the left ventricle. However, changes in the values of this marker in the early postope ... Full text Link to item Cite

Warfarin use and outcomes in patients with atrial fibrillation complicating acute coronary syndromes.

Journal Article Am J Med · February 2010 BACKGROUND: We examined warfarin use at discharge (according to Congestive heart failure, Hypertension, Age>75 years, Diabetes, Prior Stroke/transient ischemic attack score and bleeding risk) and its association with 6-month death or myocardial infarction ... Full text Link to item Cite

Percutaneous coronary intervention or coronary artery bypass surgery for cardiogenic shock and multivessel coronary artery disease?

Journal Article Am Heart J · January 2010 BACKGROUND: Despite advances in treatment of cardiogenic shock (CS), the incidence of this serious complication of acute ST-elevation myocardial infarction (STEMI) has stayed relatively constant, and rates of mortality, although somewhat improved in recent ... Full text Link to item Cite

Reoperation for bleeding in patients undergoing coronary artery bypass surgery: incidence, risk factors, time trends, and outcomes.

Journal Article Circ Cardiovasc Qual Outcomes · November 2009 BACKGROUND: Reoperation for bleeding represents an important complication in patients undergoing coronary artery bypass surgery (CABG). Yet, few studies have characterized risk factors and patient outcomes of this event. METHODS AND RESULTS: We evaluated 5 ... Full text Link to item Cite

Retrograde ascending aortic dissection during or after thoracic aortic stent graft placement: insight from the European registry on endovascular aortic repair complications.

Conference Circulation · September 15, 2009 BACKGROUND: Single-center reports have identified retrograde ascending aortic dissection (rAAD) as a potentially lethal complication of thoracic endovascular aortic repair (TEVAR). METHODS AND RESULTS: Between 1995 and 2008, 28 centers participating in the ... Full text Link to item Cite

In reply

Journal Article JAMA · September 2, 2009 Full text Cite

Prognostic Importance of Ventricular Arrhythmia in Patients Treated With Percutaneous Coronary Intervention Reply

Journal Article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · September 2, 2009 Link to item Cite

Effectiveness and safety of carotid artery stenting for significant carotid stenosis in patients with contralateral occlusion (from the German ALKK-CAS Registry experience).

Journal Article Am J Cardiol · September 1, 2009 Data on the safety of carotid artery stenting (CAS) in a large number of unselected patients with contralateral occlusion and significant ipsilateral stenosis are less known. Accordingly, we evaluated 3,137 patients undergoing CAS who were enrolled in a Ge ... Full text Link to item Cite

Endoscopic versus open vein-graft harvesting in coronary-artery bypass surgery.

Journal Article N Engl J Med · July 16, 2009 BACKGROUND: Vein-graft harvesting with the use of endoscopy (endoscopic harvesting) is a technique that is widely used to reduce postoperative wound complications after coronary-artery bypass grafting (CABG), but the long-term effects on the rate of vein-g ... Full text Link to item Cite

Aortoesophageal fistula after thoracic aortic stent-graft placement: a rare but catastrophic complication of a novel emerging technique.

Journal Article JACC Cardiovasc Interv · June 2009 OBJECTIVES: Our goal was to report characteristics and outcomes of 6 patients with aortoesophageal fistula (AEF) after thoracic endovascular aortic repair (TEVAR). BACKGROUND: Neurologic events are severe complications of TEVAR. With growing experience of ... Full text Link to item Cite

Incidence of and outcomes associated with ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention.

Journal Article JAMA · May 6, 2009 CONTEXT: The incidence and timing of sustained ventricular tachycardia or fibrillation (VT/VF) and its impact on outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) are poorly und ... Full text Link to item Cite

Characteristics and in-hospital outcomes of patients with cardiac tamponade complicating type A acute aortic dissection.

Journal Article Am J Cardiol · April 1, 2009 Cardiac tamponade (TMP) is a life-threatening complication of acute type A aortic dissection (AAD). The purpose of this study was to assess the clinical characteristics and in-hospital outcomes of TMP in the setting of AAD on the basis of the findings in t ... Full text Link to item Cite

Pre-operative homocysteine levels and morbidity and mortality following cardiac surgery.

Journal Article Eur Heart J · April 2009 AIMS: Elevated homocysteinaemia is associated not only with an increased risk for cardiovascular disease but also for increased morbidity and mortality in patients with established coronary artery or cerebrovascular disease. Whether elevated homocysteine f ... Full text Link to item Cite

In reply

Journal Article JAMA · March 18, 2009 Full text Cite

Identifying Patients at Risk for Reoperation for Bleeding After Coronary Artery Bypass Surgery

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 10, 2009 Link to item Cite

Impact of admission blood glucose on outcomes of nondiabetic patients with acute ST-elevation myocardial infarction (from the German Acute Coronary Syndromes [ACOS] Registry).

Journal Article Am J Cardiol · March 1, 2009 High blood glucose in patients with acute coronary syndromes have been associated with adverse short-term outcomes in patients without diabetes. However, the relation of admission glucose to long-term outcomes in these patients was less well established. A ... Full text Link to item Cite

Aortic remodeling in type B aortic dissection: effects of endovascular stent-graft repair and medical treatment on true and false lumen volumes.

Journal Article J Endovasc Ther · February 2009 PURPOSE: To analyze aortic remodeling processes in terms of true (TL) and false lumen (FL) volumes in patients with type B aortic dissection undergoing thoracic endovascular aortic repair (TEVAR) versus patients treated medically. METHODS: Serial contrast- ... Full text Link to item Cite

Clinical significance of post-procedural TIMI flow in patients with cardiogenic shock undergoing primary percutaneous coronary intervention.

Journal Article JACC Cardiovasc Interv · January 2009 OBJECTIVES: We sought to evaluate the impact of post-primary percutaneous coronary intervention (PCI) Thrombolysis In Myocardial Infarction (TIMI) flow grades in the infarct-related artery (IRA) in patients with ST-segment elevation myocardial infarction ( ... Full text Link to item Cite

Association of weight change with subsequent outcomes in patients hospitalized with acute decompensated heart failure.

Journal Article Am J Cardiol · January 1, 2009 The association of weight loss achieved through various decongestive strategies with clinical outcomes in patients with acute decompensated heart failure (HF) is not well described. The aim of this study was to determine the relation between weight change ... Full text Link to item Cite

Modifiable risk factors control and its relationship with 1 year outcomes after coronary artery bypass surgery: insights from the REACH registry.

Journal Article Eur Heart J · December 2008 AIMS: To evaluate the influence of achieving secondary prevention target treatment goals for cardiovascular (CV) risk factors on clinical outcomes in patients with prior coronary artery bypass surgery (CABG). METHODS AND RESULTS: Accordingly, we analysed t ... Full text Link to item Cite

Antidepressant use, depression, and survival in patients with heart failure.

Journal Article Arch Intern Med · November 10, 2008 BACKGROUND: Recent studies suggest that the use of antidepressants may be associated with increased mortality in patients with cardiac disease. Because depression has also been shown to be associated with increased mortality in these patients, it remains u ... Full text Link to item Cite

Influence of preoperative renal dysfunction on one-year bypass graft patency and two-year outcomes in patients undergoing coronary artery bypass surgery.

Journal Article J Thorac Cardiovasc Surg · November 2008 OBJECTIVE: Limited information exists on the impact of preoperative renal dysfunction on internal thoracic artery and saphenous vein graft failure and 2-year clinical outcomes in patients undergoing coronary artery bypass surgery. METHODS: We studied the i ... Full text Link to item Cite

Association of patient case-mix adjustment, hospital process performance rankings, and eligibility for financial incentives.

