Rodney Allan Radtke | Scholars@Duke

Rodney Allan Radtke
Professor of Neurology

Main focus is in epilepsy, sleep disorders, and clinical neurophysiology interpretation. Specific areas of interest include predictive outcome factors in epilepsy surgery, neuroimaging characteristics of neuronal migration disorders, development of new medical treatments of epilepsy and narcolepsy, and the pharmacogenetics of epilepsy and its treatment.

No involvement in basic laboratory research.

Ongoing clinical trials include:
1) Pharmacogenetics of epilepsy
2) behavioral treatment trial for insomnia

Special expertise recognized by serving on Professional Advisory Board of the Epilepsy Foundation of America and election as chairman of the American Board of Clinical Neurophysiology (certifying body in EEG, Evoked Potentials, Epilepsy Monitoring and Sleep).

Key words: Epilepsy
Epilepsy Surgery
Sleep Disorders
Sleep Apnea
Narcolepsy
Clinical Neurophysiology

Current Appointments & Affiliations

Professor of Neurology, Neurology, Epilepsy and Sleep, Neurology 1999

Contact Information

297 Hanes House, 315 Trent Drive, Durham, NC 27710
Duke Box 102350, Durham, NC 27710
rod.radtke@duke.edu (919) 681-3448

Background
Education, Training, & Certifications
- M.D., Northwestern University 1980
Duke Appointment History
- Associate Professor of Medicine with Tenure, Neurology, Clinical Science Departments 1994 - 1999
- Assistant Professor of Medicine, Neurology, Clinical Science Departments 1986 - 1994
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1984 - 1986
Recognition
In the News
- FEB 5, 2015 WBTV-Charlotte
  
  Remember N.C. CBD oils law? Families say it doesn't work
Research
Selected Grants
- Exploratory genomic investigations of mesial temporal lobe epilepsy awarded by National Institutes of Health 2012 - 2015
- Classifying Psychiatric, Medical, and Primary Insomnias awarded by National Institutes of Health 2003 - 2009
- same awarded by National Institutes of Health 1994 - 2003
- Dose Response Effects Of Behavioral Insomnia Therapy awarded by National Institutes of Health 1998 - 2002
- Cognitive-Behavioral Therapy For Primary Insomnia awarded by National Institutes of Health 1995 - 1997
External Relationships
- Cadent Therapeutics
- Supernus Pharmaceuticals Inc.
- UCB Pharma
- neuralis
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Radtke, Rodney. “Pediatric Sleep Pearls.” J Clin Neurophysiol 37, no. 6 (November 1, 2020): 606. https://doi.org/10.1097/WNP.0000000000000587.
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  - Perucca, Piero, Alison Anderson, Dana Jazayeri, Alison Hitchcock, Janet Graham, Marian Todaro, Torbjörn Tomson, et al. “Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load.” Ann Neurol 87, no. 6 (June 2020): 897–906. https://doi.org/10.1002/ana.25724.
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  - Heavin, Sinéad B., Mark McCormack, Stefan Wolking, Lisa Slattery, Nicole Walley, Andreja Avbersek, Jan Novy, et al. “Genomic and clinical predictors of lacosamide response in refractory epilepsies.” Epilepsia Open 4, no. 4 (December 2019): 563–71. https://doi.org/10.1002/epi4.12360.
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  - Wechsler, Robert T., Rodney A. Radtke, Michael Smith, David G. Vossler, Laura Strom, Eugen Trinka, Hailong Cheng, et al. “Serum sodium levels and related treatment-emergent adverse events during eslicarbazepine acetate use in adults with epilepsy.” Epilepsia 60, no. 7 (July 2019): 1341–52. https://doi.org/10.1111/epi.16069.
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  - International League Against Epilepsy Consortium on Complex Epilepsies, Barney. “Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.” Nat Commun 9, no. 1 (December 10, 2018): 5269. https://doi.org/10.1038/s41467-018-07524-z.
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  - Sen, Arjune, Patricia Dugan, Piero Perucca, Daniel Costello, Hyunmi Choi, Carl Bazil, Rod Radtke, et al. “The phenotype of bilateral hippocampal sclerosis and its management in "real life" clinical settings.” Epilepsia 59, no. 7 (July 2018): 1410–20. https://doi.org/10.1111/epi.14436.
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  - Brainstorm Consortium, Robin, Verneri Anttila, Brendan Bulik-Sullivan, Hilary K. Finucane, Raymond K. Walters, Jose Bras, Laramie Duncan, et al. “Analysis of shared heritability in common disorders of the brain.” Science 360, no. 6395 (June 22, 2018). https://doi.org/10.1126/science.aap8757.
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  - Pecoraro, Anthony, Eric Arehart, William Gallentine, Rodney Radtke, Edward Smith, Carolyn Pizoli, Sujay Kansagra, Elie Abdelnour, Roger McLendon, and Mohamad A. Mikati. “Epilepsy in neurofibromatosis type 1.” Epilepsy Behav 73 (August 2017): 137–41. https://doi.org/10.1016/j.yebeh.2017.05.011.
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  - Epi4K consortium, H Kim, and H Kim Epilepsy Phenome/Genome Project. “Ultra-rare genetic variation in common epilepsies: a case-control sequencing study.” Lancet Neurol 16, no. 2 (February 2017): 135–43. https://doi.org/10.1016/S1474-4422(16)30359-3.
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  - Griffin, Nicole G., Yu Wang, Christine M. Hulette, Matt Halvorsen, Kenneth D. Cronin, Nicole M. Walley, Michael M. Haglund, et al. “Differential gene expression in dentate granule cells in mesial temporal lobe epilepsy with and without hippocampal sclerosis.” Epilepsia 57, no. 3 (March 2016): 376–85. https://doi.org/10.1111/epi.13305.
