Rebecca A Previs | Scholars@Duke

Rebecca A Previs
Assistant Professor of Obstetrics and Gynecology

Current Research Interests

Immune microenviroment in gynecologic malignancies, novel therapies for ovarian and uterine cancer, PARP inhibition in uterine cancer, molecular testing of gynecologic malignancies, early Phase clinical trials

Current Appointments & Affiliations

Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018

Contact Information

Division of Gynecologic Oncology, DUMC Box 3079, Durham, NC 27710
rebecca.previs@duke.edu (919) 684-8111

Background
Education, Training, & Certifications
- M.D., University of Virginia School of Medicine 2009
Leadership & Clinical Positions at Duke
- Phase I Gynecologic Oncology disease site champion
  Duke Center for Brain and Spine Metastasis Gynecologic Oncology Champion - 2019 to present
  Department of OB/Gynecology Enhanced Recovery After Surgery (ERAS) - Co-Leader - 2018 to present
  Center for Cancer Immunology disease site champion - 2019 to present
  EMPOWER leadership - 2019 to present
  2018 Duke course on Leadership Development for Researchers (LEADER)
Academic Positions Outside Duke
- Program Committee, Society of Gynecologic Oncologists. 2020 - 2021
- GOG-Foundation Communications Committee, GOG-Foundation. 2019 - 2020
- Developmental Therapeutics/Phase 1 General Member, NRG Oncology. 2019 - 2020
- Communications Committee, NRG Oncology. 2018 - 2020
- New Investigator's Committee, NRG Oncology. 2017 - 2020
Recognition
In the News
- MAY 3, 2019
  
  Urogynecology, Gynecologic Oncology Faculty Receive Research Awards
- DEC 26, 2018 Duke Cancer Institute
  
  #MyDukeCancerStory: Virginia Woman Speaks Out
- OCT 10, 2018 Duke Cancer Institute
  
  Emerging Options For Gynecologic Cancers
- SEP 20, 2018 Duke Cancer Institute
  
  Previs Awarded Scholarship for Ovarian Cancer Research
- JAN 17, 2018 Duke OB/GYN Department
  
