Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer.

Publication ,  Journal Article
Previs, RA; Kilgore, J; Craven, R; Broadwater, G; Bean, S; Wobker, S; DiFurio, M; Bae-Jump, V; Gehrig, PA; Secord, AA
Published in: Int J Gynecol Cancer
May 2014

OBJECTIVE: The objective of this study was to evaluate prognostic risk factors for survival in women with low-grade serous epithelial ovarian cancer (LGSC). METHODS: A multicenter retrospective analysis of patients with LGSC was conducted. Potential epidemiologic risk factors evaluated included obesity, age, parity, race, smoking, oral contraceptive pill and/or hormonal replacement therapy use, and previous hysterectomy or surgery on fallopian tubes and/or ovaries. Additional factors included stage, extent of debulking, residual disease, and disease status. RESULTS: Eighty-one patients were identified, and pathologic diagnosis was independently confirmed. Median age at diagnosis was 56 years (range, 21-86 years). Thirty-four percent were obese, and 80% had optimally debulked disease. Forty-six percent were alive, 14% with disease, whereas 25% were dead of disease, 2% died of intercurrent disease, and 27% had an unknown status. In a univariate analysis, optimal surgical debulking was associated with improved progression-free survival (P = 0.01), disease-specific survival (P = 0.03), and overall survival (OS) (P < 0.001) and body mass index with worse OS (P = 0.05). On multivariate analysis, obesity (hazard ratio, 2.8; 95% confidence interval, 1.05-7.3; P = 0.04) and optimal tumor debulking (hazard ratio, 0.05; 95% confidence interval, 0.008-0.29; P = 0.001) were a significant predictor of OS. CONCLUSIONS: In a multivariate analysis, obesity and optimal tumor cytoreduction were significant predictors of OS. However, obesity was not associated with worse disease-specific survival, suggesting that mortality of obese patients with LGSC may result from other comorbidities. Interventions addressing obesity may improve survival for women diagnosed with LGSC, and further study is warranted to address the role of obesity in LGSC.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Gynecol Cancer

DOI

EISSN

1525-1438

Publication Date

May 2014

Volume

24

Issue

4

Start / End Page

670 / 675

Location

England

Related Subject Headings

  • Young Adult
  • Survival Rate
  • Prognosis
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Obesity
  • Neoplasm Grading
  • Multivariate Analysis
  • Middle Aged
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Previs, R. A., Kilgore, J., Craven, R., Broadwater, G., Bean, S., Wobker, S., … Secord, A. A. (2014). Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer. Int J Gynecol Cancer, 24(4), 670–675. https://doi.org/10.1097/IGC.0000000000000109
Previs, Rebecca Ann, Joshua Kilgore, Renatta Craven, Gloria Broadwater, Sarah Bean, Sara Wobker, Megan DiFurio, Victoria Bae-Jump, Paola A. Gehrig, and Angeles Alvarez Secord. “Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer.Int J Gynecol Cancer 24, no. 4 (May 2014): 670–75. https://doi.org/10.1097/IGC.0000000000000109.
Previs RA, Kilgore J, Craven R, Broadwater G, Bean S, Wobker S, et al. Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer. Int J Gynecol Cancer. 2014 May;24(4):670–5.
Previs, Rebecca Ann, et al. “Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer.Int J Gynecol Cancer, vol. 24, no. 4, May 2014, pp. 670–75. Pubmed, doi:10.1097/IGC.0000000000000109.
Previs RA, Kilgore J, Craven R, Broadwater G, Bean S, Wobker S, DiFurio M, Bae-Jump V, Gehrig PA, Secord AA. Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer. Int J Gynecol Cancer. 2014 May;24(4):670–675.
Journal cover image

Published In

Int J Gynecol Cancer

DOI

EISSN

1525-1438

Publication Date

May 2014

Volume

24

Issue

4

Start / End Page

670 / 675

Location

England

Related Subject Headings

  • Young Adult
  • Survival Rate
  • Prognosis
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Obesity
  • Neoplasm Grading
  • Multivariate Analysis
  • Middle Aged
  • Humans