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Rodney Allan Radtke

Professor of Neurology
Neurology, Epilepsy and Sleep
2424 Erwin Road, Suite 1001 Dept of Neurology, DUMC 2720, Durham, NC 27705
2424 Erwin Road, Suite 1001, DUMC 2720, Durham, NC 27705

Selected Publications


Rare Genetic Variation and Outcome of Surgery for Mesial Temporal Lobe Epilepsy.

Journal Article Ann Neurol · December 19, 2022 OBJECTIVE: Genetic factors have long been debated as a cause of failure of surgery for mesial temporal lobe epilepsy (MTLE). We investigated whether rare genetic variation influences seizure outcomes of MTLE surgery. METHODS: We performed an international, ... Full text Link to item Cite

Efficacy and safety of VNS therapy or continued medication management for treatment of adults with drug-resistant epilepsy: systematic review and meta-analysis.

Journal Article J Neurol · June 2022 Vagus nerve stimulation (VNS) Therapy® is an adjunctive neurostimulation treatment for people with drug-resistant epilepsy (DRE) who are unwilling to undergo resective surgery, have had unsuccessful surgery or are unsuitable for surgery. A systematic revie ... Full text Open Access Link to item Cite

Association of ultra-rare coding variants with genetic generalized epilepsy: A case-control whole exome sequencing study.

Journal Article Epilepsia · March 2022 OBJECTIVE: We aimed to identify genes associated with genetic generalized epilepsy (GGE) by combining large cohorts enriched with individuals with a positive family history. Secondarily, we set out to compare the association of genes independently with fam ... Full text Link to item Cite

Genomic analysis of "microphenotypes" in epilepsy.

Journal Article Am J Med Genet A · January 2022 Large international consortia examining the genomic architecture of the epilepsies focus on large diagnostic subgroupings such as "all focal epilepsy" and "all genetic generalized epilepsy". In addition, phenotypic data are generally entered into these lar ... Full text Link to item Cite

Successful Neonatal, Intraoperative Neuromonitoring in the Surgical Correction of a Thoracic Dermal Sinus Tract: Technical Note.

Journal Article Pediatr Neurosurg · 2022 INTRODUCTION: Intraoperative neuromonitoring (IONM) is commonly used during surgery of the spine and spinal cord for early surveillance of iatrogenic injury to the central and peripheral nervous system. However, for infants and young children under 3 years ... Full text Link to item Cite

Pediatric Sleep Pearls.

Journal Article J Clin Neurophysiol · November 1, 2020 Full text Link to item Cite

Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load.

Journal Article Ann Neurol · June 2020 OBJECTIVE: The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED-induced BDs may result from a genome-wide increase of de novo variants in the embryo, a mechanism that we investigated. METHODS: Whol ... Full text Link to item Cite

Genomic and clinical predictors of lacosamide response in refractory epilepsies.

Journal Article Epilepsia Open · December 2019 OBJECTIVE: Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real-world clinical setting. METHODS: We tested the association of clinical predictors with treatme ... Full text Link to item Cite

Serum sodium levels and related treatment-emergent adverse events during eslicarbazepine acetate use in adults with epilepsy.

Journal Article Epilepsia · July 2019 OBJECTIVE: To examine the frequency of hyponatremia and potentially related symptoms in clinical trials of eslicarbazepine acetate (ESL) in adults with focal- (partial-) onset seizures. METHODS: This post hoc, exploratory analysis included data from three ... Full text Link to item Cite

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.

Journal Article Nat Commun · December 10, 2018 The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant l ... Full text Link to item Cite

The phenotype of bilateral hippocampal sclerosis and its management in "real life" clinical settings.

Journal Article Epilepsia · July 2018 OBJECTIVE: There is little detailed phenotypic characterization of bilateral hippocampal sclerosis (HS). We therefore conducted a multicenter review of people with pharmacoresistant epilepsy and bilateral HS to better determine their clinical characteristi ... Full text Link to item Cite

Analysis of shared heritability in common disorders of the brain.

Journal Article Science · June 22, 2018 Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 pa ... Full text Link to item Cite

Epilepsy in neurofibromatosis type 1.

Journal Article Epilepsy Behav · August 2017 OBJECTIVES: To describe the characteristics of epilepsy in patients with Neurofibromatosis type 1 (NF1). METHODS: Analysis of a cohort of consecutive NF1 patients seen in our NF1 clinic during a three-year period. RESULTS: Of the 184 NF1 patients seen duri ... Full text Link to item Cite

Ultra-rare genetic variation in common epilepsies: a case-control sequencing study.

Journal Article Lancet Neurol · February 2017 BACKGROUND: Despite progress in understanding the genetics of rare epilepsies, the more common epilepsies have proven less amenable to traditional gene-discovery analyses. We aimed to assess the contribution of ultra-rare genetic variation to common epilep ... Full text Link to item Cite

Differential gene expression in dentate granule cells in mesial temporal lobe epilepsy with and without hippocampal sclerosis.

Journal Article Epilepsia · March 2016 OBJECTIVE: Hippocampal sclerosis is the most common neuropathologic finding in cases of medically intractable mesial temporal lobe epilepsy. In this study, we analyzed the gene expression profiles of dentate granule cells of patients with mesial temporal l ... Full text Link to item Cite

Challenges in identifying Lennox-Gastaut syndrome in adults: A case series illustrating its changing nature.

Journal Article Epilepsy Behav Case Rep · 2016 The variable presentation and progression of Lennox-Gastaut syndrome (LGS) can make it difficult to recognize, particularly in adults. To improve diagnosis, a retrospective chart review was conducted on patients who were diagnosed as adults and/or were fol ... Full text Link to item Cite

Diagnostic Accuracy of Electrographic Seizure Detection by Neurophysiologists and Non-Neurophysiologists in the Adult ICU Using a Panel of Quantitative EEG Trends.

Journal Article J Clin Neurophysiol · August 2015 PURPOSE: To evaluate the sensitivity and specificity of a panel of quantitative EEG (qEEG) trends for seizure detection in adult intensive care unit (ICU) patients when reviewed by neurophysiologists and non-neurophysiologists. METHODS: One hour qEEG panel ... Full text Open Access Link to item Cite

Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.

Journal Article Lancet Neurol · September 2014 BACKGROUND: The epilepsies are a clinically heterogeneous group of neurological disorders. Despite strong evidence for heritability, genome-wide association studies have had little success in identification of risk loci associated with epilepsy, probably b ... Full text Link to item Cite

Rare Genetic Variation and Outcome of Surgery for Mesial Temporal Lobe Epilepsy.

Journal Article Ann Neurol · December 19, 2022 OBJECTIVE: Genetic factors have long been debated as a cause of failure of surgery for mesial temporal lobe epilepsy (MTLE). We investigated whether rare genetic variation influences seizure outcomes of MTLE surgery. METHODS: We performed an international, ... Full text Link to item Cite

Efficacy and safety of VNS therapy or continued medication management for treatment of adults with drug-resistant epilepsy: systematic review and meta-analysis.

Journal Article J Neurol · June 2022 Vagus nerve stimulation (VNS) Therapy® is an adjunctive neurostimulation treatment for people with drug-resistant epilepsy (DRE) who are unwilling to undergo resective surgery, have had unsuccessful surgery or are unsuitable for surgery. A systematic revie ... Full text Open Access Link to item Cite

Association of ultra-rare coding variants with genetic generalized epilepsy: A case-control whole exome sequencing study.

Journal Article Epilepsia · March 2022 OBJECTIVE: We aimed to identify genes associated with genetic generalized epilepsy (GGE) by combining large cohorts enriched with individuals with a positive family history. Secondarily, we set out to compare the association of genes independently with fam ... Full text Link to item Cite

Genomic analysis of "microphenotypes" in epilepsy.

Journal Article Am J Med Genet A · January 2022 Large international consortia examining the genomic architecture of the epilepsies focus on large diagnostic subgroupings such as "all focal epilepsy" and "all genetic generalized epilepsy". In addition, phenotypic data are generally entered into these lar ... Full text Link to item Cite

Successful Neonatal, Intraoperative Neuromonitoring in the Surgical Correction of a Thoracic Dermal Sinus Tract: Technical Note.

Journal Article Pediatr Neurosurg · 2022 INTRODUCTION: Intraoperative neuromonitoring (IONM) is commonly used during surgery of the spine and spinal cord for early surveillance of iatrogenic injury to the central and peripheral nervous system. However, for infants and young children under 3 years ... Full text Link to item Cite

Pediatric Sleep Pearls.

Journal Article J Clin Neurophysiol · November 1, 2020 Full text Link to item Cite

Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load.

Journal Article Ann Neurol · June 2020 OBJECTIVE: The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED-induced BDs may result from a genome-wide increase of de novo variants in the embryo, a mechanism that we investigated. METHODS: Whol ... Full text Link to item Cite

Genomic and clinical predictors of lacosamide response in refractory epilepsies.

