Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 2009
• Research
• 

  Selected Grants

  • Funcional characterization of early Chlamydia effectors awarded by National Institutes of Health 2018 - 2023
  • Structure-Function Analysis of Chlamydia Secretion Chaperones awarded by National Institutes of Health 2016 - 2021
  • Posttranslational modifications of host proteins by Chlamydia effectors awarded by National Institutes of Health 2018 - 2020
  • Interferon-driven ubiquitin response targets Chlamydia inclusions in human cells awarded by National Institutes of Health 2017 - 2019
  • Forward and Reverse Genetics in Chlamydia awarded by National Institutes of Health 2012 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Sherry, J, Elwell, C, Bastidas, R, Weber, M, Hackstadt, T, Valdivia, RH, and Engel, JN. "Chlamydia trachomatis inclusion membrane protein CT192 interacts with dynactin to modulate centrosome positioning and parasitophorous vacuole fusion events." 2016.  Link to Item
    • Koehler, J, Chowdhury, T, Jani, N, Van Werven, F, Bastidas, R, and Heitman, J. "Candida albicans yeast but not hyphae require pescadillo to respond to TOR." September 2013.  Link to Item

  • Journal Articles

    • Mojica, SA, Salin, O, Bastidas, RJ, Sunduru, N, Hedenström, M, Andersson, CD, Núñez-Otero, C, Engström, P, Valdivia, RH, Elofsson, M, and Gylfe, Å. "N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF." Antimicrobial Agents and Chemotherapy 61, no. 10 (October 2017).  Full Text
    • Sixt, BS, Bastidas, RJ, Finethy, R, Baxter, RM, Carpenter, VK, Kroemer, G, Coers, J, and Valdivia, RH. "The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs." Cell Host & Microbe 21, no. 1 (January 2017): 113-121.  Full Text
    • Bastidas, RJ, and Valdivia, RH. "Emancipating Chlamydia: Advances in the Genetic Manipulation of a Recalcitrant Intracellular Pathogen." Microbiology and Molecular Biology Reviews : Mmbr 80, no. 2 (June 2016): 411-427. (Review)  Full Text
    • Kokes, M, Dunn, JD, Granek, JA, Nguyen, BD, Barker, JR, Valdivia, RH, and Bastidas, RJ. "Integrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia." Cell Host and Microbe 17, no. 5 (May 13, 2015): 716-725.  Full Text
    • Kokes, M, Dunn, JD, Granek, JA, Nguyen, BD, Barker, JR, Valdivia, RH, and Bastidas, RJ. "Integrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia." Cell host & microbe 17, no. 5 (May 2015): 716-725.  Full Text
    • Larson, CL, Beare, PA, Voth, DE, Howe, D, Cockrell, DC, Bastidas, RJ, Valdivia, RH, and Heinzen, RA. "Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication." Infection and Immunity 83, no. 2 (February 2015): 661-670.  Full Text
    • Marsh, JW, Wee, BA, Tyndall, JDA, Lott, WB, Bastidas, RJ, Caldwell, HD, Valdivia, RH, Kari, L, and Huston, WM. "A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production." BMC microbiology 15 (January 2015): 194-.  Full Text
    • Engström, P, Krishnan, KS, Ngyuen, BD, Chorell, E, Normark, J, Silver, J, Bastidas, RJ, Welch, MD, Hultgren, SJ, Wolf-Watz, H, Valdivia, RH, Almqvist, F, and Bergström, S. "A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis." Mbio 6, no. 1 (December 30, 2015): e02304-e02314.  Full Text
    • Calo, S, Shertz-Wall, C, Lee, SC, Bastidas, RJ, Nicolás, FE, Granek, JA, Mieczkowski, P, Torres-Martínez, S, Ruiz-Vázquez, RM, Cardenas, ME, and Heitman, J. "Antifungal drug resistance evoked via RNAi-dependent epimutations." Nature 513, no. 7519 (September 2014): 555-558.  Full Text
    • Snavely, EA, Kokes, M, Dunn, JD, Saka, HA, Nguyen, BD, Bastidas, RJ, McCafferty, DG, and Valdivia, RH. "Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches." Pathogens and Disease 71, no. 3 (August 2014): 336-351.  Full Text