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  - Piña-Garza, Jesus Eric, Steve Chung, Georgia D. Montouris, Rodney A. Radtke, Trevor Resnick, and Robert T. Wechsler. “Challenges in identifying Lennox-Gastaut syndrome in adults: A case series illustrating its changing nature.” Epilepsy Behav Case Rep 5 (2016): 38–43. https://doi.org/10.1016/j.ebcr.2016.01.004.
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  - Swisher, Christa B., Corey R. White, Brian E. Mace, Keith E. Dombrowski, Aatif M. Husain, Bradley J. Kolls, Rodney R. Radtke, Tung T. Tran, and Saurabh R. Sinha. “Diagnostic Accuracy of Electrographic Seizure Detection by Neurophysiologists and Non-Neurophysiologists in the Adult ICU Using a Panel of Quantitative EEG Trends.” J Clin Neurophysiol 32, no. 4 (August 2015): 324–30. https://doi.org/10.1097/WNP.0000000000000144.
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  - International League Against Epilepsy Consortium on Complex Epilepsies. Electronic address: epilepsy-austin@unimelb.edu.au, K Jane. “Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.” Lancet Neurol 13, no. 9 (September 2014): 893–903. https://doi.org/10.1016/S1474-4422(14)70171-1.
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  - Heinzen, Erin L., Chantal Depondt, Gianpiero L. Cavalleri, Elizabeth K. Ruzzo, Nicole M. Walley, Anna C. Need, Dongliang Ge, et al. “Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.” Am J Hum Genet 91, no. 2 (August 10, 2012): 293–302. https://doi.org/10.1016/j.ajhg.2012.06.016.
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  - McCormack, Mark, Thomas J. Urban, Kevin V. Shianna, Nicole Walley, Massimo Pandolfo, Chantal Depondt, Elijah Chaila, et al. “Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.” Pharmacogenomics 13, no. 4 (March 2012): 399–405. https://doi.org/10.2217/pgs.11.165.
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  - Cirulli, Elizabeth T., Thomas J. Urban, Susan E. Marino, Kristen N. Linney, Angela K. Birnbaum, Chantal Depondt, Deborah K. Attix, Rodney A. Radtke, and David B. Goldstein. “Genetic and environmental correlates of topiramate-induced cognitive impairment.” Epilepsia 53, no. 1 (January 2012): e5–8. https://doi.org/10.1111/j.1528-1167.2011.03322.x.
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  - Raju, D. V., and R. A. Radtke. “Sleep/wake electroencephalography across the lifespan.” Sleep Medicine Clinics 7, no. 1 (January 1, 2012): 13–22. https://doi.org/10.1016/j.jsmc.2012.01.001.
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  - Edinger, Jack D., James K. Wyatt, Edward J. Stepanski, Maren K. Olsen, Karen M. Stechuchak, Colleen E. Carney, Ambrose Chiang, et al. “Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis.” Arch Gen Psychiatry 68, no. 10 (October 2011): 992–1002. https://doi.org/10.1001/archgenpsychiatry.2011.64.
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  - McCormack, Mark, Ana Alfirevic, Stephane Bourgeois, John J. Farrell, Dalia Kasperavičiūtė, Mary Carrington, Graeme J. Sills, et al. “HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.” N Engl J Med 364, no. 12 (March 24, 2011): 1134–43. https://doi.org/10.1056/NEJMoa1013297.
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  - Kasperaviciūte, Dalia, Claudia B. Catarino, Erin L. Heinzen, Chantal Depondt, Gianpiero L. Cavalleri, Luis O. Caboclo, Sarah K. Tate, et al. “Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.” Brain 133, no. Pt 7 (July 2010): 2136–47. https://doi.org/10.1093/brain/awq130.
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  - Beskow, Laura M., Kristen N. Linney, Rodney A. Radtke, Erin L. Heinzen, and David B. Goldstein. “Ethical challenges in genotype-driven research recruitment.” Genome Res 20, no. 6 (June 2010): 705–9. https://doi.org/10.1101/gr.104455.109.
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  - Heinzen, Erin L., Rodney A. Radtke, Thomas J. Urban, Gianpiero L. Cavalleri, Chantal Depondt, Anna C. Need, Nicole M. Walley, et al. “Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.” Am J Hum Genet 86, no. 5 (May 14, 2010): 707–18. https://doi.org/10.1016/j.ajhg.2010.03.018.
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  - Chaudhry, Amarjit S., Thomas J. Urban, Jatinder K. Lamba, Angela K. Birnbaum, Rory P. Remmel, Murali Subramanian, Stephen Strom, et al. “CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.” J Pharmacol Exp Ther 332, no. 2 (February 2010): 599–611. https://doi.org/10.1124/jpet.109.161026.
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  - Edinger, J. D., J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. A. Chiang, A. D. Krystal, M. D. Lineberger, M. K. Means, and R. A. Radtke. “UTILITY, VALIDITY, AND METHODOLOGICAL FACTORS INFLUENCING ASSIGNMENT OF DSM-IV-TR INSOMNIA DIAGNOSES: CONSIDERATIONS FOR DSM-V.” Sleep 33 (January 1, 2010): A191–A191.
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  - Edinger, J. D., M. R. Green, A. A. Prather, J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. A. Chiang, A. D. Krystal, and R. A. Radtke. “VALIDITY AND RELIABILITY OF THE DSM-IV-TR AND ICSD-2 INSOMNIA NOSOLOGIES AMONG CAUCASIANS AND AFRICAN-AMERICANS.” Sleep 33 (January 1, 2010): A209–A209.
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  - Carney, C. E., J. D. Edinger, J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, A. Chiang, A. D. Krystal, M. D. Lineberger, M. K. Means, and R. A. Radtke. “SHOULD DSM-IV-TR PRIMARY INSOMNIA BE DIVIDED INTO SPECIFIC SUBTYPES?” Sleep 32 (January 1, 2009): A264–65.
