Other · September 16, 2024
<div>Abstract<p>Triple-negative breast cancers (TNBCs) tend to become invasive and metastatic at early stages in their development. Despite some treatment successes in early stage localized TNBC, the rate of distant recurrence remains h ...
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Other · September 16, 2024
<p>Contains Supplementary Figures 1-4, Supplementary Tables 1-2 and legends for Supplementary Videos 1-4</p> ...
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Other · September 16, 2024
<div>Abstract<p>Triple-negative breast cancers (TNBCs) tend to become invasive and metastatic at early stages in their development. Despite some treatment successes in early stage localized TNBC, the rate of distant recurrence remains h ...
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Other · September 16, 2024
<p>Contains Supplementary Figures 1-4, Supplementary Tables 1-2 and legends for Supplementary Videos 1-4</p> ...
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Journal ArticleNeoplasia · September 13, 2024
Single agent immune checkpoint inhibitors have been ineffective for patients with advanced stage and recurrent high grade serous ovarian cancer (HGSOC). Using pre-clinical models of HGSOC, we evaluated the anti-tumor and immune stimulatory effects of an on ...
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Journal ArticleCancer Res Commun · March 18, 2024
UNLABELLED: This study investigated the association between health care access (HCA) dimensions and racial disparities in end-of-life (EOL) care quality among non-Hispanic Black (NHB), non-Hispanic White (NHW), and Hispanic patients with ovarian cancer. Th ...
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Other · March 18, 2024
<p>Estimates of the associations between HCA dimensions, patient race and ethnicity, and EOL care quality outcomes on entire study cohort (<i>N</i> = 4,646), subcohort of patients that died from ovarian cancer (<i>N</i> ...
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Other · March 18, 2024
<p>Baseline characteristics of patients with ovarian cancer who died during study follow-up stratified by race and ethnicity (<i>N</i> = 4,646)</p> ...
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Other · March 18, 2024
<p>Relative risk ratio (RR) for receipt of any chemotherapy within 14 days of death with interaction term between accessibility score and patient race</p> ...
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Other · March 18, 2024
<p>Baseline characteristics of patients with ovarian cancer who died during study follow-up stratified by race and ethnicity (<i>N</i> = 4,646)</p> ...
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Other · March 18, 2024
<p>Participant flowchart for NHB, Hispanic and NHW patients with ovarian cancer, SEER-Medicare 2008–2015. Percentage of NHB patients presented for sensitivity purposes.</p> ...
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Other · September 16, 2024
<div>Abstract<p>Triple-negative breast cancers (TNBCs) tend to become invasive and metastatic at early stages in their development. Despite some treatment successes in early stage localized TNBC, the rate of distant recurrence remains h ...
Full textCite
Other · September 16, 2024
<p>Contains Supplementary Figures 1-4, Supplementary Tables 1-2 and legends for Supplementary Videos 1-4</p> ...
Full textCite
Other · September 16, 2024
<div>Abstract<p>Triple-negative breast cancers (TNBCs) tend to become invasive and metastatic at early stages in their development. Despite some treatment successes in early stage localized TNBC, the rate of distant recurrence remains h ...
Full textCite
Other · September 16, 2024
<p>Contains Supplementary Figures 1-4, Supplementary Tables 1-2 and legends for Supplementary Videos 1-4</p> ...
Full textCite
Journal ArticleNeoplasia · September 13, 2024
Single agent immune checkpoint inhibitors have been ineffective for patients with advanced stage and recurrent high grade serous ovarian cancer (HGSOC). Using pre-clinical models of HGSOC, we evaluated the anti-tumor and immune stimulatory effects of an on ...
Full textLink to itemCite
Journal ArticleCancer Res Commun · March 18, 2024
UNLABELLED: This study investigated the association between health care access (HCA) dimensions and racial disparities in end-of-life (EOL) care quality among non-Hispanic Black (NHB), non-Hispanic White (NHW), and Hispanic patients with ovarian cancer. Th ...
Full textLink to itemCite
Other · March 18, 2024
<p>Estimates of the associations between HCA dimensions, patient race and ethnicity, and EOL care quality outcomes on entire study cohort (<i>N</i> = 4,646), subcohort of patients that died from ovarian cancer (<i>N</i> ...
Full textCite
Other · March 18, 2024
<p>Baseline characteristics of patients with ovarian cancer who died during study follow-up stratified by race and ethnicity (<i>N</i> = 4,646)</p> ...
Full textCite
Other · March 18, 2024
<p>Relative risk ratio (RR) for receipt of any chemotherapy within 14 days of death with interaction term between accessibility score and patient race</p> ...
Full textCite
Other · March 18, 2024
<p>Baseline characteristics of patients with ovarian cancer who died during study follow-up stratified by race and ethnicity (<i>N</i> = 4,646)</p> ...
Full textCite
Other · March 18, 2024
<p>Participant flowchart for NHB, Hispanic and NHW patients with ovarian cancer, SEER-Medicare 2008–2015. Percentage of NHB patients presented for sensitivity purposes.</p> ...
Full textCite
Other · March 18, 2024
<p>Adjusted count ratio estimates of the associations between HCA dimensions, patient race and ethnicity, and counts of EOL care quality outcomes as count ratios, from fully-adjusted<a href="#tb3fn1" target="_blank"><sup>a</sup ...
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Other · March 18, 2024
<p>Patient, census tract, and regional level variables measuring dimensions of healthcare affordability, availability and accessibility</p> ...
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Other · March 18, 2024
<p>Adjusted count ratio estimates of the associations between HCA dimensions, patient race and ethnicity, and counts of EOL care quality outcomes as count ratios, from fully-adjusted<a href="#tb3fn1" target="_blank"><sup>a</sup ...
Full textCite
Other · March 18, 2024
<p>Relative risk ratio estimates of the associations between HCA dimensions, patient race/ethnicity, and EOL care quality outcomes</p> ...
Full textCite
Other · March 18, 2024
<p>Relative risk ratio (RR) for receipt of any chemotherapy within 14 days of death with interaction term between accessibility score and patient race</p> ...
Full textCite
Other · March 18, 2024
<div>Abstract<p>This study investigated the association between health care access (HCA) dimensions and racial disparities in end-of-life (EOL) care quality among non-Hispanic Black (NHB), non-Hispanic White (NHW), and Hispanic patients ...
Full textCite
Other · March 18, 2024
<p>Estimates of the associations between HCA dimensions, patient race and ethnicity, and EOL care quality outcomes on entire study cohort (<i>N</i> = 4,646), subcohort of patients that died from ovarian cancer (<i>N</i> ...
Full textCite
Other · March 18, 2024
<p>Relative risk ratio estimates of the associations between HCA dimensions, patient race/ethnicity, and EOL care quality outcomes</p> ...
Full textCite
Other · March 18, 2024
<div>Abstract<p>This study investigated the association between health care access (HCA) dimensions and racial disparities in end-of-life (EOL) care quality among non-Hispanic Black (NHB), non-Hispanic White (NHW), and Hispanic patients ...
Full textCite
Other · March 18, 2024
<p>Participant flowchart for NHB, Hispanic and NHW patients with ovarian cancer, SEER-Medicare 2008–2015. Percentage of NHB patients presented for sensitivity purposes.</p> ...
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Other · March 18, 2024
<p>EOL care quality outcomes by patient race and ethnicity (<i>N</i> = 4,646). ICU stay and ER visit outcomes not shown due to cell suppression rules. Outcomes that differ by patient race/ethnicity (<i>χ</i><sup> ...
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Other · March 18, 2024
<p>EOL care quality outcomes by patient race and ethnicity (<i>N</i> = 4,646). ICU stay and ER visit outcomes not shown due to cell suppression rules. Outcomes that differ by patient race/ethnicity (<i>χ</i><sup> ...
Full textCite
Other · March 18, 2024
<p>Patient, census tract, and regional level variables measuring dimensions of healthcare affordability, availability and accessibility</p> ...
Full textCite
Journal ArticleVaccines (Basel) · November 16, 2023
Significant progress has been achieved in the realm of therapeutic interventions for multiple myeloma (MM), leading to transformative shifts in its clinical management. While conventional modalities such as surgery, radiotherapy, and chemotherapy have impr ...
