Overview
Main focus is in epilepsy, sleep disorders, and clinical neurophysiology interpretation. Specific areas of interest include predictive outcome factors in epilepsy surgery, neuroimaging characteristics of neuronal migration disorders, development of new medical treatments of epilepsy and narcolepsy, and the pharmacogenetics of epilepsy and its treatment.
No involvement in basic laboratory research.
Ongoing clinical trials include:
1) Pharmacogenetics of epilepsy
2) behavioral treatment trial for insomnia
Special expertise recognized by serving on Professional Advisory Board of the Epilepsy Foundation of America and election as chairman of the American Board of Clinical Neurophysiology (certifying body in EEG, Evoked Potentials, Epilepsy Monitoring and Sleep).
Key words: Epilepsy
Epilepsy Surgery
Sleep Disorders
Sleep Apnea
Narcolepsy
Clinical Neurophysiology
No involvement in basic laboratory research.
Ongoing clinical trials include:
1) Pharmacogenetics of epilepsy
2) behavioral treatment trial for insomnia
Special expertise recognized by serving on Professional Advisory Board of the Epilepsy Foundation of America and election as chairman of the American Board of Clinical Neurophysiology (certifying body in EEG, Evoked Potentials, Epilepsy Monitoring and Sleep).
Key words: Epilepsy
Epilepsy Surgery
Sleep Disorders
Sleep Apnea
Narcolepsy
Clinical Neurophysiology
Current Appointments & Affiliations
Professor of Neurology
·
1999 - Present
Neurology, Epilepsy and Sleep,
Neurology
Director of the Sleep Lab in the Department of Neurology
·
2006 - Present
Neurology,
Clinical Science Departments
Recent Publications
Impact of antiseizure medication taper on electroencephalographic dynamics in focal epilepsy: A stereoelectroencephalographic study.
Journal Article Epilepsia · May 2026 OBJECTIVE: Tapering of the antiseizure medication dosage in the epilepsy monitoring unit can provoke seizures, but its effects on seizure dynamics remain poorly characterized. This study addresses three questions: (1) Does antiseizure medication tapering i ... Full text Link to item CiteTranscription Factor Binding and Individual Genetic Risk of Valproate Teratogenicity.
Journal Article Neurology · February 10, 2026 BACKGROUND AND OBJECTIVES: Valproate (VPA) use during pregnancy is associated with a wide range of structural birth defects, but not all exposed children are affected and there is evidence for a genetic predisposition. The development of a pharmacogenomic ... Full text Link to item CiteFunctional consequence of pathogenic GABRA3 variants determines whether X-linked inheritance is dominant or recessive.
Journal Article J Clin Invest · January 16, 2026 Disorders of GABRA3, the only epilepsy-associated GABAA receptor subunit gene on the X chromosome, have eluded clinical clarity due to ambiguous inheritance patterns and variable phenotypes. The long-standing assumption that all pathogenic variants cause l ... Full text Link to item CiteRecent Grants
Exploratory genomic investigations of mesial temporal lobe epilepsy
ResearchCo Investigator · Awarded by National Institutes of Health · 2012 - 2015Classifying Psychiatric, Medical, and Primary Insomnias
ResearchClinical Interviewer · Awarded by National Institutes of Health · 2003 - 2009same
ResearchCo Investigator · Awarded by National Institutes of Health · 1994 - 2003View All Grants
Education
Northwestern University ·
1980
M.D.