
The emerging complexity of Chlamydia trachomatis interactions with host cells as revealed by molecular genetic approaches.
Chlamydia trachomatis (Ct) is an intracellular bacterial pathogen that relies on the activity of secreted proteins known as effectors to promote replication and avoidance of immune clearance. Understanding the contribution of Ct effectors to pathogenesis has proven to be challenging, given that these proteins often perform multiple functions during intracellular infection. Recent advances in molecular genetic analysis of Ct have provided valuable insights into the multifaceted nature of secreted effector proteins and their impact on the interaction between Ct and host cells and tissues. This review highlights significant findings from genetic analysis of Ct effector functions, shedding light on their diverse roles. We also discuss the challenges faced in this field of study and explore potential opportunities for further research.
Duke Scholars
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- Molecular Biology
- Microbiology
- Host-Pathogen Interactions
- Chlamydia trachomatis
- Bacterial Proteins
- 1108 Medical Microbiology
- 0605 Microbiology
Citation

Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Molecular Biology
- Microbiology
- Host-Pathogen Interactions
- Chlamydia trachomatis
- Bacterial Proteins
- 1108 Medical Microbiology
- 0605 Microbiology