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Rex Colle Bentley

Rex Colle Bentley

Professor of Pathology
Pathology
rex.bentley@duke.edu
Duke Box 3712, Durham, NC 27710
216A Davison Bldg, Durham, NC

Selected Publications

High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer.

Journal Article Gynecol Oncol · December 2023 OBJECTIVE: We sought to evaluate the association between diet and angiogenic biomarkers in KpB mice, and the association between these markers, body mass index (BMI), and overall survival (OS) in high-grade serous cancers (HGSC). METHODS: Tumors previously ... Full text Link to item Cite

EWSR1::NR4A3 gene fusion in a cutaneous atypical myoepithelial neoplasm.

Journal Article J Cutan Pathol · July 2023 Myoepithelial neoplasms of the skin and soft tissue are rare and share histopathologic features with their salivary gland counterpart. We present a case of an atypical myoepithelial neoplasm from the back of a 72-year-old female. This lesion harbored an EW ... Full text Link to item Cite

BAP1 Tumor Predisposition Syndrome Presenting as a Recurrent Ovarian Sex Cord-Stromal Tumor.

Journal Article Int J Gynecol Pathol · January 1, 2023 The BRCA1-associated protein 1 ( BAP1 ) gene encodes a tumor suppressor that functions as a ubiquitin hydrolase involved in DNA damage repair. BAP1 germline mutations are associated with increased risk of multiple solid malignancies, including mesothelioma ... Full text Link to item Cite

Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma.

Journal Article Mol Oncol · October 2022 Rhabdomyosarcoma (RMS), a cancer characterized by features of skeletal muscle, is the most common soft-tissue sarcoma of childhood. With 5-year survival rates among high-risk groups at < 30%, new therapeutics are desperately needed. Previously, usin ... Full text Link to item Cite

Extended Human Papillomavirus Genotyping to Predict Progression to High-Grade Cervical Precancer: A Prospective Cohort Study in the Southeastern United States.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2, 2022 BACKGROUND: High-risk human papillomavirus (hrHPV) testing is utilized in primary cervical cancer screening, generally along with cytology, to triage abnormalities to colposcopy. Most screening-based hrHPV testing involves pooled detection of any hrHPV or ... Full text Link to item Cite

Giant Pancreatic Myoepithelial Hamartoma in a Patient With Familial Insulin-Dependent Diabetes Mellitus.

Journal Article Pancreas · August 1, 2022 Pancreatic myoepithelial hamartoma is a rare, benign solid and cystic lesion of the pancreas. We present the first case of an adult with a giant myoepithelial hamartoma extending throughout the pancreas in a patient with diabetes in 4 immediate family memb ... Full text Link to item Cite

Communicating Certainty in Pathology Reports.

Journal Article Arch Pathol Lab Med · July 1, 2022 CONTEXT.—: Pathology reports are the main modality in which results are communicated to other physicians. For various reasons, the diagnosis may be qualified on a spectrum of uncertainty. OBJECTIVE.—: To examine how communication of uncertainty is an unexa ... Full text Link to item Cite

A Hybrid Human-Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy.

Journal Article Arch Pathol Lab Med · June 1, 2022 CONTEXT.—: Prostate cancer is a common malignancy, and accurate diagnosis typically requires histologic review of multiple prostate core biopsies per patient. As pathology volumes and complexity increase, new tools to improve the efficiency of everyday pra ... Full text Link to item Cite

Case Report: Primary Alveolar Soft Part Sarcoma of the Breast

Conference AMERICAN JOURNAL OF CLINICAL PATHOLOGY · 2022 Cite

Endometrial Adenocarcinomas With No Specific Molecular Profile: Morphologic Features and Molecular Alterations of "Copy-number Low" Tumors.

Journal Article Int J Gynecol Pathol · November 1, 2021 The study evaluated morphologic patterns, mutational profiles, and β-catenin immunohistochemistry (IHC) in copy-number low (CNL) endometrial adenocarcinomas (EAs). CNL EAs (n=19) with next-generation or whole genome sequencing results and available tissue ... Full text Link to item Cite

Limited Reporting of Histopathologic Details in a Multi-Institutional Academic Cohort of Phyllodes Tumors: Time for Standardization.

Journal Article Ann Surg Oncol · November 2021 BACKGROUND: Phyllodes tumors are rare fibroepithelial neoplasms that are classified by tiered histopathologic features. While there are protocols for the reporting of cancer specimens, no standardized reporting protocol exists for phyllodes. METHODS: We pe ... Full text Link to item Cite

More Than Meets the Eye? A Cautionary Tale of Malignant Ectomesenchymoma Treated as Low-risk Orbital Rhabdomyosarcoma.

Journal Article J Pediatr Hematol Oncol · August 1, 2021 Malignant ectomesenchymoma (MEM) is a rare multiphenotypic tumor comprised of mesenchymal and neuroectodermal components. MEM is typically diagnosed in infants and younger children and outcomes are variable. The current approach for treating MEM includes t ... Full text Link to item Cite

Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia.

Journal Article Infect Agent Cancer · June 13, 2021 BACKGROUND: Epigenetic mechanisms are hypothesized to contribute substantially to the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer, although empirical data are limited. METHODS: Women (n = 419) were enrolled at colposcopic eva ... Full text Open Access Link to item Cite

Frequent Mutations of POT1 Distinguish Pulmonary Sarcomatoid Carcinoma From Other Lung Cancer Histologies.

Journal Article Clin Lung Cancer · November 2020 INTRODUCTION: Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small-cell lung cancer (NSCLC) harboring mutations in many canonical NSCLC-driver genes (eg, TP53, KRAS, MET). Protection of telomeres 1 (POT1) mutations are observed in angiosarc ... Full text Link to item Cite

Epithelioid Hyalinizing Sarcoma With MGA-NUTM1 Fusion.

Journal Article American journal of clinical pathology · November 2020 ObjectivesSoft tissue sarcomas are a group of tumors derived from the mesenchymal origin. Historically, they have been classified according to morphologic and immunohistochemical characteristics. The advent of multiplexed next-generation sequencin ... Full text Cite

Unique presentation of a gastrointestinal stromal tumor, epithelioid type, with a dual copy loss of SDHA gene as a liver primary

Journal Article Human Pathology: Case Reports · November 1, 2020 Primary gastrointestinal stromal tumors (GIST) largely occur in the luminal gastro-intestinal tract and are extremely rare in the liver. On a molecular level, a small minority of GISTs are characterized by SDH deficiency. To date, SDH-deficient GISTs have ... Full text Cite

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).

Journal Article Clin Cancer Res · October 15, 2020 PURPOSE: Gene expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been ... Full text Link to item Cite

POT1 mutation spectrum in tumour types commonly diagnosed among POT1-associated hereditary cancer syndrome families.

Journal Article J Med Genet · October 2020 BACKGROUND: The shelterin complex is composed of six proteins that protect and regulate telomere length, including protection of telomeres 1 (POT1). Germline POT1 mutations are associated with an autosomal dominant familial cancer syndrome presenting with ... Full text Link to item Cite

Prognostic gene expression signature for high-grade serous ovarian cancer.

Journal Article Ann Oncol · September 2020 BACKGROUND: Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis. The aim of this ... Full text Link to item Cite

Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype.

Journal Article Clin Breast Cancer · October 2018 BACKGROUND: Stromal tumor-infiltrating lymphocytes (TILs) might predict pathologic complete response (pCR) in patients with HER2-positive (HER2+) breast cancer treated with trastuzumab (H). Docetaxel (T), carboplatin (C), H, and pertuzumab (P) have immune- ... Full text Link to item Cite

Metastatic squamous cell carcinoma with pseudoangiosarcomatous features and aberrant expression of vascular markers.

