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Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report.

Publication ,  Journal Article
Previs, RA; Edwards, JM; Secord, AA; Nucci, MR; Bentley, RC; Hall, AHS
Published in: Int J Gynecol Pathol
January 2014

We describe clinicopathologic and immunohistochemical features of an unusual case of cystic fibrosis manifesting in the cervix as a mass lesion, mimicking cervical adenocarcinoma. A 24-year-old nulligravida with cystic fibrosis developed heavy postcoital vaginal bleeding 4 months after starting oral contraceptives and was found to have a cervical mass. She underwent a loop electrosurgical excision of the mass, and microscopic examination revealed a florid endocervical proliferation, extending to the margins. This lesion was initially interpreted as an invasive, well-differentiated endocervical adenocarcinoma. However, on subsequent review, the lesion was found to have a low rate of proliferation, no evidence of an infiltrative growth pattern, and abundant acute inflammation. Given these findings and the absence of any residual endocervical lesion on a subsequent cold knife conization, we determined that this was a benign, likely reactive, lesion. This case, together with previous studies, suggests that women with cystic fibrosis can develop proliferative endocervical lesions and that oral contraceptives may contribute to their development.

Duke Scholars

Published In

Int J Gynecol Pathol

DOI

EISSN

1538-7151

Publication Date

January 2014

Volume

33

Issue

1

Start / End Page

100 / 104

Location

United States

Related Subject Headings

  • Young Adult
  • Uterine Cervical Neoplasms
  • Pathology
  • Humans
  • Female
  • Diagnosis, Differential
  • Cystic Fibrosis
  • Adenocarcinoma
  • 3215 Reproductive medicine
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Previs, R. A., Edwards, J. M., Secord, A. A., Nucci, M. R., Bentley, R. C., & Hall, A. H. S. (2014). Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report. Int J Gynecol Pathol, 33(1), 100–104. https://doi.org/10.1097/PGP.0b013e318278b832
Previs, Rebecca A., James M. Edwards, Angeles A. Secord, Marisa R. Nucci, Rex C. Bentley, and Allison H. S. Hall. “Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report.Int J Gynecol Pathol 33, no. 1 (January 2014): 100–104. https://doi.org/10.1097/PGP.0b013e318278b832.
Previs RA, Edwards JM, Secord AA, Nucci MR, Bentley RC, Hall AHS. Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report. Int J Gynecol Pathol. 2014 Jan;33(1):100–4.
Previs, Rebecca A., et al. “Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report.Int J Gynecol Pathol, vol. 33, no. 1, Jan. 2014, pp. 100–04. Pubmed, doi:10.1097/PGP.0b013e318278b832.
Previs RA, Edwards JM, Secord AA, Nucci MR, Bentley RC, Hall AHS. Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report. Int J Gynecol Pathol. 2014 Jan;33(1):100–104.

Published In

Int J Gynecol Pathol

DOI

EISSN

1538-7151

Publication Date

January 2014

Volume

33

Issue

1

Start / End Page

100 / 104

Location

United States

Related Subject Headings

  • Young Adult
  • Uterine Cervical Neoplasms
  • Pathology
  • Humans
  • Female
  • Diagnosis, Differential
  • Cystic Fibrosis
  • Adenocarcinoma
  • 3215 Reproductive medicine
  • 1114 Paediatrics and Reproductive Medicine