Robert J Bastidas
Assistant Research Professor in Molecular Genetics and Microbiology
Current Appointments & Affiliations
- Assistant Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2016
Contact Information
- 207 Research Drive, 272 Jones Bldg, Durham, NC 27710
- Box 3853 Med Ctr, Durham, NC 27710
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robert.bastidas@duke.edu
(919) 668-2450
- Background
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Education, Training, & Certifications
- Ph.D., Duke University 2009
- Recognition
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In the News
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NOV 7, 2018
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- Research
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Selected Grants
- Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis awarded by National Institutes of Health 2019 - 2024
- Funcional characterization of early Chlamydia effectors awarded by National Institutes of Health 2018 - 2023
- Posttranslational modifications of host proteins by Chlamydia effectors awarded by National Institutes of Health 2018 - 2021
- Interferon-driven ubiquitin response targets Chlamydia inclusions in human cells awarded by National Institutes of Health 2017 - 2019
- Forward and Reverse Genetics in Chlamydia awarded by National Institutes of Health 2012 - 2017
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Panzetta, María E., Agustín L. Luján, Robert J. Bastidas, María T. Damiani, Raphael H. Valdivia, and Héctor A. Saka. “Ptr/CTL0175 Is Required for the Efficient Recovery of Chlamydia trachomatis From Stress Induced by Gamma-Interferon.” Front Microbiol 10 (2019): 756. https://doi.org/10.3389/fmicb.2019.00756.Full Text Link to Item
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Valdivia, Raphael H., and Robert J. Bastidas. “The Expanding Molecular Genetics Tool Kit in Chlamydia.” J Bacteriol 200, no. 24 (December 15, 2018). https://doi.org/10.1128/JB.00590-18.Full Text Link to Item
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Pruneda, Jonathan N., Robert J. Bastidas, Erithelgi Bertsoulaki, Kirby N. Swatek, Balaji Santhanam, Michael J. Clague, Raphael H. Valdivia, Sylvie Urbé, and David Komander. “A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.” Nat Microbiol 3, no. 12 (December 2018): 1377–84. https://doi.org/10.1038/s41564-018-0271-y.Full Text Link to Item
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Mojica, Sergio A., Olli Salin, Robert J. Bastidas, Naresh Sunduru, Mattias Hedenström, C David Andersson, Carlos Núñez-Otero, et al. “N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF.” Antimicrob Agents Chemother 61, no. 10 (October 2017). https://doi.org/10.1128/AAC.00716-17.Full Text Link to Item
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Sixt, Barbara S., Robert J. Bastidas, Ryan Finethy, Ryan M. Baxter, Victoria K. Carpenter, Guido Kroemer, Jörn Coers, and Raphael H. Valdivia. “The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs.” Cell Host Microbe 21, no. 1 (January 11, 2017): 113–21. https://doi.org/10.1016/j.chom.2016.12.002.Full Text Link to Item
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Bastidas, Robert J., and Raphael H. Valdivia. “Emancipating Chlamydia: Advances in the Genetic Manipulation of a Recalcitrant Intracellular Pathogen.” Microbiol Mol Biol Rev 80, no. 2 (June 2016): 411–27. https://doi.org/10.1128/MMBR.00071-15.Full Text Link to Item
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Marsh, James W., Bryan A. Wee, Joel D. A. Tyndall, William B. Lott, Robert J. Bastidas, Harlan D. Caldwell, Raphael H. Valdivia, L. Kari, and Wilhelmina M. Huston. “A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.” Bmc Microbiol 15 (September 30, 2015): 194. https://doi.org/10.1186/s12866-015-0533-2.Full Text Link to Item
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Kokes, Marcela, Joe Dan Dunn, Joshua A. Granek, Bidong D. Nguyen, Jeffrey R. Barker, Raphael H. Valdivia, and Robert J. Bastidas. “Integrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia.” Cell Host Microbe 17, no. 5 (May 13, 2015): 716–25. https://doi.org/10.1016/j.chom.2015.03.014.Full Text Link to Item
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Larson, Charles L., Paul A. Beare, Daniel E. Voth, Dale Howe, Diane C. Cockrell, Robert J. Bastidas, Raphael H. Valdivia, and Robert A. Heinzen. “Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication.” Infection and Immunity 83, no. 2 (February 2015): 661–70. https://doi.org/10.1128/iai.02763-14.Full Text
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Engström, Patrik, K Syam Krishnan, Bidong D. Ngyuen, Erik Chorell, Johan Normark, Jim Silver, Robert J. Bastidas, et al. “A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.” Mbio 6, no. 1 (December 30, 2014): e02304–14. https://doi.org/10.1128/mbio.02304-14.Full Text
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Calo, Silvia, Cecelia Shertz-Wall, Soo Chan Lee, Robert J. Bastidas, Francisco E. Nicolás, Joshua A. Granek, Piotr Mieczkowski, et al. “Antifungal drug resistance evoked via RNAi-dependent epimutations.” Nature 513, no. 7519 (September 25, 2014): 555–58. https://doi.org/10.1038/nature13575.Full Text Link to Item
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Snavely, Emily A., Marcela Kokes, Joe Dan Dunn, Hector A. Saka, Bidong D. Nguyen, Robert J. Bastidas, Dewey G. McCafferty, and Raphael H. Valdivia. “Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.” Pathog Dis 71, no. 3 (August 2014): 336–51. https://doi.org/10.1111/2049-632X.12179.Full Text Link to Item