Journal Article Pathol Res Pract · October 2018 Squamous cell carcinoma with pseudoangiosarcomatous features is a rare but well-recognized variant of squamous cell carcinoma. These tumors exhibit complex anastomosing channels lined by neoplastic cells, histologically mimicking a vasoformative mesenchyma ... Full text Link to item Cite

Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.

Journal Article Cancer Res · October 1, 2018 A hallmark of fusion-positive alveolar rhabdomyosarcoma (aRMS) is the presence of a chromosomal translocation encoding the PAX3-FOXO1 fusion oncogene. Primary cell-based modeling experiments have shown that PAX3-FOXO1 is necessary, but not sufficient for a ... Full text Link to item Cite

Histotype classification of ovarian carcinoma: A comparison of approaches.

Journal Article Gynecol Oncol · October 2018 OBJECTIVE: Major changes in the classification of ovarian carcinoma histotypes occurred over the last two decades, resulting in the current 2014 World Health Organization (WHO) diagnostic criteria that recognize five principal histotypes: high-grade serous ... Full text Link to item Cite

DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions.

Journal Article Int J Cancer · August 1, 2018 The role of host epigenetic mechanisms in the natural history of low-grade cervical intraepithelial neoplasia (CIN1) is not well characterized. We explored differential methylation of imprinted gene regulatory regions as predictors of the risk of CIN1 regr ... Full text Link to item Cite

The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis.

Journal Article Clin Cancer Res · June 1, 2018 Purpose: Alveolar rhabdomyosarcoma (aRMS) is a childhood soft tissue sarcoma driven by the signature PAX3-FOXO1 (P3F) fusion gene. Five-year survival for aRMS is <50%, with no improvement in over 4 decades. Although the transcriptional coactivator TAZ is o ... Full text Link to item Cite

Concordant, non-atypical breast papillomas do not require surgical excision: A 10-year multi-institution study and review of the literature.

Journal Article Clin Imaging · 2018 PURPOSE: Non-atypical papillomas (NAPs) diagnosed on core needle biopsy (CNB) frequently undergo surgical excision due to highly variable upstaging rates. The purpose of this study is to document our dual-institution upgrade rates of NAPs diagnosed on core ... Full text Link to item Cite

A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.

Journal Article Cell Rep · May 17, 2016 Some patients with cancer never develop metastasis, and their host response might provide cues for innovative treatment strategies. We previously reported an association between autoantibodies against complement factor H (CFH) and early-stage lung cancer. ... Full text Open Access Link to item Cite

The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.

Journal Article Arterioscler Thromb Vasc Biol · May 2016 OBJECTIVE: Vascular smooth muscle cell (SMC) migration is regulated by cytoskeletal remodeling as well as by certain transient receptor potential (TRP) channels, nonselective cation channels that modulate calcium influx. Proper function of multiple subfami ... Full text Open Access Link to item Cite

Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma.

Journal Article Clin Cancer Res · November 1, 2015 Featured Publication PURPOSE: Rhabdomyosarcoma (RMS) is a soft tissue sarcoma associated with the skeletal muscle lineage. Of the two predominant subtypes, known as embryonal (eRMS) and alveolar (aRMS), aRMS has the poorer prognosis, with a five-year survival rate of <50%. The ... Full text Link to item Cite

Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium.

Journal Article Biomed Opt Express · August 1, 2015 Featured Publication We evaluate a new hybrid algorithm for determining nuclear morphology using angle-resolved low coherence interferometry (a/LCI) measurements in ex vivo cervical tissue. The algorithm combines Mie theory based and continuous wavelet transform inverse light ... Full text Link to item Cite

Vaginal cuff thermal injury by mode of colpotomy at total laparoscopic hysterectomy: a randomized clinical trial.

Conference J Minim Invasive Gynecol · February 2015 Featured Publication STUDY OBJECTIVE: To evaluate if the use of Valleylab mode ("V mode") (Covidien, Mansfield, MA) electrothermal energy for colpotomy during total laparoscopic hysterectomy (LH) results in a smaller margin of thermal injury to the upper vagina compared with t ... Full text Link to item Cite

Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma.

Journal Article PLoS One · 2015 Featured Publication Rhabdomyosarcoma (RMS), a cancer characterized by features of skeletal muscle histogenesis, is the most common soft tissue sarcoma of childhood and adolescence. Survival for high-risk groups is less than 30% at 5 years. RMS also occurs during adulthood, wi ... Full text Link to item Cite

HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA.

Journal Article Cancer Causes Control · August 2014 Featured Publication PURPOSE: For poorly understood reasons, invasive cervical cancer (ICC) incidence and mortality rates are higher in women of African descent. Oncogenic human papillomavirus (HPV) genotypes distribution may vary between European American (EA) and African-Ame ... Full text Open Access Link to item Cite

Metastatic ampullary adenocarcinoma presenting as a hydrocele: a case report.

Journal Article JOP · May 27, 2014 Featured Publication CONTEXT: Metastases from ampullary malignancies are common, but spread to the testicle and paratesticular tissue is exceedingly rare with only 2 reported cases in the literature. CASE REPORT: We report a case of a 70 year-old male with a history of ampulla ... Full text Link to item Cite

Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: a single institution study of 458 patients.

Journal Article Gynecol Oncol · May 2014 Featured Publication OBJECTIVE: The aim of this study is to determine whether a minimally invasive approach to hysterectomy is associated with an increased rate of lymph vascular space invasion (LVSI) and/or malignant pelvic peritoneal cytology in endometrial cancer. METHODS: ... Full text Link to item Cite

TTF-1 Is Expressed in a Subset of Esophageal Adenocarcinomas

Conference MODERN PATHOLOGY · February 1, 2014 Featured Publication Link to item Cite

TTF-1 Is Expressed in a Subset of Esophageal Adenocarcinomas

Conference LABORATORY INVESTIGATION · February 1, 2014 Link to item Cite

Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report.

Journal Article Int J Gynecol Pathol · January 2014 Featured Publication We describe clinicopathologic and immunohistochemical features of an unusual case of cystic fibrosis manifesting in the cervix as a mass lesion, mimicking cervical adenocarcinoma. A 24-year-old nulligravida with cystic fibrosis developed heavy postcoital v ... Full text Link to item Cite

Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.

Journal Article J Clin Invest · January 2014 Featured Publication Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the paired box 3-forkhead box protein O1 (PAX3-FOXO1) fusion oncogene. Despite its discovery nearly two decades ago, the mechanisms by which PAX3-FO ... Full text Link to item Cite

Bacteria localization and chorion thinning among preterm premature rupture of membranes.

Journal Article PLoS One · 2014 Featured Publication OBJECTIVE: Bacterial colonization of the fetal membranes and its role in pathogenesis of membrane rupture is poorly understood. Prior retrospective work revealed chorion layer thinning in preterm premature rupture of membranes (PPROM) subjects. Our objecti ... Full text Open Access Link to item Cite

HPV genotypes and cervical intraepithelial Neoplasiain a multiethnic cohort in the southeastern United States

Journal Article Journal of Vaccines and Vaccination · January 1, 2014 Featured Publication Background: For poorly understood reasons, invasive cervical cancer (ICC) incidence and mortality rates are higher in women of African descent. Oncogenic human papillomavirus (HPV) genotypes distribution may vary between European American (EA) and African ... Full text Cite

HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA

Journal Article Cancer Causes and Control · January 1, 2014 Featured Publication Purpose: For poorly understood reasons, invasive cervical cancer (ICC) incidence and mortality rates are higher in women of African descent. Oncogenic human papillomavirus (HPV) genotypes distribution may vary between European American (EA) and African-Ame ... Full text Cite

The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes.