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  - Edinger, J. D., J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. Chiang, A. D. Krystal, M. D. Lineberger, M. K. Means, and R. A. Radtke. “COMPARATIVE VALIDITY OF THE DSM-IV-TR AND ICSD-2 INSOMNIA NOSOLOGIES: HOW MANY WAYS SHOULD WE SLICE THE INSOMNIA PIE?” Sleep 32 (January 1, 2009): A263–A263.
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  - Edinger, J. D., J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. Chiang, A. D. Krystal, M. D. Lineberger, M. K. Means, and R. A. Radtke. “RELIABILITY AND VALIDITY OF THE DUKE STRUCTURED INTERVIEW FOR SLEEP DISORDERS FOR INSOMNIA SCREENING.” Sleep 32 (January 1, 2009): A265–A265.
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  - Cavalleri, Gianpiero L., Michael E. Weale, Kevin V. Shianna, Rinki Singh, John M. Lynch, Bronwyn Grinton, Cassandra Szoeke, et al. “Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.” Lancet Neurol 6, no. 11 (November 2007): 970–80. https://doi.org/10.1016/S1474-4422(07)70247-8.
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  - Edinger, Jack D., William K. Wohlgemuth, Rodney A. Radtke, Cynthia J. Coffman, and Colleen E. Carney. “Dose-response effects of cognitive-behavioral insomnia therapy: a randomized clinical trial.” Sleep 30, no. 2 (February 2007): 203–12. https://doi.org/10.1093/sleep/30.2.203.
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  - Verma, Amit, and Rodney Radtke. “EEG of partial seizures.” J Clin Neurophysiol 23, no. 4 (August 2006): 333–39. https://doi.org/10.1097/01.wnp.0000228497.89734.7a.
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  - Lobello, Kasia, Joel C. Morgenlander, Rodney A. Radtke, and Cheryl D. Bushnell. “Video/EEG monitoring in the evaluation of paroxysmal behavioral events: duration, effectiveness, and limitations.” Epilepsy Behav 8, no. 1 (February 2006): 261–66. https://doi.org/10.1016/j.yebeh.2005.10.010.
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  - Means, Melanie K., Kenneth L. Lichstein, Jack D. Edinger, Daniel J. Taylor, H Heith Durrence, Aatif M. Husain, R Neal Aguillard, and Rodney A. Radtke. “Changes in depressive symptoms after continuous positive airway pressure treatment for obstructive sleep apnea.” Sleep Breath 7, no. 1 (March 2003): 31–42. https://doi.org/10.1007/s11325-003-0031-x.
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  - Gibbs, John W., Emma Ciafaloni, and Rodney A. Radtke. “Excessive daytime somnolence and increased rapid eye movement pressure in myotonic dystrophy.” Sleep 25, no. 6 (September 15, 2002): 662–65. https://doi.org/10.1093/sleep/25.6.662.
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  - Verma, A., D. Lewis, K. E. VanLandingham, A. M. Husain, A. H. Friedman, E. Thompson, and R. A. Radtke. “Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.” Epilepsy Res 47, no. 1–2 (November 2001): 9–15. https://doi.org/10.1016/s0920-1211(01)00289-3.
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  - Edinger, J. D., W. K. Wohlgemuth, R. A. Radtke, G. R. Marsh, and R. E. Quillian. “Does cognitive-behavioral insomnia therapy alter dysfunctional beliefs about sleep?” Sleep 24, no. 5 (August 1, 2001): 591–99. https://doi.org/10.1093/sleep/24.5.591.
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  - Verma, A., R. A. Radtke, K. E. VanLandingham, J. H. King, and A. M. Husain. “Slow wave sleep rebound and REM rebound following the first night of treatment with CPAP for sleep apnea: correlation with subjective improvement in sleep quality.” Sleep Med 2, no. 3 (May 2001): 215–23. https://doi.org/10.1016/s1389-9457(00)00069-1.
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  - Edinger, J. D., W. K. Wohlgemuth, R. A. Radtke, G. R. Marsh, and R. E. Quillian. “Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial.” Jama 285, no. 14 (April 11, 2001): 1856–64. https://doi.org/10.1001/jama.285.14.1856.
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  - Méndez, M., and R. A. Radtke. “Interactions between sleep and epilepsy.” J Clin Neurophysiol 18, no. 2 (March 2001): 106–27. https://doi.org/10.1097/00004691-200103000-00003.
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  - Radtke, R. “Sleep disorders in neurology.” J Clin Neurophysiol 18, no. 2 (March 2001): 77. https://doi.org/10.1097/00004691-200103000-00001.
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  - McKeown, M. J., and R. Radtke. “Phasic and tonic coupling between EEG and EMG demonstrated with independent component analysis.” J Clin Neurophysiol 18, no. 1 (January 2001): 45–57. https://doi.org/10.1097/00004691-200101000-00009.
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  - Radtke, R. A. “Pharmacokinetics of levetiracetam.” Epilepsia 42 Suppl 4 (2001): 24–27. https://doi.org/10.1046/j.1528-1157.2001.0420s4024.x.
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  - Poussaint, T. Y., J. W. Fox, W. B. Dobyns, R. Radtke, I. E. Scheffer, S. F. Berkovic, P. D. Barnes, P. R. Huttenlocher, and C. A. Walsh. “Periventricular nodular heterotopia in patients with filamin-1 gene mutations: neuroimaging findings.” Pediatr Radiol 30, no. 11 (November 2000): 748–55. https://doi.org/10.1007/s002470000312.
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  - Fernando-Dongas, M. C., R. A. Radtke, K. E. VanLandingham, and A. M. Husain. “Characteristics of valproic acid resistant juvenile myoclonic epilepsy.” Seizure 9, no. 6 (September 2000): 385–88. https://doi.org/10.1053/seiz.2000.0432.
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  - Cereghino, J. J., V. Biton, B. Abou-Khalil, F. Dreifuss, L. J. Gauer, and I. Leppik. “Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial.” Neurology 55, no. 2 (July 25, 2000): 236–42. https://doi.org/10.1212/wnl.55.2.236.
