Rebecca A Previs
Assistant Professor of Obstetrics and Gynecology
Current Research Interests
Immune microenviroment in gynecologic malignancies, novel therapies for ovarian and uterine cancer, PARP inhibition in uterine cancer, molecular testing of gynecologic malignancies, early Phase clinical trials
Current Appointments & Affiliations
- Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2017
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018
Contact Information
- Division of Gynecologic Oncology, DUMC Box 3079, Durham, NC 27710
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rebecca.previs@duke.edu
(919) 684-8111
- Background
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Education, Training, & Certifications
- M.D., University of Virginia School of Medicine 2009
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Leadership & Clinical Positions at Duke
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Phase I Gynecologic Oncology disease site champion
Duke Center for Brain and Spine Metastasis Gynecologic Oncology Champion - 2019 to present
Department of OB/Gynecology Enhanced Recovery After Surgery (ERAS) - Co-Leader
2018 Duke course on Leadership Development for Researchers (LEADER)
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Phase I Gynecologic Oncology disease site champion
- Recognition
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In the News
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MAY 3, 2019 -
DEC 26, 2018 Duke Cancer Institute -
OCT 10, 2018 Duke Cancer Institute -
SEP 20, 2018 Duke Cancer Institute -
JAN 17, 2018 Duke OB/GYN Department
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Awards & Honors
- GOG Foundation New Investigator Award Program. GOG Foundation Education/Mentoring Committee in collaboration with the NRG Oncology New Investigator Committee and the Society of Gynecologic Oncology (SGO). May 2, 2019
- The Diane Denson Tobola Fellowship in Ovarian Cancer Research. The University of Texas MD Anderson Cancer Center. 2016
- The Linda K. Manning Fellowship in Ovarian Cancer. The University of Texas MD Anderson Cancer Center. 2015
- Best resident oral presentation. Mid-Atlantic Gynecologic Oncology Society. 2012
- Speaker, 97th Annual Proclamation Night . University of Richmond. 2012
- C. Richmond Bowman Scholarship Award. University of Virginia School of Medicine. 2009
- Gold Humanism Honor Society. University of Virginia School of Medicine. 2008
- Speaker, 175th Baccalaureate Service during Commencement. University of Richmond. 2008
- Oldham Scholar. University of Richmond. 2005
- Speaker, 2005 Arts & Sciences Honors Convocation . University of Richmond. 2005
- Research
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Selected Grants
- Novel see and treat strategies for cervical cancer prevention in low-resource settings awarded by National Institutes of Health 2019 - 2024
- Immune modulation of CaMKK2 in the ovarian tumor microenvironment 2019 - 2020
- Duke-UNC-Wash U Partnership for Early Phase Clinical Trials in Cancer awarded by National Institutes of Health 2014 - 2020
- Evaluation of homologous recombination deficiency in uterine serous cancer 2018 - 2019
- Janet Burros Ovarian Cancer Repository 2018 - 2019
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Fellowships, Supported Research, & Other Grants
- Janet Burros Ovarian Cancer Repository in collaboration with the Cancer Data Initiative awarded by Janet Burros Memorial Foundation 2018
- T32 Training Grant awarded by NCI-DHHS-NIH 2013 - 2015
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Armbruster, Shannon D., Rebecca Previs, Pamela T. Soliman, Shannon N. Westin, Bryan Fellman, Anuja Jhingran, and Nicole D. Fleming. “Clinicopathologic features and treatment in patients with early stage uterine clear cell carcinoma: A 16-year experience..” Gynecol Oncol 154, no. 2 (August 2019): 328–32. https://doi.org/10.1016/j.ygyno.2019.06.001.Full Text Link to Item