Journal Article Reprod Sci · October 2013 Featured Publication Preterm premature rupture of the membranes (PPROM) is an important etiology of preterm birth and source of significant neonatal morbidity. We propose that PPROM occurs in the setting of long-standing altered tissue remodeling, which creates a vulnerable en ... Full text Link to item Cite

Molecular signatures of epithelial ovarian cancer: analysis of associations with tumor characteristics and epidemiologic risk factors.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2013 Featured Publication BACKGROUND: Six gene expression subtypes of invasive epithelial ovarian cancer were recently defined using microarrays by Tothill and colleagues. The Cancer Genome Atlas (TCGA) project subsequently replicated these subtypes and identified a signature predi ... Full text Link to item Cite

Vagina

Chapter · July 16, 2012 Cite

FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.

Journal Article Clin Cancer Res · July 15, 2012 Featured Publication PURPOSE: Rhabdomyosarcoma (RMS) is a malignancy with features of skeletal muscle, and the most common soft tissue sarcoma of childhood. Survival for high-risk groups is approximately 30% at 5 years and there are no durable therapies tailored to its genetic ... Full text Link to item Cite

Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.

Journal Article Br J Cancer · February 28, 2012 Featured Publication BACKGROUND: In early-stage breast cancer, adjuvant chemotherapy is associated with significant systemic toxicity with only a modest survival benefit. Therefore, there is considerable interest in identifying predictive markers of response to therapy. Doxoru ... Full text Link to item Cite

Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior.

Journal Article Arch Pathol Lab Med · February 2012 Featured Publication CONTEXT: Struma ovarii exhibiting malignant histology are uncommon, and an aggressive clinical course in the form of initial extraovarian spread or recurrence is even more exceptional for these tumors. OBJECTIVE: To determine whether specific histologic fe ... Full text Link to item Cite

Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers.

Journal Article Int J Gynecol Cancer · January 2012 Featured Publication BACKGROUND: Inactivating somatic mutations in the ARID1A gene are described in a significant fraction of clear cell and endometrioid ovarian cancers leading to loss of the corresponding protein (BAF250a). Expression of BAF250a was examined in clear cell an ... Full text Link to item Cite

Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.

Journal Article Clin Cancer Res · December 1, 2011 Featured Publication PURPOSE: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and remains refractory to combined-modality therapy in patients with high risk disease. In skeletal myogenesis, Notch signaling prevents muscle differentiation and promotes ... Full text Link to item Cite

The Association of Intratumoral Germinal Centers with early-stage non-small cell lung cancer.

Journal Article J Thorac Oncol · October 2011 Featured Publication INTRODUCTION: Lung cancers can display immune cell infiltration although the role of an adaptive immune response in disease pathogenesis is unknown. To investigate the possibility of a functional humoral response to the tumor, we surveyed histologic sectio ... Full text Link to item Cite

Neuronal ceroid lipofuscinosis diagnosed via skin biopsy.

Journal Article J Clin Neurosci · December 2010 Featured Publication We aim to report that skin biopsy, a non-invasive test by neurological standards, may lead to a diagnosis. A 4-year-old male presented with a 2-year history of epilepsy and progressive developmental regression. The patient had a mildly elevated ammonia lev ... Full text Link to item Cite

The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features.

Journal Article Cancer Invest · November 2010 Featured Publication In a series of 177 breast carcinomas, we found that the Oncotype DX Recurrence Score (RS) was correlated with six pathobiologic features: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status, and the three component ... Full text Link to item Cite

Neural entrapment during uterosacral ligament suspension: an anatomic study of female cadavers.

Journal Article Obstet Gynecol · September 2010 Featured Publication OBJECTIVE: To describe retroperitoneal neural structures at risk during uterosacral ligament suspension and to estimate risk of neural injury based on uterosacral ligament suspension suture placement technique. METHODS: Uterosacral ligament suspension was ... Full text Link to item Cite

Primary peritoneal and ovarian cancers: an epidemiological comparative analysis.

Journal Article Cancer Causes Control · July 2010 Featured Publication We performed case-control analyses using data from the North Carolina Ovarian Cancer Study to determine risk factors that distinguish primary peritoneal cancer (PPC) from epithelial ovarian cancer (EOC). Our risk factor analyses were restricted to invasive ... Full text Link to item Cite

Gastric ulceration in a patient treated with SIR-spheres.

Journal Article Clin Gastroenterol Hepatol · May 2010 Featured Publication Full text Link to item Cite

Is surgical excision of core biopsy proven benign papillomas of the breast necessary?

Journal Article Acad Radiol · May 2010 Featured Publication RATIONALE AND OBJECTIVES: The aim of this study was to determine if core biopsy-proven benign papillomas of the breast need to be surgically excised. MATERIALS AND METHODS: Mammographic and pathologic database review from January 1994 to January 2004 revea ... Full text Link to item Cite

Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread.

Journal Article Int J Gynecol Pathol · May 2010 Featured Publication The natural history of 27 cases of biologically malignant struma ovarii from a series of 88 cases of histologically malignant or histologically proliferative struma ovarii is described. The extraovarian spread was evident at presentation in 17 patients. Th ... Full text Link to item Cite

Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.

Journal Article PLoS One · April 8, 2010 Featured Publication BACKGROUND: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), a population-based, case-control st ... Full text Open Access Link to item Cite

Colonic schwannoma visualized on FDG PET/CT.

Journal Article Clin Nucl Med · March 2010 Featured Publication Full text Link to item Cite

Paget disease of the vulva: a study of 56 cases.

Journal Article Eur J Obstet Gynecol Reprod Biol · March 2010 Featured Publication OBJECTIVE: To resolve controversial issues regarding vulvar Paget disease through analysis of a substantial number of cases. STUDY DESIGN: The medical records and pathology slides of 56 patients with a diagnosis of vulvar Paget disease were reviewed. Possi ... Full text Link to item Cite

Paget Disease of the Vulva - A Study of 56 Cases

Conference LABORATORY INVESTIGATION · February 1, 2010 Link to item Cite

Paget disease of the vulva: a histologic study of 56 cases correlating pathologic features and disease course.

Journal Article Int J Gynecol Pathol · January 2010 Featured Publication The Duke experience with 56 vulvar Paget disease patients was analyzed emphasizing pathologic features and controversial issues. Nearly all patients were Caucasian, and their mean age was 69 years. The average length of follow-up was 5.6 years. For each ca ... Full text Link to item Cite

A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.

Journal Article Oncologist · 2010 Featured Publication INTRODUCTION: Bevacizumab is increasingly being tested with neoadjuvant regimens in patients with localized cancer, but its effects on metastasis and survival remain unknown. This study examines the long-term outcome of clinical stage II/III rectal cancer ... Full text Link to item Cite

Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.

Journal Article Oncologist · 2010 Featured Publication We explored plasma and urinary concentrations of two members of the vascular endothelial growth factor (VEGF) family and their receptors as potential response and toxicity biomarkers of bevacizumab with neoadjuvant chemoradiation in patients with localized ... Full text Link to item Cite

Paget Disease of the Vulva - A Study of 56 Cases

Conference MODERN PATHOLOGY · 2010 Featured Publication Cite

Novel tumor sampling strategies to enable microarray gene expression signatures in breast cancer: a study to determine feasibility and reproducibility in the context of clinical care.

