Scholars@Duke
Rebecca Bacon

Rebecca Bacon

Assistant Professor in Pathology
Pathology
rebecca.bacon@duke.edu
Department of Pathology, DUMC 3712, Durham, NC 27710
Department of Pathology, DUMC 3712, Durham, NC 27710

Scholarly Works

Novel promoters drive therapeutic transgene expression and evade transgene-specific immune responses in a mouse model of Pompe disease.

Journal article Mol Genet Metab · March 2026 Systemically administered gene therapy is under development for the treatment of Pompe disease, an inherited lysosomal storage disorder caused by acid alpha-glucosidase (GAA) deficiency. We evaluated recombinant AAV9 vectors expressing GAA driven by the mi ... Full text Link to item Cite

A review of chronic enterocolitis of rhesus macaques (<i>Macaca mulatta</i>) and potential as a naturally occurring model for post-infectious irritable bowel syndrome.

Journal article Frontiers in veterinary science · January 2026 Chronic enterocolitis (CE) is a disease of significant concern in colony-housed rhesus macaques, leading to chronic diarrhea and severe weight loss necessitating euthanasia in up to 25% of adults. Despite over three decades of research into this syndrome, ... Full text Open Access Cite

Single-dose cathepsin L CRISPR nanotherapy mitigates PASC-like lung damage in hamsters.

Journal article Nano Res · September 2025 Respiratory post-acute sequelae of COVID-19 (PASC) persists in many SARS-CoV-2 survivors, yet no therapies specifically address its long-term pulmonary damage. We demonstrate that a single-dose CRISPR-CasRx nanotherapy targeting the host enzyme cathepsin L ... Full text Link to item Cite

Three novel neoplasms in Nancy Ma's owl monkeys (<i>Aotus nancymaae</i>).

Journal article Veterinary pathology · May 2025 Neoplasms are only sporadically reported in New World primates and rarely in owl monkeys (Aotus spp.), specifically. Previous reports of neoplasms in owl monkeys are primarily restricted to lymphoma induced by Herpesvirus saimiri infection, a ... Full text Cite

Diversity of <i>Campylobacter</i> spp. circulating in a rhesus macaque (<i>Macaca mulatta</i>) breeding colony using culture and molecular methods.

Journal article mSphere · November 2024 Campylobacter jejuni and Campylobacter coli represent the leading causes of bacterial gastroenteritis in humans, and infections can produce post-infectious irritable bowel syndrome (PI-IBS). Rhesus macaques (Macaca mulatta) (RM) are si ... Full text Cite

Whole-genome sequences of Campylobacter coli and Campylobacter jejuni isolates from rhesus macaques (Macaca mulatta) with and without intestinal disease.

Journal article Microbiology resource announcements · April 2024 Campylobacter jejuni or Campylobacter coli infection can lead to post-infectious irritable bowel syndrome in humans and may produce a similar syndrome in rhesus macaques (Macaca mulatta). We report the complete genomes of 8 C. < ... Full text Cite

Analysis of cell populations in the normal rhesus macaque (Macaca mulatta) lower intestinal tract and diagnostic thresholds for chronic enterocolitis.

Journal article Veterinary pathology · March 2024 Rhesus macaques (Macaca mulatta) are used extensively in biomedical research, often with a focus on the gastrointestinal tract, and yet a full characterization of their normal resident intestinal cell populations has not been published. In addition, ... Full text Cite

<i>Talaromyces</i> spp. infections in dogs from the Southern United States.

Journal article Veterinary pathology · May 2022 Talaromyces spp. are soil-dwelling fungi sporadically reported to cause disease in humans and dogs. This study summarized the clinical presentations, histologic findings, and Talaromyces sp. involved in 5 dogs diagnosed through the panfungal ... Full text Cite

Pathology in Practice.

Journal article Journal of the American Veterinary Medical Association · February 2022 Full text Cite

Angioinvasive lymphoma (lymphomatoid granulomatosis) in a cat, with cutaneous and ocular metastasis.

Journal article Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · March 2021 Lymphomatoid granulomatosis (LYG) is a rare variant of an angioinvasive T-cell lymphoproliferative disorder that primarily affects the lungs, with common sites of metastasis including the skin and subcutis. In humans, it is a B-cell lymphoproliferative dis ... Full text Cite

Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma.

Journal article Helicobacter · June 2016 BackgroundOf all human cancers, gastric carcinoma is the one of the leading causes of death. Helicobacter pylori is considered a major etiologic agent of this disease. Spontaneously occurring gastric carcinoma is a rare diagnosis in nonhuman prima ... Full text Cite