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  - Armon, C., R. A. Radtke, and A. H. Friedman. “Inhibitory simple partial (non-convulsive) status epilepticus after intracranial surgery.” J Neurol Neurosurg Psychiatry 69, no. 1 (July 2000): 18–24. https://doi.org/10.1136/jnnp.69.1.18.
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  - Husain, A. M., S. T. Carwile, P. P. Miller, and R. A. Radtke. “Improved sexual function in three men taking lamotrigine for epilepsy.” South Med J 93, no. 3 (March 2000): 335–36.
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  - Foldvary, N., B. Nashold, E. Mascha, E. A. Thompson, N. Lee, J. O. McNamara, D. V. Lewis, J. S. Luther, A. H. Friedman, and R. A. Radtke. “Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis.” Neurology 54, no. 3 (February 8, 2000): 630–34. https://doi.org/10.1212/wnl.54.3.630.
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  - Verma, A., E. W. St Clair, and R. A. Radtke. “A case of sustained massive gabapentin overdose without serious side effects.” Ther Drug Monit 21, no. 6 (December 1999): 615–17. https://doi.org/10.1097/00007691-199912000-00006.
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  - Verma, A., P. Miller, S. T. Carwile, A. M. Husain, and R. A. Radtke. “Lamotrigine-induced blepharospasm.” Pharmacotherapy 19, no. 7 (July 1999): 877–80. https://doi.org/10.1592/phco.19.10.877.31554.
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  - Foldvary, N., N. Lee, M. W. Hanson, R. E. Coleman, C. M. Hulette, A. H. Friedman, M. D. Bej, and R. A. Radtke. “Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy.” Epilepsia 40, no. 1 (January 1999): 26–29. https://doi.org/10.1111/j.1528-1157.1999.tb01984.x.
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  - Husain, A. M., K. A. Mebust, and R. A. Radtke. “Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis.” J Clin Neurophysiol 16, no. 1 (January 1999): 51–58. https://doi.org/10.1097/00004691-199901000-00005.
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  - Verma, A., R. S. Bedlack, R. A. Radtke, K. E. VanLandingham, and C. W. Erwin. “Succinylcholine induced hyperkalemia and cardiac arrest death related to an EEG study.” J Clin Neurophysiol 16, no. 1 (January 1999): 46–50. https://doi.org/10.1097/00004691-199901000-00004.
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  - Fox, J. W., E. D. Lamperti, Y. Z. Ekşioğlu, S. E. Hong, Y. Feng, D. A. Graham, I. E. Scheffer, et al. “Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.” Neuron 21, no. 6 (December 1998): 1315–25. https://doi.org/10.1016/s0896-6273(00)80651-0.
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  - Kothare, S. V., K. VanLandingham, C. Armon, J. S. Luther, A. Friedman, and R. A. Radtke. “Seizure onset from periventricular nodular heterotopias: depth-electrode study.” Neurology 51, no. 6 (December 1998): 1723–27. https://doi.org/10.1212/wnl.51.6.1723.
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  - Bell, W. L., Y. D. Park, E. A. Thompson, and R. A. Radtke. “Ictal cognitive assessment of partial seizures and pseudoseizures.” Arch Neurol 55, no. 11 (November 1998): 1456–59. https://doi.org/10.1001/archneur.55.11.1456.
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  - Husain, A. M., V. T. Hope, K. A. Mebust, M. A. Nayer, and R. A. Radtke. “Cost analysis of analog versus digital elctroencephalography.” Neurodiagnostic Journal 38, no. 3 (September 1, 1998): 199–203.
  - Kothare, S. V., C. C. Chu, K. VanLandingham, K. C. Richards, D. A. Hosford, and R. A. Radtke. “Migratory leptomeningeal inflammation with relapsing polychondritis.” Neurology 51, no. 2 (August 1998): 614–17. https://doi.org/10.1212/wnl.51.2.614.
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  - Kraemer, D. L., M. L. Griebel, N. Lee, A. H. Friedman, and R. A. Radtke. “Surgical outcome in patients with epilepsy with occult vascular malformations treated with lesionectomy.” Epilepsia 39, no. 6 (June 1998): 600–607. https://doi.org/10.1111/j.1528-1157.1998.tb01428.x.
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  - Husain, A. M., S. T. Carwile, P. P. Miller, and R. A. Radtke. “Sexual dysfunction in male veterans with epilepsy.” Journal of Epilepsy 11, no. 3 (May 1, 1998): 144–47. https://doi.org/10.1016/S0896-6974(98)00006-1.
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  - Bell, W. L., T. S. Walczak, C. Shin, and R. A. Radtke. “Painful generalised clonic and tonic-clonic seizures with retained consciousness.” J Neurol Neurosurg Psychiatry 63, no. 6 (December 1997): 792–95. https://doi.org/10.1136/jnnp.63.6.792.
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  - “Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.” Arch Ophthalmol 115, no. 12 (December 1997): 1545–52.
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  - Foldvary, N., N. Lee, G. Thwaites, E. Mascha, J. Hammel, H. Kim, A. H. Friedman, and R. A. Radtke. “Clinical and electrographic manifestations of lesional neocortical temporal lobe epilepsy.” Neurology 49, no. 3 (September 1997): 757–63. https://doi.org/10.1212/wnl.49.3.757.
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  - Husain, A. M., K. A. Mebust, S. T. Carwile, P. P. Miller, and R. A. Radtke. “Depression in sleep disorders clinics.” Sleep Breath 2, no. 3 (September 1997): 73–75. https://doi.org/10.1007/BF03038869.
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  - Jain, S., S. N. Dixit, P. I. Andrews, R. Radtke, M. C. Maheshwari, and J. O. McNamara. “Disease expression among probands with juvenile myoclonic epilepsy and their family members in two population groups.” Journal of Epilepsy 9, no. 4 (December 1, 1996): 259–67. https://doi.org/10.1016/S0896-6974(96)00040-0.