Journal Article Breast Cancer Res Treat · December 2009 Featured Publication Feasibility and reproducibility of microarray biomarkers in clinical settings are doubted because of reliance on fresh frozen tissue. We sought to develop and validate a paradigm of frozen tissue collection from early breast tumors to enable use of microar ... Full text Link to item Cite

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.

Journal Article Cancer Res · October 15, 2009 Featured Publication Clinical studies converge on the observation that circulating cytokines are elevated in most cancer patients by anti-vascular endothelial growth factor (VEGF) therapy. However, the source of these molecules and their relevance in tumor escape remain unknow ... Full text Link to item Cite

Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread.

Journal Article Int J Gynecol Pathol · September 2009 Featured Publication Struma ovarii that display extraovarian spread or later recurrence is exceedingly rare. Among 88 patients with "malignant" struma ovarii followed for prolonged periods, several features helped to predict the adverse clinical course. Adhesions (graded 2 to ... Full text Link to item Cite

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.

Journal Article J Clin Oncol · June 20, 2009 Featured Publication PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 patients received four cycles of th ... Full text Link to item Cite

Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy.

Journal Article Neoplasia · April 2009 Featured Publication Cervical cancer is the second most common female cancer worldwide. The ability to quantify physiological and morphological changes in the cervix is not only useful in the diagnosis of cervical precancers but also important in aiding the design of cost-effe ... Full text Link to item Cite

Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.

Journal Article Oncogene · January 15, 2009 Featured Publication The cancer stem cell hypothesis posits that malignant growth arises from a rare population of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such cells also possess increased resistance to chemotherapeutic agents. Res ... Full text Link to item Cite

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.

Journal Article Int J Nanomedicine · 2009 Featured Publication A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular archit ... Open Access Link to item Cite

Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma.

Journal Article Cancer Res · December 1, 2008 Featured Publication Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. Despite advances in therapy, patients with a histologic variant of RMS known as alveolar (aRMS) have a 5-year survival rate of <30%. aRMS tissues exhibit a number o ... Full text Link to item Cite

Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women.

Journal Article Am J Epidemiol · May 1, 2008 Featured Publication Ovarian cancer is most frequently diagnosed in postmenopausal women; however, the strongest risk predictors, pregnancy and oral contraceptive use, occur in most women in their twenties and thirties. Relatively few studies have examined how reproductive ris ... Full text Link to item Cite

Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2008 Featured Publication BACKGROUND: The objective of this study was to determine whether cyclin E overexpression defines an etiologically distinct subgroup of ovarian cancer. METHODS: We analyzed data from 538 epithelial ovarian cancer cases and 629 controls enrolled in a populat ... Full text Link to item Cite

Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer.

Journal Article Biomark Insights · February 1, 2008 Featured Publication Tumor hypoxia is associated with adverse outcome in many malignancies. The goal of this study was to determine if elevated expression of carbonic anhydrase IX (CAIX), a biomarker of hypoxia, predicts for recurrence in early-stage cervical cancer. The chart ... Full text Link to item Cite

Desmoplastic small round cell tumor masquerading as advanced ovarian cancer.

Journal Article Int J Gynecol Cancer · 2008 Featured Publication Desmoplastic small round cell tumor (DSRCT) is a rare abdominal malignancy usually diagnosed in young adult males. Most patients have widespread disease at presentation, with an organ of origin difficult to ascertain. A 33-year-old female presented to her ... Full text Link to item Cite

A clinicogenomic model to predict lymph node metastasis in breast cancer

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2008 Featured Publication Full text Cite

Novel approaches to Breast Tissue Banking: The Duke Breast SPORE experience

Conference MODERN PATHOLOGY · 2008 Featured Publication Cite

Stem cell marker CD133 (PROMININ-1) is epigenetically regulated in ovarian cancer

Conference CANCER BIOMARKERS · 2008 Featured Publication Cite

Stem cell marker CD133 (PROMININ-1) is epigenetically regulated in ovarian cancer

Conference GYNECOLOGIC ONCOLOGY · 2008 Featured Publication Cite

Clinical challenges and images in GI. Invasive candidal enterocolitis.

Journal Article Gastroenterology · August 2007 Featured Publication Full text Link to item Cite

Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.

Journal Article Nat Clin Pract Oncol · May 2007 Featured Publication BACKGROUND: Localized rectal cancer responds well to 5-fluorouracil and radiation-based regimens. A phase I-II trial is currently testing the efficacy of adding bevacizumab, a VEGF-specific antibody, to standard chemoradiotherapy. The case presented here i ... Full text Link to item Cite

Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia.

Journal Article Int J Gynecol Pathol · April 2007 Featured Publication Endometrial "hyperplasia," as currently diagnosed, includes the changes caused by an abnormal hormonal state and those caused by a separate category of monoclonal premalignant disease. The appearance of the disease in these 2 functional categories is disco ... Full text Link to item Cite

Three-dimensional imaging of whole rodent organs using optical computed and emission tomography.

Journal Article J Biomed Opt · 2007 Featured Publication We explore the potential of optical computed tomography (optical-CT) and optical emission computed tomography (optical-ECT) in a new area-whole organ imaging. The techniques are implemented on an in-house prototype benchtop system with improved image quali ... Full text Link to item Cite

Primary primitive neuroectodermal tumor of the breast.

Journal Article J Ultrasound Med · October 2006 Featured Publication Full text Link to item Cite

Transtubal spread of serous adenocarcinoma of the endometrium: an underrecognized mechanism of metastasis.

Journal Article Int J Gynecol Pathol · April 2006 Featured Publication Most endometrial carcinomas metastasize by invading myometrial lymphatics and spreading to regional lymph nodes. However, uterine serous carcinomas (USCs) metastasize frequently to peritoneal surfaces even when only minimally invasive. This study examines ... Full text Link to item Cite

Tissue transglutaminase expression in early-stage cervical cancer

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2006 Featured Publication Full text Cite

Anthropometric measurements and epithelial ovarian cancer risk in African-American and White women.

Journal Article Cancer Causes Control · October 2005 Featured Publication Previous studies of anthropometric factors and ovarian cancer risk have been inconsistent and none have evaluated the association among African-American women. Data from a population-based, case-control study of 593 cases and 628 controls were used to eval ... Full text Link to item Cite

Longitudinal mechanical tension induces growth in the small bowel of juvenile rats.

Journal Article Gut · August 2005 Featured Publication INTRODUCTION: The aim of our study was to apply longitudinal force to the small bowel to increase the length of intestine in juvenile rats. METHODS: Fifty juvenile rats had double barrelled, blind loop ostomies created using an isolated segment of bowel. O ... Full text Link to item Cite

Genetic modeling of human rhabdomyosarcoma.

Journal Article Cancer Res · June 1, 2005 Featured Publication Rhabdomyosarcoma, a malignancy showing features of skeletal muscle differentiation, is the most common soft tissue sarcoma of childhood. The identification of distinct clinical presentation patterns, histologic tumor types, and risk groups suggests that rh ... Full text Link to item Cite

Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk.

Journal Article Gynecol Oncol · May 2005 Featured Publication OBJECTIVES: It has been suggested that the 6A allele of the type I TGFbeta receptor (TGFbetaR1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer. METHODS: The TGFbetaR1 polyalanine polymo ... Full text Link to item Cite

Acoustic radiation force impulse (ARFI) imaging of the gastrointestinal tract.