Journal Article Epilepsia Open · December 2019 OBJECTIVE: Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real-world clinical setting. METHODS: We tested the association of clinical predictors with treatme ... Full text Link to item Cite

Serum sodium levels and related treatment-emergent adverse events during eslicarbazepine acetate use in adults with epilepsy.

Journal Article Epilepsia · July 2019 OBJECTIVE: To examine the frequency of hyponatremia and potentially related symptoms in clinical trials of eslicarbazepine acetate (ESL) in adults with focal- (partial-) onset seizures. METHODS: This post hoc, exploratory analysis included data from three ... Full text Link to item Cite

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.

Journal Article Nat Commun · December 10, 2018 The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant l ... Full text Link to item Cite

The phenotype of bilateral hippocampal sclerosis and its management in "real life" clinical settings.

Journal Article Epilepsia · July 2018 OBJECTIVE: There is little detailed phenotypic characterization of bilateral hippocampal sclerosis (HS). We therefore conducted a multicenter review of people with pharmacoresistant epilepsy and bilateral HS to better determine their clinical characteristi ... Full text Link to item Cite

Analysis of shared heritability in common disorders of the brain.

Journal Article Science · June 22, 2018 Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 pa ... Full text Link to item Cite

Epilepsy in neurofibromatosis type 1.

Journal Article Epilepsy Behav · August 2017 OBJECTIVES: To describe the characteristics of epilepsy in patients with Neurofibromatosis type 1 (NF1). METHODS: Analysis of a cohort of consecutive NF1 patients seen in our NF1 clinic during a three-year period. RESULTS: Of the 184 NF1 patients seen duri ... Full text Link to item Cite

Ultra-rare genetic variation in common epilepsies: a case-control sequencing study.

Journal Article Lancet Neurol · February 2017 BACKGROUND: Despite progress in understanding the genetics of rare epilepsies, the more common epilepsies have proven less amenable to traditional gene-discovery analyses. We aimed to assess the contribution of ultra-rare genetic variation to common epilep ... Full text Link to item Cite

Differential gene expression in dentate granule cells in mesial temporal lobe epilepsy with and without hippocampal sclerosis.

Journal Article Epilepsia · March 2016 OBJECTIVE: Hippocampal sclerosis is the most common neuropathologic finding in cases of medically intractable mesial temporal lobe epilepsy. In this study, we analyzed the gene expression profiles of dentate granule cells of patients with mesial temporal l ... Full text Link to item Cite

Challenges in identifying Lennox-Gastaut syndrome in adults: A case series illustrating its changing nature.

Journal Article Epilepsy Behav Case Rep · 2016 The variable presentation and progression of Lennox-Gastaut syndrome (LGS) can make it difficult to recognize, particularly in adults. To improve diagnosis, a retrospective chart review was conducted on patients who were diagnosed as adults and/or were fol ... Full text Link to item Cite

Diagnostic Accuracy of Electrographic Seizure Detection by Neurophysiologists and Non-Neurophysiologists in the Adult ICU Using a Panel of Quantitative EEG Trends.

Journal Article J Clin Neurophysiol · August 2015 PURPOSE: To evaluate the sensitivity and specificity of a panel of quantitative EEG (qEEG) trends for seizure detection in adult intensive care unit (ICU) patients when reviewed by neurophysiologists and non-neurophysiologists. METHODS: One hour qEEG panel ... Full text Open Access Link to item Cite

Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.

Journal Article Lancet Neurol · September 2014 BACKGROUND: The epilepsies are a clinically heterogeneous group of neurological disorders. Despite strong evidence for heritability, genome-wide association studies have had little success in identification of risk loci associated with epilepsy, probably b ... Full text Link to item Cite

Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.

Journal Article Am J Hum Genet · August 10, 2012 Idiopathic generalized epilepsy (IGE) is a complex disease with high heritability, but little is known about its genetic architecture. Rare copy-number variants have been found to explain nearly 3% of individuals with IGE; however, it remains unclear wheth ... Full text Link to item Cite

Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.

Journal Article Pharmacogenomics · March 2012 AIMS: An association between carbamazepine-induced hypersensitivity and HLA-A*3101 has been reported in populations of both European and Asian descent. We aimed to investigate HLA-A*3101 and other common variants across the genome as markers for cutaneous ... Full text Link to item Cite

Genetic and environmental correlates of topiramate-induced cognitive impairment.

