Scholars@Duke
William James Richardson

William James Richardson

Professor of Orthopaedic Surgery
Orthopaedic Surgery
richa015@mc.duke.edu
Box 3077 Med Ctr, Durham, NC 27710
5340 Duke South, Orange Zone, Durham, NC 27710
Office hours 7:30am-4:00pm  

Selected Publications

Gene Therapy and Spinal Fusion: Systematic Review and Meta-Analysis of the Available Data.

Journal Article World Neurosurg · June 2024 OBJECTIVE: To analyze the extant literature describing the application of gene therapy to spinal fusion. METHODS: A systematic review of the English-language literature was performed. The search query was designed to include all published studies examining ... Full text Open Access Link to item Cite

Osteoimmunology: Interactions With the Immune System in Spinal Fusion.

Journal Article Int J Spine Surg · December 27, 2023 Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the o ... Full text Open Access Link to item Cite

Ropivacaine-Epinephrine-Clonidine-Ketorolac Cocktail as a Local Anesthetic for Lumbar Decompression Surgery: A Single Institutional Experience.

Journal Article World Neurosurg · August 2023 OBJECTIVE: The goal of this study is to discuss our initial experience with a multimodal opioid-sparing cocktail containing ropivacaine, epinephrine, clonidine, and ketorolac (RECK) in the postoperative management of lumbar decompression surgeries. METHODS ... Full text Open Access Link to item Cite

In Silico Re-Optimization of Atezolizumab Dosing Using Population Pharmacokinetic Simulation and Exposure-Response Simulation.

Journal Article J Clin Pharmacol · June 2023 Atezolizumab, a humanized monoclonal antibody against programmed cell death ligand 1 (PD-L1), was initially approved in 2016, around the same time that the sponsor published the minimum serum concentration to maintain the saturation of receptor occupancy ( ... Full text Open Access Link to item Cite

Determination of metarrestin (ML-246) in human plasma for a first-in-human clinical pharmacokinetic application by a simple and efficient uHPLC-MS/MS assay.

Journal Article J Chromatogr B Analyt Technol Biomed Life Sci · May 30, 2023 Metarrestin is a first-in-class small molecule inhibitor targeting the perinucleolar compartment, a subnuclear body associated with metastatic capacity. Promising preclinical results led to the clinical translation of the compound into a first-in-human pha ... Full text Open Access Link to item Cite

Quantitation of the next-generation imipridone ONC206 in human plasma by a simple and sensitive UPLC-MS/MS assay for clinical pharmacokinetic application.

Journal Article J Pharm Biomed Anal · May 10, 2022 ONC206 is an imipridone derivative that is being developed clinically as a single agent given orally in a first-in-human trial (NCT04541082). This ongoing clinical trial requires pharmacokinetic analysis of ONC206 to fully characterize its pharmacologic pr ... Full text Open Access Link to item Cite

Invasive Staphylococcus aureus Infection among Patients Undergoing Elective, Posterior, Instrumented Spinal Fusion Surgeries: A Retrospective Cohort Study.

Journal Article Surg Infect (Larchmt) · February 2022 Background: Post-surgical invasive Staphylococcus aureus infections among spinal fusion patients are serious complications that can worsen clinical outcomes and increase healthcare utilization. Risk of such infections at the population level remains unknow ... Full text Link to item Cite

Pharmacokinetics and tolerability of the dual TORC1/2 inhibitor sapanisertib in combination with the MEK inhibitor trametinib in dogs.

Journal Article Front Vet Sci · 2022 Activation of one or both the Ras/MAPK and PI3K/Akt/mTOR signal transduction pathways are known to mediate oncogenicity of several canine and human cancers, including mucosal melanomas. Reciprocal cross activation between the two pathways can be a source o ... Full text Open Access Link to item Cite

Systematic review of diagnostic accuracy of patient history, clinical findings, and physical tests in the diagnosis of lumbar spinal stenosis.

Journal Article Eur Spine J · January 2020 PURPOSE: To update evidence of diagnostic potential for identification of lumbar spinal stenosis (LSS) based on demographic and patient history, clinical findings, and physical tests, and report posttest probabilities associated with test findings. METHODS ... Full text Open Access Link to item Cite

Patient Dose Comparison for Intraoperative Imaging Devices Used in Orthopaedic Lumbar Spinal Surgery.

Journal Article J Am Acad Orthop Surg Glob Res Rev · July 2018 BACKGROUND: The aim of this study was to determine the amount of radiation exposure from intraoperative imaging during two-level and four-level lumbar fusions. METHODS: Five imaging systems were studied: multidetector CT (MDCT) scanner (CT A); two mobile C ... Full text Open Access Link to item Cite

Hip Fracture in the Elderly Patients: A Sentinel Event.

Journal Article Am J Hosp Palliat Care · April 2018 IMPORTANCE: Hip fracture in the elderly patients is associated with increased morbidity and mortality. There is great need for advance care planning should a patient fail to rehabilitate or experience an adverse event during or after recovery. This study w ... Full text Open Access Link to item Cite

Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration.

Journal Article J Orthop Res · August 2016 Previous study claimed that disc degeneration may be preceded by structure and matrix changes in the intervertebral disc (IVD) which coincide with the loss of distinct notochordally derived nucleus pulposus (NP) cells. However, the fate of notochordal cell ... Full text Open Access Link to item Cite

Surgical Team Stability and Risk of Sharps-Related Blood and Body Fluid Exposures During Surgical Procedures.

Journal Article Infect Control Hosp Epidemiol · May 2016 OBJECTIVE: To explore whether surgical teams with greater stability among their members (ie, members have worked together more in the past) experience lower rates of sharps-related percutaneous blood and body fluid exposures (BBFE) during surgical procedur ... Full text Open Access Link to item Cite

Surgical Procedure Characteristics and Risk of Sharps-Related Blood and Body Fluid Exposure.

Journal Article Infect Control Hosp Epidemiol · January 2016 OBJECTIVE To use a unique multicomponent administrative data set assembled at a large academic teaching hospital to examine the risk of percutaneous blood and body fluid (BBF) exposures occurring in operating rooms. DESIGN A 10-year retrospective cohort de ... Full text Open Access Link to item Cite

Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells

Journal Article · January 1, 2011 Interleukin-17 (IL-17) is a cytokine recently shown to be elevated, along with interferon-γ (IFNγ) and tumor necrosis factor (TNFα), in degenerated and herniated intervertebral disc (IVD) tissues, suggesting a role for these cytokines in intervertebral dis ... Full text Open Access Cite

New directions and therapeutics in surgical spine treatment

Chapter · January 1, 2004 Spine therapeutics and surgery for spine diseases have undergone long development periods - spine surgeries, particularly laminectomies, have been performed for over a century. Hypotheses concerning spine diseases are now undergoing radical revamping based ... Cite

Diaphyseal lengthening for shortness of the toe.

Journal Article Foot Ankle · 1985 A method of bone lengthening for bilateral shortness of the fourth toe in a 23-year-old woman is described. The symptomatic short fourth toes were successfully treated by metatarsal and phalangeal diaphyseal lengthenings with metatarsophalangeal joint pres ... Full text Link to item Cite