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Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes.

Publication ,  Journal Article
Bentley, RC; Devlin, B; Kaufman, RE; Borowitz, M; Ratech, H
Published in: Hum Pathol
June 1993

Malignant lymphoma of the testis occurs bilaterally more often than any other tumor type. We report the case of a 62-year-old man who presented with synchronous, bilateral, testicular malignant lymphomas without clinical or radiologic evidence of extratesticular disease. The patient received no therapy other than bilateral orchiectomy and subsequently developed widespread disease 6 months later. Southern blot DNA analysis was performed on the initial orchiectomy samples for immunoglobulin (Ig) gene rearrangements. These genotypic analyses showed different clonal rearrangements in the Ig heavy chain JH region but identical clonal rearrangements in the Ig light chain C Kappa region. To our knowledge this is the first genotypic demonstration of a common clonal origin in synchronous, bilateral, testicular malignant lymphomas. We interpret these findings as molecular evidence that the patient's malignant lymphoma was already disseminated at initial presentation, although it was clinically undetectable at that time.

Duke Scholars

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

June 1993

Volume

24

Issue

6

Start / End Page

675 / 678

Location

United States

Related Subject Headings

  • Testicular Neoplasms
  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, B-Cell
  • Immunoglobulin Light Chains
  • Immunoglobulin Heavy Chains
  • Immunoglobulin G
  • Humans
  • Genotype
 

Citation

APA
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ICMJE
MLA
NLM
Bentley, R. C., Devlin, B., Kaufman, R. E., Borowitz, M., & Ratech, H. (1993). Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes. Hum Pathol, 24(6), 675–678. https://doi.org/10.1016/0046-8177(93)90249-g
Bentley, R. C., B. Devlin, R. E. Kaufman, M. Borowitz, and H. Ratech. “Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes.Hum Pathol 24, no. 6 (June 1993): 675–78. https://doi.org/10.1016/0046-8177(93)90249-g.
Bentley RC, Devlin B, Kaufman RE, Borowitz M, Ratech H. Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes. Hum Pathol. 1993 Jun;24(6):675–8.
Bentley, R. C., et al. “Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes.Hum Pathol, vol. 24, no. 6, June 1993, pp. 675–78. Pubmed, doi:10.1016/0046-8177(93)90249-g.
Bentley RC, Devlin B, Kaufman RE, Borowitz M, Ratech H. Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes. Hum Pathol. 1993 Jun;24(6):675–678.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

June 1993

Volume

24

Issue

6

Start / End Page

675 / 678

Location

United States

Related Subject Headings

  • Testicular Neoplasms
  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, B-Cell
  • Immunoglobulin Light Chains
  • Immunoglobulin Heavy Chains
  • Immunoglobulin G
  • Humans
  • Genotype