  Rebecca Previs, MD, Selected for Leadership Development Program
Awards & Honors
Research
Selected Grants
- Novel see and treat strategies for cervical cancer prevention in low-resource settings awarded by National Institutes of Health 2019 - 2024
- Duke-UNC-Wash U Partnership for Early Phase Clinical Trials in Cancer awarded by National Institutes of Health 2014 - 2021
- Immune modulation of CaMKK2 in the ovarian tumor microenvironment 2019 - 2020
- Evaluation of homologous recombination deficiency in uterine serous cancer 2018 - 2019
- Janet Burros Ovarian Cancer Repository 2018 - 2019
Fellowships, Supported Research, & Other Grants
- Janet Burros Ovarian Cancer Repository in collaboration with the Cancer Data Initiative awarded by Janet Burros Memorial Foundation 2018
- Molecular classification of medically managed endometrial tumors awarded by Charles Hammond Research Fund 2018
- T32 Training Grant awarded by NCI-DHHS-NIH 2013 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Siamakpour-Reihani, Sharareh, Lauren Patterson Cobb, Chen Jiang, Dadong Zhang, Rebecca A. Previs, Kouros Owzar, Andrew B. Nixon, and Angeles Alvarez Secord. “Differential expression of immune related genes in high-grade ovarian serous carcinoma.” Gynecol Oncol 156, no. 3 (March 2020): 662–68. https://doi.org/10.1016/j.ygyno.2019.12.019.
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  - Previs, Rebecca A. “Becoming a surgeon-scientist: my transition from fellowship to faculty.” Clin Adv Hematol Oncol 17, no. 12 (December 2019): 677–78.
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  - Armbruster, Shannon D., Rebecca Previs, Pamela T. Soliman, Shannon N. Westin, Bryan Fellman, Anuja Jhingran, and Nicole D. Fleming. “Clinicopathologic features and treatment in patients with early stage uterine clear cell carcinoma: A 16-year experience.” Gynecol Oncol 154, no. 2 (August 2019): 328–32. https://doi.org/10.1016/j.ygyno.2019.06.001.
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  - Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.
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  - Davidson, Brittany A., Gloria Broadwater, Aleia Crim, Robert Boccacio, Kristin Bixel, Floor Backes, Rebecca A. Previs, et al. “Surgical complexity score and role of laparoscopy in women with advanced ovarian cancer treated with neoadjuvant chemotherapy.” Gynecol Oncol 152, no. 3 (March 2019): 554–59. https://doi.org/10.1016/j.ygyno.2018.12.011.
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  - Previs, Rebecca Ann, and Angeles Alvarez Secord. “Ovarian Cancer: Clinical Trial Breakthroughs and Impact on Management.” Obstet Gynecol Clin North Am 46, no. 1 (March 2019): 67–88. https://doi.org/10.1016/j.ogc.2018.09.005.
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  - Kurnit, Katherine C., Rebecca A. Previs, Pamela T. Soliman, Shannon N. Westin, Ann H. Klopp, Bryan M. Fellman, Karen H. Lu, Lois M. Ramondetta, and Nicole D. Fleming. “Prognostic factors impacting survival in early stage uterine carcinosarcoma.” Gynecol Oncol 152, no. 1 (January 2019): 31–37. https://doi.org/10.1016/j.ygyno.2018.10.034.
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  - Secord, Angeles Alvarez, Rebecca A. Previs, and Andrew B. Nixon. “Cabozantinib in ovarian clear cell cancers: UnMET expectations.” Gynecol Oncol 150, no. 1 (July 2018): 1–2. https://doi.org/10.1016/j.ygyno.2018.06.006.
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  - Allen, Julie K., Guillermo N. Armaiz-Pena, Archana S. Nagaraja, Nouara C. Sadaoui, Tatiana Ortiz, Robert Dood, Merve Ozcan, et al. “Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction.” Cancer Res 78, no. 12 (June 15, 2018): 3233–42. https://doi.org/10.1158/0008-5472.CAN-16-1701.
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  - Huang, Yan, Wei Hu, Jie Huang, Fangrong Shen, Yunjie Sun, Cristina Ivan, Sunila Pradeep, et al. “Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer.” Mol Cancer Ther 17, no. 2 (February 2018): 464–73. https://doi.org/10.1158/1535-7163.MCT-17-0006.
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  - Dalton, Heather J., Sunila Pradeep, Michael McGuire, Yared Hailemichael, Shaolin Ma, Yasmin Lyons, Guillermo N. Armaiz-Pena, et al. “Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression.” Clin Cancer Res 23, no. 22 (November 15, 2017): 7034–46. https://doi.org/10.1158/1078-0432.CCR-17-0647.
