Rebecca A Previs | Scholars@Duke

Rebecca A Previs
Assistant Professor of Obstetrics and Gynecology

Current Research Interests

Immune microenviroment in gynecologic malignancies, novel therapies for ovarian and uterine cancer, PARP inhibition in uterine cancer, molecular testing of gynecologic malignancies, early Phase clinical trials

Current Appointments & Affiliations

Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2017

Contact Information

Dept Of Obgyn, Box 3616, Durham, NC 27710
rebecca.previs@duke.edu (919) 684-8111

Background
Education, Training, & Certifications
- M.D., University of Virginia School of Medicine 2009
Leadership & Clinical Positions at Duke
- 2018 Duke course on Leadership Development for Researchers (LEADER)
  Phase I Gynecologic Oncology champion
Recognition
In the News
- JAN 17, 2018 Duke OB/GYN Department
  
  Rebecca Previs, MD, Selected for Leadership Development Program
Research
Fellowships, Supported Research, & Other Grants
- Janet Burros Ovarian Cancer Repository in collaboration with the Cancer Data Initiative awarded by Janet Burros Memorial Foundation 2018
- T32 Training Grant awarded by NCI-DHHS-NIH 2013 - 2015
Publications & Artistic Works
Selected Publications
- Book Sections
  - Previs, RA, and Bodurka, DC. "Diagnosis and management of stage II endometrial cancer." In Uterine Cancer: Diagnosis and Treatment, 293-305. August 27, 2015. Full Text
- Journal Articles
  - Huang, Y, Hu, W, Huang, J, Shen, F, Sun, Y, Ivan, C, Pradeep, S, Dood, R, Haemmerle, M, Jiang, D, Mangala, LS, Noh, K, Hansen, JM, Dalton, HJ, Previs, RA, Nagaraja, AS, McGuire, M, Jennings, NB, Broaddus, R, Coleman, RL, and Sood, AK. "Inhibiting nuclear phospho-progesterone receptor enhances antitumor activity of onapristone in uterine cancer." Molecular Cancer Therapeutics 17, no. 2 (February 1, 2018): 464-473. Full Text
  - Previs, RA, Armaiz-Pena, GN, Ivan, C, Dalton, HJ, Rupaimoole, R, Hansen, JM, Lyons, Y, Huang, J, Haemmerle, M, Wagner, MJ, Gharpure, KM, Nagaraja, AS, Filant, J, McGuire, MH, Noh, K, Dorniak, PL, Linesch, SL, Mangala, LS, Pradeep, S, Wu, SY, and Sood, AK. "Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies." JNCI Journal of the National Cancer Institute 109, no. 7 (July 2017). Full Text
  - Huang, Y, Lichtenberger, LM, Taylor, M, Bottsford-Miller, JN, Haemmerle, M, Wagner, MJ, Lyons, Y, Pradeep, S, Hu, W, Previs, RA, Hansen, JM, Fang, D, Dorniak, PL, Filant, J, Dial, EJ, Shen, F, Hatakeyama, H, and Sood, AK. "Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer." Molecular cancer therapeutics 15, no. 12 (December 2016): 2894-2904. Full Text
  - Previs, RA, Sood, AK, Mills, GB, and Westin, SN. "The rise of genomic profiling in ovarian cancer." Expert review of molecular diagnostics 16, no. 12 (December 2016): 1337-1351. (Review) Full Text
  - Highley, LL, Previs, RA, Dotters-Katz, SK, Brancazio, LR, and Grotegut, CA. "Cesarean delivery among women with prolonged labor induction." Journal of perinatal medicine 44, no. 7 (October 2016): 759-766. Full Text
  - Whiting, N, Hu, J, Zacharias, NM, Lokesh, GLR, Volk, DE, Menter, DG, Rupaimoole, R, Previs, R, Sood, AK, and Bhattacharya, P. "Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer." Journal of Medical Imaging 3, no. 3 (August 10, 2016): 036001-036001. Full Text
  - Rupaimoole, R, Ivan, C, Yang, D, Gharpure, KM, Wu, SY, Pecot, CV, Previs, RA, Nagaraja, AS, Armaiz-Pena, GN, McGuire, M, Pradeep, S, Mangala, LS, Rodriguez-Aguayo, C, Huang, L, Bar-Eli, M, Zhang, W, Lopez-Berestein, G, Calin, GA, and Sood, AK. "Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression." Oncogene 35, no. 33 (August 2016): 4312-4320. Full Text
