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Raphael H. Valdivia

Nanaline H. Duke Distinguished Professor of Molecular Genetics and Microbiology
Integrative Immunobiology
4112 MSRB III, Box 3580, Durham, NC 27710
4112 MSRB III Box 3580, 3 Genome Court, Durham, NC 27710

Selected Grants


Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028

Duke Training Grant in Digestive Diseases and Nutrition

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027

Building Interdisciplinary Research Careers in Women's Health - BIRCWH

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2027

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Summer Scholars in Genome Sciences & Medicine

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2017 - 2026

Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028

Duke Training Grant in Digestive Diseases and Nutrition

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027

Building Interdisciplinary Research Careers in Women's Health - BIRCWH

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2027

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Summer Scholars in Genome Sciences & Medicine

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2017 - 2026

Mechanisms of microbial modulation of cancer immunotherapy

FellowshipPrincipal Investigator · Awarded by Damon Runyon Cancer Research Foundation · 2022 - 2026

Investigating the Mucin Utilization Capabilities of Akkermansia muciniphila

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2026

Akkermansia muciniphila as a mucosal vaccine platform for emerging pathogens

ResearchPrincipal Investigator · Awarded by Howard Hughes Medical Institute · 2022 - 2025

The Role of Host Genetics in Modulating the Beneficial Effects of the Gut Commensal Akkermansia muciniphila

ResearchPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2023 - 2025

A spatial transcriptional analsysis of Chlamydia-mediated upper genital tract pathology

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2025

Duke Women's Reproductive Health Research Scholars

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Genetic and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Basic Immunology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Characterizing and Exploiting Ruminococcus gnavus mediated induction of antimicrobial peptides

FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2021 - 2024

Viral Oncology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1980 - 2024

The role of Akkermansia muciniphila in the progression of Amyotrophic lateral sclerosis (ALS) disease

ResearchPrincipal Investigator · Awarded by Bloom Science · 2023 - 2024

Genetic analysis of mucin utilization by Akkermansia muciniphila and its impact on host physiology

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2023

Functional characterization of early Chlamydia effectors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2023

Defining human interferon-stimulated genes with novel functions in host defense to Chlamydia infections

FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2020 - 2023

Subversion of the host cell cytoskeleton and innate immunity during Chlamydia infection

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2022

Child Health and Human Development Extramural Research

ResearchPrincipal Investigator · Awarded by Weill Cornell Medicine · 2021 - 2022

Mechanisms of methylthioadenosine signaling during Salmonella infection

FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2019 - 2022

The impact of genetic diversity among Akkermansia strains on the effectivenes of immune checkpoint inhibitors in cancer immunotherapies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2022

Structure-Function Analysis of Chlamydia Secretion Chaperones

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2022

Posttranslational modifications of host proteins by Chlamydia effectors

ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2021

Genetic analysis of a beneficial gut bacterium

FellowshipPrincipal Investigator · Awarded by American Heart Association · 2018 - 2020

Genetics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Biochemistry and Structure of Lipid A Enzymes

ResearchCollaborator · Awarded by National Institutes of Health · 2016 - 2020

Enzymology of Chlamydial Pathogenesis

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2013 - 2020

Human Genetic Variance and Cellular Responses to Sexually Transmitted Infections

ResearchPD/PI · Awarded by University of Maryland · 2009 - 2019

The use of NExtGEn Genetics to determine gene function in genetically intractable but medically important microbes

FellowshipMentor · Awarded by Cincinnati Children's Hospital Medical Center · 2018 - 2019

Interferon-driven ubiquitin response targets Chlamydia inclusions in human cells

ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2019

BWF Ad Hoc grant Request ID# 1018498

ConferencePrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2017 - 2018

Genetic Analysis in an intractable gut microbe

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018

Characterization of a novel Salmonella regulator of IL-10 production and its role in pathogenesis

FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2016 - 2018

Forward and Reverse Genetics in Chlamydia

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2017

Investigating the Type II Secretion System of Chlamydia trachomatis

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2017

Institutional Training Grant in Pediatric Infectious Disease

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2011 - 2016

The role of cyclic-di-AMP in the regulation of Chlamydia cellular functions

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2016

Small Molecule Inhibitors of Polysaccharide Capsule Biogenesis as Novel Therapeutics for Urinary Tract Infections

FellowshipMentor · Awarded by Cincinnati Children's Hospital Medical Center · 2012 - 2015

Instrumentation for Quantitative Phosphoproteomics and Acetylomics

EquipmentMajor User · Awarded by National Institutes of Health · 2014 - 2015

Chlamydia Effector Proteins

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2014

IsoCyte Laser Scanning Plate Cytometer for High-throughput, High-content Assays

EquipmentMajor User · Awarded by National Institutes of Health · 2011 - 2012

Genetic Analysis in Chlamydia

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2010 - 2012

Chlamydia co-option of Eukaryotic Lipid Droplets

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2011

Live cell widefield fluorescence microscope with activation and bleaching lasers

EquipmentMajor User · Awarded by National Institutes of Health · 2010 - 2011

Identification of Coxiella burnetti Effector Proteins

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2009

Integrated instrument systems for maintenance and delivery of RNAi libraries

EquipmentCo Investigator · Awarded by National Institutes of Health · 2008 - 2009

Alternative Endpoints for Plague Challenge Models

ResearchConsultant · Awarded by National Institutes of Health · 2004 - 2008

Functional Genomic Analysis of the Chlamydia Inclusion

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2006

External Relationships


  • American Asssociation of Medical Colleges
  • Bloom Science, Inc.

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.