Journal Article Ultrason Imaging · April 2005 Featured Publication The evaluation of lesions in the gastrointestinal (GI) tract using ultrasound can suffer from poor contrast between healthy and diseased tissue. Acoustic Radiation Force Impulse (ARFI) imaging provides information about the mechanical properties of tissue ... Full text Link to item Cite

Decreased E-cadherin expression correlates with higher stage of Wilms' tumors.

Journal Article J Pediatr Surg · February 2005 Featured Publication PURPOSE: The aim of this study was to examine the association between E-cadherin expression and markers of Wilms' tumor aggression, including metastasis and recurrence. METHODS: Forty Wilms' tumor samples from the National Wilms' Tumor Study Group underwen ... Full text Link to item Cite

Retrograde transtubal spread in extra-uterine metastasis of uterine serous carcinoma

Conference LABORATORY INVESTIGATION · 2005 Featured Publication Cite

Acoustic radiation force impulse imaging of the mechanical properties of arteries: in vivo and ex vivo results.

Journal Article Ultrasound Med Biol · September 2004 Featured Publication We present results of a pilot study of ex vivo and in vivo acoustic radiation force impulse (ARFI) imaging demonstrating measurements of the mechanical properties of the carotid and popliteal arteries. The results were obtained on a modified commercial sca ... Full text Link to item Cite

Phase III randomized trial of doxorubicin + cisplatin versus doxorubicin + 24-h paclitaxel + filgrastim in endometrial carcinoma: a Gynecologic Oncology Group study.

Journal Article Ann Oncol · August 2004 Featured Publication BACKGROUND: This study was performed to determine whether 24-h paclitaxel plus doxorubicin and filgrastim was superior to cisplatin plus doxorubicin in patients with endometrial cancer with respect to response, progression-free survival (PFS) and overall s ... Full text Link to item Cite

HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors.

Journal Article Clin Cancer Res · June 15, 2004 Featured Publication PURPOSE: This study investigated the connection among HER-2 gene amplification, HER-2 protein expression, and markers of tumor angiogenesis and oxygenation in patients with operable, invasive breast tumors. EXPERIMENTAL DESIGN: From 1988 to 1995, 425 patie ... Full text Link to item Cite

Radical hysterectomy and pelvic lymphadenectomy for stage IB2 cervical cancer.

Journal Article Gynecol Oncol · May 2004 Featured Publication OBJECTIVE: We wished to evaluate survival and adverse outcomes of patients with stage IB2 cervical cancer treated primarily with radical hysterectomy and lymphadenectomy. METHODS: A review was performed of all patients undergoing primary radical hysterecto ... Full text Link to item Cite

Estrogen receptor alpha (ESR1) mutant A908G is not a common feature in benign and malignant proliferations of the breast.

Journal Article Genes Chromosomes Cancer · May 2004 Featured Publication Alterations in estrogen responsive pathways are thought to contribute to benign and malignant breast disease. It has been reported previously that more than a third of typical epithelial hyperplasia lesions harbor the missense mutation A908G in the estroge ... Full text Link to item Cite

Acoustic Radiation Force Impulse (ARFI) imaging of the gastrointestinal tract

Conference Proceedings - IEEE Ultrasonics Symposium · 2004 Featured Publication Currently, the evaluation of lesions in the gastrointestinal (GI) tract using ultrasound suffers from poor contrast between healthy and diseased tissue. Acoustic Radiation Force Impulse (ARFI) imaging provides information about the mechanical properties of ... Cite

Accuracy of MRI in the detection of residual breast cancer after neoadjuvant chemotherapy.

Journal Article AJR Am J Roentgenol · November 2003 Featured Publication OBJECTIVE: This study was undertaken to evaluate the ability of MRI to accurately show residual primary breast malignancy in women treated with neoadjuvant chemotherapy. MATERIALS AND METHODS: Twenty-one patients with locally advanced primary breast carcin ... Full text Link to item Cite

Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer.

Journal Article Clin Cancer Res · October 1, 2003 Featured Publication PURPOSE: Because inherited BRCA1 or BRCA2 mutations strikingly increase ovarian cancer risk, polymorphisms in these genes could represent low penetrance susceptibility alleles. Previous studies of the BRCA2 N372H polymorphism suggested that HH homozygotes ... Link to item Cite

Pathology of gestational trophoblastic disease.

Journal Article Clin Obstet Gynecol · September 2003 Featured Publication Full text Link to item Cite

Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer.

Journal Article J Soc Gynecol Investig · September 2003 Featured Publication OBJECTIVE: It has been suggested that the 2G allele of a guanine insertion-deletion promoter polymorphism in the promoter of the matrix metalloproteinase-1 (MMP1) gene may increase susceptibility to ovarian cancer. The 2G allele also has been associated wi ... Full text Link to item Cite

Increased sectioning of pathologic specimens with ductal carcinoma in situ of the breast: are there clinical consequences?

Journal Article Clin Breast Cancer · August 2003 Featured Publication To assess if there has been increased sectioning of pathologic specimens with ductal carcinoma in situ (DCIS), identify sources of this change, and consider the clinical consequences, pathologic data from patients who underwent initial excisional biopsies ... Full text Link to item Cite

Fine mapping of Wilms' tumors with 16q loss of heterozygosity localizes the putative tumor suppressor gene to a region of 6.7 megabases.

Journal Article Ann Surg Oncol · March 2003 Featured Publication BACKGROUND: The aim of this study was to more precisely map the region of 16q loss of heterozygosity (LOH) in Wilms' tumors and to examine the expression of putative tumor suppressor. METHODS: We performed polymerase chain reaction-based LOH analysis on th ... Full text Link to item Cite

Development of a novel tissue acquisition protocol for biomarker studies in early stage breast cancer.

Conference BREAST CANCER RESEARCH AND TREATMENT · 2003 Featured Publication Cite

Imaging-guided core needle biopsy of papillary lesions of the breast.

Journal Article AJR Am J Roentgenol · November 2002 Featured Publication OBJECTIVE: Our objective was to assess the incidence of papillary lesions of the breast diagnosed at imaging-guided core needle biopsy and the need for surgical excision after a benign diagnosis. MATERIALS AND METHODS: This retrospective study included 137 ... Full text Link to item Cite

Observations of tissue response to acoustic radiation force: opportunities for imaging.

Journal Article Ultrason Imaging · July 2002 Featured Publication Acoustic Radiation Force Impulse (ARFI) imaging is a method for characterizing local variations in tissue mechanical properties. In this method, a single ultrasonic transducer array is used to both apply temporally short localized radiation forces within t ... Full text Link to item Cite

Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta.

Journal Article J Natl Cancer Inst · January 2, 2002 Featured Publication BACKGROUND: Oral contraceptive (OC) use is associated with a reduced risk of ovarian cancer. An OC component, progestin, induces apoptosis in the primate ovarian epithelium. One regulator of apoptosis is transforming growth factor-beta (TGF-beta). We deter ... Full text Link to item Cite

Acoustic radiation force impulse imaging: Remote palpation of the mechanical properties of tissue

Journal Article Proceedings of the IEEE Ultrasonics Symposium · 2002 Featured Publication An overview is given of the Acoustic Radiation Force Impulse (ARFI) imaging. It discusses the derivation of radiation force, the response of tissue to radiation force, and the potential for this imaging method to evaluate the mechanical properties of tissu ... Cite

Acoustic radiation force impulse imaging: EX vivo and in vivo demonstration of transient shear wave propagation

Conference Proceedings - International Symposium on Biomedical Imaging · January 1, 2002 Acoustic Radiation Force Impulse (ARFI) imaging utilizes brief, high energy, focused acoustic pulses to generate radiation force in remote locations in tissue, and conventional diagnostic ultrasound methods to detect the resulting tissue displacements in o ... Full text Cite

Does increased sectioning of ductal carcinoma in-situ (DCIS) pathologic specimens have clinical consequences?