  - Huang, J, Hu, W, Hu, L, Previs, RA, Dalton, HJ, Yang, X-Y, Sun, Y, McGuire, M, Rupaimoole, R, Nagaraja, AS, Kang, Y, Liu, T, Nick, AM, Jennings, NB, Coleman, RL, Jaffe, RB, and Sood, AK. "Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth." Molecular cancer therapeutics 15, no. 6 (June 2016): 1344-1352. Full Text
  - Nagaraja, AS, Dorniak, PL, Sadaoui, NC, Kang, Y, Lin, T, Armaiz-Pena, G, Wu, SY, Rupaimoole, R, Allen, JK, Gharpure, KM, Pradeep, S, Zand, B, Previs, RA, Hansen, JM, Ivan, C, Rodriguez-Aguayo, C, Yang, P, Lopez-Berestein, G, Lutgendorf, SK, Cole, SW, and Sood, AK. "Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis." Oncogene 35, no. 18 (May 2016): 2390-2397. Full Text
  - Kang, Y, Nagaraja, AS, Armaiz-Pena, GN, Dorniak, PL, Hu, W, Rupaimoole, R, Liu, T, Gharpure, KM, Previs, RA, Hansen, JM, Rodriguez-Aguayo, C, Ivan, C, Ram, P, Sehgal, V, Lopez-Berestein, G, Lutgendorf, SK, Cole, SW, and Sood, AK. "Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 22, no. 7 (April 2016): 1713-1724. Full Text
  - Zand, B, Previs, RA, Zacharias, NM, Rupaimoole, R, Mitamura, T, Nagaraja, AS, Guindani, M, Dalton, HJ, Yang, L, Baddour, J, Achreja, A, Hu, W, Pecot, CV, Ivan, C, Wu, SY, McCullough, CR, Gharpure, KM, Shoshan, E, Pradeep, S, Mangala, LS, Rodriguez-Aguayo, C, Wang, Y, Nick, AM, Davies, MA, Armaiz-Pena, G, Liu, J, Lutgendorf, SK, Baggerly, KA, Eli, MB, Lopez-Berestein, G, Nagrath, D, Bhattacharya, PK, and Sood, AK. "Role of Increased n-acetylaspartate Levels in Cancer." JNCI Journal of the National Cancer Institute 108, no. 6 (January 26, 2016): djv426-. Full Text
  - Rupaimoole, R, Lee, J, Haemmerle, M, Ling, H, Previs, RA, Pradeep, S, Wu, SY, Ivan, C, Ferracin, M, Dennison, JB, Millward, NMZ, Nagaraja, AS, Gharpure, KM, McGuire, M, Sam, N, Armaiz-Pena, GN, Sadaoui, NC, Rodriguez-Aguayo, C, Calin, GA, Drapkin, RI, Kovacs, J, Mills, GB, Zhang, W, Lopez-Berestein, G, Bhattacharya, PK, and Sood, AK. "Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis." Cell reports 13, no. 11 (December 9, 2015): 2395-2402. Full Text
  - Fuh, KC, Secord, AA, Bevis, KS, Huh, W, ElNaggar, A, Blansit, K, Previs, R, Tillmanns, T, Kapp, DS, and Chan, JK. "Comparison of bevacizumab alone or with chemotherapy in recurrent ovarian cancer patients." Gynecologic oncology 139, no. 3 (December 2015): 413-418. Full Text
  - Previs, RA, Armaiz-Pena, GN, Lin, YG, Davis, AN, Pradeep, S, Dalton, HJ, Hansen, JM, Merritt, WM, Nick, AM, Langley, RR, Coleman, RL, and Sood, AK. "Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer." Molecular cancer therapeutics 14, no. 12 (December 2015): 2677-2686. Full Text
  - Pradeep, S, Huang, J, Mora, EM, Nick, AM, Cho, MS, Wu, SY, Noh, K, Pecot, CV, Rupaimoole, R, Stein, MA, Brock, S, Wen, Y, Xiong, C, Gharpure, K, Hansen, JM, Nagaraja, AS, Previs, RA, Vivas-Mejia, P, Han, HD, Hu, W, Mangala, LS, Zand, B, Stagg, LJ, Ladbury, JE, Ozpolat, B, Alpay, SN, Nishimura, M, Stone, RL, Matsuo, K, Armaiz-Peña, GN, Dalton, HJ, Danes, C, Goodman, B, Rodriguez-Aguayo, C, Kruger, C, Schneider, A, Haghpeykar, S, Jaladurgam, P, Hung, M-C, Coleman, RL, Liu, J, Li, C, and Urbauer, D et al. "Erythropoietin Stimulates Tumor Growth via EphB4." Cancer cell 28, no. 5 (November 2015): 610-622. Full Text