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  - Previs, Rebecca A., Guillermo N. Armaiz-Pena, Cristina Ivan, Heather J. Dalton, Rajesha Rupaimoole, Jean M. Hansen, Yasmin Lyons, et al. “Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies.” J Natl Cancer Inst 109, no. 7 (July 1, 2017). https://doi.org/10.1093/jnci/djw296.
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  - Lyons, Y. A., S. Pradeep, S. Y. Wu, M. Haemmerle, J. M. Hansen, M. J. Wagner, A. Villar-Prados, et al. “Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy.” Oncotarget 8, no. 57 (January 1, 2017): 96496–505. https://doi.org/10.18632/oncotarget.20410.
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  - Huang, Yan, Lenard M. Lichtenberger, Morgan Taylor, Justin N. Bottsford-Miller, Monika Haemmerle, Michael J. Wagner, Yasmin Lyons, et al. “Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer.” Mol Cancer Ther 15, no. 12 (December 2016): 2894–2904. https://doi.org/10.1158/1535-7163.MCT-16-0074.
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  - Previs, Rebecca A., Anil K. Sood, Gordon B. Mills, and Shannon N. Westin. “The rise of genomic profiling in ovarian cancer.” Expert Rev Mol Diagn 16, no. 12 (December 2016): 1337–51. https://doi.org/10.1080/14737159.2016.1259069.
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  - Highley, Louise L., Rebecca A. Previs, Sarah K. Dotters-Katz, Leo R. Brancazio, and Chad A. Grotegut. “Cesarean delivery among women with prolonged labor induction.” J Perinat Med 44, no. 7 (October 1, 2016): 759–66. https://doi.org/10.1515/jpm-2014-0357.
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  - Rupaimoole, R., C. Ivan, D. Yang, K. M. Gharpure, S. Y. Wu, C. V. Pecot, R. A. Previs, et al. “Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.” Oncogene 35, no. 33 (August 18, 2016): 4312–20. https://doi.org/10.1038/onc.2015.492.
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  - Whiting, N., J. Hu, N. M. Zacharias, G. L. R. Lokesh, D. E. Volk, D. G. Menter, R. Rupaimoole, R. Previs, A. K. Sood, and P. Bhattacharya. “Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer.” Journal of Medical Imaging 3, no. 3 (July 1, 2016). https://doi.org/10.1117/1.JMI.3.3.036001.
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  - Huang, Jie, Wei Hu, Limin Hu, Rebecca A. Previs, Heather J. Dalton, Xiao-Yun Yang, Yunjie Sun, et al. “Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth.” Mol Cancer Ther 15, no. 6 (June 2016): 1344–52. https://doi.org/10.1158/1535-7163.MCT-15-0144.
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  - Nagaraja, A. S., P. L. Dorniak, N. C. Sadaoui, Y. Kang, T. Lin, G. Armaiz-Pena, S. Y. Wu, et al. “Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis.” Oncogene 35, no. 18 (May 5, 2016): 2390–97. https://doi.org/10.1038/onc.2015.302.
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  - Kang, Yu, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Piotr L. Dorniak, Wei Hu, Rajesha Rupaimoole, Tao Liu, et al. “Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer.” Clin Cancer Res 22, no. 7 (April 1, 2016): 1713–24. https://doi.org/10.1158/1078-0432.CCR-15-1275.
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  - Zand, Behrouz, Rebecca A. Previs, Niki M. Zacharias, Rajesha Rupaimoole, Takashi Mitamura, Archana Sidalaghatta Nagaraja, Michele Guindani, et al. “Role of Increased n-acetylaspartate Levels in Cancer.” J Natl Cancer Inst 108, no. 6 (January 26, 2016): djv426. https://doi.org/10.1093/jnci/djv426.
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  - Rupaimoole, Rajesha, Jaehyuk Lee, Monika Haemmerle, Hui Ling, Rebecca A. Previs, Sunila Pradeep, Sherry Y. Wu, et al. “Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.” Cell Rep 13, no. 11 (December 22, 2015): 2395–2402. https://doi.org/10.1016/j.celrep.2015.11.047.
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  - Fuh, Katherine C., Angeles A. Secord, Kerri S. Bevis, Warner Huh, Adam ElNaggar, Kevin Blansit, Rebecca Previs, Todd Tillmanns, Daniel S. Kapp, and John K. Chan. “Comparison of bevacizumab alone or with chemotherapy in recurrent ovarian cancer patients.” Gynecol Oncol 139, no. 3 (December 2015): 413–18. https://doi.org/10.1016/j.ygyno.2015.06.041.