Journal Article Epilepsia · January 2012 Topiramate is an antiepileptic drug that has marked treatment-limiting side effects on specific aspects of cognitive performance in both patients and healthy volunteers. Because these severe side effects occur only in certain individuals, identifying genet ... Full text Link to item Cite

Sleep/wake electroencephalography across the lifespan

Journal Article Sleep Medicine Clinics · January 1, 2012 The development of organized sleep/wake states is a major feature of the neonatal period and developing infant. Although subsequent changes in the sleep/wake cycle with age are less profound, they represent predictable physiologic changes occurring as a fu ... Full text Cite

Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis.

Journal Article Arch Gen Psychiatry · October 2011 CONTEXT: Distinctive diagnostic classification schemes for insomnia diagnoses are available, but the optimal insomnia nosology has yet to be determined. OBJECTIVES: To test the reliability and validity of insomnia diagnoses listed in the American Psychiatr ... Full text Link to item Cite

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

Journal Article N Engl J Med · March 24, 2011 BACKGROUND: Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syn ... Full text Link to item Cite

Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

Journal Article Brain · July 2010 Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease r ... Full text Link to item Cite

Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.

Journal Article Am J Hum Genet · May 14, 2010 Deletions at 16p13.11 are associated with schizophrenia, mental retardation, and most recently idiopathic generalized epilepsy. To evaluate the role of 16p13.11 deletions, as well as other structural variation, in epilepsy disorders, we used genome-wide sc ... Full text Link to item Cite

CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.

Journal Article J Pharmacol Exp Ther · February 2010 The commonly prescribed antiepileptic drug phenytoin has a narrow therapeutic range and wide interindividual variability in clearance explained in part by CYP2C9 and CYP2C19 coding variants. After finding a paradoxically low urinary phenytoin metabolite (S ... Full text Link to item Cite

Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.

Journal Article Lancet Neurol · November 2007 BACKGROUND: The Epilepsy Genetics (EPIGEN) Consortium was established to undertake genetic mapping analyses with augmented statistical power to detect variants that influence the development and treatment of common forms of epilepsy. METHODS: We examined c ... Full text Link to item Cite

Dose-response effects of cognitive-behavioral insomnia therapy: a randomized clinical trial.

Journal Article Sleep · February 2007 SUBJECT OBJECTIVE: To determine the optimal number of therapist-guided Cognitive-Behavioral Insomnia Therapy (CBT) sessions required for treating primary sleep-maintenance insomnia. DESIGN AND SETTING: Randomized, parallel-group, clinical trial at a single ... Full text Link to item Cite

EEG of partial seizures.

Journal Article J Clin Neurophysiol · August 2006 EEG remains the primary technique in the diagnosis, characterization, and localization of partial seizures. This review examines the significance and character of interictal epileptiform abnormalities, periodic lateralized epileptiform discharges, and icta ... Full text Link to item Cite

Video/EEG monitoring in the evaluation of paroxysmal behavioral events: duration, effectiveness, and limitations.

Journal Article Epilepsy Behav · February 2006 To establish the number of monitoring days needed to distinguish psychogenic nonepileptic seizures (PNES) from epileptic seizures (ES) in adult patients admitted for video/EEG monitoring (VEM), we performed a retrospective chart review on 199 consecutive a ... Full text Link to item Cite

Changes in depressive symptoms after continuous positive airway pressure treatment for obstructive sleep apnea.

Journal Article Sleep Breath · March 2003 It is generally believed that obstructive sleep apnea (OSA) causes depression in some patients, yet it is unknown whether this depression is an actual clinical phenomenon or purely a result of overlapping somatic/physical symptoms shared by both disorders. ... Full text Link to item Cite

Excessive daytime somnolence and increased rapid eye movement pressure in myotonic dystrophy.

Journal Article Sleep · September 15, 2002 STUDY OBJECTIVES: Sleep studies at Duke University Medical Center were retrospectively reviewed to investigate causes of excessive daytime sleepiness (EDS) in our myotonic dystrophy1 (DM1) patient population, identified by an abnormal CTG expansion on chro ... Full text Link to item Cite

Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.

Journal Article Epilepsy Res · November 2001 Determination of side of seizure onset is critical for a successful outcome following epilepsy surgery. Little is known about the significance of lateralized seizure termination. Sustained seizure activity contralateral to side of seizure onset, following ... Full text Link to item Cite

Does cognitive-behavioral insomnia therapy alter dysfunctional beliefs about sleep?