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Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction..” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.Full Text Open Access Copy Link to Item
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Davidson, Brittany A., Gloria Broadwater, Aleia Crim, Robert Boccacio, Kristin Bixel, Floor Backes, Rebecca A. Previs, et al. “Surgical complexity score and role of laparoscopy in women with advanced ovarian cancer treated with neoadjuvant chemotherapy..” Gynecol Oncol 152, no. 3 (March 2019): 554–59. https://doi.org/10.1016/j.ygyno.2018.12.011.Full Text Link to Item
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Previs, Rebecca Ann, and Angeles Alvarez Secord. “Ovarian Cancer: Clinical Trial Breakthroughs and Impact on Management..” Obstet Gynecol Clin North Am 46, no. 1 (March 2019): 67–88. https://doi.org/10.1016/j.ogc.2018.09.005.Full Text Link to Item
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Kurnit, Katherine C., Rebecca A. Previs, Pamela T. Soliman, Shannon N. Westin, Ann H. Klopp, Bryan M. Fellman, Karen H. Lu, Lois M. Ramondetta, and Nicole D. Fleming. “Prognostic factors impacting survival in early stage uterine carcinosarcoma..” Gynecol Oncol 152, no. 1 (January 2019): 31–37. https://doi.org/10.1016/j.ygyno.2018.10.034.Full Text Link to Item
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Secord, Angeles Alvarez, Rebecca A. Previs, and Andrew B. Nixon. “Cabozantinib in ovarian clear cell cancers: UnMET expectations..” Gynecol Oncol 150, no. 1 (July 2018): 1–2. https://doi.org/10.1016/j.ygyno.2018.06.006.Full Text Link to Item
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Allen, Julie K., Guillermo N. Armaiz-Pena, Archana S. Nagaraja, Nouara C. Sadaoui, Tatiana Ortiz, Robert Dood, Merve Ozcan, et al. “Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction..” Cancer Res 78, no. 12 (June 15, 2018): 3233–42. https://doi.org/10.1158/0008-5472.CAN-16-1701.Full Text Link to Item
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Huang, Yan, Wei Hu, Jie Huang, Fangrong Shen, Yunjie Sun, Cristina Ivan, Sunila Pradeep, et al. “Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer..” Mol Cancer Ther 17, no. 2 (February 2018): 464–73. https://doi.org/10.1158/1535-7163.MCT-17-0006.Full Text Link to Item
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Dalton, Heather J., Sunila Pradeep, Michael McGuire, Yared Hailemichael, Shaolin Ma, Yasmin Lyons, Guillermo N. Armaiz-Pena, et al. “Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression..” Clin Cancer Res 23, no. 22 (November 15, 2017): 7034–46. https://doi.org/10.1158/1078-0432.CCR-17-0647.Full Text Link to Item
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Previs, Rebecca A., Guillermo N. Armaiz-Pena, Cristina Ivan, Heather J. Dalton, Rajesha Rupaimoole, Jean M. Hansen, Yasmin Lyons, et al. “Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies..” J Natl Cancer Inst 109, no. 7 (July 1, 2017). https://doi.org/10.1093/jnci/djw296.Full Text Link to Item
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Lyons, Y. A., S. Pradeep, S. Y. Wu, M. Haemmerle, J. M. Hansen, M. J. Wagner, A. Villar-Prados, et al. “Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy.” Oncotarget 8, no. 57 (January 1, 2017): 96496–505. https://doi.org/10.18632/oncotarget.20410.Full Text
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Huang, Yan, Lenard M. Lichtenberger, Morgan Taylor, Justin N. Bottsford-Miller, Monika Haemmerle, Michael J. Wagner, Yasmin Lyons, et al. “Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer..” Mol Cancer Ther 15, no. 12 (December 2016): 2894–2904. https://doi.org/10.1158/1535-7163.MCT-16-0074.Full Text Link to Item
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Previs, Rebecca A., Anil K. Sood, Gordon B. Mills, and Shannon N. Westin. “The rise of genomic profiling in ovarian cancer..” Expert Rev Mol Diagn 16, no. 12 (December 2016): 1337–51. https://doi.org/10.1080/14737159.2016.1259069.Full Text Link to Item