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  - Layish Daniel, T., J. A. Govert, and R. A. Radtke. “Physician practices in the diagnostic evaluation of suspected Obstructive Sleep Apnea (OSA).” Chest 110, no. 4 SUPPL. (October 1, 1996).
  - Layish Daniel, T., J. A. Govert, and R. A. Radtke. “Variation in physician threshold to treat Obstructive Sleep Apnea (OSA).” Chest 110, no. 4 SUPPL. (October 1, 1996).
  - Armon, C., R. A. Radtke, A. H. Friedman, and D. V. Dawson. “Predictors of outcome of epilepsy surgery: multivariate analysis with validation.” Epilepsia 37, no. 9 (September 1996): 814–21. https://doi.org/10.1111/j.1528-1157.1996.tb00033.x.
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  - Dobyns, W. B., E. Andermann, F. Andermann, D. Czapansky-Beilman, F. Dubeau, O. Dulac, R. Guerrini, et al. “X-linked malformations of neuronal migration.” Neurology 47, no. 2 (August 1996): 331–39. https://doi.org/10.1212/wnl.47.2.331.
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  - Lewis, D. V., R. J. Thompson, C. C. Santos, W. J. Oakes, R. A. Radtke, A. H. Friedman, N. Lee, and H. S. Swartzwelder. “Outcome of temporal lobectomy in adolescents.” Journal of Epilepsy 9, no. 3 (January 1, 1996): 198–205. https://doi.org/10.1016/0896-6974(96)00013-8.
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  - Montine, T. J., J. M. Powers, F. S. Vogel, and R. A. Radtke. “Alpers' syndrome presenting with seizures and multiple stroke-like episodes in a 17-year-old male.” Clin Neuropathol 14, no. 6 (November 1995): 322–26.
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  - Dubeau, F., D. Tampieri, N. Lee, E. Andermann, S. Carpenter, R. Leblanc, A. Olivier, R. Radtke, J. G. Villemure, and F. Andermann. “Periventricular and subcortical nodular heterotopia. A study of 33 patients.” Brain 118 ( Pt 5) (October 1995): 1273–87. https://doi.org/10.1093/brain/118.5.1273.
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  - Lee, N., R. D. Tien, D. V. Lewis, A. H. Friedman, G. J. Felsberg, B. Crain, C. Hulette, A. K. Osumi, J. S. Smith, and K. E. VanLandingham. “Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients.” Epilepsia 36, no. 9 (September 1995): 899–904. https://doi.org/10.1111/j.1528-1157.1995.tb01633.x.
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  - Park, J. D., and R. A. Radtke. “Hypersomnolence in myotonic dystrophy: demonstration of sleep onset REM sleep.” J Neurol Neurosurg Psychiatry 58, no. 4 (April 1995): 512–13. https://doi.org/10.1136/jnnp.58.4.512.
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  - FOLDVARY, N., N. LEE, M. W. HANSON, R. E. COLEMAN, A. H. FRIEDMAN, and R. A. RADTKE. “PET HYPOMETABOLISM IN MESIAL TEMPORAL-LOBE EPILEPSY (MTLE) - CORRELATION WITH HIPPOCAMPAL NEURONAL DENSITY.” Epilepsia 36 (January 1, 1995): A8–A8.
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  - LEE, N., R. D. TIEN, A. H. FRIEDMAN, G. THWAITES, D. V. LEWIS, K. E. VANLANDINGHAM, and R. A. RADTKE. “ANTERIOR TEMPORAL LOBECTOMY IN PATIENTS WITH MRI EVIDENCE OF BILATERAL HIPPOCAMPAL SCLEROSIS.” Epilepsia 36 (January 1, 1995): 368–368.
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  - NASHOLD, B. S., N. FOLDVARY, W. P. WILSON, N. LEE, E. A. THOMPSON, J. S. LUTHER, A. H. FRIEDMAN, D. V. LEWIS, J. O. MCNAMARA, and R. A. RADTKE. “LONG-TERM OUTCOME FOLLOWING TEMPORAL LOBECTOMY FOR TEMPORAL-LOBE EPILEPSY.” Epilepsia 36 (January 1, 1995): 374–374.
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  - RADTKE, R. A., N. LEE, M. W. HANSON, R. D. TIEN, N. FOLDVARY, K. E. VANLANDINGHAM, and A. H. FRIEDMAN. “COMPARISON OF VOLUMETRIC HIPPOCAMPAL MRI AND FDG-PET - CORRELATION WITH SURGICAL OUTCOME IN MESIAL TLE.” Epilepsia 36 (January 1, 1995): 371–371.
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  - Shedlack, K. J., E. K. Lee, R. A. Radtke, A. H. Friedman, B. J. Crain, O. Boyko, and K. R. Krishnan. “Ipsilateral subcortical atrophy associated with temporal lobectomy.” Psychiatry Res 54, no. 3 (December 1994): 295–304. https://doi.org/10.1016/0165-1781(94)90023-x.
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  - Glantz, M. J., P. C. Burger, A. H. Friedman, R. A. Radtke, E. W. Massey, and S. C. Schold. “Treatment of radiation-induced nervous system injury with heparin and warfarin.” Neurology 44, no. 11 (November 1994): 2020–27. https://doi.org/10.1212/wnl.44.11.2020.
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  - Heinz, R., N. Ferris, E. K. Lee, R. Radtke, B. Crain, J. M. Hoffman, M. Hanson, S. Paine, and A. Friedman. “MR and positron emission tomography in the diagnosis of surgically correctable temporal lobe epilepsy.” Ajnr Am J Neuroradiol 15, no. 7 (August 1994): 1341–48.
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  - Worley, G., C. W. Erwin, J. M. Schuster, Y. Park, O. B. Boyko, M. L. Griebel, E. R. Weidman, R. A. Radtke, and W. J. Oakes. “BAEPs in infants with myelomeningocele and later development of Chiari II malformation-related brainstem dysfunction.” Dev Med Child Neurol 36, no. 8 (August 1994): 707–15. https://doi.org/10.1111/j.1469-8749.1994.tb11913.x.
