Scholars@Duke
Richard Barfield

Richard Barfield

Biostatistician, Senior
Biostatistics & Bioinformatics
richard.barfield@duke.edu
Duke Box 2721, Durham, NC 27710
2424 Erwin Road Suite 1106, 11028A Hock Plaza, Durham, NC 27705

Selected Publications

Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV.

Journal Article JCI Insight · March 22, 2023 Rhesus cytomegalovirus-based (RhCMV-based) vaccine vectors induce immune responses that protect ~60% of rhesus macaques (RMs) from SIVmac239 challenge. This efficacy depends on induction of effector memory-based (EM-biased) CD8+ T cells recognizing SIV pep ... Full text Link to item Cite

Association between germline variants and somatic mutations in colorectal cancer.

Journal Article Scientific reports · June 2022 Colorectal cancer (CRC) is a heterogeneous disease with evidence of distinct tumor types that develop through different somatically altered pathways. To better understand the impact of the host genome on somatically mutated genes and pathways, we assessed ... Full text Cite

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.

Journal Article Sci Rep · July 14, 2021 A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely mutate ... Full text Link to item Cite