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Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer.

Publication ,  Journal Article
Whiting, N; Hu, J; Zacharias, NM; Lokesh, GLR; Volk, DE; Menter, DG; Rupaimoole, R; Previs, R; Sood, AK; Bhattacharya, P
Published in: J Med Imaging (Bellingham)
July 2016

Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization, which increases magnetic resonance imaging signals by several orders-of-magnitude through enhanced nuclear spin alignment, has recently been developed to allow silicon particles to function as contrast agents for in vivo magnetic resonance imaging. The enhanced spin polarization of silicon lasts significantly longer than other hyperpolarized agents (tens of minutes, whereas [Formula: see text] for other species at room temperature), allowing a wide range of potential applications. We report our recent characterizations of hyperpolarized silicon particles, with the ultimate goal of targeted, noninvasive, and nonradioactive molecular imaging of various cancer systems. A variety of particle sizes (20 nm to [Formula: see text]) were found to have hyperpolarized relaxation times ranging from [Formula: see text] to 50 min. The addition of various functional groups to the particle surface had no effect on the hyperpolarization buildup or decay rates and allowed in vivo imaging over long time scales. Additional in vivo studies examined a variety of particle administration routes in mice, including intraperitoneal injection, rectal enema, and oral gavage.

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Published In

J Med Imaging (Bellingham)

DOI

ISSN

2329-4302

Publication Date

July 2016

Volume

3

Issue

3

Start / End Page

036001

Location

United States

Related Subject Headings

  • 4003 Biomedical engineering
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Whiting, N., Hu, J., Zacharias, N. M., Lokesh, G. L. R., Volk, D. E., Menter, D. G., … Bhattacharya, P. (2016). Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. J Med Imaging (Bellingham), 3(3), 036001. https://doi.org/10.1117/1.JMI.3.3.036001
Whiting, Nicholas, Jingzhe Hu, Niki M. Zacharias, Ganesh L. R. Lokesh, David E. Volk, David G. Menter, Rajesha Rupaimoole, Rebecca Previs, Anil K. Sood, and Pratip Bhattacharya. “Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer.J Med Imaging (Bellingham) 3, no. 3 (July 2016): 036001. https://doi.org/10.1117/1.JMI.3.3.036001.
Whiting N, Hu J, Zacharias NM, Lokesh GLR, Volk DE, Menter DG, et al. Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. J Med Imaging (Bellingham). 2016 Jul;3(3):036001.
Whiting, Nicholas, et al. “Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer.J Med Imaging (Bellingham), vol. 3, no. 3, July 2016, p. 036001. Pubmed, doi:10.1117/1.JMI.3.3.036001.
Whiting N, Hu J, Zacharias NM, Lokesh GLR, Volk DE, Menter DG, Rupaimoole R, Previs R, Sood AK, Bhattacharya P. Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. J Med Imaging (Bellingham). 2016 Jul;3(3):036001.

Published In

J Med Imaging (Bellingham)

DOI

ISSN

2329-4302

Publication Date

July 2016

Volume

3

Issue

3

Start / End Page

036001

Location

United States

Related Subject Headings

  • 4003 Biomedical engineering
  • 3202 Clinical sciences