Journal Article JAMA · October 22, 2008 CONTEXT: While most comparisons of hospital outcomes adjust for patient characteristics, process performance comparisons typically do not. OBJECTIVE: To evaluate the degree to which hospital process performance ratings and eligibility for financial incenti ... Full text Link to item Cite

Clinical characteristics associated with poor long-term survival among patients with diabetes mellitus undergoing saphenous vein graft interventions.

Journal Article Am Heart J · October 2008 BACKGROUND: Limited data exist on the long-term outcomes among diabetic patients undergoing saphenous vein graft (SVG) interventions. Thus, the baseline clinical factors associated with long-term adverse events in these patients are less known. METHODS: Ac ... Full text Link to item Cite

Short- and long-term outcomes following atrial fibrillation in patients with acute coronary syndromes with or without ST-segment elevation.

Journal Article Heart · July 2008 OBJECTIVE: To assess variables associated with the occurrence of atrial fibrillation (AF) and the relation of AF with short- and long-term outcomes and with other in-hospital complications in patients with acute coronary syndromes (ACS) with and without ST ... Full text Link to item Cite

Achieving rapid reperfusion with primary percutaneous coronary intervention remains a challenge: insights from American Heart Association's Get With the Guidelines program.

Journal Article Am Heart J · June 2008 BACKGROUND: The speed of reperfusion (door-to-balloon [D2B] time) is a well established performance metric for patients with ST-elevation myocardial infarction. Although preferably D2B times should be Full text Link to item Cite

Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.

Journal Article JAMA · April 16, 2008 CONTEXT: Coronary artery bypass graft (CABG) surgery is frequently performed and effective; however, perioperative complications related to ischemia-reperfusion injury, including myocardial infarction (MI), remain common and result in significant morbidity ... Full text Link to item Cite

Influence of the timing of cardiac catheterization and the amount of contrast media on acute renal failure after cardiac surgery.

Journal Article Am J Cardiol · April 15, 2008 Postoperative acute renal failure (ARF) is not uncommon after cardiac surgery and after angiography. However, limited information exists regarding the influence of the interval between cardiac catheterization and subsequent cardiac surgery and amount of co ... Full text Link to item Cite

Clinical implications of systemic inflammatory response syndrome following thoracic aortic stent-graft placement.

Journal Article J Endovasc Ther · April 2008 PURPOSE: To quantify inflammatory markers in a large cohort of patients undergoing thoracic endovascular aortic repair (TEVAR) and investigate if profound biomarker elevations may be predictors of postprocedural death. METHODS: We analyzed data from 103 pa ... Full text Link to item Cite

A randomized, double-blind, placebo-controlled, multicenter study to evaluate the cardioprotective effects of MC-1 in patients undergoing high-risk coronary artery bypass graft surgery: MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery Trial (MEND-CABG) II--study design and rationale.

Journal Article Am Heart J · April 2008 BACKGROUND: Coronary artery bypass graft (CABG) surgery is effective in relieving angina and improving survival and quality of life in patients with obstructive coronary artery disease; however, recurrent angina, myocardial infarction, neurological injury, ... Full text Link to item Cite

Variation in the use of stress testing and outcomes in patients with non-ST-elevation acute coronary syndromes: insights from GUSTO IIb.

Journal Article Eur Heart J · April 2008 AIMS: Non-invasive risk stratification of low- and intermediate-risk non-ST-elevation acute coronary syndromes (NSTE ACS) patients has been recommended, but limited data exist about the variation in clinical practice of stress testing in these patients and ... Full text Link to item Cite

Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go.

Journal Article Eur Heart J · March 2008 AIM: Many patients who are eligible for acute reperfusion therapy receive it after substantial delays or not at all. We wanted to determine whether over the years more patients are receiving reperfusion therapy. METHODS AND RESULTS: This analysis is based ... Full text Link to item Cite

Clinical characteristics and in-hospital outcomes of patients with cardiogenic shock undergoing coronary artery bypass surgery: insights from the Society of Thoracic Surgeons National Cardiac Database.

Journal Article Circulation · February 19, 2008 BACKGROUND: There exist few studies that characterize contemporary clinical features and outcomes or risk factors for operative mortality in cardiogenic shock (CS) patients undergoing coronary artery bypass grafting (CABG). METHODS AND RESULTS: We evaluate ... Full text Link to item Cite

Body mass index and effectiveness of reperfusion strategies: implications for the management of patients with ST-elevation myocardial infarction.

Journal Article J Interv Cardiol · February 2008 BACKGROUND: Fibrinolytic therapy has maximum dose limit in patients with ST-elevation myocardial infarction (STEMI). Consequently, obese patients receive lower dose of fibrinolytic per kg body weight compared to lower weight patients. Whether the relativel ... Full text Link to item Cite

Outcomes with the use of glycoprotein IIb/IIIa inhibitors in non-ST-segment elevation acute coronary syndromes.

Journal Article Heart · February 2008 OBJECTIVE: To compare the characteristics, management, and outcomes of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) who would have been eligible for inclusion in clinical trials of glycoprotein (GP) IIb/IIIa inhibitors with th ... Full text Link to item Cite

Clinical and angiographic correlates of short- and long-term mortality in patients undergoing coronary artery bypass grafting.

Journal Article Am J Cardiol · November 15, 2007 Differences in the clinical and angiographic factors associated with short- and long-term outcomes in patients undergoing coronary artery bypass grafting (CABG) are less known. Accordingly, differences were examined in clinical and angiographic correlates ... Full text Link to item Cite

Clinical quality in non-ST-elevation acute coronary syndromes.

Journal Article Am J Med · November 2007 We have entered a new era of medicine in which both the interest of scientific rigor and pressure from health care purchasers demand increased adoption of empirically based standards of care. Certain therapeutic areas have seen rapid transformation from a ... Full text Link to item Cite

The relation between clinical features, angiographic findings, and the target lesion revascularization rate in patients receiving the endeavor zotarolimus-eluting stent for treatment of native coronary artery disease: an analysis of ENDEAVOR I, ENDEAVOR II, ENDEAVOR II Continued Access Registry, and ENDEAVOR III.

Journal Article Am J Cardiol · October 22, 2007 The clinical and angiographic factors that predict clinically driven target lesion revascularization (TLR) in patients treated with the zotarolimus-eluting stent (ZES) are not known. Accordingly, the differences between ZES-treated patients who required TL ... Full text Link to item Cite

Trials and tribulations of carotid artery stenting: The Interventionalists' perspective on SAPPHIRE, EVA-3S, and SPACE Trials.

Journal Article J Interv Cardiol · October 2007 Three recently completed randomized studies of carotid artery stenting (CAS) versus endarterectomy-Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy (SAPPHIRE), Endarterectomy versus Stenting in Patients with Symptomatic ... Full text Link to item Cite

Acute ST-segment elevation myocardial infarction: critical care perspective.

Journal Article Crit Care Clin · October 2007 More than 1.2 million patients suffer from new or recurrent ischemic events occur annually. This includes an estimated 565,000 cases of first and 300,000 cases of recurrent myocardial infarction (MI). Although mortality from acute MI has declined in recent ... Full text Link to item Cite

Timing of death and myocardial infarction in patients with non-ST elevation acute coronary syndromes: insights from randomized clinical trials.