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  - Previs, Rebecca A., Guillermo N. Armaiz-Pena, Yvonne G. Lin, Ashley N. Davis, Sunila Pradeep, Heather J. Dalton, Jean M. Hansen, et al. “Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer.” Mol Cancer Ther 14, no. 12 (December 2015): 2677–86. https://doi.org/10.1158/1535-7163.MCT-14-0630.
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  - Pradeep, Sunila, Jie Huang, Edna M. Mora, Alpa M. Nick, Min Soon Cho, Sherry Y. Wu, Kyunghee Noh, et al. “Erythropoietin Stimulates Tumor Growth via EphB4.” Cancer Cell 28, no. 5 (November 9, 2015): 610–22. https://doi.org/10.1016/j.ccell.2015.09.008.
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  - Matsuo, Koji, Kosei Hasegawa, Kiyoshi Yoshino, Ryusuke Murakami, Takeshi Hisamatsu, Rebecca L. Stone, Rebecca A. Previs, et al. “Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma.” Eur J Cancer 51, no. 14 (September 2015): 1978–88. https://doi.org/10.1016/j.ejca.2015.07.012.
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  - Previs, Rebecca, Charles A. Leath, Robert L. Coleman, Thomas J. Herzog, Thomas C. Krivak, Stacey L. Brower, Chunqiao Tian, and Angeles Alvarez Secord. “Evaluation of in vitro chemoresponse profiles in women with Type I and Type II epithelial ovarian cancers: An observational study ancillary analysis.” Gynecol Oncol 138, no. 2 (August 2015): 267–71. https://doi.org/10.1016/j.ygyno.2015.05.038.
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  - Miyake, Takahito, Sunila Pradeep, Sherry Y. Wu, Rajesha Rupaimoole, Behrouz Zand, Yunfei Wen, Kshipra M. Gharpure, et al. “XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.” Clin Cancer Res 21, no. 14 (July 15, 2015): 3286–97. https://doi.org/10.1158/1078-0432.CCR-14-1953.
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  - Thanapprapasr, Duangmani, Rebecca A. Previs, Wei Hu, Cristina Ivan, Guillermo N. Armaiz-Pena, Piotr L. Dorniak, Jean M. Hansen, et al. “PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer.” Mol Cancer Ther 14, no. 6 (June 2015): 1466–75. https://doi.org/10.1158/1535-7163.MCT-14-1077.
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  - Gonzalez-Villasana, Vianey, Enrique Fuentes-Mattei, Cristina Ivan, Heather J. Dalton, Cristian Rodriguez-Aguayo, Ricardo J. Fernandez-de Thomas, Burcu Aslan, et al. “Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer.” Clin Cancer Res 21, no. 9 (May 1, 2015): 2127–37. https://doi.org/10.1158/1078-0432.CCR-14-2279.
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  - Previs, Rebecca A., Robert L. Coleman, Adrian L. Harris, and Anil K. Sood. “Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer.” Clin Cancer Res 21, no. 5 (March 1, 2015): 955–61. https://doi.org/10.1158/1078-0432.CCR-14-0809.
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  - Armaiz-Pena, Guillermo N., Vianey Gonzalez-Villasana, Archana S. Nagaraja, Cristian Rodriguez-Aguayo, Nouara C. Sadaoui, Rebecca L. Stone, Koji Matsuo, et al. “Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth.” Oncotarget 6, no. 6 (February 28, 2015): 4266–73. https://doi.org/10.18632/oncotarget.2887.
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  - Bottsford-Miller, Justin, Hyun-Jin Choi, Heather J. Dalton, Rebecca L. Stone, Min Soon Cho, Monika Haemmerle, Alpa M. Nick, et al. “Differential platelet levels affect response to taxane-based therapy in ovarian cancer.” Clin Cancer Res 21, no. 3 (February 1, 2015): 602–10. https://doi.org/10.1158/1078-0432.CCR-14-0870.
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  - Wen, Yunfei, Whitney S. Graybill, Rebecca A. Previs, Wei Hu, Cristina Ivan, Lingegowda S. Mangala, Behrouz Zand, et al. “Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer.” Clin Cancer Res 21, no. 2 (January 15, 2015): 448–59. https://doi.org/10.1158/1078-0432.CCR-14-1578.
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  - Hu, Wei, Tao Liu, Cristina Ivan, Yunjie Sun, Jie Huang, Lingegowda S. Mangala, Takahito Miyake, et al. “Notch3 pathway alterations in ovarian cancer.” Cancer Res 74, no. 12 (June 15, 2014): 3282–93. https://doi.org/10.1158/0008-5472.CAN-13-2066.