Journal Article Sleep · August 1, 2001 STUDY OBJECTIVES: This study was conducted to exam the degree to which cognitive-behavioral insomnia therapy (CBT) reduces dysfunctional beliefs about sleep and to determine if such cognitive changes correlate with sleep improvements. DESIGN: The study use ... Full text Link to item Cite

Slow wave sleep rebound and REM rebound following the first night of treatment with CPAP for sleep apnea: correlation with subjective improvement in sleep quality.

Journal Article Sleep Med · May 2001 Objective: The purpose of this study was to correlate changes in PSG parameters between the diagnostic polysomnogram (dPSG) and the first night of treatment with continuous positive airway pressure (CPAP) (cpapPSG) to subjective improvement in sleep qualit ... Full text Link to item Cite

Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial.

Journal Article JAMA · April 11, 2001 CONTEXT: Use of nonpharmacological behavioral therapy has been suggested for treatment of chronic primary insomnia, but well-blinded, placebo-controlled trials demonstrating effective behavioral therapy for sleep-maintenance insomnia are lacking. OBJECTIVE ... Full text Link to item Cite

Sleep disorders in neurology.

Journal Article J Clin Neurophysiol · March 2001 Full text Link to item Cite

Interactions between sleep and epilepsy.

Journal Article J Clin Neurophysiol · March 2001 Sleep is one of the best-documented factors influencing the expression of seizures and interictal discharges. Janz studied the relation between seizures and the sleep/wake cycle and divided the epilepsies into three categories: nocturnal, awakening, and di ... Full text Link to item Cite

Phasic and tonic coupling between EEG and EMG demonstrated with independent component analysis.

Journal Article J Clin Neurophysiol · January 2001 The authors describe a method for demonstrating the tonic and phasic couplings between suitably time-aligned surface eletromyographs (sEMGs) and the simultaneously recorded EEGs. The method, based on independent component analysis, was applied to data reco ... Full text Link to item Cite

Pharmacokinetics of levetiracetam.

Journal Article Epilepsia · 2001 Major considerations in the acceptance and impact of new antiepileptic drugs include their pharmacokinetics and their potential for interaction with other drugs. The pharmacokinetics of levetiracetam, a newly approved add-on antiepileptic agent for partial ... Full text Link to item Cite

Periventricular nodular heterotopia in patients with filamin-1 gene mutations: neuroimaging findings.

Journal Article Pediatr Radiol · November 2000 BACKGROUND: The filamin-1 (FLN-1) gene is responsible for periventricular nodular heterotopia (PNH), which is an X-linked dominant neuronal migration disorder. OBJECTIVE: To review the clinical and imaging findings in a series of patients with documented f ... Full text Link to item Cite

Characteristics of valproic acid resistant juvenile myoclonic epilepsy.

Journal Article Seizure · September 2000 Juvenile myoclonic epilepsy (JME) is often exquisitely responsive to treatment with valproic acid (VPA). However, a subset of patients does not respond to this medication and often has intractable seizures. We wanted to identify differences between these t ... Full text Link to item Cite

Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial.

Journal Article Neurology · July 25, 2000 OBJECTIVE: To evaluate the efficacy and safety of 500 mg bid and 1500 mg bid levetiracetam as adjunctive therapy for refractory partial seizures in a double-blind, randomized, placebo-controlled, parallel-group, multicenter trial. METHODS: The authors stud ... Full text Link to item Cite

Inhibitory simple partial (non-convulsive) status epilepticus after intracranial surgery.

Journal Article J Neurol Neurosurg Psychiatry · July 2000 OBJECTIVES: To report on five patients who developed, 2 to 4 days after an intracranial neurosurgical procedure, new, persistent, focal neurological deficits which were due to inhibitory simple partial (non-convulsive) status epilepticus, and resolved with ... Full text Link to item Cite

Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group.

Conference Neurology · March 14, 2000 OBJECTIVE: This is one of two separate clinical trials to evaluate the efficacy and safety of modafinil, a novel wake-promoting agent, in patients with excessive daytime sleepiness (EDS) associated with narcolepsy. METHODS: In this 9-week, randomized, plac ... Full text Link to item Cite

Improved sexual function in three men taking lamotrigine for epilepsy.

Journal Article South Med J · March 2000 Little information exists about the effects of newer antiepileptic drugs (AEDs) on sexual function in men with epilepsy. We report a series of three male veterans whose sexual disorders improved with lamotrigine. All three had partial seizures. One patient ... Link to item Cite

Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis.