Journal Article J Interv Cardiol · October 2007 BACKGROUND: Adverse events occur following non-ST elevation acute coronary syndromes (NSTE ACS). However, the timing of these events in relation to index event is less clear. METHODS: Accordingly, we evaluated 26,466 NSTE ACS patients from the Global Use o ... Full text Link to item Cite

Influence of inpatient service specialty on care processes and outcomes for patients with non ST-segment elevation acute coronary syndromes.

Journal Article Circulation · September 4, 2007 BACKGROUND: Since the broad dissemination of practice guidelines, the association of specialty care with the treatment of patients with acute coronary syndromes has not been studied. METHODS AND RESULTS: We evaluated 55 994 patients with non-ST-segment ele ... Full text Link to item Cite

The association between guideline-based treatment instructions at the point of discharge and lower 1-year mortality in Medicare patients after acute myocardial infarction: the American College of Cardiology's Guidelines Applied in Practice (GAP) initiative in Michigan.

Journal Article Am Heart J · September 2007 BACKGROUND: The American College of Cardiology's Guidelines Applied in Practice (GAP) initiative for acute myocardial infarction (AMI) has been shown to increase the use of guideline-based therapies and improve outcomes in patients with AMI. It is unknown ... Full text Link to item Cite

Comparison of early platelet activation in patients undergoing on-pump versus off-pump coronary artery bypass surgery.

Conference J Thorac Cardiovasc Surg · July 2007 OBJECTIVE: Cardiopulmonary bypass has been shown to be associated with platelet dysfunction, which has a potential for increasing the risk of perioperative bleeding. Off-pump coronary artery bypass surgery is thought to avoid this deleterious effect of pum ... Full text Link to item Cite

High-speed heart.

Journal Article Am J Med · June 2007 Full text Link to item Cite

Prognostic role of transesophageal echocardiography in acute type A aortic dissection.

Journal Article Am Heart J · June 2007 BACKGROUND: Acute type A aortic dissection (AAD) remains a highly lethal entity for which emergent surgical correction is standard care. Prior studies have identified specific clinical findings as being predictive of outcome. The prognostic significance of ... Full text Link to item Cite

Performance measures have a major effect on cardiovascular outcomes: a review.

Journal Article Am J Med · May 2007 Improved application of existing therapies, directed by evidence-based guidelines, may offer immediate savings of life and function to patients with cardiovascular disease. We sought to evaluate the evidence that use of performance measures derived from cl ... Full text Link to item Cite

Comparison of in-hospital outcomes of patients with versus without previous carotid endarterectomy undergoing carotid stenting (from the German ALKK CAS Registry).

Journal Article Am J Cardiol · May 1, 2007 Repeat carotid endarterectomy (CEA) for recurrent stenosis remains a challenging treatment option associated with high morbidity and mortality. Carotid artery stenting (CAS) is an attractive alternative management option for these patients. However, data a ... Full text Link to item Cite

Documented traditional cardiovascular risk factors and mortality in non-ST-segment elevation myocardial infarction.

Journal Article Am Heart J · April 2007 BACKGROUND: Although documented traditional cardiovascular risk factors (hypertension, diabetes, smoking, and dyslipidemia) increase the risk of developing coronary artery disease, their influence on the treatments and outcomes of patients with non-ST-segm ... Full text Link to item Cite

Impact of initial heart rate and systolic blood pressure on relation of age and mortality among fibrinolytic-treated patients with acute ST-elevation myocardial infarction presenting with cardiogenic shock.

Journal Article Am J Cardiol · March 15, 2007 Older age is associated with worse outcomes in patients with cardiogenic shock complicating ST-elevation myocardial infarction (STEMI). However, significant heterogeneity exists in different age groups with respect to outcomes. Identification of factors th ... Full text Link to item Cite

Valve surgery in octogenarians: in-hospital and long-term outcomes.

Journal Article Can J Cardiol · March 1, 2007 BACKGROUND: Global population aging and greater age-related incidence of ischemic, degenerative and calcific valve disease have led to an increasing number of very elderly patients being referred for valve surgery. However, their preoperative risk factors, ... Full text Link to item Cite

Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · March 2007 BACKGROUND: Secondary prevention medications are beneficial after acute coronary syndromes, but these benefits are less clear after coronary artery bypass graft surgery. We investigated whether greater use of secondary prevention medications after coronary ... Full text Link to item Cite

The impact of anthropomorphic indices on clinical outcomes in patients with acute ST-elevation myocardial infarction.

Journal Article Eur Heart J · February 2007 AIMS: Multiple studies have focused on the relationship of body anthropometric measures with clinical events in ST-elevation myocardial infarction (STEMI) patients, highlighting the 'obesity paradox'. However, the relative prognostic importance of these me ... Full text Link to item Cite

Hemolytic anemia: a rare but potentially serious adverse effect of captopril.

Journal Article Herz · February 2007 Captopril was the first oral angiotensin-converting enzyme (ACE) inhibitor available and, as such, has been extensively studied and in clinical use for many years. Several studies have defined captopril's efficacy in the treatment of congestive heart failu ... Full text Link to item Cite

Thoracic aorta endografts: variations in practice among medical specialists.

Journal Article Catheter Cardiovasc Interv · December 2006 BACKGROUND: Endovascular stent-graft placement is emerging as a novel treatment option for patients with diseases of the descending thoracic aorta. However, currently no consensus guidelines exist to direct uniformity in stent-graft procedures as well as f ... Full text Link to item Cite

Bedside tool for predicting the risk of postoperative dialysis in patients undergoing cardiac surgery.

Journal Article Circulation · November 21, 2006 BACKGROUND: Estimation of an individual patient's risk for postoperative dialysis can support informed clinical decision making and patient counseling. METHODS AND RESULTS: To develop a simple bedside risk algorithm for estimating patients' probability for ... Full text Link to item Cite

Insurance coverage and care of patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Ann Intern Med · November 21, 2006 BACKGROUND: The impact of insurance coverage on the care of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) is unclear. OBJECTIVE: To compare NSTE ACS care patterns by insurance type. DESIGN: Comparison of Medicaid patients young ... Full text Link to item Cite

Reperfusion of acute myocardial infarction in North Carolina emergency departments (RACE): study design.

Journal Article Am Heart J · November 2006 Despite the accumulation of almost 2 decades of data in support of rapid reperfusion therapy for ST-segment elevation myocardial infarction (STEMI), the United States healthcare system still faces serious challenges in providing reperfusion to all eligible ... Full text Link to item Cite

Recent trends in the care of patients with non-ST-segment elevation acute coronary syndromes: insights from the CRUSADE initiative.

Journal Article Arch Intern Med · October 9, 2006 BACKGROUND: The extent to which national health quality improvement initiatives have altered reported treatment gaps among patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) is unknown. We sought to determine recent trends in adhere ... Full text Link to item Cite

The impact of emergency department structure and care processes in delivering care for non-ST-segment elevation acute coronary syndromes.

Journal Article Am Heart J · October 2006 BACKGROUND: We sought to assess the influence of emergency department (ED) structure and care processes on adherence to practice guidelines for the treatment of patients with non-ST-segment elevation acute coronary syndromes. METHODS: We surveyed emergency ... Full text Link to item Cite

Clinical correlates of long-term mortality after percutaneous interventions of saphenous vein grafts.