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  - Roh, Ju-Won, Jie Huang, Wei Hu, XiaoYun Yang, Nicholas B. Jennings, Vasudha Sehgal, Bo Hwa Sohn, et al. “Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer.” Clin Cancer Res 20, no. 10 (May 15, 2014): 2740–50. https://doi.org/10.1158/1078-0432.CCR-13-2507.
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  - Previs, Rebecca Ann, Joshua Kilgore, Renatta Craven, Gloria Broadwater, Sarah Bean, Sara Wobker, Megan DiFurio, Victoria Bae-Jump, Paola A. Gehrig, and Angeles Alvarez Secord. “Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer.” Int J Gynecol Cancer 24, no. 4 (May 2014): 670–75. https://doi.org/10.1097/IGC.0000000000000109.
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  - Wu, Sherry Y., Xianbin Yang, Kshipra M. Gharpure, Hiroto Hatakeyama, Martin Egli, Michael H. McGuire, Archana S. Nagaraja, et al. “2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.” Nat Commun 5 (March 12, 2014): 3459. https://doi.org/10.1038/ncomms4459.
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  - Previs, R. A., K. S. Bevis, W. Huh, T. Tillmanns, L. Perry, K. Moore, J. Chapman, et al. “A prognostic nomogram to predict overall survival in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy.” Gynecol Oncol 132, no. 3 (March 2014): 531–36. https://doi.org/10.1016/j.ygyno.2014.01.036.
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  - Previs, Rebecca A., James M. Edwards, Angeles A. Secord, Marisa R. Nucci, Rex C. Bentley, and Allison H. S. Hall. “Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report.” Int J Gynecol Pathol 33, no. 1 (January 2014): 100–104. https://doi.org/10.1097/PGP.0b013e318278b832.
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- Book Sections
  - Previs, R. A., and D. C. Bodurka. “Diagnosis and management of stage II endometrial cancer.” In Uterine Cancer: Diagnosis and Treatment, 293–305, 2015. https://doi.org/10.1007/978-81-322-1892-0_25.
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Teaching & Mentoring
Advising & Mentoring
- OB/Gyn Coaching Program
  OB/Gyn Resident Mentor for Resident Research Day - 2018-present
Teaching Activities
- Lecture to medical students and residents: "How to develop a research idea," 2020
  Grand Rounds Presentation: "ERAS for Gyencologic Surgery," 2019
  Longitudinal integrative clerkship program preceptor for medical students, 2018-2019, 2019-2020
  Cased Base Learning group leader for OB/GYN medical students, spring 2018
  Lectures in gynecologic oncology fellowship, obstetrics/gynecology and radiation oncology residency series
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
- Gail Parkins Memorial Ovarian Cancer Walk & 5K Run. September 21, 2019 2019
- Educational Forum Speaker. Gail Parkins Memorial Ovarian Cancer Walk & 5K Run. September 15, 2018 2018
Academic & Administrative Activities
- Duke Committees
  EMPOWER Women in Oncology Committee member - 2019 to present
  Duke Center for Brain and Spine Metastasis Gynecologic Oncology Champion - 2019 to present
  Duke CCPS Neuro Complications Working Group - 2019 to present
  Center for Cancer Immunology disease site champion - 2019 to present
  Duke Institutional Review Board Committee member - 2018 to present
  Cancer Protocol Committee member - 2018 to present
  Department On-boarding Task Force Committee - 2018 to present
  OB/GYN Residency Admissions Committee member - 2017 to present
  
  National Committees
  Society for Gynecologic Oncology Program Committee - 2020-2021
  NRG Oncology Developmental Therapeutics/Phase 1 - 2019 to present
  NRG Oncology Communications Committee - 2019 to present
  GOG-F Communications Committee - 2019 to present
  NRG Oncology Young Investigator Committee 2017 to present
  
  Journal Reviewer
  BMC Cancer
  Endocrine-Related Cancer
  Journal of Minimally Invasive Gynecology
  Oncology
  Targeted Oncology

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Education, Training, & Certifications

Leadership & Clinical Positions at Duke

Academic Positions Outside Duke

In the News

Awards & Honors

Selected Grants

Fellowships, Supported Research, & Other Grants

Selected Publications

Academic Articles

Book Sections

Advising & Mentoring

Teaching Activities

Presentations & Appearances

Outreach & Engaged Scholarship

Academic & Administrative Activities