Journal Article Neurology · February 8, 2000 OBJECTIVE: To determine seizure outcome and its predictors in patients with medically refractory temporal lobe epilepsy (TLE) after temporal lobectomy (TL). BACKGROUND: TL is the most common surgical procedure performed in adolescents and adults for the tr ... Full text Link to item Cite

A case of sustained massive gabapentin overdose without serious side effects.

Journal Article Ther Drug Monit · December 1999 Gabapentin is an antiepileptic agent that is indicated for use as adjunctive therapy for partial seizures. It has a relatively benign side effect profile, but little data exists on massive overdoses with this agent. The authors present a case of a patient ... Full text Link to item Cite

Lamotrigine-induced blepharospasm.

Journal Article Pharmacotherapy · July 1999 Movement disorders such as tremor and ataxia occur commonly during therapy with antiepileptic drugs (AEDs). Dystonias, however, are rare. Blepharospasm, although reported with neuroleptic agents, has never been reported with AEDs. Our patient developed ble ... Full text Link to item Cite

Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy.

Journal Article Epilepsia · January 1999 PURPOSE: Interictal [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) reveals regional hypometabolism in 60-80% of patients with mesial temporal lobe epilepsy (MTLE). The extent of hypometabolism generally extends beyond the epileptogenic zo ... Full text Link to item Cite

Succinylcholine induced hyperkalemia and cardiac arrest death related to an EEG study.

Journal Article J Clin Neurophysiol · January 1999 Changes in EEGs during cardiac arrest have been described in detail by many authors; however, mortality because of an EEG has never been reported. The authors report the case of a patient who developed cardiac arrest causally related to administration of s ... Full text Link to item Cite

Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis.

Journal Article J Clin Neurophysiol · January 1999 Generalized periodic epileptiform discharges (GPEDs) are generalized, synchronous electrographic discharges. This study investigates etiologies, relationship to status epilepticus (SE), and the prognosis for patients with GPEDs. All EEGs with GPEDs perform ... Full text Link to item Cite

Seizure onset from periventricular nodular heterotopias: depth-electrode study.

Journal Article Neurology · December 1998 The association between gray matter heterotopias and seizures is well established; whether seizures originate from these lesions is not known. We evaluated three patients with intractable complex partial seizures and periventricular nodular heterotopias (P ... Full text Link to item Cite

Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.

Journal Article Neuron · December 1998 Long-range, directed migration is particularly dramatic in the cerebral cortex, where postmitotic neurons generated deep in the brain migrate to form layers with distinct form and function. In the X-linked dominant human disorder periventricular heterotopi ... Full text Link to item Cite

Ictal cognitive assessment of partial seizures and pseudoseizures.

Journal Article Arch Neurol · November 1998 BACKGROUND: Previous studies suggest that responsiveness is impaired during complex partial seizures (CPS) and pseudoseizures (PS); however, to our knowledge, there has been no systematic comparison using both response and memory testing. OBJECTIVE: To com ... Full text Link to item Cite

Cost analysis of analog versus digital elctroencephalography

Journal Article Neurodiagnostic Journal · September 1, 1998 Though analog electroencephalography (AEEG) has been used by EEG laboratories for many years, many laboratories have switched recently to the newer digital EEG (DEEG) technology. We analyzed the cost-effectiveness and long-term financial implications of DE ... Cite

Migratory leptomeningeal inflammation with relapsing polychondritis.

Journal Article Neurology · August 1998 We report a case of relapsing polychondritis with focal sensorimotor seizures, aseptic meningitis, and migratory leptomeningeal enhancement on contrast MRI. These abnormalities on imaging studies correlated accurately with laterality of the patient's seizu ... Full text Link to item Cite

Surgical outcome in patients with epilepsy with occult vascular malformations treated with lesionectomy.

Journal Article Epilepsia · June 1998 PURPOSE: This retrospective study reports the long-term surgical outcome of patients with medically refractory epilepsy and vascular malformations who were treated with lesionectomy. A detailed analysis of surgical failures had been performed in an attempt ... Full text Link to item Cite

Sexual dysfunction in male veterans with epilepsy

Journal Article Journal of Epilepsy · May 1, 1998 Much has been written about sexual dysfunction in men with epilepsy. We wanted to determine the frequency and nature of sexual disorders in our highly selected population of male veterans. Charts of the 184 men with epilepsy followed in the Neurodiagnostic ... Full text Cite

Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy

Conference Annals of Neurology · January 1998 AbstractNarcolepsy is a central nervous system disorder characterized by excessive daytime sleepiness and cataplexy. This placebocontrolled, double‐blind, randomized, parallel‐group, 18‐center study assessed the efficacy an ... Full text Cite

Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.

