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The rise of genomic profiling in ovarian cancer.

Publication ,  Journal Article
Previs, RA; Sood, AK; Mills, GB; Westin, SN
Published in: Expert Rev Mol Diagn
December 2016

Next-generation sequencing and advances in 'omics technology have rapidly increased our understanding of the molecular landscape of epithelial ovarian cancers. Areas covered: Once characterized only by histologic appearance and clinical behavior, we now understand many of the molecular phenotypes that underlie the different ovarian cancer subtypes. While the current approach to treatment involves standard cytotoxic therapies after cytoreductive surgery for all ovarian cancers regardless of histologic or molecular characteristics, focus has shifted beyond a 'one size fits all' approach to ovarian cancer. Expert commentary: Genomic profiling offers potentially 'actionable' opportunities for development of targeted therapies and a more individualized approach to treatment with concomitant improved outcomes and decreased toxicity.

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Published In

Expert Rev Mol Diagn

DOI

EISSN

1744-8352

Publication Date

December 2016

Volume

16

Issue

12

Start / End Page

1337 / 1351

Location

England

Related Subject Headings

  • Treatment Outcome
  • Signal Transduction
  • Prognosis
  • Precision Medicine
  • Practice Guidelines as Topic
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Ovarian Neoplasms
  • Neoplasms, Glandular and Epithelial
  • Mutation
  • Molecular Targeted Therapy
 

Citation

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Previs, R. A., Sood, A. K., Mills, G. B., & Westin, S. N. (2016). The rise of genomic profiling in ovarian cancer. Expert Rev Mol Diagn, 16(12), 1337–1351. https://doi.org/10.1080/14737159.2016.1259069
Previs, Rebecca A., Anil K. Sood, Gordon B. Mills, and Shannon N. Westin. “The rise of genomic profiling in ovarian cancer.Expert Rev Mol Diagn 16, no. 12 (December 2016): 1337–51. https://doi.org/10.1080/14737159.2016.1259069.
Previs RA, Sood AK, Mills GB, Westin SN. The rise of genomic profiling in ovarian cancer. Expert Rev Mol Diagn. 2016 Dec;16(12):1337–51.
Previs, Rebecca A., et al. “The rise of genomic profiling in ovarian cancer.Expert Rev Mol Diagn, vol. 16, no. 12, Dec. 2016, pp. 1337–51. Pubmed, doi:10.1080/14737159.2016.1259069.
Previs RA, Sood AK, Mills GB, Westin SN. The rise of genomic profiling in ovarian cancer. Expert Rev Mol Diagn. 2016 Dec;16(12):1337–1351.
Journal cover image

Published In

Expert Rev Mol Diagn

DOI

EISSN

1744-8352

Publication Date

December 2016

Volume

16

Issue

12

Start / End Page

1337 / 1351

Location

England

Related Subject Headings

  • Treatment Outcome
  • Signal Transduction
  • Prognosis
  • Precision Medicine
  • Practice Guidelines as Topic
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Ovarian Neoplasms
  • Neoplasms, Glandular and Epithelial
  • Mutation
  • Molecular Targeted Therapy