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Journal ArticleCancer Res · September 1, 2023
UNLABELLED: Triple-negative breast cancers (TNBC) tend to become invasive and metastatic at early stages in their development. Despite some treatment successes in early-stage localized TNBC, the rate of distant recurrence remains high, and long-term surviv ...
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Other · September 1, 2023
<p>Contains Supplementary Figures 1-4, Supplementary Tables 1-2 and legends for Supplementary Videos 1-4</p> ...
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Other · September 1, 2023
<p>Contains Supplementary Figures 1-4, Supplementary Tables 1-2 and legends for Supplementary Videos 1-4</p> ...
Full textCite
Other · September 1, 2023
<div>Abstract<p>Triple-negative breast cancers (TNBC) tend to become invasive and metastatic at early stages in their development. Despite some treatment successes in early-stage localized TNBC, the rate of distant recurrence remains hi ...
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Journal ArticleJ Mol Diagn · July 2023
NRG1 gene fusions are rare, therapeutically relevant, oncogenic drivers that occur across solid tumor types. To understand the landscape of NRG1 gene fusions, 4397 solid tumor formalin-fixed, paraffin-embedded samples consecutively tested by comprehensive ...
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Journal ArticleJ Mol Diagn · July 2023
Genomic profiling is critical for precision oncology to guide treatment decisions. Liquid biopsy testing is a complementary approach to tissue testing, particularly when tissue is not readily available. The Labcorp Plasma Focus test is a circulating cell-f ...
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Journal ArticleJ Clin Oncol · March 20, 2023
PURPOSE: Preclinical cancer models harboring CCNE1 amplification were more sensitive to adavosertib treatment, a WEE1 kinase inhibitor, than models without amplification. Thus, we conducted this phase II study to assess the antitumor activity of adavoserti ...
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ConferenceCancer Causes Control · February 2023
PURPOSE: Clinical trials advance the standard of care for patients. Patients enrolled in trials should represent the population who would benefit from the intervention in clinical practice. The aim of this study was to assess whether clinical trials enroll ...
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Journal ArticleCancers (Basel) · January 15, 2023
Background: Uterine serous carcinomas represent 10% of uterine carcinomas but account for nearly 40% of deaths from the disease. Improved molecular characterization of these tumors is instrumental in guiding targeted treatment and improving outcomes. This ...
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Journal ArticleCancer Epidemiol Biomarkers Prev · January 9, 2023
BACKGROUND: Ovarian cancer survival disparities have persisted for decades, driven by lack of access to quality treatment. We conducted structural equation modeling (SEM) to define latent variables representing three healthcare access (HCA) domains: afford ...
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Journal ArticleInt J Gynecol Pathol · January 1, 2023
The BRCA1-associated protein 1 ( BAP1 ) gene encodes a tumor suppressor that functions as a ubiquitin hydrolase involved in DNA damage repair. BAP1 germline mutations are associated with increased risk of multiple solid malignancies, including mesothelioma ...
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Journal ArticleJ Pain Symptom Manage · December 2022
OBJECTIVE: Lack of access to supportive care (SC) among cancer patients have been well documented. However, the role of affordability in this disparity among ovarian cancer (OC) patients remain poorly understood. METHODS: Patients with OC between 2008 and ...
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Journal ArticleBrain Behav Immun Health · December 2022
Mounting evidence suggests that chronic stress and subsequent distress can promote ovarian cancer progression. These altered psychological states have been linked to sustained release of stress hormones, activation of the β-adrenergic receptors in ovarian ...
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ConferenceAJOG Global Reports · November 1, 2022
BACKGROUND: Telemedicine uses technology to deliver medical care remotely and has been shown to provide similar patient satisfaction and care outcomes compared with in-person visits. OBJECTIVE: This study aimed to assess the gynecologic oncology patient te ...
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Journal ArticleJ Natl Compr Canc Netw · November 2022
BACKGROUND: Racial disparities exist in receipt of guideline-concordant treatment of ovarian cancer (OC). However, few studies have evaluated how various dimensions of healthcare access (HCA) contribute to these disparities. METHODS: We analyzed data from ...
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Journal ArticleAJOG Glob Rep · November 2022
BACKGROUND: Telemedicine uses technology to deliver medical care remotely and has been shown to provide similar patient satisfaction and care outcomes compared with in-person visits. OBJECTIVE: This study aimed to assess the gynecologic oncology patient te ...
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Journal ArticleJ Ovarian Res · October 20, 2022
BACKGROUND: Epithelial ovarian cancer (OC) is the most lethal gynecological malignancy and patients present with significant metastatic burden, particularly to the adipose-rich microenvironment of the omentum. Recent evidence has highlighted the importance ...
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Journal ArticleCancers (Basel) · August 30, 2022
Despite advances in surgery and targeted therapies, the prognosis for women with high-grade serous ovarian cancer remains poor. Moreover, unlike other cancers, immunotherapy has minimally impacted outcomes in patients with ovarian cancer. Progress in this ...
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Journal ArticleCancer Epidemiol Biomarkers Prev · July 1, 2022
BACKGROUND: Differential access to quality care is associated with racial disparities in ovarian cancer survival. Few studies have examined the association of multiple healthcare access (HCA) dimensions with racial disparities in quality treatment metrics, ...
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Journal ArticleCell Rep · June 28, 2022
Ovarian cancer (OC) is the most lethal gynecological malignancy, with aggressive metastatic disease responsible for the majority of OC-related deaths. In particular, OC tumors preferentially metastasize to and proliferate rapidly in the omentum. Here, we s ...
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Journal ArticleGynecol Oncol · May 2022
OBJECTIVE: To assess, using a national surgical outcomes database, the association of various malnutrition definitions with post-operative morbidity in three gynecologic malignancies. METHODS: Patients undergoing resection of ovarian, uterine, or cervical ...
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Chapter · January 1, 2022
The prior dichotomous classification of endometrial cancer into high and low risk subtypes based primarily on histology has been shown to be inadequate in predicting outcome and treatment response. More nuanced molecular categorization of these cancers pro ...
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Journal ArticleInt J Gynecol Pathol · November 1, 2021
The study evaluated morphologic patterns, mutational profiles, and β-catenin immunohistochemistry (IHC) in copy-number low (CNL) endometrial adenocarcinomas (EAs). CNL EAs (n=19) with next-generation or whole genome sequencing results and available tissue ...
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Journal ArticleGynecol Oncol Rep · November 2021
OBJECTIVE: While primary cytoreductive surgery (PCS) is considered the standard of care for women who present with stage IV endometrial cancer, neoadjuvant chemotherapy (NACT) followed by interval cytoreductive surgery (ICS) has emerged as an alternative t ...
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Journal ArticleAm J Obstet Gynecol · September 2021
OBJECTIVE: Endometrial cancer uncommonly presents at an advanced stage and little prospective evidence exists to guide the management thereof. We aimed to summarize the evidence about primary cytoreductive surgery in the treatment of advanced stage endomet ...
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Journal ArticleGynecol Oncol · September 2021
OBJECTIVE: Neoadjuvant chemotherapy (NACT) has emerged as an alternative to primary cytoreductive surgery (PCS) for stage IV uterine cancer. We examined utilization, perioperative outcomes and survival for NACT and PCS for stage IV uterine cancer. METHODS: ...
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Journal ArticleSci Rep · August 19, 2021
In low-income countries, up to 80% of women diagnosed with cervical dysplasia do not return for follow-up care, primarily due to treatment being inaccessible. Here, we describe development of a low-cost, portable treatment suitable for such settings. It is ...
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Journal ArticleObstet Gynecol Surv · July 2021
IMPORTANCE: Adnexal masses are identified in approximately 0.05% to 2.4% of pregnancies, and more recent data note a higher incidence due to widespread use of antenatal ultrasound. Whereas most adnexal masses are benign, approximately 1% to 6% are malignan ...
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Journal ArticleCancers (Basel) · June 7, 2021
BACKGROUND: The aim of this study was to evaluate whether molecular classification prognosticates treatment response in women with endometrial cancers and endometrial intraepithelial neoplasia (EIN) treated with levonorgestrel intrauterine system (LNG-IUS) ...
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Journal ArticleInt J Environ Res Public Health · June 4, 2021
Palliative care improves quality-of-life and extends survival, however, is underutilized among gynecological cancer patients in the United States (U.S.). Our objective was to evaluate associations between healthcare access (HCA) measures and palliative car ...