Conference BREAST CANCER RESEARCH AND TREATMENT · 2002 Featured Publication Cite

CD34 expression in desmoplastic melanoma.

Journal Article J Cutan Pathol · November 2001 Featured Publication BACKGROUND: Primary and metastatic malignant melanoma can simulate various soft tissue tumors, including dermatofibrosarcoma protuberans (DFSP). Expression of CD34, a marker characteristic of DFSP, as well as other spindle cell tumors, has not been previou ... Full text Link to item Cite

Mucolipidosis II (I-cell disease) presenting as neonatal cholestasis.

Journal Article J Inherit Metab Dis · October 2001 Featured Publication Full text Link to item Cite

Primary chondroid melanoma.

Journal Article J Cutan Pathol · October 2001 Featured Publication BACKGROUND: Malignant melanoma is notorious for the wide range of histologic patterns it can assume, among the least frequent of which is chondroid melamona. METHODS: Two cases of primary chondroid melanoma of the distal lower extremity were studied. Tissu ... Full text Link to item Cite

Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.

Journal Article Gynecol Oncol · August 2001 Featured Publication OBJECTIVE: The regulation of the metastatic process in epithelial ovarian cancer has not been well defined. Similar to other tumor types, the angiogenic phenotype in ovarian cancer strongly influences clinical outcome, suggesting that the acquisition of a ... Full text Link to item Cite

Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities.

Journal Article Ann Surg · June 2001 Featured Publication OBJECTIVE: To evaluate the accuracy of percutaneous, image-guided core-needle breast biopsy (CNBx) and to compare the surgical management of patients with breast cancer diagnosed by CNBx with patients diagnosed by surgical needle-localization biopsy (SNLBx ... Full text Link to item Cite

Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types.

Journal Article Int J Gynecol Pathol · April 2001 Featured Publication One thousand consecutive cases of surgically proven endometriosis were reviewed to evaluate the frequency and types of pelvic cancers that were associated with ovarian and extraovarian endometriosis. The frequency and types of histologic abnormalities pres ... Full text Link to item Cite

Comparison of methods of measuring HER-2 in metastatic breast cancer patients treated with high-dose chemotherapy.

Journal Article J Clin Oncol · March 15, 2001 Featured Publication PURPOSE: HER-2 is overexpressed in 20% to 30% of human breast cancer and is associated with poor outcome. Studies suggest an association between HER-2 overexpression and resistance to alkylating agents. To further evaluate this relationship, we assessed th ... Full text Link to item Cite

K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.

Journal Article Gynecol Oncol · February 2001 Featured Publication OBJECTIVE: Müllerian inclusion cysts (MIC) are small benign appearing glands that are occasionally noted in lymph nodes and peritoneal biopsies. They occur most frequently in women with serous ovarian tumors, with borderline tumors (SBOT) having a higher i ... Full text Link to item Cite

Pathologic quiz case: pituitary mass in a 48-year-old woman.

Journal Article Arch Pathol Lab Med · February 2001 Featured Publication Full text Link to item Cite

Mammographic-pathologic correlation: Part 2. Malignant breast lesions

Journal Article Journal of Women's Imaging · 2001 Featured Publication The primary goal of the radiologist in interpreting mammograms is to detect abnormalities that are suggestive of malignancy. Unfortunately, great deal of overlap exists between the imaging patterns produced by benign and malignant breast lesions, creating ... Full text Cite

In vivo demonstration of acoustic radiation force impulse (ARFI) imaging in the thyroid, abdomen, and breast

Journal Article Proceedings of the IEEE Ultrasonics Symposium · 2001 Featured Publication Acoustic Radiation Force Impulse (ARFI) imaging is proposed as a method for characterizing local variations in tissue mechanical response. In this method, a single ultrasonic transducer array is used to both apply localized radiation forces within tissue a ... Cite

Mammographic-pathologic correlation: Part 1. Benign breast lesions

Journal Article Journal of Women's Imaging · 2001 Featured Publication A great deal of overlap exists in the mammographic appearance of benign and malignant breast lesions. This makes the radiologist's job more difficult and results in a substantial false-positive rate. Thorough knowledge of the clinical presentation, mammogr ... Cite

Pathologic quiz case - Pituitary mass in a 48-year-old woman - Pathologic diagnosis: Granular cell tumor of the infundibulum

Journal Article ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE · 2001 Featured Publication Cite

Pathology and pathophysiology of uterine smooth-muscle tumors.

Journal Article Environ Health Perspect · October 2000 Featured Publication Smooth-muscle tumors of uterine origin encompass a broad family of neoplasms. The leiomyoma, by far the most common of all the neoplasms, generally is hormone sensitive, with rates of growth semiquantitatively related to estrogen and progesterone receptor ... Full text Link to item Cite

Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans.

Journal Article Ann Surg · August 2000 Featured Publication OBJECTIVE: To determine whether ischemic preconditioning protects the human liver against a subsequent period of ischemia in patients undergoing hemihepatectomy, and to identify possible underlying protective mechanisms of ischemic preconditioning, such as ... Full text Link to item Cite

Bilateral pelvic lymph node metastases in a case of FIGO stage IA(1) adenocarcinoma of the cervix.

Journal Article Gynecol Oncol · June 2000 Featured Publication INTRODUCTION: Although the FIGO staging system has been recently described for microinvasive adenocarcinoma of the cervix, the precise role it will have on determining how patients are treated remains uncertain. Using various definitions for the classifica ... Full text Link to item Cite

Some mullerian inclusion cysts in lymph nodes may sometimes be metastases from serous borderline tumors of the ovary.

Journal Article Am J Surg Pathol · May 2000 Featured Publication Glandular inclusions that appear morphologically benign are occasionally found in lymph nodes as well as in peritoneal and omental biopsies. In patients with gynecologic malignancies, the nature and significance of these mullerian inclusion cysts (MIC) pre ... Full text Link to item Cite

The outcome of stage I-II clinically and surgically staged papillary serous and clear cell endometrial cancers when compared with endometrioid carcinoma.

Journal Article Gynecol Oncol · April 2000 Featured Publication PURPOSE: The aim of this study was to compare survival and recurrence in clinical and surgical stage I-II papillary serous (PS), clear cell (CC), and endometrioid (EM) cancers of the endometrium and examine the prognostic utility of myometrial invasion. ME ... Full text Link to item Cite

Tubular adenomas of the breast: imaging findings with histologic correlation.

Journal Article AJR Am J Roentgenol · March 2000 Featured Publication OBJECTIVE: The purpose of this study is to describe the imaging features of tubular adenomas, which are rare benign breast tumors usually found in women younger than 35 years old. CONCLUSION: In young women, tubular adenomas can look like noncalcified fibr ... Full text Link to item Cite

Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver.

Journal Article Gastroenterology · January 2000 Featured Publication BACKGROUND & AIMS: Sinusoidal endothelial cell (SEC) apoptosis is a central feature of reperfusion injury in liver transplantation. Platelet sequestration occurs after transplantation with possible deleterious effects. We tested the hypothesis that platele ... Full text Link to item Cite

Focal fibrosis: a common breast lesion diagnosed at imaging-guided core biopsy.

Journal Article AJR Am J Roentgenol · December 1999 Featured Publication OBJECTIVE: Focal fibrosis is a benign breast lesion commonly diagnosed by imaging-guided core biopsy. The goal of this study is to determine the frequency of focal fibrosis diagnosed at core biopsy and to describe its imaging features. MATERIALS AND METHOD ... Full text Link to item Cite

Epidemiologic and surgicopathologic findings of papillary serous and clear cell endometrial cancers when compared to endometrioid carcinoma.

