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High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer.

Publication ,  Journal Article
Baumann, KE; Siamakpour-Reihani, S; Dottino, J; Dai, Y; Bentley, R; Jiang, C; Zhang, D; Sibley, AB; Zhou, C; Berchuck, A; Owzar, K; Secord, AA ...
Published in: Gynecol Oncol
December 2023

OBJECTIVE: We sought to evaluate the association between diet and angiogenic biomarkers in KpB mice, and the association between these markers, body mass index (BMI), and overall survival (OS) in high-grade serous cancers (HGSC). METHODS: Tumors previously obtained from KpB mice subjected to high-fat diets (HFD, n = 10) or low-fat diets (LFD, n = 10) were evaluated for angiogenesis based on CD-31 microvessel density (MVD). Data from prior microarray analysis (Agilent 244 K arrays) conducted in 10 mice were utilized to assess associations between diet and angiogenetic biomarkers. Agilent (mouse) and Affymetrix Human Genome U133a probes were linked to 162 angiogenic-related genes. The associations between biomarkers, BMI, and OS were evaluated in an HGSC internal database (IDB) (n = 40). Genes with unadjusted p < 0.05 were evaluated for association with OS in the TCGA-OV database (n = 339). RESULTS: There was no association between CD-31 and diet in mice (p = 0.66). Sixteen angiogenic-related genes passed the p < 0.05 threshold for association with HFD vs. LFD. Transforming growth factor-alpha (TGFA) demonstrated 72% higher expression in HFD vs. LFD mice (p = 0.04). Similar to the mouse study, in our HGSC IDB, higher TGFA expression correlated with higher BMI (p = 0.01) and shorter survival (p = 0.001). In the TCGA-OV dataset, BMI data was not available and there was no association between TGFA and OS (p = 0.48). CONCLUSIONS: HFD and obesity may promote tumor progression via differential modulation of TGFA. We were unable to confirm this finding in the TCGA dataset. Further evaluation of TGFA is needed to determine if this is a target unique to obesity-driven HGSC.

Duke Scholars

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Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

December 2023

Volume

179

Start / End Page

97 / 105

Location

United States

Related Subject Headings

  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Obesity
  • Mice, Inbred C57BL
  • Mice
  • Humans
  • Gene Expression
  • Female
  • Diet, High-Fat
  • Carcinoma, Ovarian Epithelial
 

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Baumann, K. E., Siamakpour-Reihani, S., Dottino, J., Dai, Y., Bentley, R., Jiang, C., … Secord, A. A. (2023). High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer. Gynecol Oncol, 179, 97–105. https://doi.org/10.1016/j.ygyno.2023.11.002
Baumann, Katherine E., Sharareh Siamakpour-Reihani, Joseph Dottino, Yanwan Dai, Rex Bentley, Chen Jiang, Dadong Zhang, et al. “High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer.Gynecol Oncol 179 (December 2023): 97–105. https://doi.org/10.1016/j.ygyno.2023.11.002.
Baumann KE, Siamakpour-Reihani S, Dottino J, Dai Y, Bentley R, Jiang C, et al. High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer. Gynecol Oncol. 2023 Dec;179:97–105.
Baumann, Katherine E., et al. “High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer.Gynecol Oncol, vol. 179, Dec. 2023, pp. 97–105. Pubmed, doi:10.1016/j.ygyno.2023.11.002.
Baumann KE, Siamakpour-Reihani S, Dottino J, Dai Y, Bentley R, Jiang C, Zhang D, Sibley AB, Zhou C, Berchuck A, Owzar K, Bae-Jump V, Secord AA. High-fat diet and obesity are associated with differential angiogenic gene expression in epithelial ovarian cancer. Gynecol Oncol. 2023 Dec;179:97–105.
Journal cover image

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

December 2023

Volume

179

Start / End Page

97 / 105

Location

United States

Related Subject Headings

  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Obesity
  • Mice, Inbred C57BL
  • Mice
  • Humans
  • Gene Expression
  • Female
  • Diet, High-Fat
  • Carcinoma, Ovarian Epithelial