Scholars@Duke
Reid C Chamberlain

Reid C Chamberlain

Assistant Professor of Pediatrics
Pediatrics, Cardiology

Selected Publications

Urine biomarkers, acute kidney injury, and fluid overload in neonatal cardiac surgery.

Conference Cardiol Young · February 6, 2025 BACKGROUND: Cardiac surgery-associated acute kidney injury (CS-AKI) and fluid overload (FO) are common among neonates who undergo cardiopulmonary bypass, and increase mortality risk. Current diagnostic criteria may delay diagnosis. Thus, there is a need to ... Full text Link to item Cite

Additive value of invasive haemodynamic assessment for predicting post-operative outcomes after Fontan.

Journal Article Cardiol Young · October 2024 Routine pre-Fontan cardiac catheterization remains standard practice at most centres. However, with advances in non-invasive risk assessment, an invasive haemodynamic assessment may not be necessary for all patients.Using retrospective data from patients u ... Full text Link to item Cite

Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure.

Journal Article Cardiovascular engineering and technology · August 2024 PurposrThis study created 3D CFD models of the Norwood procedure for hypoplastic left heart syndrome (HLHS) using standard angiography and echocardiogram data to investigate the impact of shunt characteristics on pulmonary artery (PA) hemodynamics ... Full text Cite

Population Pharmacokinetics of Caffeine in Neonates with Congenital Heart Disease and Associations with Acute Kidney Injury.

Journal Article J Clin Pharmacol · March 2024 Cardiac surgery-associated acute kidney injury (CS-AKI) occurs in approximately 65% of neonates undergoing cardiac surgery on cardiopulmonary bypass and contributes to morbidity and mortality. Caffeine may reduce CS-AKI by counteracting adenosine receptor ... Full text Link to item Cite

Hybrid approach to pulmonary vein stenting after Fontan palliation.

Journal Article Catheter Cardiovasc Interv · November 2023 Pulmonary vein stenosis is poorly tolerated in patients who have undergone Fontan palliation and typically requires surgical or transcatheter intervention. Percutaneous transcatheter approaches to intervention can be technically difficult due to challengin ... Full text Link to item Cite

Update on Transcatheter Device Closure of Congenital Septal Defects.

Journal Article Curr Cardiol Rep · September 2023 PURPOSE OF REVIEW: The goal of this paper is to review currently available devices for closure of atrial septal defects (ASDs) and ventricular septal defects (VSDs). RECENT FINDINGS: Favorable results from the ASSURED trial resulted in FDA approval for the ... Full text Link to item Cite

Association of Urine Biomarkers With Acute Kidney Injury and Fluid Overload in Infants After Cardiac Surgery: A Single Center Ancillary Cohort of the Steroids to Reduce Systemic Inflammation After Infant Heart Surgery Trial.

Journal Article Crit Care Explor · May 2023 UNLABELLED: To examine the association between three perioperative urine biomarker concentrations (urine cystatin C [uCysC], urine neutrophil gelatinase-associated lipocalin [uNGAL], and urine kidney injury molecule 1 [uKIM-1]), and cardiac surgery-associa ... Full text Link to item Cite

Whole-Chest Three-Dimensional Modeling Aids Hybrid Pulmonary Valve Replacement Following Double Switch Operation.

Journal Article World J Pediatr Congenit Heart Surg · January 2023 The double switch operation for congenitally corrected transposition of the great arteries (CC-TGA) has been associated with high rates of reintervention, including the need for pulmonary valve replacement. Hybrid interventional approaches can avoid bypass ... Full text Link to item Cite

Postoperative Renal Failure, Shunt Type, and Mortality After Norwood Palliation.

Journal Article Ann Thorac Surg · June 2022 BACKGROUND: The Single Ventricle Reconstruction Trial demonstrated increased risk of death or heart transplant 1 year after Norwood among subjects randomly assigned to modified Blalock-Taussig shunts compared with right ventricle to pulmonary artery (RV-PA ... Full text Link to item Cite

Characterization of hemodynamics in anomalous aortic origin of coronary arteries using patient-specific modeling.

Journal Article J Biomech · February 2022 The anomalous aortic origin of coronary arteries (AAOCA) is a congenital disease that can lead to sudden cardiac death (SCD) during strenuous physical activity. Despite AAOCA being the second leading cause of SCD among young athletes, the mechanism behind ... Full text Link to item Cite

Electrocardiogram Before Tricyclic Antidepressant Use: Minimal Impact in Pediatric Functional Gastrointestinal Disorders.

Journal Article J Pediatr Gastroenterol Nutr · October 1, 2021 OBJECTIVES: The aim of this study was to determine the effect of electrocardiogram (ECG) findings on the initiation of tricyclic antidepressants (TCAs) for functional gastrointestinal disorders (FGIDs) and to evaluate cardiac outcomes related to low dose T ... Full text Link to item Cite

Transition to Ductal Stenting for Single Ventricle Patients Led to Improved Survival: An Institutional Case Series.

Journal Article World J Pediatr Congenit Heart Surg · July 2021 BACKGROUND: The use of systemic-to-pulmonary shunts (SPS) in neonates with single ventricle heart defects and ductal-dependent pulmonary blood flow (ddPBF) was historically associated with high morbidity and mortality at our center. As a result, we transit ... Full text Link to item Cite

A systematic review of the evidence supporting post-operative diuretic use following cardiopulmonary bypass in children with Congenital Heart Disease.

Journal Article Cardiol Young · May 2021 BACKGROUND: Paediatric cardiac surgery on cardiopulmonary bypass induces substantial physiologic changes that contribute to post-operative morbidity and mortality. Fluid overload and oedema are prevalent complications, routinely treated with diuretics. The ... Full text Link to item Cite

Outcomes of Operator-Directed Sedation and Anesthesiologist Care in the Pediatric/Congenital Catheterization Laboratory: A Study Utilizing Data From the IMPACT Registry.

Journal Article JACC Cardiovasc Interv · February 22, 2021 OBJECTIVES: The objective of this study was to assess contemporary use of operator directed sedation (ODS) and anesthesiologist care (AC) in the pediatric/congenital cardiac catheterization laboratory (PCCL), specifically evaluating whether the use of oper ... Full text Link to item Cite

An evidence-based review of the use of vasoactive and inotropic medications in post-operative paediatric patients after cardiac surgery with cardiopulmonary bypass from 2000 to 2020.

Journal Article Cardiol Young · December 2020 BACKGROUND: Infants with moderate-to-severe CHD frequently undergo cardiopulmonary bypass surgery in childhood. Morbidity and mortality are highest in those who develop post-operative low cardiac output syndrome. Vasoactive and inotropic medications are ma ... Full text Link to item Cite

Mustard Baffle Revision With Systemic Ventricular Assist Device Placement.

Journal Article Ann Thorac Surg · October 2020 Systemic right ventricle failure often develops in patients with dextro-transposition of the great arteries who have undergone atrial-level switch procedures. An adult with dextro-transposition of the great arteries with Mustard repair in childhood present ... Full text Link to item Cite

Palliating Premature Infants With Obstructed Total Anomalous Pulmonary Venous Connection via Catheterization.

Journal Article World J Pediatr Congenit Heart Surg · July 2020 Obstructed total anomalous pulmonary venous connection (TAPVC) involves anomalous drainage of all pulmonary veins to a location other than the left atrium and typically causes significant respiratory symptoms requiring urgent surgical repair. Premature inf ... Full text Link to item Cite

Preprocedural three-dimensional planning aids in transcatheter ductal stent placement: A single-center experience.

Journal Article Catheter Cardiovasc Interv · May 1, 2020 OBJECTIVES: Describe the use of three-dimensional (3D) patent ductus arteriosus (PDA) modeling to better define ductal anatomy to improve preprocedural planning for ductal stent placement. BACKGROUND: Ductal stenting is an alternative to surgical shunting ... Full text Link to item Cite

Rationale and design of the STeroids to REduce Systemic inflammation after infant heart Surgery (STRESS) trial.

Journal Article Am Heart J · February 2020 For decades, physicians have administered corticosteroids in the perioperative period to infants undergoing heart surgery with cardiopulmonary bypass (CPB) to reduce the postoperative systemic inflammatory response to CPB. Some question this practice becau ... Full text Link to item Cite

Estimating radiation exposure during paediatric cardiac catheterisation: a potential for radiation reduction with air gap technique.

Journal Article Cardiol Young · December 2019 INTRODUCTION: The air gap technique (AGT) is an approach to radiation dose optimisation during fluoroscopy where an "air gap" is used in place of an anti-scatter grid to reduce scatter irradiation. The AGT is effective in adults but remains largely unteste ... Full text Link to item Cite

Postoperative Transcatheter Interventions in Children Undergoing Congenital Heart Surgery.

Journal Article Circ Cardiovasc Interv · June 2019 Background Postoperative transcatheter interventions (TCIs) are performed after congenital heart surgery to treat residual or recurrent anatomic lesions. We used the Society of Thoracic Surgeons Congenital Heart Surgery Database to evaluate rates of postop ... Full text Link to item Cite

The Use of Echocardiography for Pediatric Patients Presenting with Syncope.

Journal Article J Pediatr · November 2017 OBJECTIVES: To assess the frequency, yield, and cost of echocardiograms meeting "rarely appropriate" criteria. STUDY DESIGN: Retrospective, single-center study of pediatric patients presenting with syncope. Patients were categorized according to the approp ... Full text Link to item Cite

Evaluating Appropriate Use of Pediatric Echocardiograms for Chest Pain in Outpatient Clinics.

Journal Article J Am Soc Echocardiogr · July 2017 BACKGROUND: Echocardiography is often used in the evaluation of pediatric chest pain, but the incidence of cardiac pathology is low. In 2014, the American College of Cardiology published appropriate use criteria (AUC) for echocardiography including recomme ... Full text Link to item Cite

Novel Rod Domain Duplication in Dystrophin Resulting in X-Linked Dilated Cardiomyopathy.

Journal Article Pediatr Neurol · November 2015 BACKGROUND: X-linked dilated cardiomyopathy is a rare, cardio-specific form of dystrophinopathy allelic to Duchenne and Becker muscular dystrophy that results in heart failure without skeletal muscle weakness. PATIENT DESCRIPTION: We describe a previously ... Full text Link to item Cite

Got Bio? A short course introducing students to the applications of biochemistry

Journal Article Journal of Chemical Education · January 1, 2008 Full text Cite