Overview
Outcome-based research on pathology of endometrial carcinoma, including prognostic significance of histologic features of endometrial carcinoma, variants of endometrial carcinoma, definitions of atypia and well-differentiated carcinoma, and collaborative studies of oncogenes and tumor suppressor genes in endometrial carcinoma.
Endometrial pathology, especially as it relates to molecular/genetic alterations in neoplasms.
Ovarian pathology, especially as it relates to molecular and genetic alterations in neoplasms.
Improving accuracy of radiographic screening for breast cancer, by careful patho-radiographic correlation and study of improved imaging techniques (especially ultrasound).
Use of electron microscopy as a diagnostic and research technique.
Objective measures of pathology resident performance.
Endometrial pathology, especially as it relates to molecular/genetic alterations in neoplasms.
Ovarian pathology, especially as it relates to molecular and genetic alterations in neoplasms.
Improving accuracy of radiographic screening for breast cancer, by careful patho-radiographic correlation and study of improved imaging techniques (especially ultrasound).
Use of electron microscopy as a diagnostic and research technique.
Objective measures of pathology resident performance.
Current Appointments & Affiliations
Professor of Pathology
·
2012 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
1986 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer.
Journal Article Gynecol Oncol · December 2023 OBJECTIVE: We sought to evaluate the association between diet and angiogenic biomarkers in KpB mice, and the association between these markers, body mass index (BMI), and overall survival (OS) in high-grade serous cancers (HGSC). METHODS: Tumors previously ... Full text Link to item CiteEWSR1::NR4A3 gene fusion in a cutaneous atypical myoepithelial neoplasm.
Journal Article J Cutan Pathol · July 2023 Myoepithelial neoplasms of the skin and soft tissue are rare and share histopathologic features with their salivary gland counterpart. We present a case of an atypical myoepithelial neoplasm from the back of a 72-year-old female. This lesion harbored an EW ... Full text Link to item CiteBAP1 Tumor Predisposition Syndrome Presenting as a Recurrent Ovarian Sex Cord-Stromal Tumor.
Journal Article Int J Gynecol Pathol · January 1, 2023 The BRCA1-associated protein 1 ( BAP1 ) gene encodes a tumor suppressor that functions as a ubiquitin hydrolase involved in DNA damage repair. BAP1 germline mutations are associated with increased risk of multiple solid malignancies, including mesothelioma ... Full text Link to item CiteRecent Grants
Validation of UM1 candidate targets in fusion-positive rhabdomyosarcoma preclinical models
ResearchCollaborator · Awarded by Massachusetts Institute of Technology · 2024 - 2029ZEB2 as a cell fate switch in fusion-positive rhabdomyosarcoma
ResearchCollaborator · Awarded by Hyundai Hope on Wheels · 2024 - 2026Targeting the Macro lncRNA KCNQ1OT1 in Rhabdomyosarcoma Tumorigenesis
ResearchCollaborator · Awarded by Department of Defense · 2024 - 2026View All Grants
Education, Training & Certifications
Harvard University ·
1986
M.D.