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Highley, Louise L., Rebecca A. Previs, Sarah K. Dotters-Katz, Leo R. Brancazio, and Chad A. Grotegut. “Cesarean delivery among women with prolonged labor induction..” J Perinat Med 44, no. 7 (October 1, 2016): 759–66. https://doi.org/10.1515/jpm-2014-0357.Full Text Link to Item
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Rupaimoole, R., C. Ivan, D. Yang, K. M. Gharpure, S. Y. Wu, C. V. Pecot, R. A. Previs, et al. “Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression..” Oncogene 35, no. 33 (August 18, 2016): 4312–20. https://doi.org/10.1038/onc.2015.492.Full Text Link to Item
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Whiting, N., J. Hu, N. M. Zacharias, G. L. R. Lokesh, D. E. Volk, D. G. Menter, R. Rupaimoole, R. Previs, A. K. Sood, and P. Bhattacharya. “Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer.” Journal of Medical Imaging 3, no. 3 (July 1, 2016). https://doi.org/10.1117/1.JMI.3.3.036001.Full Text
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Huang, Jie, Wei Hu, Limin Hu, Rebecca A. Previs, Heather J. Dalton, Xiao-Yun Yang, Yunjie Sun, et al. “Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth..” Mol Cancer Ther 15, no. 6 (June 2016): 1344–52. https://doi.org/10.1158/1535-7163.MCT-15-0144.Full Text Link to Item
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Nagaraja, A. S., P. L. Dorniak, N. C. Sadaoui, Y. Kang, T. Lin, G. Armaiz-Pena, S. Y. Wu, et al. “Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis..” Oncogene 35, no. 18 (May 5, 2016): 2390–97. https://doi.org/10.1038/onc.2015.302.Full Text Link to Item
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Kang, Yu, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Piotr L. Dorniak, Wei Hu, Rajesha Rupaimoole, Tao Liu, et al. “Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer..” Clin Cancer Res 22, no. 7 (April 1, 2016): 1713–24. https://doi.org/10.1158/1078-0432.CCR-15-1275.Full Text Link to Item
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Zand, Behrouz, Rebecca A. Previs, Niki M. Zacharias, Rajesha Rupaimoole, Takashi Mitamura, Archana Sidalaghatta Nagaraja, Michele Guindani, et al. “Role of Increased n-acetylaspartate Levels in Cancer..” J Natl Cancer Inst 108, no. 6 (January 26, 2016). https://doi.org/10.1093/jnci/djv426.Full Text Link to Item
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Rupaimoole, Rajesha, Jaehyuk Lee, Monika Haemmerle, Hui Ling, Rebecca A. Previs, Sunila Pradeep, Sherry Y. Wu, et al. “Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis..” Cell Rep 13, no. 11 (December 22, 2015): 2395–2402. https://doi.org/10.1016/j.celrep.2015.11.047.Full Text Link to Item
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Fuh, Katherine C., Angeles A. Secord, Kerri S. Bevis, Warner Huh, Adam ElNaggar, Kevin Blansit, Rebecca Previs, Todd Tillmanns, Daniel S. Kapp, and John K. Chan. “Comparison of bevacizumab alone or with chemotherapy in recurrent ovarian cancer patients..” Gynecol Oncol 139, no. 3 (December 2015): 413–18. https://doi.org/10.1016/j.ygyno.2015.06.041.Full Text Link to Item
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Previs, Rebecca A., Guillermo N. Armaiz-Pena, Yvonne G. Lin, Ashley N. Davis, Sunila Pradeep, Heather J. Dalton, Jean M. Hansen, et al. “Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer..” Mol Cancer Ther 14, no. 12 (December 2015): 2677–86. https://doi.org/10.1158/1535-7163.MCT-14-0630.Full Text Link to Item
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Pradeep, Sunila, Jie Huang, Edna M. Mora, Alpa M. Nick, Min Soon Cho, Sherry Y. Wu, Kyunghee Noh, et al. “Erythropoietin Stimulates Tumor Growth via EphB4..” Cancer Cell 28, no. 5 (November 9, 2015): 610–22. https://doi.org/10.1016/j.ccell.2015.09.008.Full Text Link to Item
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Matsuo, Koji, Kosei Hasegawa, Kiyoshi Yoshino, Ryusuke Murakami, Takeshi Hisamatsu, Rebecca L. Stone, Rebecca A. Previs, et al. “Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma..” Eur J Cancer 51, no. 14 (September 2015): 1978–88. https://doi.org/10.1016/j.ejca.2015.07.012.Full Text Link to Item