    • Chen, Y-S, Bastidas, RJ, Saka, HA, Carpenter, VK, Richards, KL, Plano, GV, and Valdivia, RH. "The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling." PLoS pathogens 10, no. 2 (February 20, 2014): e1003954-.  Full Text
    • Saka, HA, Baxter, R, Bastidas, RJ, Panzetta, ME, and Valdivia, RH. "IDENTIFICATION OF Chlamydia trachomatis MUTANTS DEFECTIVE FOR PERSISTENCE." BIOCELL 38 (2014): 132-132.  Link to Item
    • Engström, P, Nguyen, BD, Normark, J, Nilsson, I, Bastidas, RJ, Gylfe, A, Elofsson, M, Fields, KA, Valdivia, RH, Wolf-Watz, H, and Bergström, S. "Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity." Journal of Bacteriology 195, no. 18 (September 2013): 4221-4230.  Full Text
    • Bastidas, RJ, Elwell, CA, Engel, JN, and Valdivia, RH. "Chlamydial intracellular survival strategies." Cold Spring Harbor Perspectives in Medicine 3, no. 5 (May 2013): a010256-null. (Review)  Full Text
    • Bastidas, RJ, Elwell, CA, Engel, JN, and Valdivia, RH. "Chlamydial intracellular survival strategies." Cold Spring Harbor perspectives in medicine 3, no. 5 (May 1, 2013). (Review)  Full Text
    • Bastidas, RJ, Shertz, CA, Lee, SC, Heitman, J, and Cardenas, ME. "Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor." Eukaryotic Cell 11, no. 3 (March 2012): 270-281.  Full Text
    • Shertz, CA, Bastidas, RJ, Li, W, Heitman, J, and Cardenas, ME. "Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom." Bmc Genomics 11 (September 23, 2010): 510-null.  Full Text  Open Access Copy
    • Bastidas, RJ, and Cardenas, ME. "TORC1 signaling in the budding yeast endomembrane system and control of cell-cell adhesion in pathogenic fungi." Enzymes 27, no. C (2010): 199-227.  Full Text
    • Bastidas, RJ, and Heitman, J. "Trimorphic stepping stones pave the way to fungal virulence." Proceedings of the National Academy of Sciences of the United States of America 106, no. 2 (January 7, 2009): 351-352. (Review)  Full Text
    • Bastidas, RJ, Heitman, J, and Cardenas, ME. "The protein kinase Tor1 regulates adhesin gene expression in Candida albicans." PLoS Pathogens 5, no. 2 (2009).  Full Text
    • Bastidas, RJ, Reedy, JL, Morales-Johansson, H, Heitman, J, and Cardenas, ME. "Signaling cascades as drug targets in model and pathogenic fungi." Current Opinion in Investigational Drugs (London, England : 2000) 9, no. 8 (August 2008): 856-864. (Review)
    • Rohde, JR, Bastidas, R, Puria, R, and Cardenas, ME. "Nutritional control via Tor signaling in Saccharomyces cerevisiae." Current Opinion in Microbiology 11, no. 2 (April 8, 2008): 153-160. (Review)  Full Text
    • Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, and York, JD. "A conserved family of enzymes that phosphorylate inositol hexakisphosphate." Science (New York, N.Y.) 316, no. 5821 (April 2007): 106-109.  Full Text
    • Reedy, JL, Bastidas, RJ, and Heitman, J. "The Virulence of Human Pathogenic Fungi: Notes from the South of France." Cell Host and Microbe 2, no. 2 (2007): 77-83.  Full Text
    • Stevenson-Paulik, J, Bastidas, RJ, Chiou, S-T, Frye, RA, and York, JD. "Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases." Proceedings of the National Academy of Sciences of the United States of America 102, no. 35 (August 17, 2005): 12612-12617.  Full Text
    • Seeds, AM, Bastidas, RJ, and York, JD. "Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae." The Journal of Biological Chemistry 280, no. 30 (July 2005): 27654-27661.  Full Text

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