Journal Article Arch Ophthalmol · December 1997 OBJECTIVE: To assess the 5-year visual course, including the incidence of recurrent optic neuritis, in 454 patients enrolled in the Optic Neuritis Treatment Trial. METHODS: Five-year follow-up vision testing, which included measures of visual acuity, contr ... Link to item Cite

Painful generalised clonic and tonic-clonic seizures with retained consciousness.

Journal Article J Neurol Neurosurg Psychiatry · December 1997 Two patients in whom consciousness and memory were retained during bilateral clonic or tonic-clonic seizures are reported on, and three patients reported on previously are reviewed. Ictal semiology differed from myoclonic and supplementary motor seizures, ... Full text Link to item Cite

Clinical and electrographic manifestations of lesional neocortical temporal lobe epilepsy.

Journal Article Neurology · September 1997 To determine whether lesional neocortical temporal lobe epilepsy (NTLE) can be differentiated from mesial temporal lobe epilepsy (MTLE) during the noninvasive presurgical evaluation, we compared the historical features, seizure symptomatology, and surface ... Full text Link to item Cite

Depression in sleep disorders clinics.

Journal Article Sleep Breath · September 1997 PURPOSE: The purpose of this paper was to determine the incidence of depression in our sleep disorders clinics (and it's relation to patient characteristics) and to determine whether the incidence of depression varies in patients with and without sleep apn ... Full text Link to item Cite

Disease expression among probands with juvenile myoclonic epilepsy and their family members in two population groups

Journal Article Journal of Epilepsy · December 1, 1996 We report clinical and EEG features of 65 probands with juvenile myoclonic epilepsy (JME) and the occurrence and character of epilepsy among 664 blood relatives of 26 of the 65 probands with a positive family history of seizures. Forty-six families from In ... Full text Cite

Physician practices in the diagnostic evaluation of suspected Obstructive Sleep Apnea (OSA)

Journal Article Chest · October 1, 1996 Purpose: To determine if physician training alters diagnostic testing for suspected OSA. Methods: Questionnaires were mailed to a random national sample of 2000 board-certified physicians from various specialties. Physicians were asked which diagnostic tes ... Cite

Variation in physician threshold to treat Obstructive Sleep Apnea (OSA)

Journal Article Chest · October 1, 1996 Purpose: To determine the factors which influence physician decision making in regard to the threshold for treatment in OSA. Methods: Questionnaires were mailed to a random national sample of 2000 board-certified physicians from various specialties. Physic ... Cite

Predictors of outcome of epilepsy surgery: multivariate analysis with validation.

Journal Article Epilepsia · September 1996 PURPOSE: To identify predictors of outcome of epilepsy surgery, using the Duke experience, applying multivariate analysis and validation techniques. To compare the results of different modeling algorithms. Few previous studies have reported multivariate an ... Full text Link to item Cite

X-linked malformations of neuronal migration.

Journal Article Neurology · August 1996 Malformations of neuronal migration such as lissencephaly (agyria-pachygyria spectrum) are well-known causes of mental retardation and epilepsy that are often genetic. For example, isolated lissencephaly sequence and Miller-Dieker syndrome are caused by de ... Full text Link to item Cite

Outcome of temporal lobectomy in adolescents

Journal Article Journal of Epilepsy · January 1, 1996 We performed temporal lobectomy in 23 young patients with intractable complex partial seizures (CPS) at an average age of 14.5 years. At a mean follow-up interval of 4.8 years, we reevaluated the patients to assess the surgical outcome; 74% were seizure-fr ... Full text Cite

Periventricular and subcortical nodular heterotopia. A study of 33 patients.

Journal Article Brain · October 1995 Grey matter heterotopias, demonstrated by MRI, may present with a broad spectrum of clinical severity. We have studied 33 patients with periventricular nodular heterotopias (PNH); 19 (58%) had unilateral and 14 (42%) bilateral lesions. Thirteen of the 19 p ... Full text Link to item Cite

Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients.

Journal Article Epilepsia · September 1995 To assess the value of magnetic resonance imaging (MRI)-measured hippocampal volume in the detection of hippocampal sclerosis, we studied 28 patients undergoing anterior temporal lobectomy for medically intractable mesial temporal lobe epilepsy. Hippocampa ... Full text Link to item Cite

Alpers' syndrome presenting with seizures and multiple stroke-like episodes in a 17-year-old male.