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Journal ArticleInt J Gynecol Cancer · February 2021
INTRODUCTION: The surgical approach for interval debulking surgery after neoadjuvant chemotherapy has been extrapolated from primary tumor reductive surgery for high-grade ovarian cancer. The study objective was to compare pathologic distribution of malign ...
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Journal ArticleGynecol Oncol · February 2021
BACKGROUND: Palliative care (PC) is recommended for gynecological cancer patients to improve survival and quality-of-life. Our objective was to evaluate racial/ethnic disparities in PC utilization among patients with metastatic gynecologic cancer. METHODS: ...
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Journal ArticleData Brief · February 2021
The National Comprehensive Cancer Network recommends palliative care should be integrated in to cancer care starting from cancer diagnosis. However, traditionally palliative care is prioritized for cancer patients at the end-of-life. In our main article ti ...
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Journal ArticleGynecol Oncol · January 2021
OBJECTIVE: To determine the feasibility and effectiveness of a quality improvement initiative (QI) to adopt universal screening for Lynch syndrome in uterine cancer patients at an institution that previously employed age-based screening. METHODS: Prior to ...
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Journal ArticleTarget Oncol · January 2021
BACKGROUND: Recent advances in next-generation sequencing have allowed for an increase in molecular tumor profiling. OBJECTIVE: We sought to assess the actionability and clinical utilization of molecular tumor profiling results obtained via Foundation Medi ...
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Journal ArticleInt J Gynecol Cancer · October 2020
OBJECTIVE: Limited information exists regarding risk reduction strategies for women with moderate and low penetrance ovarian cancer susceptibility mutations. We sought to assess current risk reduction practice patterns for carriers of these mutations throu ...
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Journal ArticleGynecol Oncol · March 2020
OBJECTIVE: To identify novel immunologic targets and biomarkers associated with overall survival (OS) in high-grade serous ovarian cancer (HGSC). METHODS: In this retrospective study, microarray data from 51 HGSC specimens were analyzed (Affymetrix HG-U133 ...
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Journal ArticleJ Alzheimers Dis · 2020
BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ...
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Journal ArticleGynecol Oncol · August 2019
OBJECTIVE: To evaluate clinicopathologic factors and adjuvant treatment effects on recurrence free (RFS) and overall survival (OS) in early stage uterine clear cell carcinoma (UCCC). METHODS: Our retrospective review included central pathology confirmed st ...
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Journal ArticleJ Am Geriatr Soc · April 2019
BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ...
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Journal ArticleGynecol Oncol · March 2019
OBJECTIVES: To evaluate surgical complexity scores (SCS) and minimally invasive surgery (MIS) at interval debulking surgery (IDS) in advanced epithelial ovarian cancer (EOC) patients receiving neoadjuvant chemotherapy (NACT). METHODS: A multi-institutional ...
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Journal ArticleObstet Gynecol Clin North Am · March 2019
Ovarian cancer treatment continues to evolve. Despite aggressive surgery and chemotherapy, most women will ultimately die from disease. Improvement in disease control are due to the incorporation of molecular targeted agents and the adoption of maintenance ...
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Journal ArticleGynecol Oncol · January 2019
OBJECTIVE: Evaluate the impact of clinicopathologic characteristics and adjuvant treatment on survival outcomes in early stage uterine carcinosarcoma patients. METHODS: We performed a retrospective cohort study of women with stage I or II uterine carcinosa ...
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Journal ArticleCancer Res · June 15, 2018
Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic neurotransmitters are delivered to the ...
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Journal ArticleMol Cancer Ther · February 2018
Although progesterone receptor (PR)-targeted therapies are modestly active in patients with uterine cancer, their underlying molecular mechanisms are not well understood. The clinical use of such therapies is limited because of the lack of biomarkers that ...
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Journal ArticleClin Cancer Res · November 15, 2017
Purpose: VEGF-targeted therapies have modest efficacy in cancer patients, but acquired resistance is common. The mechanisms underlying such resistance are poorly understood.Experimental Design: To evaluate the potential role of immune cells in the developm ...
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Journal ArticleOncotarget · November 14, 2017
Anti-angiogenesis therapy has shown clinical benefit in patients with high-grade serous ovarian cancer (HGSC), but adaptive resistance rapidly emerges. Thus, approaches to overcome such resistance are needed. We developed the setting of adaptive resistance ...