Journal Article Am Heart J · October 2006 BACKGROUND: Increasing number of patients undergo percutaneous intervention of saphenous vein grafts (SVGs). However, the clinical factors associated with long-term mortality after SVG interventions are currently less known. Accordingly, the goal of presen ... Full text Link to item Cite

Challenges in predicting the need for coronary artery bypass grafting at presentation in patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Am J Cardiol · September 1, 2006 In the case of non-ST-segment elevation acute coronary syndromes (NSTE-ACSs), the acute use of certain antiplatelet agents is complicated by concerns about perioperative bleeding risks in patients requiring coronary artery bypass grafting (CABG) during the ... Full text Link to item Cite

Frequency and outcomes of acute renal failure following thoracic aortic stent-graft placement.

Journal Article Am J Cardiol · August 15, 2006 We assessed the incidence, correlates, and outcomes of acute renal failure (ARF) after thoracic aortic stent-graft placement. Postprocedural ARF is an inherent complication of catheter-based interventional procedures that use intra-arterial contrast agents ... Full text Link to item Cite

Does proximal location of culprit lesion confer worse prognosis in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction?

Journal Article J Interv Cardiol · August 2006 ST segment elevation myocardial infarction (STEMI) from proximally located culprit lesion is associated with greater myocardium at jeopardy. In STEMI patients treated with thrombolytics, proximal culprit lesions are known to have worse prognosis. This rela ... Full text Link to item Cite

Acute clopidogrel use and outcomes in patients with non-ST-segment elevation acute coronary syndromes undergoing coronary artery bypass surgery.

Journal Article J Am Coll Cardiol · July 18, 2006 OBJECTIVES: We sought to characterize patterns of clopidogrel use before coronary artery bypass grafting (CABG) and examine the drug's impact on risks for postoperative transfusions among patients with non-ST-segment elevation acute coronary syndromes (NST ... Full text Link to item Cite

Impact of internal mammary artery conduit on long-term outcomes after percutaneous intervention of saphenous vein graft.

Journal Article Circulation · July 4, 2006 BACKGROUND: The influence of an internal mammary artery (IMA) graft on long-term outcomes after percutaneous saphenous vein graft (SVG) intervention is currently unknown. METHODS AND RESULTS: To examine the impact of IMA on outcomes in patients undergoing ... Full text Link to item Cite

Sex differences in the application of evidence-based therapies for the treatment of acute myocardial infarction: the American College of Cardiology's Guidelines Applied in Practice projects in Michigan.

Journal Article Arch Intern Med · June 12, 2006 BACKGROUND: Studies have shown that women with acute myocardial infarction (AMI) are less likely to receive evidence-based care compared with men. The American College of Cardiology's AMI Guidelines Applied in Practice (GAP) program has been shown to incre ... Full text Link to item Cite

Association of peripheral artery disease with treatment and outcomes in acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE).

Journal Article Am Heart J · May 2006 BACKGROUND: National guidelines recommend the use of secondary prevention modalities for patients with peripheral artery disease (PAD) and coronary artery disease. The effect of prior PAD on the treatment and outcomes of patients with acute coronary syndro ... Full text Link to item Cite

Prediction of one-year mortality among 30-day survivors after primary percutaneous coronary interventions.

Journal Article Am J Cardiol · March 15, 2006 Little information exists on the features that influence risk factors for death at 1 year among 30-day survivors of ST-elevation myocardial infarction (STEMI) that is treated with primary percutaneous coronary intervention (PCI). Accordingly, we examined 3 ... Full text Link to item Cite

Feasibility of real-time magnetic resonance-guided stent-graft placement in a swine model of descending aortic dissection.

Journal Article Eur Heart J · March 2006 AIMS: To evaluate the pre-clinical feasibility of real-time magnetic resonance imaging (rtMRI) to guide stent-graft placement for experimental aortic dissection (AD) and to alleviate disadvantages of ionising radiation and nephrotoxic contrast media. Endov ... Full text Link to item Cite

Differences in the clinical features and outcomes in African Americans and whites with myocardial infarction.

Journal Article Am J Med · January 2006 PURPOSE: Less is known about the differences in clinical and angiographic features and the outcomes of African Americans with ST-elevation myocardial infarction compared with whites with ST-elevation myocardial infarction. Accordingly, the current study ex ... Full text Link to item Cite

Guideline-based standardized care is associated with substantially lower mortality in medicare patients with acute myocardial infarction: the American College of Cardiology's Guidelines Applied in Practice (GAP) Projects in Michigan.

Journal Article J Am Coll Cardiol · October 4, 2005 OBJECTIVES: We sought to assess the impact of the American College of Cardiology's Guidelines Applied in Practice (GAP) project for acute myocardial infarction (AMI) care, encompassing 33 acute-care hospitals in southeastern Michigan, on rates of mortality ... Full text Link to item Cite

Comparison of coronary stenting versus conventional balloon angioplasty on five-year mortality in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

Journal Article Am J Cardiol · October 1, 2005 Little is known about the influence of stenting versus balloon angioplasty on long-term outcomes (particularly mortality) after primary percutaneous coronary intervention (PCI). We evaluated 2,087 patients with ST-elevation myocardial infarction enrolled i ... Full text Link to item Cite

Treating patients with acute coronary syndromes with aggressive antiplatelet therapy (from the Global Registry of Acute Coronary Events).

Journal Article Am J Cardiol · October 1, 2005 Few data exist on the use of aggressive combination therapy with thienopyridines and glycoprotein IIb/IIIa inhibitors in higher risk patients with an acute coronary syndrome (ACS). The aim of this study was to characterize the combined use of these agents ... Full text Link to item Cite

Relation of timing of cardiac catheterization to outcomes in patients with non-ST-segment elevation myocardial infarction or unstable angina pectoris enrolled in the multinational global registry of acute coronary events.

Journal Article Am J Cardiol · June 15, 2005 We assessed whether timing of catheterization is associated with the type of non-ST-segment elevation acute coronary syndrome and/or outcome in patients who were enrolled in the Global Registry of Acute Coronary Events. Overall, 8,853 patients who had unst ... Full text Link to item Cite

Impact of combined pharmacologic treatment with clopidogrel and a statin on outcomes of patients with non-ST-segment elevation acute coronary syndromes: perspectives from a large multinational registry.

Journal Article Eur Heart J · June 2005 AIMS: To evaluate clinical outcomes associated with the combined use of clopidogrel and statins vs. clopidogrel alone on a background of aspirin therapy in patients with the spectrum of acute coronary syndromes (ACS). METHODS AND RESULTS: Utilizing data fr ... Full text Link to item Cite

Ischemia-driven target vessel revascularization after-primary percutaneous coronary intervention: patients at risk and their outcomes.

Journal Article J Interv Cardiol · June 2005 Clinical and angiographic correlates of ischemia-driven target vessel revascularization (ITVR) in patients undergoing primary percutaneous coronary interventions (PCI) are currently less well known. Accordingly, we examined 2,981 patients enrolled in diffe ... Full text Link to item Cite

Improved quality of stroke care for hospitalized Medicare beneficiaries in Michigan.

Journal Article Stroke · June 2005 BACKGROUND AND PURPOSE: We reported previously that acute ischemic stroke patients encountered delays in obtaining neuroimaging and receiving thrombolysis, and that deep venous thrombosis prophylaxis was used only in a minority of eligible patients. We inv ... Full text Link to item Cite

Differences in quality of care among patients hospitalized with atrial fibrillation as primary or secondary cause for admission.

Journal Article Int J Qual Health Care · June 2005 OBJECTIVE: Several factors have been linked to the variation in the quality of care for patients with atrial fibrillation (AF). Whether hospitalization primarily for AF (primary diagnosis of AF) as opposed to another primary diagnosis but having concomitan ... Full text Link to item Cite

Association of height with outcomes in patients with acute myocardial infarction receiving reperfusion therapy.

