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Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia.

Publication ,  Journal Article
Mutter, GL; Zaino, RJ; Baak, JPA; Bentley, RC; Robboy, SJ
Published in: Int J Gynecol Pathol
April 2007

Endometrial "hyperplasia," as currently diagnosed, includes the changes caused by an abnormal hormonal state and those caused by a separate category of monoclonal premalignant disease. The appearance of the disease in these 2 functional categories is discontinuous, permitting more specific diagnosis of the condition using the terms "benign endometrial hyperplasia" and "endometrial intraepithelial neoplasia" (EIN), respectively. Benign endometrial hyperplasia involves the entire endometrial compartment and, with protracted estrogen exposure, shows the progressive development of cysts, remodeled glands, vascular thrombi, and stromal microinfarcts. They are best construed as a sequence of changes whereby the appearance at any single time point is uniquely dependent on the preceding combination and the duration of hormonal exposures. In contrast, the premalignant clone of an EIN lesion is characteristically offset from the background endometrium by its altered cytology and crowded architecture. The use of an internal standard for cytology assessment, combined with the distinctive topography of a clonal process, enables the diagnosis of EIN lesions with a long-term cancer risk 45-fold greater than that of their benign endometrial hyperplasia counterparts. The resolution of hormonal and premalignant subsets of traditional "endometrial hyperplasias" is possible using redefined diagnostic criteria, enabling patient therapy to be appropriately matched with the underlying disease mechanisms.

Duke Scholars

Published In

Int J Gynecol Pathol

DOI

ISSN

0277-1691

Publication Date

April 2007

Volume

26

Issue

2

Start / End Page

103 / 114

Location

United States

Related Subject Headings

  • Precancerous Conditions
  • Pathology
  • Humans
  • Female
  • Endometrial Neoplasms
  • Endometrial Hyperplasia
  • Disease Progression
  • Diagnosis, Differential
  • Cell Proliferation
  • Carcinoma in Situ
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mutter, G. L., Zaino, R. J., Baak, J. P. A., Bentley, R. C., & Robboy, S. J. (2007). Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol, 26(2), 103–114. https://doi.org/10.1097/PGP.0b013e31802e4696
Mutter, George L., Richard J. Zaino, Jan P. A. Baak, Rex C. Bentley, and Stanley J. Robboy. “Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia.Int J Gynecol Pathol 26, no. 2 (April 2007): 103–14. https://doi.org/10.1097/PGP.0b013e31802e4696.
Mutter GL, Zaino RJ, Baak JPA, Bentley RC, Robboy SJ. Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol. 2007 Apr;26(2):103–14.
Mutter, George L., et al. “Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia.Int J Gynecol Pathol, vol. 26, no. 2, Apr. 2007, pp. 103–14. Pubmed, doi:10.1097/PGP.0b013e31802e4696.
Mutter GL, Zaino RJ, Baak JPA, Bentley RC, Robboy SJ. Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol. 2007 Apr;26(2):103–114.

Published In

Int J Gynecol Pathol

DOI

ISSN

0277-1691

Publication Date

April 2007

Volume

26

Issue

2

Start / End Page

103 / 114

Location

United States

Related Subject Headings

  • Precancerous Conditions
  • Pathology
  • Humans
  • Female
  • Endometrial Neoplasms
  • Endometrial Hyperplasia
  • Disease Progression
  • Diagnosis, Differential
  • Cell Proliferation
  • Carcinoma in Situ