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Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth.

Publication ,  Journal Article
Armaiz-Pena, GN; Gonzalez-Villasana, V; Nagaraja, AS; Rodriguez-Aguayo, C; Sadaoui, NC; Stone, RL; Matsuo, K; Dalton, HJ; Previs, RA; Dorniak, P ...
Published in: Oncotarget
February 28, 2015

Increased adrenergic signaling facilitates tumor progression, but the underlying mechanisms remain poorly understood. We examined factors responsible for stress-mediated effects on monocyte/macrophage recruitment into the tumor microenvironment, and the resultant effects on tumor growth. In vitro, MCP1 was significantly increased after catecholamine exposure, which was mediated by cAMP and PKA. Tumor samples from mice subjected to daily restraint stress had elevated MCP1 gene and protein levels, increased CD14+ cells, and increased infiltration of CD68+ cells. hMCP1 siRNA-DOPC nanoparticles significantly abrogated daily restraint stress-induced tumor growth and inhibited infiltration of CD68+ and F4/80+ cells. In ovarian cancer patients, elevated peripheral blood monocytes and tumoral macrophages were associated with worse overall survival. Collectively, we demonstrate that increased adrenergic signaling is associated with macrophage infiltration and mediated by tumor cell-derived MCP1 production.

Duke Scholars

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

February 28, 2015

Volume

6

Issue

6

Start / End Page

4266 / 4273

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Real-Time Polymerase Chain Reaction
  • Ovarian Neoplasms
  • Norepinephrine
  • Mice, Nude
  • Mice
  • Macrophages
  • Kaplan-Meier Estimate
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Armaiz-Pena, G. N., Gonzalez-Villasana, V., Nagaraja, A. S., Rodriguez-Aguayo, C., Sadaoui, N. C., Stone, R. L., … Lopez-Berestein, G. (2015). Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget, 6(6), 4266–4273. https://doi.org/10.18632/oncotarget.2887
Armaiz-Pena, Guillermo N., Vianey Gonzalez-Villasana, Archana S. Nagaraja, Cristian Rodriguez-Aguayo, Nouara C. Sadaoui, Rebecca L. Stone, Koji Matsuo, et al. “Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth.Oncotarget 6, no. 6 (February 28, 2015): 4266–73. https://doi.org/10.18632/oncotarget.2887.
Armaiz-Pena GN, Gonzalez-Villasana V, Nagaraja AS, Rodriguez-Aguayo C, Sadaoui NC, Stone RL, et al. Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget. 2015 Feb 28;6(6):4266–73.
Armaiz-Pena, Guillermo N., et al. “Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth.Oncotarget, vol. 6, no. 6, Feb. 2015, pp. 4266–73. Pubmed, doi:10.18632/oncotarget.2887.
Armaiz-Pena GN, Gonzalez-Villasana V, Nagaraja AS, Rodriguez-Aguayo C, Sadaoui NC, Stone RL, Matsuo K, Dalton HJ, Previs RA, Jennings NB, Dorniak P, Hansen JM, Arevalo JMG, Cole SW, Lutgendorf SK, Sood AK, Lopez-Berestein G. Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget. 2015 Feb 28;6(6):4266–4273.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

February 28, 2015

Volume

6

Issue

6

Start / End Page

4266 / 4273

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Real-Time Polymerase Chain Reaction
  • Ovarian Neoplasms
  • Norepinephrine
  • Mice, Nude
  • Mice
  • Macrophages
  • Kaplan-Meier Estimate
  • Humans
  • Female