Journal Article Gynecol Oncol · September 1999 Featured Publication PURPOSE: The aim of this study was to identify similarities and differences in epidemiologic and surgicopathologic staging results for papillary serous (PS) and clear cell (CC) endometrial cancers compared with endometrioid (EM) carcinoma of the endometriu ... Full text Link to item Cite

Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver.

Journal Article Transplantation · April 27, 1999 Featured Publication BACKGROUND: Ischemic injury of the liver is generally considered to result in necrosis, but it has recently been recognized that mediators of apoptosis are activated during ischemia/reperfusion. This study was designed to characterize the extent and the ty ... Full text Link to item Cite

Malignant melanoma presenting as a mediastinal mass.

Journal Article Ann Thorac Surg · March 1999 Featured Publication A case of malignant melanoma presenting as a mediastinal mass without an extrathoracic primary is reported. Microscopically the tumor appeared consistent with malignant melanoma, with the presence of focal melanin pigment in large epithelioid cells. Fontan ... Full text Link to item Cite

Pseudoanaplastic giant cell tumor of bone.

Journal Article Arch Pathol Lab Med · February 1999 Featured Publication Marked nuclear atypia can be found in a variety of benign mesenchymal tumors, including ancient schwannomas, symplastic leiomyomas, osteoblastomas, and chondromyxoid fibromas. Such nuclear atypia is believed to represent a degenerative phenomenon and does ... Full text Link to item Cite

Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis.

Journal Article Gastroenterology · January 1999 Featured Publication BACKGROUND & AIMS: Calpain proteases have been implicated in cell death by necrosis and more recently by apoptosis. Experiments were designed to determine the role of calpain proteases in ischemic rat liver injury by measurement of cytosolic calpain activi ... Full text Link to item Cite

Meningioma of the fourth ventricle.

Journal Article Clin Neuropathol · 1999 Featured Publication Meningiomas are primary meningeal based tumors of the central nervous system that rarely are located strictly within the fourth ventricle. We report a 72-year-old man operated upon for such a tumor. The pre-operative magnetic resonance images revealed a we ... Link to item Cite

Critical commentary to Cotyledonoid dissecting leiomyoma (Sternberg tumor): An unusual form of leiomyoma

Journal Article Pathology Research and Practice · 1999 Featured Publication Cite

Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study.

Journal Article Am J Surg Pathol · November 1998 Featured Publication Papillary endometrioid or villoglandular adenocarcinoma (VGA) is a relatively common type of endometrial adenocarcinoma, but studies describing its behavior have yielded conflicting results. Patients with a component of VGA were identified in a review of 8 ... Full text Link to item Cite

Goblet-cell mucinous epithelium lining the endometrium and endocervix: evidence of metastasis from an appendiceal primary tumor through the use of cytokeratin-7 and -20 immunostains.

Journal Article Int J Gynecol Pathol · October 1998 Featured Publication Differential staining with cytokeratin (CK)-7 and CK-20, two members of a complex family of proteins in human epithelial cells, proved critical in showing that the extremely well-differentiated goblet-cell (intestinal) mucinous epithelium lining the surfac ... Full text Link to item Cite

Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.

Journal Article Cancer Res · June 15, 1998 Featured Publication Mutation and deletion of the PTEN tumor suppressor gene occurs in about 40% of endometrial carcinomas. The purpose of this study was to determine whether PTEN mutations also are present in endometrial hyperplasias, which are premalignant precursors of inva ... Link to item Cite

Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation.

Journal Article Hepatology · June 1998 Featured Publication In livers excised for transplantation, sinusoidal endothelium appears especially vulnerable to injury during organ preservation in the cold and subsequent reperfusion. The degree of endothelial cell injury correlates with functional impairment of the graft ... Full text Link to item Cite

Solitary fibrous tumor of the meninges occurring after irradiation of a mixed germ cell tumor of the pineal gland.

Journal Article Clin Neuropathol · 1998 Featured Publication Twenty-nine months after surgery, irradiation, and systemic chemotherapy for a pineal mixed germ cell tumor, an 11-year-old Caucasian male developed a 3 cm dural based nodule in the occipital lobe that proved to be a solitary fibrous tumor by immunohistoch ... Link to item Cite

Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation.

Journal Article Gastroenterology · November 1997 Featured Publication BACKGROUND & AIMS: Low temperature preservation causes unique liver injuries to the sinusoidal lining cells characterized by endothelial cell detachment and rounding and Kupffer cell activation. These changes are similar to those observed during the early ... Full text Link to item Cite

Gastric graft-versus-host disease: a blinded histologic study.

Journal Article Am J Surg Pathol · September 1997 Featured Publication Acute graft-versus-host disease (GvHD) of the upper gastrointestinal (GI) tract is common after allogeneic bone marrow transplantation (BMT). However, diagnosis cannot be made on clinical presentation and endoscopic findings alone, because these are nonspe ... Full text Link to item Cite

Malignant supratentorial glial-neuronal neoplasms: report of two cases and review of the literature.

Journal Article Arch Pathol Lab Med · May 1997 Featured Publication OBJECTIVE: Malignant neoplasms exhibiting mixed populations of neuronal and glial cells occurring in the cerebral hemispheres of young adults and children are well recognized, but rare. A confusing array of diagnostic terms has arisen. We describe two pati ... Link to item Cite

Signet-ring cell carcinoma of the endometrium: a primary tumor masquerading as a metastasis.

Journal Article Int J Gynecol Pathol · April 1997 Featured Publication Extragenital metastases to the endometrium are unusual, but several histologic features have been suggested as highly suggestive or even pathognomonic for this diagnosis. We report an endometrial carcinoma with a prominent signet-ring cell morphology and a ... Full text Link to item Cite

Implantation metastasis of primary malignant rhabdoid tumor of the brain in an adult (one case report).

Journal Article Med Pediatr Oncol · March 1997 Featured Publication Primary malignant rhabdoid tumor (PMRT) of the brain is a rare and recently described neoplasm of youth. We report magnetic resonance imaging (MRI), computed tomography (CT), and pathology of one case of PMRT in an adult which seeded along the needle track ... Full text Link to item Cite

Aneurysmal bone cyst formation within a chondroblastoma: case report.

Journal Article Can Assoc Radiol J · February 1997 Featured Publication Link to item Cite

The detection of breast microcalcifications with medical ultrasound.

Journal Article J Acoust Soc Am · January 1997 Featured Publication Microcalcifications are small crystals of calcium apatites which form in human tissue through a number of mechanisms. The size, morphology, and distribution of microcalcifications are important indicators in the mammographic screening for and diagnosis of ... Full text Link to item Cite

Human endometrial transforming growth factor-alpha: a transmembrane, surface epithelial protein that transiently disappears during the midsecretory phase of the menstrual cycle.

Journal Article J Soc Gynecol Investig · 1997 Featured Publication OBJECTIVES: To characterize the forms of transforming growth factor-alpha (TGF-alpha) in normal human endometrium, to evaluate the regional and temporal changes in TGF-alpha expression, and to correlate the pattern of TGF-alpha expression with physiologic ... Full text Link to item Cite

p53lyn and p56lyn: a new signaling pathway in human endometrium and endometrial adenocarcinomas.

