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The emerging complexity of Chlamydia trachomatis interactions with host cells as revealed by molecular genetic approaches.

Publication ,  Journal Article
Bastidas, RJ; Valdivia, RH
Published in: Curr Opin Microbiol
August 2023

Chlamydia trachomatis (Ct) is an intracellular bacterial pathogen that relies on the activity of secreted proteins known as effectors to promote replication and avoidance of immune clearance. Understanding the contribution of Ct effectors to pathogenesis has proven to be challenging, given that these proteins often perform multiple functions during intracellular infection. Recent advances in molecular genetic analysis of Ct have provided valuable insights into the multifaceted nature of secreted effector proteins and their impact on the interaction between Ct and host cells and tissues. This review highlights significant findings from genetic analysis of Ct effector functions, shedding light on their diverse roles. We also discuss the challenges faced in this field of study and explore potential opportunities for further research.

Duke Scholars

Published In

Curr Opin Microbiol

DOI

EISSN

1879-0364

Publication Date

August 2023

Volume

74

Start / End Page

102330

Location

England

Related Subject Headings

  • Molecular Biology
  • Microbiology
  • Host-Pathogen Interactions
  • Chlamydia trachomatis
  • Bacterial Proteins
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bastidas, R. J., & Valdivia, R. H. (2023). The emerging complexity of Chlamydia trachomatis interactions with host cells as revealed by molecular genetic approaches. Curr Opin Microbiol, 74, 102330. https://doi.org/10.1016/j.mib.2023.102330
Bastidas, Robert J., and Raphael H. Valdivia. “The emerging complexity of Chlamydia trachomatis interactions with host cells as revealed by molecular genetic approaches.Curr Opin Microbiol 74 (August 2023): 102330. https://doi.org/10.1016/j.mib.2023.102330.
Bastidas, Robert J., and Raphael H. Valdivia. “The emerging complexity of Chlamydia trachomatis interactions with host cells as revealed by molecular genetic approaches.Curr Opin Microbiol, vol. 74, Aug. 2023, p. 102330. Pubmed, doi:10.1016/j.mib.2023.102330.
Journal cover image

Published In

Curr Opin Microbiol

DOI

EISSN

1879-0364

Publication Date

August 2023

Volume

74

Start / End Page

102330

Location

England

Related Subject Headings

  • Molecular Biology
  • Microbiology
  • Host-Pathogen Interactions
  • Chlamydia trachomatis
  • Bacterial Proteins
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology