Scholars@Duke
Reginald (Gino) Lerebours

Reginald (Gino) Lerebours

Biostatistician II
Biostatistics & Bioinformatics

Selected Publications

Retrospective Comparison of Patients Evaluated for Pediatric Autoimmune Encephalitis with Typical and Atypical Premorbid Neuropsychiatric Development.

Journal Article J Autism Dev Disord · June 2025 PURPOSE: Patients with neurodevelopmental disorders (NDD) (i.e. autism, developmental delay, early-onset psychiatric or seizure disorders) increasingly seek evaluation of new or exacerbated symptoms concerning for autoimmune encephalitis (AE). Clinical AE ... Full text Link to item Cite

Behavioral characteristics of toddlers later identified with an autism diagnosis, ADHD symptoms, or combined autism and ADHD symptoms.

Journal Article J Child Psychol Psychiatry · February 2025 BACKGROUND: Autism commonly co-occurs with attention-deficit/hyperactivity disorder (ADHD), but less is known regarding how ADHD symptoms impact the early presentation of autism. This study examined early behavioral characteristics of a community sample of ... Full text Link to item Cite

Brief Report: Relationships Between Caregiver-Reported Externalizing and Internalizing Behaviors and the Modified Checklist for Autism in Toddlers.

Journal Article J Autism Dev Disord · July 12, 2024 PURPOSE: Early detection and intervention are associated with improved outcomes for autistic children. Thus, it is important to understand factors influencing early screening tools designed to detect autism. This study examined the relationship between car ... Full text Link to item Cite

Meaning-centered pain coping skills training for patients with metastatic cancer: Protocol for a randomized controlled efficacy trial.

Journal Article Contemp Clin Trials · December 2023 BACKGROUND: Many patients with advanced cancer describe pain as a debilitating symptom that greatly interferes with daily activities and enjoyment of life. Psychosocial interventions can improve cancer-related pain but rarely address spiritual concerns (e. ... Full text Link to item Cite

Exploratory analysis of mesenteric-portal axis CT radiomic features for survival prediction of patients with pancreatic ductal adenocarcinoma.

Journal Article Eur Radiol · August 2023 OBJECTIVE: To develop and evaluate task-based radiomic features extracted from the mesenteric-portal axis for prediction of survival and response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Consecutive patients ... Full text Link to item Cite

Meaning-centered pain coping skills training for patients with metastatic cancer: Results of a randomized controlled pilot trial.

Journal Article Psychooncology · July 2023 OBJECTIVE: For patients with advanced cancer, pain is a common and debilitating symptom that can negatively impact physical, emotional, and spiritual well-being. This trial examined the feasibility and initial effects of Meaning-Centered Pain Coping Skills ... Full text Link to item Cite

MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials.

Journal Article Radiology · March 2023 Background Several early-phase clinical trials for the treatment of nonalcoholic steatohepatitis (NASH) use liver fat content as measured with the MRI-derived proton density fat fraction (PDFF) for a primary outcome. These trials have shown relative reduct ... Full text Open Access Link to item Cite

Association and Trends in Medicare Denials and Utilization for Brain CT: Indirect Impacts by Targeted Policy Intervention?

Journal Article Curr Probl Diagn Radiol · 2023 Twenty-five years of annual Medicare Physician/Supplier Procedure Summary (PSPS) Master File data were used to assess trends in normalized volume and claim denial rates for brain computerized tomography. Alongside growth in utilization of brain computerize ... Full text Open Access Link to item Cite

Clinical and imaging predictors of the natural course of bland portal vein thrombus in cirrhotic patients.

Journal Article Abdom Radiol (NY) · November 2022 BACKGROUND: Portal vein thrombus (PVT) in cirrhotic patients is associated with worsening portal hypertension, leads to increased complexity of necessary interventions such as transjugular liver portosystemic shunt or liver transplantation, and is associat ... Full text Link to item Cite

Trends in risk factors for readmission after bariatric surgery 2015-2018.

Journal Article Surg Obes Relat Dis · May 2022 BACKGROUND: Readmission after bariatric surgery is multifactorial. Understanding the trends in risk factors for readmission provides opportunity to optimize patients prior to surgery identify disparities in care, and improve outcomes. OBJECTIVES: This stud ... Full text Link to item Cite

CT Radiomic Features of Superior Mesenteric Artery Involvement in Pancreatic Ductal Adenocarcinoma: A Pilot Study.

Journal Article Radiology · December 2021 Background Current imaging methods for prediction of complete margin resection (R0) in patients with pancreatic ductal adenocarcinoma (PDAC) are not reliable. Purpose To investigate whether tumor-related and perivascular CT radiomic features improve preope ... Full text Open Access Link to item Cite

Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.