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Previs, Rebecca, Charles A. Leath, Robert L. Coleman, Thomas J. Herzog, Thomas C. Krivak, Stacey L. Brower, Chunqiao Tian, and Angeles Alvarez Secord. “Evaluation of in vitro chemoresponse profiles in women with Type I and Type II epithelial ovarian cancers: An observational study ancillary analysis..” Gynecol Oncol 138, no. 2 (August 2015): 267–71. https://doi.org/10.1016/j.ygyno.2015.05.038.Full Text Link to Item
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Miyake, Takahito, Sunila Pradeep, Sherry Y. Wu, Rajesha Rupaimoole, Behrouz Zand, Yunfei Wen, Kshipra M. Gharpure, et al. “XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A..” Clin Cancer Res 21, no. 14 (July 15, 2015): 3286–97. https://doi.org/10.1158/1078-0432.CCR-14-1953.Full Text Link to Item
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Thanapprapasr, Duangmani, Rebecca A. Previs, Wei Hu, Cristina Ivan, Guillermo N. Armaiz-Pena, Piotr L. Dorniak, Jean M. Hansen, et al. “PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer..” Mol Cancer Ther 14, no. 6 (June 2015): 1466–75. https://doi.org/10.1158/1535-7163.MCT-14-1077.Full Text Link to Item
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Gonzalez-Villasana, Vianey, Enrique Fuentes-Mattei, Cristina Ivan, Heather J. Dalton, Cristian Rodriguez-Aguayo, Ricardo J. Fernandez-de Thomas, Burcu Aslan, et al. “Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer..” Clin Cancer Res 21, no. 9 (May 1, 2015): 2127–37. https://doi.org/10.1158/1078-0432.CCR-14-2279.Full Text Link to Item
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Previs, Rebecca A., Robert L. Coleman, Adrian L. Harris, and Anil K. Sood. “Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer..” Clin Cancer Res 21, no. 5 (March 1, 2015): 955–61. https://doi.org/10.1158/1078-0432.CCR-14-0809.Full Text Link to Item
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Armaiz-Pena, Guillermo N., Vianey Gonzalez-Villasana, Archana S. Nagaraja, Cristian Rodriguez-Aguayo, Nouara C. Sadaoui, Rebecca L. Stone, Koji Matsuo, et al. “Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth..” Oncotarget 6, no. 6 (February 28, 2015): 4266–73. https://doi.org/10.18632/oncotarget.2887.Full Text Link to Item
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Bottsford-Miller, Justin, Hyun-Jin Choi, Heather J. Dalton, Rebecca L. Stone, Min Soon Cho, Monika Haemmerle, Alpa M. Nick, et al. “Differential platelet levels affect response to taxane-based therapy in ovarian cancer..” Clin Cancer Res 21, no. 3 (February 1, 2015): 602–10. https://doi.org/10.1158/1078-0432.CCR-14-0870.Full Text Link to Item
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Wen, Yunfei, Whitney S. Graybill, Rebecca A. Previs, Wei Hu, Cristina Ivan, Lingegowda S. Mangala, Behrouz Zand, et al. “Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer..” Clin Cancer Res 21, no. 2 (January 15, 2015): 448–59. https://doi.org/10.1158/1078-0432.CCR-14-1578.Full Text Link to Item
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Hu, Wei, Tao Liu, Cristina Ivan, Yunjie Sun, Jie Huang, Lingegowda S. Mangala, Takahito Miyake, et al. “Notch3 pathway alterations in ovarian cancer..” Cancer Res 74, no. 12 (June 15, 2014): 3282–93. https://doi.org/10.1158/0008-5472.CAN-13-2066.Full Text Link to Item
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Roh, Ju-Won, Jie Huang, Wei Hu, XiaoYun Yang, Nicholas B. Jennings, Vasudha Sehgal, Bo Hwa Sohn, et al. “Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer..” Clin Cancer Res 20, no. 10 (May 15, 2014): 2740–50. https://doi.org/10.1158/1078-0432.CCR-13-2507.Full Text Link to Item
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Previs, Rebecca Ann, Joshua Kilgore, Renatta Craven, Gloria Broadwater, Sarah Bean, Sara Wobker, Megan DiFurio, Victoria Bae-Jump, Paola A. Gehrig, and Angeles Alvarez Secord. “Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer..” Int J Gynecol Cancer 24, no. 4 (May 2014): 670–75. https://doi.org/10.1097/IGC.0000000000000109.Full Text Link to Item