  - Matsuo, K, Hasegawa, K, Yoshino, K, Murakami, R, Hisamatsu, T, Stone, RL, Previs, RA, Hansen, JM, Ikeda, Y, Miyara, A, Hiramatsu, K, Enomoto, T, Fujiwara, K, Matsumura, N, Konishi, I, Roman, LD, Gabra, H, Fotopoulou, C, and Sood, AK. "Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma." European journal of cancer (Oxford, England : 1990) 51, no. 14 (September 2015): 1978-1988. Full Text
  - Previs, R, Leath, CA, Coleman, RL, Herzog, TJ, Krivak, TC, Brower, SL, Tian, C, and Secord, AA. "Evaluation of in vitro chemoresponse profiles in women with Type I and Type II epithelial ovarian cancers: An observational study ancillary analysis." Gynecologic oncology 138, no. 2 (August 2015): 267-271. Full Text
  - Miyake, T, Pradeep, S, Wu, SY, Rupaimoole, R, Zand, B, Wen, Y, Gharpure, KM, Nagaraja, AS, Hu, W, Cho, MS, Dalton, HJ, Previs, RA, Taylor, ML, Hisamatsu, T, Kang, Y, Liu, T, Shacham, S, McCauley, D, Hawke, DH, Wiktorowicz, JE, Coleman, RL, and Sood, AK. "XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A." Clinical cancer research : an official journal of the American Association for Cancer Research 21, no. 14 (July 2015): 3286-3297. Full Text
  - Thanapprapasr, D, Previs, RA, Hu, W, Ivan, C, Armaiz-Pena, GN, Dorniak, PL, Hansen, JM, Rupaimoole, R, Huang, J, Dalton, HJ, Ali-Fehmi, R, Coleman, RL, and Sood, AK. "PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer." Molecular cancer therapeutics 14, no. 6 (June 2015): 1466-1475. Full Text
  - Gonzalez-Villasana, V, Fuentes-Mattei, E, Ivan, C, Dalton, HJ, Rodriguez-Aguayo, C, Fernandez-de Thomas, RJ, Aslan, B, Del C Monroig, P, Velazquez-Torres, G, Previs, RA, Pradeep, S, Kahraman, N, Wang, H, Kanlikilicer, P, Ozpolat, B, Calin, G, Sood, AK, and Lopez-Berestein, G. "Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 21, no. 9 (May 2015): 2127-2137. Full Text
  - Previs, RA, Coleman, RL, Harris, AL, and Sood, AK. "Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 21, no. 5 (March 2015): 955-961. (Review) Full Text
  - Armaiz-Pena, GN, Gonzalez-Villasana, V, Nagaraja, AS, Rodriguez-Aguayo, C, Sadaoui, NC, Stone, RL, Matsuo, K, Dalton, HJ, Previs, RA, Jennings, NB, Dorniak, P, Hansen, JM, Arevalo, JMG, Cole, SW, Lutgendorf, SK, Sood, AK, and Lopez-Berestein, G. "Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth." Oncotarget 6, no. 6 (February 2015): 4266-4273. Full Text
  - Bottsford-Miller, J, Choi, H-J, Dalton, HJ, Stone, RL, Cho, MS, Haemmerle, M, Nick, AM, Pradeep, S, Zand, B, Previs, RA, Pecot, CV, Crane, EK, Hu, W, Lutgendorf, SK, Afshar-Kharghan, V, and Sood, AK. "Differential platelet levels affect response to taxane-based therapy in ovarian cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 21, no. 3 (February 2015): 602-610. Full Text
  - Wen, Y, Graybill, WS, Previs, RA, Hu, W, Ivan, C, Mangala, LS, Zand, B, Nick, AM, Jennings, NB, Dalton, HJ, Sehgal, V, Ram, P, Lee, J-S, Vivas-Mejia, PE, Coleman, RL, and Sood, AK. "Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 21, no. 2 (January 2015): 448-459. Full Text
  - Hu, W, Liu, T, Ivan, C, Sun, Y, Huang, J, Mangala, LS, Miyake, T, Dalton, HJ, Pradeep, S, Rupaimoole, R, Previs, RA, Han, HD, Bottsford-Miller, J, Zand, B, Kang, Y, Pecot, CV, Nick, AM, Wu, SY, Lee, J-S, Sehgal, V, Ram, P, Liu, J, Tucker, SL, Lopez-Berestein, G, Baggerly, KA, Coleman, RL, and Sood, AK. "Notch3 pathway alterations in ovarian cancer." Cancer research 74, no. 12 (June 2014): 3282-3293. Full Text
  - Previs, RA, Kilgore, J, Craven, R, Broadwater, G, Bean, S, Wobker, S, DiFurio, M, Bae-Jump, V, Gehrig, PA, and Secord, AA. "Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 24, no. 4 (May 2014): 670-675. Full Text
