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Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.

Publication ,  Journal Article
Eichenberger, EM; Ruffin, F; Dagher, M; Lerebours, R; Jung, S-H; Sharma-Kuinkel, B; Macintyre, AN; Thaden, JT; Sinclair, M; Hale, L; Kohler, C ...
Published in: Am J Transplant
June 2021

We undertook a prospective, matched cohort study of patients with Staphylococcus aureus bacteremia (SAB) and gram-negative bacteremia (GNB) to compare the characteristics, outcomes, and chemokine and cytokine response in transplant recipients to immunocompetent, nontransplant recipients. Fifty-five transplant recipients (GNB n = 29; SAB n = 26) and 225 nontransplant recipients (GNB n = 114; SAB n = 111) were included for clinical analysis. Transplant GNB had a significantly lower incidence of septic shock than nontransplant GNB (10.3% vs 30.7%, p = .03). Thirty-day mortality did not differ significantly between transplant and nontransplant recipients with GNB (10.3% vs 15.8%, p = .57) or SAB (0.0% vs 11.7%, p = .13). Next, transplant patients were matched 1:1 with nontransplant patients for the chemokine and cytokine analysis. Five cytokines and chemokines were significantly lower in transplant GNB vs nontransplant GNB: IL-2 (median [IQR]: 7.1 pg/ml [7.1, 7.1] vs 32.6 pg/ml [7.1, 88.0]; p = .001), MIP-1β (30.7 pg/ml [30.7, 30.7] vs 243.3 pg/ml [30.7, 344.4]; p = .001), IL-8 (32.0 pg/ml [5.6, 53.1] vs 59.1 pg/ml [39.2, 119.4]; p = .003), IL-15 (12.0 pg/ml [12.0, 12.0] vs 12.0 pg/ml [12.0, 126.7]; p = .03), and IFN-α (5.1 pg/mL [5.1, 5.1] vs 5.1 pg/ml [5.1, 26.3]; p = .04). Regulated upon Activation, Normal T Cell Expressed and Secreted (RANTES) was higher in transplant SAB vs nontransplant SAB (mean [SD]: 750.2 pg/ml [194.6] vs 656.5 pg/ml [147.6]; p = .046).

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

June 2021

Volume

21

Issue

6

Start / End Page

2113 / 2122

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Surgery
  • Prospective Studies
  • Organ Transplantation
  • Humans
  • Cytokines
  • Cohort Studies
  • Bacteremia
  • 3204 Immunology
  • 3202 Clinical sciences
 

Citation

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ICMJE
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Eichenberger, E. M., Ruffin, F., Dagher, M., Lerebours, R., Jung, S.-H., Sharma-Kuinkel, B., … Maskarinec, S. A. (2021). Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study. Am J Transplant, 21(6), 2113–2122. https://doi.org/10.1111/ajt.16388
Eichenberger, Emily M., Felicia Ruffin, Michael Dagher, Reginald Lerebours, Sin-Ho Jung, Batu Sharma-Kuinkel, Andrew N. Macintyre, et al. “Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.Am J Transplant 21, no. 6 (June 2021): 2113–22. https://doi.org/10.1111/ajt.16388.
Eichenberger EM, Ruffin F, Dagher M, Lerebours R, Jung S-H, Sharma-Kuinkel B, et al. Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study. Am J Transplant. 2021 Jun;21(6):2113–22.
Eichenberger, Emily M., et al. “Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.Am J Transplant, vol. 21, no. 6, June 2021, pp. 2113–22. Pubmed, doi:10.1111/ajt.16388.
Eichenberger EM, Ruffin F, Dagher M, Lerebours R, Jung S-H, Sharma-Kuinkel B, Macintyre AN, Thaden JT, Sinclair M, Hale L, Kohler C, Palmer SM, Alexander BD, Fowler VG, Maskarinec SA. Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study. Am J Transplant. 2021 Jun;21(6):2113–2122.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

June 2021

Volume

21

Issue

6

Start / End Page

2113 / 2122

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Surgery
  • Prospective Studies
  • Organ Transplantation
  • Humans
  • Cytokines
  • Cohort Studies
  • Bacteremia
  • 3204 Immunology
  • 3202 Clinical sciences