Journal Article Am J Cardiol · June 1, 2005 Data were evaluated for patients with acute ST-elevation myocardial infarction (n = 94,182) enrolled in 6 large clinical trials evaluating the efficacy of various reperfusion strategies. It was found that compared with the tallest quartile, incidences of i ... Full text Link to item Cite

Relationship of incorrect dosing of fibrinolytic therapy and clinical outcomes.

Journal Article JAMA · April 13, 2005 CONTEXT: Incorrect dosing of alteplase has been associated with worse clinical outcomes in patients. However, patients at high risk of adverse events are more prone to dosing errors, thus confounding this relationship. OBJECTIVE: To determine if the associ ... Full text Link to item Cite

Acute intramural hematoma of the aorta: a mystery in evolution.

Journal Article Circulation · March 1, 2005 BACKGROUND: The definition, prevalence, outcomes, and appropriate treatment strategies for acute intramural hematoma (IMH) continue to be debated. METHODS AND RESULTS: We studied 1010 patients with acute aortic syndromes who were enrolled in the Internatio ... Full text Link to item Cite

Reperfusion strategies for acute myocardial infarction in the elderly: benefits and risks.

Journal Article J Am Coll Cardiol · February 15, 2005 The optimal reperfusion strategy in elderly patients with ST-segment elevation myocardial infarction (STEMI) remains a topic of debate. This lack of consensus stems from the exclusion or under-representation of the elderly in clinical trials. This review e ... Full text Link to item Cite

The winter peak in the occurrence of acute aortic dissection is independent of climate.

Journal Article Chronobiol Int · 2005 We recently reported the existence of a higher risk of acute aortic dissection (AAD) during the winter months. However, it is not known whether this winter peak is affected by climate. To address this issue, we evaluated data from 969 AAD patients who were ... Full text Link to item Cite

Contemporary results of surgery in acute type A aortic dissection: The International Registry of Acute Aortic Dissection experience.

Journal Article J Thorac Cardiovasc Surg · January 2005 BACKGROUND: Surgical mortality for acute type A aortic dissection reported in different experiences from single centers or surgeons varies from 7% to 30%. The International Registry of Acute Aortic Dissection, collecting patients from 18 referral centers w ... Full text Link to item Cite

Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE).

Journal Article Am Heart J · January 2005 BACKGROUND: Evidence-based cardiac therapies are underutilized in elderly patients. We assessed differences in practice patterns, comorbidities, and in-hospital event rates, by age and type of acute coronary syndrome (ACS). METHODS: We studied 24165 ACS pa ... Full text Link to item Cite

Does circadian and seasonal variation in occurrence of acute aortic dissection influence in-hospital outcomes?

Journal Article Chronobiol Int · 2005 The risk of acute aortic dissection (AAD) exhibits chronobiological variations with peak onset in the morning and in winter. However, it is not known whether the time of day or season of the year of the AAD affects clinical outcomes. We studied 1,032 patie ... Full text Link to item Cite

Rapid-cycle improvement in quality of care for patients hospitalized with acute myocardial infarction or heart failure: moving from a culture of missed opportunity to a system of accountability.

Journal Article The Journal of cardiovascular management : the official journal of the American College of Cardiovascular Administrators · January 1, 2005 We describe a 1-year multidisciplinary initiative to improve the quality of care for patients with acute myocardial infarction and heart failure. In January 2002, this rapid-cycle improvement project began with a partnership of inpatient cardiology nursing ... Cite

Clinical characteristics of hypotension in patients with acute aortic dissection

Journal Article American Journal of Cardiology · January 1, 2005 To evaluate the clinical characteristics, risk factors, and outcomes of hypotension in unselected patients who had acute aortic dissection (AAD), we studied 1,073 such patients who were enrolled in the International Registry of Acute Aortic Dissection betw ... Full text Cite

Influence of circadian rhythm on mortality after myocardial infarction: data from a prospective cohort of emergency calls.

Journal Article Am J Emerg Med · November 2004 Myocardial infarction (MI) occurs more frequently in the morning as a result of the concomitant unfavorable timing of several physiological parameters and/or biochemical conditions. However, little is known about the possible influence of this circadian pa ... Full text Link to item Cite

Branch vessel complications are increased in aortic dissection patients with renal insufficiency.

Journal Article Vasc Med · November 2004 Morbidity and mortality from aortic dissection remain high despite advances in diagnosis and treatment. Simple markers to identify patients at high risk for non-aortic complications of dissection are lacking. We investigated the effect of renal insufficien ... Full text Link to item Cite

Procedural success versus clinical risk status in determining discharge of patients after primary angioplasty for acute myocardial infarction.

Journal Article J Am Coll Cardiol · October 6, 2004 OBJECTIVES: We evaluated whether patients' clinical status, angioplasty success, or both, should guide discharge after primary angioplasty (i.e., percutaneous coronary intervention [PCI]) for acute myocardial infarction (AMI). BACKGROUND: Current guideline ... Full text Link to item Cite

Differences in clinical presentation, management, and outcomes of acute type a aortic dissection in patients with and without previous cardiac surgery.

Journal Article Circulation · September 14, 2004 BACKGROUND: There are less data on the clinical and diagnostic imaging characteristics, management, and outcomes of patients with previous cardiac surgery (PCS) presenting with acute type A aortic dissection (AAD). METHODS AND RESULTS: In 617 patients with ... Full text Link to item Cite

Impact of interventionalist volume, experience, and board certification on coronary angioplasty outcomes in the era of stenting.

Journal Article Am J Cardiol · August 15, 2004 It has been suggested that percutaneous coronary intervention (PCI) by high-volume operators may be associated with better outcomes. However, the relation between operator and outcome is confounded by hospital caseloads of PCI, with busier hospitals genera ... Full text Link to item Cite

Comparison of aortic dissection in patients with and without Marfan's syndrome (results from the International Registry of Aortic Dissection).

Journal Article Am J Cardiol · August 1, 2004 Among 1,049 patients diagnosed with aortic dissection in a multinational registry, patients with Marfan's syndrome were typically younger and had unique presentations. Despite their younger age at presentation, patients with Marfan's syndrome and aortic di ... Full text Link to item Cite

Chronobiology of rupture and dissection of aortic aneurysms.

Journal Article J Vasc Surg · August 2004 A growing body of evidence suggests that the occurrence of cardiovascular events is not evenly distributed over time, but shows peculiar temporal patterns that vary with time of day, day of the week, and month (season) of the year. These patterns coincide ... Full text Link to item Cite

Cardiac-specific norepinephrine mass transport and its relationship to left ventricular size and systolic performance.

Journal Article Am J Physiol Heart Circ Physiol · August 2004 Objectives of this study were to develop a technique for quantifying cardiac-specific norepinephrine (NE) mass transport and determine whether cardiac NE kinetic modeling parameters were related to physiological variables of left ventricular (LV) size and ... Full text Link to item Cite

Gender-related differences in acute aortic dissection.

Journal Article Circulation · June 22, 2004 BACKGROUND: Few data exist on gender-related differences in clinical presentation, diagnostic findings, management, and outcomes in acute aortic dissection (AAD). METHODS AND RESULTS: Accordingly, we evaluated 1078 patients enrolled in the International Re ... Full text Link to item Cite

Enhancing quality of care for acute myocardial infarction: shifting the focus of improvement from key indicators to process of care and tool use: the American College of Cardiology Acute Myocardial Infarction Guidelines Applied in Practice Project in Michigan: Flint and Saginaw Expansion.