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  - Park, Y. D., J. M. Hoffman, R. A. Radtke, and G. R. DeLong. “Focal cerebral metabolic abnormality in a patient with continuous spike waves during slow-wave sleep.” J Child Neurol 9, no. 2 (April 1994): 139–43. https://doi.org/10.1177/088307389400900207.
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  - Lee, N., R. A. Radtke, L. Gray, P. C. Burger, T. J. Montine, G. R. DeLong, D. V. Lewis, W. J. Oakes, A. H. Friedman, and J. M. Hoffman. “Neuronal migration disorders: positron emission tomography correlations.” Ann Neurol 35, no. 3 (March 1994): 290–97. https://doi.org/10.1002/ana.410350308.
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  - Meyer, M. A., R. A. Radtke, and J. M. Hoffman. “Temporal lobe hypometabolism [8].” Neurology 44, no. 3 I (1994): 583–85.
  - Radtke, R. A., M. W. Hanson, J. M. Hoffman, E. R. Heinz, T. S. Walczak, D. V. Lewis, R. E. Coleman, and A. F. Friedman. “Positron emission tomography: Comparison of clinical utility in temporal lobe and extratemporal epilepsy.” Journal of Epilepsy 7, no. 1 (January 1, 1994): 27–33. https://doi.org/10.1016/0896-6974(94)90116-3.
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  - Tien, R. D., G. J. Felsberg, C. Campi de Castro, A. K. Osumi, D. V. Lewis, A. H. Friedman, B. Crain, and R. A. Radtke. “Complex partial seizures and mesial temporal sclerosis: evaluation with fast spin-echo MR imaging.” Radiology 189, no. 3 (December 1993): 835–42. https://doi.org/10.1148/radiology.189.3.8234712.
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  - Edinger, J. D., and R. A. Radtke. “Use of in vivo desensitization to treat a patient's claustrophobic response to nasal CPAP.” Sleep 16, no. 7 (October 1993): 678–80.
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  - Radtke, R. A., M. W. Hanson, J. M. Hoffman, B. J. Crain, T. S. Walczak, D. V. Lewis, C. Beam, R. E. Coleman, and A. H. Friedman. “Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy.” Neurology 43, no. 6 (June 1993): 1088–92. https://doi.org/10.1212/wnl.43.6.1088.
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  - HANSON, M. W., J. M. HOFFMAN, E. K. LEE, R. A. RADTKE, B. J. CRAIN, S. S. PAINE, C. A. BEAM, A. H. FRIEDMAN, and R. E. COLEMAN. “THE PREDICTIVE IMPORTANCE OF FDG-PET IN PATIENTS WITH TEMPORAL-LOBE SEIZURES.” Journal of Nuclear Medicine 34, no. 5 (May 1, 1993): P23–P23.
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  - Weiner, R. D., J. Balla, R. A. Radtke, and T. E. Sibert. “ECT-induced status.” Neurology 43, no. 4 (April 1993): 847–48. https://doi.org/10.1212/wnl.43.4.847-b.
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  - Wilkins, R. H., R. A. Radtke, and P. C. Burger. “Spontaneous temporal encephalocele. Case report.” J Neurosurg 78, no. 3 (March 1993): 492–98. https://doi.org/10.3171/jns.1993.78.3.0492.
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  - Lee, E. K., C. Armon, T. M. Duginski, D. V. Lewis, and R. A. Radtke. “False lateralization of scalp EEG seizure onset.” Journal of Epilepsy 6, no. 4 (January 1, 1993): 220–23. https://doi.org/10.1016/0896-6974(93)90004-T.
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  - Weiner, R. D., J. Balla, R. A. Radtke, T. E. Sibert, S. I. Lee, and N. K. Varma. “ECT-induced status [3].” Neurology 43, no. 4 I (1993): 847–48.
  - Walczak, T. S., R. A. Radtke, and D. V. Lewis. “Accuracy and interobserver reliability of scalp ictal EEG.” Neurology 42, no. 12 (December 1992): 2279–85. https://doi.org/10.1212/wnl.42.12.2279.
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  - Edinger, J. D., W. V. McCall, G. R. Marsh, R. A. Radtke, C. W. Erwin, and A. Lininger. “Periodic limb movement variability in older DIMS patients across consecutive nights of home monitoring.” Sleep 15, no. 2 (April 1992): 156–61.
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  - Radtke, R. A. “Preferred instruments, inc.” Journal of Clinical Neurophysiology 9, no. 2 (January 1, 1992): 311.
  - “The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group.” Arch Ophthalmol 109, no. 12 (December 1991): 1673–78. https://doi.org/10.1001/archopht.1991.01080120057025.
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  - Chung, M. Y., T. S. Walczak, D. V. Lewis, D. V. Dawson, and R. Radtke. “Temporal lobectomy and independent bitemporal interictal activity: what degree of lateralization is sufficient?” Epilepsia 32, no. 2 (March 1991): 195–201. https://doi.org/10.1111/j.1528-1157.1991.tb05244.x.
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  - Armon, C., R. A. Radtke, and E. W. Massey. “Therapy of seizures associated with stroke.” Clin Neuropharmacol 14, no. 1 (February 1991): 17–27. https://doi.org/10.1097/00002826-199102000-00002.
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  - Walczak, T. S., D. V. Lewis, and R. Radtke. “Scalp EEG differs in temporal and extratemporal complex partial seizures.” Journal of Epilepsy 4, no. 1 (January 1, 1991): 25–28. https://doi.org/10.1016/0896-6974(91)90118-3.
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  - Wilkins, R. H., R. A. Radtke, and C. W. Erwin. “Value of intraoperative brainstem auditory evoked potential monitoring in reducing the auditory morbidity associated with microvascular decompression of cranial nerves.” Skull Base Surg 1, no. 2 (1991): 106–9. https://doi.org/10.1055/s-2008-1056989.
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  - Heinz, E. R., B. J. Crain, R. A. Radtke, P. C. Burger, A. H. Friedman, W. T. Djang, and W. E. Wilkinson. “MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings.” Ajr Am J Roentgenol 155, no. 3 (September 1990): 581–86. https://doi.org/10.2214/ajr.155.3.2117360.
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  - Heinz, E. R., B. J. Crain, R. A. Radtke, P. C. Burger, A. H. Friedman, W. T. Djang, and W. E. Wilkinson. “MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings.” Ajnr Am J Neuroradiol 11, no. 4 (July 1990): 827–32.
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  - Walczak, T. S., R. A. Radtke, J. O. McNamara, D. V. Lewis, J. S. Luther, E. Thompson, W. P. Wilson, A. H. Friedman, and B. S. Nashold. “Anterior temporal lobectomy for complex partial seizures: evaluation, results, and long-term follow-up in 100 cases.” Neurology 40, no. 3 Pt 1 (March 1990): 413–18. https://doi.org/10.1212/wnl.40.3_part_1.413.
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  - Bell, W. L., J. Horner, P. Logue, and R. A. Radtke. “Reply: Speech automatisms.” Neurology 40, no. 8 (January 1, 1990): 1320.
  - Bell, W. L., J. Horner, P. Logue, and R. A. Radtke. “Neologistic speech automatisms during complex partial seizures.” Neurology 40, no. 1 (January 1990): 49–52. https://doi.org/10.1212/wnl.40.1.49.
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  - Bell, W. L., J. Horner, P. Logue, and R. A. Radtke. “Speech automatisms (I: Reply).” Neurology 40, no. 8 (January 1, 1990): 1320. https://doi.org/10.1212/wnl.40.8.1320-a.
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  - Hoelscher, T. J., J. D. Edinger, G. R. Marsh, R. A. Radtke, and C. W. Erwin. “Nothing new about insomnia (I: Reply).” Sleep 13, no. 2 (January 1, 1990): 191–92. https://doi.org/10.1093/sleep/13.2.191.
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  - Edinger, J. D., T. J. Hoelscher, M. D. Webb, G. R. Marsh, R. A. Radtke, and C. W. Erwin. “Polysomnographic assessment of DIMS: empirical evaluation of its diagnostic value.” Sleep 12, no. 4 (August 1989): 315–22.
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  - Heinz, E. R., T. R. Heinz, R. Radtke, R. Darwin, B. P. Drayer, E. Fram, and W. T. Djang. “Efficacy of MR vs CT in epilepsy.” Ajr Am J Roentgenol 152, no. 2 (February 1989): 347–52. https://doi.org/10.2214/ajr.152.2.347.
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  - Radtke, R. A., C. W. Erwin, and R. H. Wilkins. “Intraoperative brainstem auditory evoked potentials: significant decrease in postoperative morbidity.” Neurology 39, no. 2 Pt 1 (February 1989): 187–91. https://doi.org/10.1212/wnl.39.2.187.
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  - Hanson, M. W., R. A. Radtke, C. S. Schold, M. J. Glantz, S. S. Rosenfeld, and R. E. Coleman. “Utility of FDG-PET in the evaluation of seizures and primary brain tumors.” Journal of Nuclear Medicine 30, no. 11 (January 1, 1989).
  - Radtke, R. A., and C. W. Erwin. “Intraoperative monitoring of auditory and brain-stem function.” Neurol Clin 6, no. 4 (November 1988): 899–915.
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  - Heinz, E. R., T. R. Heinz, R. Radtke, R. Darwin, B. P. Drayer, E. Fram, and W. T. Djang. “Efficacy of MR vs CT in epilepsy.” American Journal of Neuroradiology 9, no. 6 (January 1, 1988): 1123–28.
  - Hoelscher, T. J., C. W. Erwin, G. R. Marsh, M. D. Webb, R. A. Radtke, and A. Lininger. “Ambulatory sleep monitoring with the Oxford-Medilog 9000: technical acceptability, patient acceptance, and clinical indications.” Sleep 10, no. 6 (December 1987): 606–7.
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  - Radtke, R. A., A. Erwin, and C. W. Erwin. “Abnormal sensory evoked potentials in amyotrophic lateral sclerosis.” Neurology 36, no. 6 (June 1986): 796–801. https://doi.org/10.1212/wnl.36.6.796.
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  - Piatt, J. H., R. A. Radtke, and C. W. Erwin. “Limitations of brain stem auditory evoked potentials for intraoperative monitoring during a posterior fossa operation: case report and technical note.” Neurosurgery 16, no. 6 (June 1985): 818–21. https://doi.org/10.1227/00006123-198506000-00015.
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  - PIATT, J. H., C. W. ERWIN, R. A. RADTKE, P. W. GILMER, and R. D. FITCH. “SCIATIC-NERVE POTENTIALS-EVOKED BY DORSAL EPIDURAL SPINAL-CORD STIMULATION - DO THEY REFLECT CORTICOSPINAL TRACT FUNCTIONS.” Electroencephalography and Clinical Neurophysiology 61, no. 2 (January 1, 1985): P19–P19.
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  - Erwin, C. W., E. R. Somerville, and R. A. Radtke. “A review of electroencephalographic features of normal sleep.” J Clin Neurophysiol 1, no. 3 (July 1984): 253–74. https://doi.org/10.1097/00004691-198407000-00001.
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- Book Sections
  - Madala, R., and R. A. Radtke. “Approach to a Patient with Narcolepsy.” In Sleep Medicine in Neurology, 43–50, 2013. https://doi.org/10.1002/9781118764152.ch5.
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  - Chokroverty, S., R. A. Radtke, and J. M. Mullington. “Polysomnography: Technical and clinical aspects.” In Niedermeyer’s Electroencephalography: Basic Principles, Clinical Applications, and Related Fields: Sixth Edition, 817–64, 2012.