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Wu, Sherry Y., Xianbin Yang, Kshipra M. Gharpure, Hiroto Hatakeyama, Martin Egli, Michael H. McGuire, Archana S. Nagaraja, et al. “2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity..” Nat Commun 5 (March 12, 2014). https://doi.org/10.1038/ncomms4459.Full Text Link to Item
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Previs, R. A., K. S. Bevis, W. Huh, T. Tillmanns, L. Perry, K. Moore, J. Chapman, et al. “A prognostic nomogram to predict overall survival in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy..” Gynecol Oncol 132, no. 3 (March 2014): 531–36. https://doi.org/10.1016/j.ygyno.2014.01.036.Full Text Link to Item
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Previs, Rebecca A., James M. Edwards, Angeles A. Secord, Marisa R. Nucci, Rex C. Bentley, and Allison H. S. Hall. “Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report..” Int J Gynecol Pathol 33, no. 1 (January 2014): 100–104. https://doi.org/10.1097/PGP.0b013e318278b832.Full Text Link to Item
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Book Sections
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Previs, R. A., and D. C. Bodurka. “Diagnosis and management of stage II endometrial cancer.” In Uterine Cancer: Diagnosis and Treatment, 293–305, 2015. https://doi.org/10.1007/978-81-322-1892-0_25.Full Text
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- Teaching & Mentoring
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Advising & Mentoring
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OB/Gyn Coaching Program
OB/Gyn Resident Mentor for Resident Research Day - 2018-present
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OB/Gyn Coaching Program
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Teaching Activities
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Longitudinal integrative clerkship program preceptor for medical students, 2018-2019
Cased Base Learning group leader for OB/GYN medical students, spring 2018
Lectures in gynecologic oncology fellowship, obstetrics/gynecology and radiation oncology residency series
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Longitudinal integrative clerkship program preceptor for medical students, 2018-2019
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Immune modulation of CaMKK2 in the ovarian tumor microenvironment. Felix Rutledge Society Annual Meeting. October 18, 2018 2018
- Advances in the Management of GYN Malignancies - Highlights from 2018. Duke Cancer Review. July 2018 2018
- Two to tango: Biological activity and companion predictive markers for a novel dual AKT and P70S6K inhibitor in ovarian and uterine malignancies. Seminars in Women's Cancer. March 22, 2018 2018
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Outreach & Engaged Scholarship
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Academic & Administrative Activities
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Duke Committees
EMPOWER Women in Oncology Committee member - 2019 to present
Duke Center for Brain and Spine Metastasis Gynecologic Oncology Champion - 2019 to present
Duke CCPS Neuro Complications Working Group - 2019 to present
Duke Institutional Review Board Committee member - 2018 to present
Cancer Protocol Committee member - 2018 to present
Department On-boarding Task Force Committee - 2018 to present
OB/GYN Residency Admissions Committee member - 2017 to present
National Committees
NRG Oncology Communications Committee - 2019 to present
GOG-F Communications Committee - 2019 to present
NRG Oncology Young Investigator Committee 2017 to present
Journal Reviewer
BMC Cancer
Endocrine-Related Cancer
Journal of Minimally Invasive Gynecology
Oncology
Targeted Oncology
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Duke Committees
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