Journal Article Am J Emerg Med · August 2021 OBJECTIVE: High-sensitivity cardiac troponin assays (hs-cTn) aid in diagnosis of myocardial infarction (MI). These assays have lower specificity for non-ST Elevation MI (NSTEMI) in patients with renal disease. Our objective was to determine an optimized cu ... Full text Link to item Cite

Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.

Journal Article Am J Transplant · June 2021 We undertook a prospective, matched cohort study of patients with Staphylococcus aureus bacteremia (SAB) and gram-negative bacteremia (GNB) to compare the characteristics, outcomes, and chemokine and cytokine response in transplant recipients to immunocomp ... Full text Open Access Link to item Cite

Automated Structured Reporting for Thyroid Ultrasound: Effect on Reporting Errors and Efficiency.

Journal Article J Am Coll Radiol · February 2021 PURPOSE: To compare the effectiveness of different reporting templates using the ACR Thyroid Imaging Reporting and Data System (TI-RADS) for thyroid ultrasound. METHODS: In this retrospective study, four radiologists implemented ACR TI-RADS while dictating ... Full text Open Access Link to item Cite

Exploring Factors Associated With Morbidity and Mortality in Patients With Do-Not-Resuscitate Orders: A National Surgical Quality Improvement Program Database Analysis Within Surgical Groups.

Journal Article Anesth Analg · February 1, 2021 BACKGROUND: Anesthesiologists caring for patients with do-not-resuscitate (DNR) orders may have ethical concerns because of their resuscitative wishes and may have clinical concerns because of their known increased risk of morbidity/mortality. Patient hete ... Full text Link to item Cite

Racial Disparities in Bariatric Surgery Complications and Mortality Using the MBSAQIP Data Registry.

Journal Article Obes Surg · August 2020 BACKGROUND: Racial disparities in postoperative complications have been demonstrated in bariatric surgery, yet the relationship of race to complication severity is unknown. STUDY DESIGN: Adult laparoscopic primary bariatric procedures were queried from the ... Full text Link to item Cite

Determining changes in bone metabolism after bariatric surgery in postmenopausal women.

Journal Article Surg Endosc · April 2020 BACKGROUND: Accelerated bone loss is a known complication after bariatric surgery. Bone mineral density has been shown to decrease significantly after Laparoscopic Roux-en-Y gastric bypass (RYGB). Laparoscopic sleeve gastrectomy (SG) effects on bone densit ... Full text Link to item Cite

Correlation of preoperative imaging characteristics with donor outcomes and operative difficulty in laparoscopic donor nephrectomy.

Journal Article Am J Transplant · March 2020 This study aimed to understand the relationship of preoperative measurements and risk factors on operative time and outcomes of laparoscopic donor nephrectomy. Two hundred forty-two kidney donors between 2010 and 2017 were identified. Patients' demographic ... Full text Open Access Link to item Cite

The LI-RADS Version 2018 MRI Treatment Response Algorithm: Evaluation of Ablated Hepatocellular Carcinoma.

Journal Article Radiology · February 2020 Background The Liver Imaging Reporting and Data System (LI-RADS) treatment response algorithm (TRA) is used to assess presumed hepatocellular carcinoma (HCC) after local-regional therapy, but its performance has not been extensively assessed. Purpose To as ... Full text Open Access Link to item Cite

Current trends and 30-day surgical outcomes for thyroglossal duct cyst excision in children.

Journal Article Int J Pediatr Otorhinolaryngol · January 2020 OBJECTIVE: Identify current trends, adverse events, and clinical predictors in children treated with thyroglossal duct cyst surgery. METHODS: Cross-sectional analysis using American College of Surgeons (ACS) National Surgical Quality Improvement Program® ( ... Full text Link to item Cite

Cross-sectional CT Assessment of the Extent of Injectate Spread at CT Fluoroscopy-guided Cervical Epidural Interlaminar Steroid Injections.

Journal Article Radiology · September 2019 Background Previous studies analyzed contrast agent spread during cervical interlaminar epidural steroid injections (CILESIs) by using planar fluoroscopy and reported wide variance of the rate of spread to the ventral epidural space (VES). Cross-sectional ... Full text Open Access Link to item Cite

Objective Assessment of the Early Stages of the Learning Curve for the Senhance Surgical Robotic System.

Journal Article J Surg Educ · 2019 OBJECTIVE: The purpose of this research is to study the early stages of the Senhance learning curve to report how force feedback impacts learning rate. This serves as an exploratory investigation into assumptions that fellows and faculty will adjust faster ... Full text Link to item Cite

A Bayesian Framework for the Classification of Microbial Gene Activity States.

Journal Article Frontiers in microbiology · January 2016 Numerous methods for classifying gene activity states based on gene expression data have been proposed for use in downstream applications, such as incorporating transcriptomics data into metabolic models in order to improve resulting flux predictions. Thes ... Full text Cite