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Chen, Yi-Shan, Robert J. Bastidas, Hector A. Saka, Victoria K. Carpenter, Kristian L. Richards, Gregory V. Plano, and Raphael H. Valdivia. “The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling.” Plos Pathog 10, no. 2 (February 2014): e1003954. https://doi.org/10.1371/journal.ppat.1003954.Full Text Link to Item
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Saka, H. A., R. Baxter, R. J. Bastidas, M. E. Panzetta, and R. H. Valdivia. “IDENTIFICATION OF Chlamydia trachomatis MUTANTS DEFECTIVE FOR PERSISTENCE.” Biocell 38 (January 1, 2014): 132–132.Link to Item
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Engström, Patrik, Bidong D. Nguyen, Johan Normark, Ingela Nilsson, Robert J. Bastidas, Asa Gylfe, Mikael Elofsson, et al. “Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity.” J Bacteriol 195, no. 18 (September 2013): 4221–30. https://doi.org/10.1128/JB.00506-13.Full Text Link to Item
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Bastidas, Robert J., Cherilyn A. Elwell, Joanne N. Engel, and Raphael H. Valdivia. “Chlamydial intracellular survival strategies.” Cold Spring Harb Perspect Med 3, no. 5 (May 1, 2013): a010256. https://doi.org/10.1101/cshperspect.a010256.Full Text Link to Item
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Bastidas, Robert J., Cecelia A. Shertz, Soo Chan Lee, Joseph Heitman, and Maria E. Cardenas. “Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.” Eukaryot Cell 11, no. 3 (March 2012): 270–81. https://doi.org/10.1128/EC.05284-11.Full Text Link to Item
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Shertz, Cecelia A., Robert J. Bastidas, Wenjun Li, Joseph Heitman, and Maria E. Cardenas. “Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom.” Bmc Genomics 11 (September 23, 2010): 510. https://doi.org/10.1186/1471-2164-11-510.Full Text Open Access Copy Link to Item
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Bastidas, R. J., and M. E. Cardenas. “TORC1 signaling in the budding yeast endomembrane system and control of cell-cell adhesion in pathogenic fungi” 27, no. C (January 1, 2010): 199–227. https://doi.org/10.1016/S1874-6047(10)27011-7.Full Text
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Bastidas, Robert J., Joseph Heitman, and Maria E. Cardenas. “The protein kinase Tor1 regulates adhesin gene expression in Candida albicans.” Plos Pathog 5, no. 2 (February 2009): e1000294. https://doi.org/10.1371/journal.ppat.1000294.Full Text Link to Item
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Bastidas, Robert J., and Joseph Heitman. “Trimorphic stepping stones pave the way to fungal virulence.” Proc Natl Acad Sci U S A 106, no. 2 (January 13, 2009): 351–52. https://doi.org/10.1073/pnas.0811994106.Full Text Link to Item
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Bastidas, Robert J., Jennifer L. Reedy, Helena Morales-Johansson, Joseph Heitman, and Maria E. Cardenas. “Signaling cascades as drug targets in model and pathogenic fungi.” Curr Opin Investig Drugs 9, no. 8 (August 2008): 856–64.Link to Item
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Rohde, John R., Robert Bastidas, Rekha Puria, and Maria E. Cardenas. “Nutritional control via Tor signaling in Saccharomyces cerevisiae.” Curr Opin Microbiol 11, no. 2 (April 2008): 153–60. https://doi.org/10.1016/j.mib.2008.02.013.Full Text Link to Item
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Reedy, Jennifer L., Robert J. Bastidas, and Joseph Heitman. “The virulence of human pathogenic fungi: notes from the South of France.” Cell Host Microbe 2, no. 2 (August 16, 2007): 77–83. https://doi.org/10.1016/j.chom.2007.07.004.Full Text Link to Item
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Mulugu, Sashidhar, Wenli Bai, Peter C. Fridy, Robert J. Bastidas, James C. Otto, D Eric Dollins, Timothy A. Haystead, Anthony A. Ribeiro, and John D. York. “A conserved family of enzymes that phosphorylate inositol hexakisphosphate.” Science 316, no. 5821 (April 6, 2007): 106–9. https://doi.org/10.1126/science.1139099.Full Text Link to Item
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Stevenson-Paulik, Jill, Robert J. Bastidas, Shean-Tai Chiou, Roy A. Frye, and John D. York. “Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases.” Proc Natl Acad Sci U S A 102, no. 35 (August 30, 2005): 12612–17. https://doi.org/10.1073/pnas.0504172102.Full Text Link to Item
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Seeds, Andrew M., Robert J. Bastidas, and John D. York. “Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae.” J Biol Chem 280, no. 30 (July 29, 2005): 27654–61. https://doi.org/10.1074/jbc.M505089200.Full Text Link to Item
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Book Sections
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Kędzior, Mateusz, and Robert J. Bastidas. “Forward and Reverse Genetic Analysis of Chlamydia.,” 2042:185–204, 2019. https://doi.org/10.1007/978-1-4939-9694-0_13.Full Text Link to Item
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Conference Papers
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Sherry, J., C. Elwell, R. Bastidas, M. Weber, T. Hackstadt, R. H. Valdivia, and J. N. Engel. “Chlamydia trachomatis inclusion membrane protein CT192 interacts with dynactin to modulate centrosome positioning and parasitophorous vacuole fusion events.” In Molecular Biology of the Cell, Vol. 27. AMER SOC CELL BIOLOGY, 2016.Link to Item
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Koehler, Julia, Tahmeena Chowdhury, Niketa Jani, Folkert Van Werven, Robert Bastidas, and Joseph Heitman. “Candida albicans yeast but not hyphae require pescadillo to respond to TOR.” In Yeast, 30:51–51. WILEY-BLACKWELL, 2013.Link to Item
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