Journal Article J Am Coll Cardiol · June 16, 2004 OBJECTIVES: This project evaluated if by focusing on process changes and tool use rather than key indicator rates, the use of evidence-based therapies in patients with acute myocardial infarction (AMI) would increase. BACKGROUND: The use of tools designed ... Full text Link to item Cite

Association of statin therapy with outcomes of acute coronary syndromes: the GRACE study.

Journal Article Ann Intern Med · June 1, 2004 BACKGROUND: Statins administered early in patients with acute coronary syndromes may lead to modest reductions in recurrent ischemic events. OBJECTIVE: To examine the association between previous and early in-hospital statin therapy and the presentation an ... Full text Link to item Cite

Sustained ventricular tachycardia or fibrillation in the cardiac catheterization laboratory among patients receiving primary percutaneous coronary intervention: incidence, predictors, and outcomes.

Journal Article J Am Coll Cardiol · May 19, 2004 OBJECTIVES: We sought to evaluate the incidence, predictors, and outcomes of ventricular tachycardia and/or ventricular fibrillation (VT/VF) in the cardiac catheterization laboratory among patients undergoing primary percutaneous coronary intervention (PCI ... Full text Link to item Cite

Acute type B aortic dissection in elderly patients: clinical features, outcomes, and simple risk stratification rule.

Journal Article Ann Thorac Surg · May 2004 BACKGROUND: The clinical features and outcomes of elderly patients with acute type B aortic dissection (ABAD) are less well known. Accordingly, we sought to evaluate the clinical features and outcomes and derive a simple risk stratification rule for elderl ... Full text Link to item Cite

Changes in systemic sympathetic nervous system activity after mitral valve surgery and their relationship to changes in left ventricular size and systolic performance in patients with mitral regurgitation.

Journal Article Am Heart J · April 2004 BACKGROUND: We have shown that the systemic sympathetic nervous system (SNS) is activated in patients with chronic mitral regurgitation (MR). However, the fate of systemic SNS activity after surgical correction of MR is currently unknown. METHODS: We exami ... Full text Link to item Cite

Characterizing the young patient with aortic dissection: results from the International Registry of Aortic Dissection (IRAD).

Journal Article J Am Coll Cardiol · February 18, 2004 OBJECTIVES: The goal of this study was to better characterize the young patient with aortic dissection (AoD). BACKGROUND: Aortic dissection is unusual in young patients, and frequently associated with unusual presentations. METHODS: Data were collected on ... Full text Link to item Cite

Effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction.

Journal Article Am Heart J · February 2004 BACKGROUND: Few data exist from a community-based perspective on the relative effectiveness of primary percutaneous coronary intervention (PCI) as compared with thrombolytic therapy (TT) in elderly patients with ST-elevation myocardial infarction (STEMI), ... Full text Link to item Cite

Clinical association between renal insufficiency and positive troponin I in patients with acute coronary syndrome.

Journal Article Cardiology · 2004 BACKGROUND: Whether renal insufficiency (RI) influences troponin levels in patients with acute coronary syndromes (ACS) is controversial. We attempted to determine whether there is an association between RI and troponin I (TnI) elevation in patients presen ... Full text Link to item Cite

Association of painless acute aortic dissection with increased mortality

Journal Article Mayo Clinic Proceedings · January 1, 2004 OBJECTIVE: To evaluate the clinical characteristics and outcomes of patients with painless acute aortic dissection (AAD). PATIENTS AND METHODS: For this study conducted from 1997 to 2001, we searched the International Registry of Acute Aortic Dissection to ... Full text Cite

Seasonal variation in onset of pulmonary embolism is independent of patients' underlying risk comorbid conditions.

Journal Article Clin Appl Thromb Hemost · January 2004 As for many cardiovascular events, pulmonary embolism (PE) is not randomly distributed over time, but shows rhythmic patterns. The purpose of this study was to investigate whether such temporal pattern of occurrence varied in subgroups of patients accordin ... Full text Link to item Cite

Prognostic significance of transient no-reflow during primary percutaneous coronary intervention for ST-elevation acute myocardial infarction.

Journal Article Am J Cardiol · December 15, 2003 We found that of 1,192 patients who underwent primary percutaneous coronary intervention and who had final Thrombolysis In Myocardial Infarction grade 3 flow at the conclusion of the procedure, transient no-reflow occurred in 16 patients (1.3%). Compared w ... Full text Link to item Cite

Prognostic significance of an elevated creatine kinase in the absence of an elevated troponin I during an acute coronary syndrome.

Journal Article Am J Cardiol · December 15, 2003 In patients with troponin-negative acute coronary syndromes, creatine kinase (CK)-MB elevation predicts a significantly higher risk of death and major acute cardiac events compared with CK-MB negative patients. This risk is accentuated in troponin-negative ... Full text Link to item Cite

Clinical and angiographic correlates and outcomes of suboptimal coronary flow inpatients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

Journal Article J Am Coll Cardiol · November 19, 2003 OBJECTIVES: The purpose of this study was to determine the clinical and angiographic correlates and outcomes of patients with suboptimal coronary flow after primary percutaneous coronary interventions (PCI). BACKGROUND: The clinical and angiographic correl ... Full text Link to item Cite

Comparison of outcomes of patients with acute coronary syndromes with and without atrial fibrillation.

Journal Article Am J Cardiol · November 1, 2003 Preexisting or new-onset atrial fibrillation (AF) commonly occurs in patients with an acute coronary syndrome (ACS). However, it is currently unknown if previous or new-onset AF confers different risks in these patients. To determine the prognostic signifi ... Full text Link to item Cite

Clinical profiles and outcomes of acute type B aortic dissection in the current era: lessons from the International Registry of Aortic Dissection (IRAD).

Journal Article Circulation · September 9, 2003 BACKGROUND: Clinical profiles and outcomes of patients with acute type B aortic dissection have not been evaluated in the current era. METHODS AND RESULTS: Accordingly, we analyzed 384 patients (65+/-13 years, males 71%) with acute type B aortic dissection ... Full text Link to item Cite

A rapid-cycle collaborative model to promote guidelines for acute myocardial infarction.

Journal Article Jt Comm J Qual Saf · September 2003 BACKGROUND: This American College of Cardiology (ACC) Acute Myocardial Infarction (AMI) Guidelines Applied in Practice (GAP) collaborative in Michigan represented ACC's third initiative, in partnership with local health care coalitions and the Michigan Pee ... Full text Link to item Cite

Comparison of patients with acute coronary syndrome with and without systemic hypertension.

Journal Article Am J Cardiol · August 1, 2003 The role of systemic hypertension in acute coronary syndrome (ACS) has not been well studied. We studied consecutive subjects admitted to the University of Michigan Health System (Ann Arbor, Michigan) with symptoms of ACS. Data were collected using a stand ... Full text Link to item Cite

Compared with control subjects, the systemic sympathetic nervous system is activated in patients with mitral regurgitation.

Journal Article Am Heart J · June 2003 BACKGROUND: Whether the systemic sympathetic nervous system is activated as a compensatory mechanism in response to mitral regurgitation (MR) in humans is unknown. We tested the hypotheses that the systemic sympathetic nervous system would be activated in ... Full text Link to item Cite

Influence of concurrent renal dysfunction on outcomes of patients with acute coronary syndromes and implications of the use of glycoprotein IIb/IIIa inhibitors.

