Scholars@Duke publication: Erythropoietin Stimulates Tumor Growth via EphB4.

Erythropoietin Stimulates Tumor Growth via EphB4.

Publication , Journal Article

Pradeep, S; Huang, J; Mora, EM; Nick, AM; Cho, MS; Wu, SY; Noh, K; Pecot, CV; Rupaimoole, R; Stein, MA; Brock, S; Wen, Y; Xiong, C; Han, HD ...

Published in: Cancer Cell

November 9, 2015

Published version (DOI) Link to item

While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative Epo receptor. Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression. In human ovarian and breast cancer samples, expression of EphB4 rather than the canonical EpoR correlated with decreased disease-specific survival in rhEpo-treated patients. These results identify EphB4 as a critical mediator of erythropoietin-induced tumor progression and further provide clinically significant dimension to the biology of erythropoietin.

Duke Scholars

Author Rebecca A Previs Obstetrics and Gynecology, Gynecologic Oncology

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Published In

Cancer Cell

DOI

10.1016/j.ccell.2015.09.008

EISSN

1878-3686

Publication Date

November 9, 2015

Volume

Issue

Start / End Page

610 / 622

Location

United States

Related Subject Headings

Young Adult
STAT3 Transcription Factor
Reverse Transcriptase Polymerase Chain Reaction
Recombinant Proteins
Receptors, Erythropoietin
Receptor, EphB4
Protein Binding
Ovarian Neoplasms
Oncology & Carcinogenesis
Middle Aged

Citation

APA

Chicago

ICMJE

MLA

NLM

Pradeep, S., Huang, J., Mora, E. M., Nick, A. M., Cho, M. S., Wu, S. Y., … Sood, A. K. (2015). Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell, 28(5), 610–622. https://doi.org/10.1016/j.ccell.2015.09.008

Pradeep, Sunila, Jie Huang, Edna M. Mora, Alpa M. Nick, Min Soon Cho, Sherry Y. Wu, Kyunghee Noh, et al. “Erythropoietin Stimulates Tumor Growth via EphB4.” Cancer Cell 28, no. 5 (November 9, 2015): 610–22. https://doi.org/10.1016/j.ccell.2015.09.008.

Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, et al. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 2015 Nov 9;28(5):610–22.

Pradeep, Sunila, et al. “Erythropoietin Stimulates Tumor Growth via EphB4.” Cancer Cell, vol. 28, no. 5, Nov. 2015, pp. 610–22. Pubmed, doi:10.1016/j.ccell.2015.09.008.

Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Armaiz-Peña GN, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung M-C, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 2015 Nov 9;28(5):610–622.

Published In

Cancer Cell

DOI

10.1016/j.ccell.2015.09.008

EISSN

1878-3686

Publication Date

November 9, 2015

Volume

Issue

Start / End Page

610 / 622

Location

United States

Related Subject Headings

Young Adult
STAT3 Transcription Factor
Reverse Transcriptase Polymerase Chain Reaction
Recombinant Proteins
Receptors, Erythropoietin
Receptor, EphB4
Protein Binding
Ovarian Neoplasms
Oncology & Carcinogenesis
Middle Aged