Scholars@Duke
RAJESHKUMAR MANNE

RAJESHKUMAR MANNE

Research Associate, Senior
Pathology
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Selected Publications

NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance.

Journal Article Cell Metab · October 3, 2023 Glucose metabolism is known to orchestrate oncogenesis. Whether glucose serves as a signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive. Here, we report that glucose is a cofactor binding to methyltransferase NSUN2 ... Full text Link to item Cite

FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis

Journal Article Cell Death & Disease · September 22, 2023 AbstractOncogene Moesin plays critical role in initiation, progression, and metastasis of multiple cancers. It exerts oncogenic activity due to its high-level expression as well as posttranslational modification in cancer. ... Full text Cite

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation.

Journal Article Cell Rep · January 31, 2023 Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) significantly attenua ... Full text Open Access Link to item Cite

Correction: Akt: a key transducer in cancer

Journal Article Journal of Biomedical Science · January 25, 2023 Full text Cite

Deregulated transcription factors in cancer cell metabolisms and reprogramming.

Journal Article Semin Cancer Biol · November 2022 Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to generate not only energy and building blocks but also produce numerous key signali ... Full text Link to item Cite

Akt: a key transducer in cancer

Journal Article Journal of Biomedical Science · October 1, 2022 AbstractGrowth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinase is a ... Full text Cite

SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling.

Journal Article J Clin Invest · March 1, 2022 Cancer stem-like cells (CSLCs) acquire enhanced immune checkpoint responses to evade immune cell killing and promote tumor progression. Here we showed that signal regulatory protein γ (SIRPγ) determined CSLC properties and immune evasiveness in a small pop ... Full text Open Access Link to item Cite

Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK.

Journal Article Mol Cell · September 16, 2021 Mitochondrial dynamics regulated by mitochondrial fusion and fission maintain mitochondrial functions, whose alterations underline various human diseases. Here, we show that inositol is a critical metabolite directly restricting AMPK-dependent mitochondria ... Full text Open Access Link to item Cite

The Skp2 Pathway: A Critical Target for Cancer Therapy.

Journal Article Semin Cancer Biol · December 2020 Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for various cellular processes whose dysregulation is linked to serious diseases including cancer. Skp2, a well characterized component of Skp2-SCF E3 ligase complex, ... Full text Open Access Link to item Cite

F‐box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β‐catenin function

Journal Article The Journal of Pathology · July 2019 AbstractAberrant activation of β‐catenin has been implicated in a variety of human diseases, including cancer. In spite of significant progress, the regulation of active Wnt/β‐catenin‐signaling pathways is still poorly unde ... Full text Cite

FBXO32 activates NF-κB through IκBα degradation in inflammatory and genotoxic stress

Journal Article The International Journal of Biochemistry & Cell Biology · November 2017 Full text Cite

NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance.

Journal Article Cell Metab · October 3, 2023 Glucose metabolism is known to orchestrate oncogenesis. Whether glucose serves as a signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive. Here, we report that glucose is a cofactor binding to methyltransferase NSUN2 ... Full text Link to item Cite

FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis

Journal Article Cell Death & Disease · September 22, 2023 AbstractOncogene Moesin plays critical role in initiation, progression, and metastasis of multiple cancers. It exerts oncogenic activity due to its high-level expression as well as posttranslational modification in cancer. ... Full text Cite

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation.

Journal Article Cell Rep · January 31, 2023 Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) significantly attenua ... Full text Open Access Link to item Cite

Correction: Akt: a key transducer in cancer

Journal Article Journal of Biomedical Science · January 25, 2023 Full text Cite

Deregulated transcription factors in cancer cell metabolisms and reprogramming.

Journal Article Semin Cancer Biol · November 2022 Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to generate not only energy and building blocks but also produce numerous key signali ... Full text Link to item Cite

Akt: a key transducer in cancer

Journal Article Journal of Biomedical Science · October 1, 2022 AbstractGrowth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinase is a ... Full text Cite

SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling.

Journal Article J Clin Invest · March 1, 2022 Cancer stem-like cells (CSLCs) acquire enhanced immune checkpoint responses to evade immune cell killing and promote tumor progression. Here we showed that signal regulatory protein γ (SIRPγ) determined CSLC properties and immune evasiveness in a small pop ... Full text Open Access Link to item Cite

Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK.

Journal Article Mol Cell · September 16, 2021 Mitochondrial dynamics regulated by mitochondrial fusion and fission maintain mitochondrial functions, whose alterations underline various human diseases. Here, we show that inositol is a critical metabolite directly restricting AMPK-dependent mitochondria ... Full text Open Access Link to item Cite

The Skp2 Pathway: A Critical Target for Cancer Therapy.

Journal Article Semin Cancer Biol · December 2020 Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for various cellular processes whose dysregulation is linked to serious diseases including cancer. Skp2, a well characterized component of Skp2-SCF E3 ligase complex, ... Full text Open Access Link to item Cite

F‐box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β‐catenin function

Journal Article The Journal of Pathology · July 2019 AbstractAberrant activation of β‐catenin has been implicated in a variety of human diseases, including cancer. In spite of significant progress, the regulation of active Wnt/β‐catenin‐signaling pathways is still poorly unde ... Full text Cite

FBXO32 activates NF-κB through IκBα degradation in inflammatory and genotoxic stress

Journal Article The International Journal of Biochemistry & Cell Biology · November 2017 Full text Cite

Synthesis, characterization, TDDFT calculation and biological activity of tetradentate ligand based square pyramidal Cu() complexes

Journal Article RSC Advances · 2015 Fluorescent Cu(ii) compounds have been synthesized, and characterized by structure analyses and DFT/TD-DFT calculations. Compounds show catecholase and anticancer activities. ... Full text Cite