Overview
Outcome-based research on pathology of endometrial carcinoma, including prognostic significance of histologic features of endometrial carcinoma, variants of endometrial carcinoma, definitions of atypia and well-differentiated carcinoma, and collaborative studies of oncogenes and tumor suppressor genes in endometrial carcinoma.
Endometrial pathology, especially as it relates to molecular/genetic alterations in neoplasms.
Ovarian pathology, especially as it relates to molecular and genetic alterations in neoplasms.
Improving accuracy of radiographic screening for breast cancer, by careful patho-radiographic correlation and study of improved imaging techniques (especially ultrasound).
Use of electron microscopy as a diagnostic and research technique.
Objective measures of pathology resident performance.
Endometrial pathology, especially as it relates to molecular/genetic alterations in neoplasms.
Ovarian pathology, especially as it relates to molecular and genetic alterations in neoplasms.
Improving accuracy of radiographic screening for breast cancer, by careful patho-radiographic correlation and study of improved imaging techniques (especially ultrasound).
Use of electron microscopy as a diagnostic and research technique.
Objective measures of pathology resident performance.
Current Duke Appointments & Affiliations
Professor of Pathology
·
2012 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
1986 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
CDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-driven Alveolar Rhabdomyosarcoma.
Journal article Cancer Discov · July 14, 2026 Alveolar rhabdomyosarcoma (aRMS) is a fusion-driven pediatric cancer with poor survival and limited therapeutic options. To uncover novel vulnerabilities, we employed complex-based analysis of the DepMap functional genomic data, identifying CDK8 as a depen ... Full text Link to item CiteStandardized Pathologic Reporting for Phyllodes Tumors: Where are We after 3 Years?
Journal article Ann Surg Oncol · February 2026 Full text Link to item CiteAutomation of fluorescent in situ hybridization (FISH) leading to cost savings and consistent high-quality results.
Journal article J Clin Pathol · January 19, 2026 AIMS: Despite continually improving guidelines, human epidermal growth factor receptor 2 (HER2) testing for breast and gastro-oesophageal carcinoma continues to be a technical challenge in clinical laboratories. Manual HER2 fluorescence in situ hybridisati ... Full text Link to item CiteRecent Grants
Analysis of the local and global responses in the placenta syncytiotrophoblast
ResearchCollaborator · Awarded by National Institutes of Health · 2026 - 2031Validation of UM1 candidate targets in fusion-positive rhabdomyosarcoma preclinical models
ResearchCollaborator · Awarded by Massachusetts Institute of Technology · 2024 - 2029Identification of Oncofusion-Interacting Proteins as Essential Drug Targets for Common and Rare Oncofusions in Rhabdomyosarcoma
ResearchCollaborator · Awarded by Department of Defense · 2025 - 2028View All Grants
Education
Harvard University ·
1986
M.D.