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Journal ArticleJ Natl Cancer Inst · July 1, 2017
BACKGROUND: The PI3K/AKT/P70S6K pathway is an attractive therapeutic target in ovarian and uterine malignancies because of its high rate of deregulation and key roles in tumor growth. Here, we examined the biological effects of MSC2363318A, which is a nove ...
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Journal ArticleOncotarget · January 1, 2017
Anti-angiogenesis therapy has shown clinical benefit in patients with highgrade serous ovarian cancer (HGSC), but adaptive resistance rapidly emerges. Thus, approaches to overcome such resistance are needed. We developed the setting of adaptive resistance ...
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Journal ArticleMol Cancer Ther · December 2016
To determine the efficacy of a novel and safer (for gastrointestinal tract) aspirin (aspirin-PC) in preclinical models of ovarian cancer, in vitro dose-response studies were performed to compare the growth-inhibitory effect of aspirin-PC versus aspirin on ...
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Journal ArticleExpert Rev Mol Diagn · December 2016
Next-generation sequencing and advances in 'omics technology have rapidly increased our understanding of the molecular landscape of epithelial ovarian cancers. Areas covered: Once characterized only by histologic appearance and clinical behavior, we now un ...
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Journal ArticleJ Perinat Med · October 1, 2016
OBJECTIVE: The objective of this study was to determine characteristics associated with cesarean delivery among women with labor induction lasting over 24 h. STUDY DESIGN: Women with live singleton pregnancies without prior cesarean delivery undergoing a l ...
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Journal ArticleOncogene · August 18, 2016
MicroRNAs (miRNAs) are small RNA molecules that affect cellular processes by controlling gene expression. Recent studies have shown that hypoxia downregulates Drosha and Dicer, key enzymes in miRNA biogenesis, causing a decreased pool of miRNAs in cancer a ...
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Journal ArticleJ Med Imaging (Bellingham) · July 2016
Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method of hyperpolarizing silicon particles usi ...
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Journal ArticleMol Cancer Ther · June 2016
Delta-like ligand 4 (Dll4), one of the Notch ligands, is overexpressed in ovarian cancer, especially in tumors resistant to anti-VEGF therapy. Here, we examined the biologic effects of dual anti-Dll4 and anti-VEGF therapy in ovarian cancer models. Using Dl ...
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Journal ArticleOncogene · May 5, 2016
Adrenergic stimulation adversely affects tumor growth and metastasis, but the underlying mechanisms are not well understood. Here, we uncovered a novel mechanism by which catecholamines induce inflammation by increasing prostaglandin E2 (PGE2) levels in ov ...
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Journal ArticleClin Cancer Res · April 1, 2016
PURPOSE: Chronic adrenergic activation has been shown to associate with adverse clinical outcomes in cancer patients, but the underlying mechanisms are not well understood. The focus of the current study was to determine the functional and biologic effects ...
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Journal ArticleJ Natl Cancer Inst · January 26, 2016
BACKGROUND: The clinical and biological effects of metabolic alterations in cancer are not fully understood. METHODS: In high-grade serous ovarian cancer (HGSOC) samples (n = 101), over 170 metabolites were profiled and compared with normal ovarian tissues ...
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Journal ArticleCell Rep · December 22, 2015
Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumo ...
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Journal ArticleGynecol Oncol · December 2015
BACKGROUND: To compare the efficacy of chemotherapy (C) combined with bevacizumab (Bev) versus Bev alone in recurrent, heavily pretreated epithelial ovarian cancer (EOC). METHODS: A multicenter analysis of patients treated from 2004 to 2011 was performed. ...
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Journal ArticleMol Cancer Ther · December 2015
There is growing recognition of the important role of metronomic chemotherapy in cancer treatment. On the basis of their unique antiangiogenic effects, we tested the efficacy of nab-paclitaxel, which stimulates thrombospondin-1, and topotecan, which inhibi ...
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Journal ArticleCancer Cell · November 9, 2015
While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo's effects ...
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Journal ArticleEur J Cancer · September 2015
BACKGROUND: We compared survival outcomes and risk of venous thromboembolism (VTE) among patients with advanced and early-stage ovarian clear cell carcinoma (OCCC) and serous ovarian carcinoma (SOC), as well as potential links with interleukin-6 (IL-6) lev ...