  - Roh, J-W, Huang, J, Hu, W, Yang, X, Jennings, NB, Sehgal, V, Sohn, BH, Han, HD, Lee, SJ, Thanapprapasr, D, Bottsford-Miller, J, Zand, B, Dalton, HJ, Previs, RA, Davis, AN, Matsuo, K, Lee, J-S, Ram, P, Coleman, RL, and Sood, AK. "Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 20, no. 10 (May 2014): 2740-2750. Full Text
  - Wu, SY, Yang, X, Gharpure, KM, Hatakeyama, H, Egli, M, McGuire, MH, Nagaraja, AS, Miyake, TM, Rupaimoole, R, Pecot, CV, Taylor, M, Pradeep, S, Sierant, M, Rodriguez-Aguayo, C, Choi, HJ, Previs, RA, Armaiz-Pena, GN, Huang, L, Martinez, C, Hassell, T, Ivan, C, Sehgal, V, Singhania, R, Han, H-D, Su, C, Kim, JH, Dalton, HJ, Kovvali, C, Keyomarsi, K, McMillan, NAJ, Overwijk, WW, Liu, J, Lee, J-S, Baggerly, KA, Lopez-Berestein, G, Ram, PT, Nawrot, B, and Sood, AK. "2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity." Nature communications 5 (March 12, 2014): 3459-. Full Text
  - Previs, RA, Bevis, KS, Huh, W, Tillmanns, T, Perry, L, Moore, K, Chapman, J, McClung, C, Kiet, T, Java, J, Chan, J, and Secord, AA. "A prognostic nomogram to predict overall survival in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy." Gynecologic Oncology 132, no. 3 (January 1, 2014): 531-536. Full Text
  - Previs, RA, Edwards, JM, Secord, AA, Nucci, MR, Bentley, RC, and Hall, AHS. "Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: A case report." International Journal of Gynecological Pathology 33, no. 1 (January 1, 2014): 100-104. Full Text
  - Dalton, HJ, Pradeep, S, McGuire, M, Hailemichael, Y, MA, S, Lyons, Y, Armaiz-Pena, GN, Previs, RA, Hansen, JM, Rupaimoole, R, Gonzalez-Villasana, V, Cho, MS, Wu, SY, Mangala, LS, Jennings, NB, Hu, W, Langley, R, Mu, H, Andreeff, M, Bar-Eli, M, Overwijk, W, Ram, P, Lopez-Berestein, G, Coleman, RL, and Sood, AK. "Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression (Published online)." Clinical Cancer Research . Full Text
  - Lyons, YA, Pradeep, S, Wu, SY, Haemmerle, M, Hansen, JM, Wagner, MJ, Villar-Prados, A, Nagaraja, AS, Dood, RL, Previs, RA, Hu, W, Zhao, Y, Mak, DH, Xiao, Z, Melendez, BD, Lizee, GA, Mercado-Uribe, I, Baggerly, KA, Hwu, P, Liu, J, Overwijk, WW, Coleman, RL, and Sood, AK. "Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy (Published online)." Oncotarget . Full Text
Teaching & Mentoring
Advising & Mentoring
- OB/Gyn Coaching Program
Teaching Activities
- Cased Base Learning group leader for OB/Gyn medical students, spring 2018
  Lectures in gynecologic oncology fellowship and radiation oncology residency series
Scholarly, Clinical, & Service Activities
Presentations & Appearances
- Two to tango: Biological activity and companion predictive markers for a novel dual AKT and P70S6K inhibitor in ovarian and uterine malignancies. Seminars in Women's Cancer. March 22, 2018 2018
Academic & Administrative Activities
- Duke Committees
  Duke Institutional Review Board Committee member - 2018
  Cancer Protocol Committee member - 2018
  OB/GYN Residency Admissions Committee member - 2018
  
  National Committees
  NRG Oncology Young Investigator Committee 2017-2018
  
  Journal Reviewer
  BMC Cancer
  Endocrine-Related Cancer
  Journal of Minimally Invasive Gynecology
  Oncology

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Education, Training, & Certifications

Leadership & Clinical Positions at Duke

In the News

Fellowships, Supported Research, & Other Grants

Selected Publications

Book Sections

Journal Articles

Advising & Mentoring

Teaching Activities

Presentations & Appearances

Academic & Administrative Activities