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Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma.

Publication ,  Journal Article
Matsuo, K; Hasegawa, K; Yoshino, K; Murakami, R; Hisamatsu, T; Stone, RL; Previs, RA; Hansen, JM; Ikeda, Y; Miyara, A; Hiramatsu, K; Roman, LD ...
Published in: Eur J Cancer
September 2015

BACKGROUND: We compared survival outcomes and risk of venous thromboembolism (VTE) among patients with advanced and early-stage ovarian clear cell carcinoma (OCCC) and serous ovarian carcinoma (SOC), as well as potential links with interleukin-6 (IL-6) levels. METHODS: A multicenter case-control study was conducted in 370 patients with OCCC and 938 with SOC. In a subset of 200 cases, pretreatment plasma IL-6 levels were examined. FINDINGS: Patients with advanced OCCC had the highest 2-year cumulative VTE rates (advanced OCCC 43.1%, advanced SOC 16.2%, early-stage OCCC 11.9% and early-stage SOC 6.4%, P<0.0001) and the highest median levels of IL-6 (advanced OCCC 17.8 pg/mL, advanced SOC 9.0 pg/mL, early-stage OCCC 4.2 pg/mL and early-stage SOC 5.0 pg/mL, P=0.006). Advanced OCCC (hazard ratio [HR] 3.38, P<0.0001), thrombocytosis (HR 1.42, P=0.032) and elevated IL-6 (HR 8.90, P=0.046) were independent predictors of VTE. In multivariate analysis, patients with advanced OCCC had significantly poorer 5-year progression-free and overall survival rates than those with advanced SOC (P<0.01), and thrombocytosis was an independent predictor of decreased survival outcomes (P<0.01). Elevated IL-6 levels led to poorer 2-year progression-free survival rates in patients with OCCC (50% versus 87.5%, HR 4.89, P=0.016) than in those with SOC (24.9% versus 40.8%, HR 1.40, P=0.07). INTERPRETATION: Advanced OCCC is associated with an increased incidence of VTE and decreased survival outcomes, which has major implications for clinical management of OCCC.

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Published In

Eur J Cancer

DOI

EISSN

1879-0852

Publication Date

September 2015

Volume

51

Issue

14

Start / End Page

1978 / 1988

Location

England

Related Subject Headings

  • Venous Thromboembolism
  • Up-Regulation
  • United States
  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Proportional Hazards Models
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms, Cystic, Mucinous, and Serous
 

Citation

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Matsuo, K., Hasegawa, K., Yoshino, K., Murakami, R., Hisamatsu, T., Stone, R. L., … Sood, A. K. (2015). Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma. Eur J Cancer, 51(14), 1978–1988. https://doi.org/10.1016/j.ejca.2015.07.012
Matsuo, Koji, Kosei Hasegawa, Kiyoshi Yoshino, Ryusuke Murakami, Takeshi Hisamatsu, Rebecca L. Stone, Rebecca A. Previs, et al. “Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma.Eur J Cancer 51, no. 14 (September 2015): 1978–88. https://doi.org/10.1016/j.ejca.2015.07.012.
Matsuo K, Hasegawa K, Yoshino K, Murakami R, Hisamatsu T, Stone RL, et al. Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma. Eur J Cancer. 2015 Sep;51(14):1978–88.
Matsuo, Koji, et al. “Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma.Eur J Cancer, vol. 51, no. 14, Sept. 2015, pp. 1978–88. Pubmed, doi:10.1016/j.ejca.2015.07.012.
Matsuo K, Hasegawa K, Yoshino K, Murakami R, Hisamatsu T, Stone RL, Previs RA, Hansen JM, Ikeda Y, Miyara A, Hiramatsu K, Enomoto T, Fujiwara K, Matsumura N, Konishi I, Roman LD, Gabra H, Fotopoulou C, Sood AK. Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma. Eur J Cancer. 2015 Sep;51(14):1978–1988.
Journal cover image

Published In

Eur J Cancer

DOI

EISSN

1879-0852

Publication Date

September 2015

Volume

51

Issue

14

Start / End Page

1978 / 1988

Location

England

Related Subject Headings

  • Venous Thromboembolism
  • Up-Regulation
  • United States
  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Proportional Hazards Models
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms, Cystic, Mucinous, and Serous