- Conference Papers
  - Urban, Thomas J., N. M. Walley, P. Nicoletti, E. L. Heinzen, D. Ge, K. V. Shianna, R. A. Radtke, and D. B. Goldstein. “NRXN1 VARIANTS ARE ASSOCIATED WITH BEHAVIORAL DIFFICULTY IN RESPONSE TO LEVETIRACETAM.” In Epilepsia, 50:98–98. WILEY-BLACKWELL PUBLISHING, INC, 2009.
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  - Edinger, J. D., J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. Chiang, A. D. Krystal, M. K. Means, and R. A. Radtke. “How valid are the DSM-IV-TR and ICSD-2 insomnia nosologies? Preliminary results from a multi-trait/multi-method diagnostic trial.” In Sleep, 31:A249–A249. OXFORD UNIV PRESS INC, 2008.
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  - Edinger, J. D., W. K. Wohlgemuth, R. A. Radtke, and G. R. Marsh. “Mediators of symptomatic improvements derived from behavioral insomnia therapy.” In Sleep, 27:266–67. OXFORD UNIV PRESS INC, 2004.
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  - Edinger, J. D., W. K. Wolhgemuth, R. A. Radtke, and G. R. Marsh. “Dose response effects of behavioral insomnia therapy: Final report.” In Sleep, 27:265–265. OXFORD UNIV PRESS INC, 2004.
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  - Edinger, J. D., W. K. Wohlgemuth, R. A. Radtke, and G. R. Marsh. “Dose response effects of behavioral insomnia therapy: Clinical trial update.” In Sleep, 26:A306–A306. AMER ACADEMY SLEEP MEDICINE, 2003.
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  - Means, M. K., K. L. Lichstein, J. D. Edinger, D. J. Taylor, H. H. Durrence, A. M. Husain, and R. A. Radtke. “Changes in Beck depression inventory (BDI) symptoms after continuous positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA).” In Sleep, 25:A218–19. AMER ACAD SLEEP MEDICINE, 2002.
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  - Edinger, J. D., W. K. Wohlgemuth, R. A. Radtke, G. R. Marsh, and R. E. Quillian. “Does cognitive-behavioral insomnia therapy really alter dysfunctional beliefs about sleep?” In Sleep, 24:A65–66. AMER ACAD SLEEP MEDICINE, 2001.
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  - Edinger, J. D., W. K. Wohlgemuth, R. A. Radtke, and G. R. Marsh. “Dose response effects of behavioral insomnia therapy: How many sessions are enough?” In Sleep, 24:A64–65. AMER ACAD SLEEP MEDICINE, 2001.
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  - Gibbs, J. W., and R. A. Radtke. “Excessive daytime somnolence and increased REM pressure in myotonic dystrophy.” In Sleep, 24:A37–38. AMER ACAD SLEEP MEDICINE, 2001.
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  - “Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group.” In Neurology, 54:1166–75, 2000. https://doi.org/10.1212/wnl.54.5.1166.
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  - Fry, D. “Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy.” In Annals of Neurology, 43:88–97. Wiley, 1998. https://doi.org/10.1002/ana.410430115.
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  - BELL, W. L., J. HORNER, and R. A. RADTKE. “NEOLOGISTIC SPEECH AUTOMATISMS DURING COMPLEX PARTIAL SEIZURES.” In Epilepsia, 29:686–686. LIPPINCOTT-RAVEN PUBL, 1988.
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  - RADTKE, R. A., E. R. HEINZ, B. J. CRAIN, D. V. LEWIS, J. O. MCNAMARA, and A. H. FRIEDMAN. “MAGNETIC-RESONANCE IMAGING - PATHOLOGIC CORRELATION AFTER TEMPORAL LOBECTOMY.” In Epilepsia, 29:684–684. LIPPINCOTT-RAVEN PUBL, 1988.
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  - WALCZAK, T. S., R. A. RADTKE, D. V. LEWIS, J. O. MCNAMARA, E. THOMPSON, A. H. FRIEDMAN, and B. S. NASHOLD. “FACTORS PREDICTING SUCCESS IN TEMPORAL LOBECTOMY FOR COMPLEX PARTIAL SEIZURES.” In Epilepsia, 28:610–610. LIPPINCOTT-RAVEN PUBL, 1987.
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  - RADTKE, R. A., T. P. BOHAN, D. V. LEWIS, and C. W. ERWIN. “ISOLATED ABSENCE OF WAVE-III IN BRAIN-STEM AUDITORY EVOKED-POTENTIALS - ARGUMENT FOR PARALLEL PATHWAYS OF WAVE FORM GENERATION.” In Electroencephalography and Clinical Neurophysiology, 64:P69–P69. ELSEVIER SCI IRELAND LTD, 1986.
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  - RADTKE, R. A., J. O. MCNAMARA, D. V. LEWIS, and E. R. HEINZ. “USEFULNESS OF MAGNETIC-RESONANCE-IMAGING IN PRESURGICAL EVALUATION OF INTRACTABLE COMPLEX PARTIAL SEIZURES.” In Epilepsia, 27:612–612. LIPPINCOTT-RAVEN PUBL, 1986.
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  - RADTKE, R. A., C. W. ERWIN, G. M. WORLEY, and W. J. OAKES. “BRAIN-STEM AUDITORY EVOKED-POTENTIALS IN CHILDREN WITH MYELOMENINGOCELE AND ARNOLD-CHIARI MALFORMATION.” In Electroencephalography and Clinical Neurophysiology, 64:P42–P42. ELSEVIER SCI IRELAND LTD, 1986.
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  - RADTKE, R. A., M. P. ROZEAR, and C. W. ERWIN. “USEFULNESS OF INTRAOPERATIVE BRAIN-STEM AUDITORY EVOKED-POTENTIALS.” In Electroencephalography and Clinical Neurophysiology, 64:P30–P30. ELSEVIER SCI IRELAND LTD, 1986.
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