Journal Article J Soc Gynecol Investig · 1997 Featured Publication OBJECTIVE: To identify specific tyrosine kinases that are involved in endometrial signaling and to study their in vivo expression in normal and abnormal endometrium. We hypothesized that proteins that are differentially expressed would be more likely to be ... Link to item Cite

Axillary lymph nodes: mammographic, pathologic, and clinical correlation.

Journal Article AJR Am J Roentgenol · January 1997 Featured Publication OBJECTIVE: The purpose of this study was to determine the cause and frequency of axillary abnormalities seen mammographically and to evaluate the imaging characteristics of lymphadenopathy that are associated with malignancy. MATERIALS AND METHODS: Ninety- ... Full text Link to item Cite

Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis.

Journal Article Int J Gynecol Pathol · October 1996 Featured Publication This study evaluates the morphologic features of squamous epithelial repair of the uterine cervix, a condition describing a state of regeneration, and compares them with the features of its two histologic mimics, squamous metaplasia and mild dysplasia. The ... Full text Link to item Cite

Prospective correlation of cervicovaginal cytologic and histologic specimens.

Journal Article Am J Clin Pathol · September 1996 Featured Publication An effective, prospective, computer-guided method of correlation is reported. The mechanism for identification of cases, comparison of diagnoses, and reconciliation of discrepancies are explained. The results are similar to prior, retrospective, correlatio ... Full text Link to item Cite

M6P/IGF2 receptor: a candidate breast tumor suppressor gene.

Journal Article Oncogene · May 2, 1996 Featured Publication The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2r) functions in the activation of TGFbeta, a potent growth inhibitor for most cell types, the degradation of the mitogen, IGF2, and the intracellular trafficking of lysosomal enzymes. W ... Link to item Cite

Production and characterization of two ependymoma xenografts.

Journal Article J Neuropathol Exp Neurol · May 1996 Featured Publication Childhood ependymomas exhibit epidemiologic, anatomic, histologic, and biologic features and distinguish them from other gliomas. Because of their propensity to grow in functionally sensitive regions of the brain, adequate tumor sampling for basic and ther ... Full text Link to item Cite

Microcalcifications as elastic scatterers under ultrasound: implications for medical imaging

Journal Article Proceedings of the IEEE Ultrasonics Symposium · 1996 Featured Publication Microcalcifications are small crystals of calcium phosphates which form in human tissue through a number of mechanisms. The size, morphology, and distribution of microcalcifications (MCs) are important indicators in the mammographic screening for and diagn ... Cite

Gastric graft-versus-host disease: A coded histopathologic study

Journal Article LABORATORY INVESTIGATION · January 1, 1996 Link to item Cite

Endometrioid carcinoma of the endometrium with sertoliform differentiation.

Journal Article Int J Gynecol Pathol · October 1995 Featured Publication Ovarian endometrioid tumors with areas mimicking sex cord-stromal tumors are well documented in the literature, but it is unclear whether a similar tumor occurs in the endometrium. We report here a patient with an endometrial endometrioid adenocarcinoma re ... Full text Link to item Cite

Anaplastic renal cell carcinoma following neuroblastoma.

Journal Article Med Pediatr Oncol · July 1995 Featured Publication Renal cell carcinoma is unusual in children. We report a case of anaplastic renal cell carcinoma arising in a 7-year-old girl following treatment for Stage III neuroblastoma. The renal cell carcinoma has unusual histologic and ultrastructural features, whi ... Full text Link to item Cite

Villoglandular adenocarcinoma of the cervix: a case report.

Journal Article Obstet Gynecol · May 1995 Featured Publication BACKGROUND: Villoglandular adenocarcinoma of the cervix is a rare neoplasm associated with a favorable outcome and has not been described as a complication of pregnancy. CASE: A gravida at 20 weeks' gestation was found to have a bulky stage-IB adenocarcino ... Full text Link to item Cite

Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein.

Journal Article Cancer Res · March 1, 1995 Featured Publication In the mouse uterus, lactoferrin is a major estrogen-inducible uterine secretory protein, and its expression correlates directly with the period of peak epithelial cell proliferation. In this study, we examine the expression of lactoferrin mRNA and protein ... Link to item Cite

Papillary carcinoma of the breast: imaging findings.

Journal Article AJR Am J Roentgenol · February 1995 Featured Publication Papillary carcinoma is a rare malignant tumor of the breast for which the survival rate is better than for most breast carcinomas. Histologically, invasive and in situ forms occur; the in situ form can extend throughout a ductal system (intraductal) or can ... Full text Link to item Cite

Borderline and malignant serous tumor arising in pelvic lymph nodes: evidence of origin in benign glandular inclusions.

Journal Article Int J Gynecol Pathol · January 1995 Featured Publication This report describes two cases of malignant serous cancers with areas of borderline malignancy, which appear to have arisen within benign glandular inclusions of coelomic origin in pelvic or para-aortic lymph nodes. The patients were 44 and 62 years of ag ... Full text Link to item Cite

Evaluation of the ultrasonic detectability of microcalcifications

Journal Article Proceedings of the IEEE Ultrasonics Symposium · 1995 Featured Publication Microcalcifications are small crystals of calcium apatites which form in human tissue through a number of mechanisms. The size, morphology, and distribution of microcalcifications are important indicators in the mammographic screening for and diagnosis of ... Cite

Pathology of epithelial ovarian tumors.

Journal Article Clin Obstet Gynecol · June 1994 Featured Publication Full text Link to item Cite

Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer.

Journal Article Cancer · May 1, 1994 Featured Publication BACKGROUND: Several molecular-genetic alterations in endometrial cancers, including aneuploidy and aberrant expression of p53 and HER-2/neu, have been associated with poor prognosis. To determine the importance of molecular-genetic factors relative to more ... Full text Link to item Cite

Synoptic reports in gynecologic pathology.

Journal Article Int J Gynecol Pathol · April 1994 Featured Publication Full text Link to item Cite

Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes.

Journal Article Hum Pathol · June 1993 Featured Publication Malignant lymphoma of the testis occurs bilaterally more often than any other tumor type. We report the case of a 62-year-old man who presented with synchronous, bilateral, testicular malignant lymphomas without clinical or radiologic evidence of extratest ... Full text Link to item Cite

Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein.

Journal Article Mol Cell Biol · April 1991 Featured Publication We have investigated the sequence elements influencing RNA recognition in two closely related small nuclear ribonucleoprotein particle (snRNP) proteins, U1 snRNP-A and U2 snRNP-B". A 5-amino-acid segment in the RNA-binding domain of the U2 snRNP-B" protein ... Full text Link to item Cite

Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.

Journal Article Clin Immunol Immunopathol · February 1990 Featured Publication To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in ... Full text Link to item Cite

A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component.

Journal Article Mol Cell Biol · November 1989 Featured Publication We have defined the nucleotide sequence of a protein-binding domain within U1 RNA that specifically recognizes and binds both to a U1 small nuclear ribonucleoprotein component (the 70K protein) and to the previously defined RNA-binding domain of the 70K pr ... Full text Link to item Cite

A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.

Journal Article Cell · April 7, 1989 Featured Publication We have defined the RNA binding domain of the 70K protein component of the U1 small nuclear ribonucleoprotein to a region of 111 amino acids. This domain encompasses an octamer sequence that has been observed in other proteins associated with RNA, but has ... Full text Link to item Cite

Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid.

Journal Article Endocrinology · December 1984 Featured Publication Glucagon, a pancreatic peptide hormone of 29 amino acids that regulates carbohydrate, fat, and protein metabolism, is one of a family of structurally similar regulatory peptides which include GH-releasing hormone, vasoactive intestinal peptide, secretin, a ... Full text Link to item Cite