Journal Article J Am Coll Cardiol · March 5, 2003 OBJECTIVES: The purpose of this study was to examine the in-hospital outcome and influence of glycoprotein (GP) IIb/IIIa antagonists on patients with acute coronary syndromes (ACS) across a range of renal function. BACKGROUND: Recent studies demonstrate in ... Full text Link to item Cite

Effects of age on the quality of care provided to older patients with acute myocardial infarction.

Journal Article Am J Med · March 2003 PURPOSE: Older patients are less likely to receive guideline-recommended medical therapies during acute myocardial infarction. However, it is unclear whether the lower rates of treatment reflect elderly patients' increased number of comorbid conditions, ph ... Full text Link to item Cite

Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation.

Journal Article Circulation · February 18, 2003 BACKGROUND: In an animal model, stretch was shown to induce myocardial tumor necrosis factor-alpha (TNF-alpha) expression. The purposes of this study were to determine whether the left ventricular (LV) volume overload that occurs in patients with chronic m ... Full text Link to item Cite

The new definition of myocardial infarction.

Journal Article Arch Intern Med · January 27, 2003 Full text Link to item Cite

Influence of age on outcomes in patients undergoing mitral valve replacement.

Journal Article Ann Thorac Surg · November 2002 BACKGROUND: Although increasing age has been associated with greater risk of mortality for patients undergoing mitral valve replacement, it is less clear whether this elevated risk is related to age-related differences in comorbidity or other clinical char ... Full text Link to item Cite

Syncope in acute aortic dissection: diagnostic, prognostic, and clinical implications.

Journal Article Am J Med · October 15, 2002 BACKGROUND: Syncope is a well-recognized symptom of acute aortic dissection, often indicating the development of dangerous complications such as cardiac tamponade. SUBJECTS AND METHODS: We identified consecutive patients with acute aortic dissection at 18 ... Full text Link to item Cite

Patient outcomes after fibrinolytic therapy for acute myocardial infarction at hospitals with and without coronary revascularization capability.

Journal Article J Am Coll Cardiol · September 18, 2002 OBJECTIVES: This study evaluated clinical outcomes in patients with acute myocardial infarction (MI) treated with fibrinolytic therapy in hospitals with and without coronary revascularization capability. BACKGROUND: Patients with MI may have better outcome ... Full text Link to item Cite

Asymptomatic coronary artery disease in a pregnant patient. A case report and review of literature.

Journal Article Herz · September 2002 BACKGROUND: Acute myocardial infarction during pregnancy has been reported and has been shown to be associated with poor maternal and fetal outcomes. However, the vast majority of these patients do not have previously recognized ischemic heart disease. Pre ... Full text Link to item Cite

Effects of end-of-month admission on length of stay and quality of care among inpatients with myocardial infarction.

Journal Article Am J Med · September 2002 PURPOSE: We studied whether transfer of care when house staff and faculty switch services affects length of stay or quality of care among hospitalized patients. SUBJECTS AND METHODS: We performed a retrospective analysis in 976 consecutive patients admitte ... Full text Link to item Cite

Chronobiological patterns of acute aortic dissection.

Journal Article Circulation · August 27, 2002 BACKGROUND: Chronobiological rhythms have been shown to influence the occurrence of a variety of cardiovascular disorders. However, the effects of the time of the day, the day of the week, or monthly/seasonal changes on acute aortic dissection (AAD) have n ... Full text Link to item Cite

Acute type A aortic dissection in the elderly: clinical characteristics, management, and outcomes in the current era.

Journal Article J Am Coll Cardiol · August 21, 2002 OBJECTIVES: We sought to evaluate the clinical characteristics, management, and outcomes of elderly patients with acute type A aortic dissection. BACKGROUND: Few data exist on the clinical manifestations and outcomes of acute type A aortic dissection in an ... Full text Link to item Cite

The new definition of myocardial infarction: diagnostic and prognostic implications in patients with acute coronary syndromes.

Journal Article Arch Intern Med · July 22, 2002 BACKGROUND: The clinical implications of the recently revised criteria for diagnosis of acute myocardial infarction (AMI) in patients with suspected acute coronary syndromes are unknown. METHODS: To evaluate the prognostic implications of the new diagnosti ... Full text Link to item Cite

Prolonged low-dose thrombolytic therapy: a novel adjunctive strategy in the management of an infected right atrial thrombus.

Journal Article Clin Cardiol · July 2002 An 81-year-old man presented with a large, infected right atrial thrombus that was refractory to anticoagulants and several courses of antibiotics. The risk of surgical removal of the thrombus, which was associated with a pacemaker electrode, was considere ... Full text Link to item Cite

Assessing performance reports to individual providers in the care of acute coronary syndromes.

Journal Article Jt Comm J Qual Improv · May 2002 BACKGROUND: As part of a quality improvement initiative in the management of acute coronary syndromes, performance reports on care of patients with acute myocardial infarction (MI) or unstable angina (UA) who were admitted to two cardiology services at the ... Full text Link to item Cite

Usefulness of pulse deficit to predict in-hospital complications and mortality in patients with acute type A aortic dissection.

Journal Article Am J Cardiol · April 1, 2002 Vascular compromise seen with pulse deficits is common in patients with type A dissection. However, patient characteristics and in-hospital outcomes associated with pulse deficits have not been evaluated. Accordingly, we studied 513 patients (mean age 62 + ... Full text Link to item Cite

Improving quality of care for acute myocardial infarction: The Guidelines Applied in Practice (GAP) Initiative.

Journal Article JAMA · March 13, 2002 CONTEXT: Quality of care of patients with acute myocardial infarction (AMI) has received intense attention. However, it is unknown if a structured initiative for improving care of patients with AMI can be effectively implemented at a wide variety of hospit ... Full text Link to item Cite

Iatrogenic aortic dissection.

Journal Article Am J Cardiol · March 1, 2002 Full text Link to item Cite

Effect of losartan in aging-related endothelial impairment.

Journal Article Am J Cardiol · March 1, 2002 Aging is associated with progressive deterioration in endothelial function. We hypothesized that losartan may represent a useful therapeutic strategy to ameliorate endothelial function in aged subjects. Eighteen healthy older subjects (mean age 75 +/- 3 ye ... Full text Link to item Cite

Predicting death in patients with acute type a aortic dissection.

Journal Article Circulation · January 15, 2002 BACKGROUND: Given the high mortality rates in patients with type A aortic dissection, predictive tools to identify patients at increased risk of death are needed to assist clinicians for optimal treatment. METHODS AND RESULTS: Accordingly, we evaluated 547 ... Full text Link to item Cite

Taking the national guideline for care of acute myocardial infarction to the bedside: developing the guideline applied in practice (GAP) initiative in Southeast Michigan.

Journal Article Jt Comm J Qual Improv · January 2002 BACKGROUND: The Guideline Applied in Practice (GAP) program was developed in 2000 to improve the quality of care by improving adherence to clinical practice guidelines. For the first GAP project, the American College of Cardiology (ACC) partnered with the ... Full text Link to item Cite

Implications of increased left ventricular mass index on in-hospital outcomes in patients undergoing aortic valve surgery.

Journal Article J Thorac Cardiovasc Surg · November 2001 BACKGROUND: Increased left ventricular mass index has been shown to be associated with higher mortality in epidemiologic studies. However, the effect of increased left ventricular mass index on outcomes in patients undergoing aortic valve replacement is un ... Full text Link to item Cite

Acute myocardial infarction in the elderly: differences by age.