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Journal ArticleGynecol Oncol · August 2015
OBJECTIVE: Type I epithelial ovarian cancers (EOCs) are reported to be relatively chemoresistant. This study sought to compare pretreatment chemoresponse assays in Type I vs. Type II EOCs. STUDY DESIGN: 383 women with stage III-IV EOC enrolled in an observ ...
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Journal ArticleClin Cancer Res · July 15, 2015
PURPOSE: XPO1 inhibitors have shown promise for cancer treatment, and yet the underlying mechanisms for the antitumor effects are not well understood. In this study, we explored the usefulness of selective inhibitors of nuclear export (SINE) compounds that ...
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Journal ArticleMol Cancer Ther · June 2015
PTEN is known to be frequently mutated in uterine cancer and also dephosphorylates FAK. Here, we examined the impact of PTEN alterations on the response to treatment with a FAK inhibitor (GSK2256098). In vitro and in vivo therapeutic experiments were carri ...
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Journal ArticleClin Cancer Res · May 1, 2015
PURPOSE: Zoledronic acid is being increasingly recognized for its antitumor properties, but the underlying functions are not well understood. In this study, we hypothesized that zoledronic acid inhibits ovarian cancer angiogenesis preventing Rac1 activatio ...
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Journal ArticleClin Cancer Res · March 1, 2015
Over 100 years have passed since the first observation of the notched wing phenotype in Drosophila melanogaster, and significant progress has been made to characterize the role of the Notch receptor, its ligands, downstream targets, and cross-talk with oth ...
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Journal ArticleOncotarget · February 28, 2015
Increased adrenergic signaling facilitates tumor progression, but the underlying mechanisms remain poorly understood. We examined factors responsible for stress-mediated effects on monocyte/macrophage recruitment into the tumor microenvironment, and the re ...
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Journal ArticleClin Cancer Res · February 1, 2015
PURPOSE: We hypothesized that platelet levels during therapy could serve as a biomarker for response to therapy and that manipulation of platelet levels could impact responsiveness to chemotherapy. EXPERIMENTAL DESIGN: The medical records of patients with ...
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Journal ArticleClin Cancer Res · January 15, 2015
PURPOSE: Cancer cells are highly dependent on folate metabolism, making them susceptible to drugs that inhibit folate receptor activities. Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. We investigated ...
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Journal ArticleCancer Res · June 15, 2014
The Notch pathway plays an important role in the growth of high-grade serous ovarian (HGS-OvCa) and other cancers, but its clinical and biologic mechanisms are not well understood. Here, we found that the Notch pathway alterations are prevalent and signifi ...
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Journal ArticleClin Cancer Res · May 15, 2014
PURPOSE: Platelet-derived growth factor receptor α (PDGFRα) expression is frequently observed in many kinds of cancer and is a candidate for therapeutic targeting. This preclinical study evaluated the biologic significance of PDGFRα and PDGFRα blockade (us ...
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Journal ArticleInt J Gynecol Cancer · May 2014
OBJECTIVE: The objective of this study was to evaluate prognostic risk factors for survival in women with low-grade serous epithelial ovarian cancer (LGSC). METHODS: A multicenter retrospective analysis of patients with LGSC was conducted. Potential epidem ...
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Journal ArticleNat Commun · March 12, 2014
Improving small interfering RNA (siRNA) efficacy in target cell populations remains a challenge to its clinical implementation. Here, we report a chemical modification, consisting of phosphorodithioate (PS2) and 2'-O-Methyl (2'-OMe) MePS2 on one nucleotide ...
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Journal ArticleGynecol Oncol · March 2014
OBJECTIVE: To develop a nomogram to predict overall survival (OS) in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy. METHODS: A multicenter retrospective study was conducted. Potential prognostic variables included age; stage ...
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Journal ArticleInt J Gynecol Pathol · January 2014
We describe clinicopathologic and immunohistochemical features of an unusual case of cystic fibrosis manifesting in the cervix as a mass lesion, mimicking cervical adenocarcinoma. A 24-year-old nulligravida with cystic fibrosis developed heavy postcoital v ...
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