Journal Article J Am Coll Cardiol · September 2001 OBJECTIVES: We evaluated the clinical characteristics and outcomes of elderly patients hospitalized with acute myocardial infarction (AMI) to describe differences by age. BACKGROUND: Elderly patients with AMI are perceived as a homogeneous population, thou ... Full text Link to item Cite

Cardiac risk assessment for noncardiac surgery: current concepts.

Journal Article Compr Ther · 2001 Strategies for perioperative risk assessment in patients undergoing noncardiac surgery vary among physicians and are aimed to estimate the risk and minimize complications. We propose simplistic guidelines for assessing and modifying risk for patients under ... Full text Link to item Cite

Relation of systemic sympathetic nervous system activation to echocardiographic left ventricular size and performance and its implications in patients with mitral regurgitation.

Journal Article Am J Cardiol · December 1, 2000 We have previously demonstrated that the systemic sympathetic nervous system (SNS) is activated in proportion to an increase in cineventriculographic left ventricular (LV) end-systolic volume and decrease in ejection fraction (EF) in patients with chronic ... Full text Link to item Cite

Quality improvement initiative and its impact on the management of patients with acute myocardial infarction.

Journal Article Arch Intern Med · November 13, 2000 BACKGROUND: Wide variation exists in acute myocardial infarction (AMI) management, leading to differences in outcomes. OBJECTIVE: To assess the impact of the quality improvement initiative on appropriate management of AMI. DESIGN: Prospective patient ident ... Full text Link to item Cite

The treatment of elderly diabetic patients with acute myocardial infarction: insight from Michigan's Cooperative Cardiovascular Project.

Journal Article Arch Intern Med · May 8, 2000 BACKGROUND: Diabetic patients with acute myocardial infarction (AMI) have higher morbidity and mortality rates than nondiabetic patients with AMI. Thus, reliable adherence to quality care is necessary in these patients to improve outcomes. We analyzed data ... Full text Link to item Cite

Current concepts in secondary prevention after acute myocardial infarction.

Journal Article Herz · February 2000 Acute myocardial infarction (MI) is the leading cause of death around the globe. Advances in the field of cardiology have identified several effective treatments that have lead to decrease in mortality from this cause over the past 3 decades. The purpose o ... Full text Link to item Cite

Perioperative cardiac risk assessment for noncardiac surgery.

Journal Article Cardiologia · May 1999 Patients with coronary artery disease who undergo noncardiac surgery are at risk of cardiac complications. It is, therefore, imperative to assess the risk of noncardiac surgery in these patients in a variety of operative settings. We propose a simplified a ... Link to item Cite

How to assess cardiac risk before noncardiac surgery

Journal Article Patient Care · April 15, 1999 Patients with heart disease pose a special challenge during the preoperative assessment. This step-by-step evaluation helps identify patients at risk for cardiac complications during noncardiac surgery. ... Cite

Elderly patients at highest risk with acute myocardial infarction are more frequently transferred from community hospitals to tertiary centers: Reality or myth?

Journal Article American Heart Journal · January 1, 1999 Background: The objective of this study was to assess the characteristics of patients with acute myocardial infarction transferred from community hospitals. The study was designed as a retrospective chart review, and the data source was the Cooperative Car ... Full text Cite

Coronary stent implantation in acute myocardial infarction

Journal Article American Heart Journal · January 1, 1999 Background: The purpose of this study was to provide an overview on stenting in acute myocardial infarction (MI). Methods and Results: A search of MEDLINE and the scientific sessions abstracts in peer review journals through May 1998 was carried out to ide ... Full text Cite

Association of chronotropic incompetence with echocardiographic ischemia and prognosis.

Journal Article Journal of the American College of Cardiology · November 1998 ObjectivesThis study sought to examine the prognostic importance of chronotropic incompetence among patients referred for stress echocardiography.BackgroundAlthough chronotropic incompetence has been shown to be predictive of an adverse p ... Full text Cite

How to assess cardiac risk before noncardiac surgery

Journal Article IM - Internal Medicine · January 1, 1998 This step-by-step evaluation can help you identify surgical patients at risk for cardiac complications. ... Cite

Cardiac outcomes in coronary patients with submaximum dobutamine stress echocardiography.

Journal Article Am J Cardiol · September 15, 1997 This study evaluated the prediction of cardiac events (cardiac death, myocardial infarction, unstable angina, or late myocardial revascularization) in patients with submaximum responses to dobutamine stress, defined by attainment of <85% age-predicted hear ... Full text Link to item Cite

Prognostic implications of exercise echocardiography in women with known or suspected coronary artery disease.

Journal Article J Am Coll Cardiol · August 1997 OBJECTIVES: The purpose of this study was to define the value of exercise echocardiography as an independent predictor of cardiac events in women with known or suspected coronary artery disease (CAD), incremental to the data provided by clinical evaluation ... Full text Link to item Cite

Use of exercise echocardiography for prognostic evaluation of patients with known or suspected coronary artery disease.

Journal Article J Am Coll Cardiol · July 1997 OBJECTIVES: This study prospectively compared the incremental prognostic benefit of exercise echocardiography with that of exercise testing in a large cohort. BACKGROUND: Exercise echocardiography is widely accepted as a diagnostic tool, but the prognostic ... Full text Link to item Cite

Flail aortic valve in systemic lupus erythematosus: Diagnosis by transesophageal echocardiography

Journal Article Echocardiography · January 1, 1996 This case report describes a patient with systemic lupus erythematosus who demonstrated by transesophageal echocardiography (TEE) a flail right coronary cusp of the aortic valve causing severe aortic regurgitation. This finding was confirmed at surgery, wh ... Full text Cite

Left Ventricular Lipoma by Transesophageal and in Vitro Echocardiographic Studies

Journal Article Echocardiography · January 1, 1995 This case report describes a patient with a known left ventricular mass which was documented by transthoracic echocardiography and which had not changed in size after anticoagulation. The mass was characterized as fatty tumor or hemorrhagic by cardiovascul ... Full text Cite

Atypical Aortic Dissection Diagnosed by Transesophageal Echocardiography

Journal Article Echocardiography · January 1, 1994 This case report describes a patient in whom a thin dissection of the proximal aorta was diagnosed by transesophageal echocardiography. Dissection was not firmly diagnosed in our patient with computed tomography, angiography, or magnetic resonance imaging. ... Full text Cite

Uses and limitations of transthoracic echocardiography in the assessment of atrial septal defect in the adult.

Journal Article Am J Cardiol · February 1, 1991 Two-dimensional and color Doppler echocardiography accurately detected the presence of an atrial septal defect (ASD) in 47 of 50 adults (mean age 40 years) confirmed by surgery or cardiac catheterization, or both. It correctly categorized all patients with ... Full text Link to item Cite

Transesophageal Doppler color flow mapping assessment of atrial septal defect.

Journal Article J Am Coll Cardiol · October 1990 Transesophageal Doppler color flow imaging was performed in 19 adult patients (mean age 35 years) with an atrial septal defect demonstrated by cardiac catheterization or at surgery, or both. The transesophageal study correctly identified and classified 19 ... Full text Link to item Cite

Screening tests for intrauterine growth retardation: a comparison of umbilical artery Doppler to real-time ultrasound.

Journal Article Echocardiography · March 1990 In a study designed to compare Doppler umbilical artery velocimetry to ultrasound morphometric measurements in the prediction of intrauterine growth retardation, 636 paired ultrasound and Doppler umbilical artery examinations were performed between 24 and ... Full text Link to item Cite