Journal Article Clin Neuropathol · 1995 Alpers' syndrome is a progressive neurodegenerative disorder with liver disease that usually presents in the first few years of life. Only rarely have patients presented later in life with delayed onset of Alpers' syndrome. Herein we present a case of a 17 ... Link to item Cite

Ipsilateral subcortical atrophy associated with temporal lobectomy.

Journal Article Psychiatry Res · December 1994 Stereologic methods for determining the volume of cerebral structures in vivo via magnetic resonance imaging have identified unilateral hippocampal atrophy among patients with complex partial epilepsy of temporal lobe origin. Metabolic imaging has also ide ... Full text Link to item Cite

Treatment of radiation-induced nervous system injury with heparin and warfarin.

Journal Article Neurology · November 1994 When radiation is used to treat nervous system cancer, exposure of adjacent normal nervous system tissue is unavoidable, and radiation-induced injury may occur. Acute injury is usually mild and transient, but late forms of radiation-induced nervous system ... Full text Link to item Cite

BAEPs in infants with myelomeningocele and later development of Chiari II malformation-related brainstem dysfunction.

Journal Article Dev Med Child Neurol · August 1994 Thirty-seven infants with myelomeningocele received brainstem auditory evoked potentials (BAEPs) at a median age of eight days. No infant had brainstem dysfunction at the time of testing. Median follow-up was at 30 months. Of 12 infants who subsequently de ... Full text Link to item Cite

MR and positron emission tomography in the diagnosis of surgically correctable temporal lobe epilepsy.

Journal Article AJNR Am J Neuroradiol · August 1994 PURPOSE: To determine the association of an MR abnormality and a positron emission tomography (PET) abnormality with a good outcome in patients with temporal lobe epilepsy after lobectomy, the association of combined PET and MR findings with good outcomes ... Link to item Cite

Focal cerebral metabolic abnormality in a patient with continuous spike waves during slow-wave sleep.

Journal Article J Child Neurol · April 1994 We report an 11-year-old boy with continuous spike-wave discharges during sleep accompanied by partial motor and atypical absence seizures, psychomotor regression, and severe behavior problems. During wakefulness, epileptiform discharges occurred over the ... Full text Link to item Cite

Neuronal migration disorders: positron emission tomography correlations.

Journal Article Ann Neurol · March 1994 We analyzed the interictal [18F]fluoro-2-deoxy-D-glucose positron emission tomography (PET) findings of 17 epileptic patients with neuronal migration disorders (NMDs). Fifteen patients had abnormal PET findings, i.e., focal hypometabolism in 9 patients and ... Full text Link to item Cite

Positron emission tomography: Comparison of clinical utility in temporal lobe and extratemporal epilepsy

Journal Article Journal of Epilepsy · January 1, 1994 Sixty consecutive patients admitted for possible surgical treatment of intractable epilepsy underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) as part of a standardized presurgical protocol. Patients were classified as having tempora ... Full text Cite

Temporal lobe hypometabolism [8]

Journal Article Neurology · 1994 Cite

Complex partial seizures and mesial temporal sclerosis: evaluation with fast spin-echo MR imaging.

Journal Article Radiology · December 1993 PURPOSE: This study was performed to determine the sensitivity and specificity of fast spin-echo (FSE) magnetic resonance (MR) imaging in detecting mesial temporal sclerosis. MATERIALS AND METHODS: Twenty-one patients with a diagnosis of complex partial se ... Full text Link to item Cite

Use of in vivo desensitization to treat a patient's claustrophobic response to nasal CPAP.

Journal Article Sleep · October 1993 Continuous positive airway pressure (CPAP) has proven to be a safe, effective treatment for sleep apnea patients. However, many patients display claustrophobic reactions to the CPAP nasal mask and cannot tolerate this treatment. The current report describe ... Link to item Cite

Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy.

Journal Article Neurology · June 1993 To investigate the relationship of temporal lobe hypometabolism demonstrated on PET to surgical outcome and underlying pathology, we reviewed 30 consecutive epilepsy patients who underwent interictal PET studies with 18F fluorodeoxyglucose before temporal ... Full text Link to item Cite

THE PREDICTIVE IMPORTANCE OF FDG-PET IN PATIENTS WITH TEMPORAL-LOBE SEIZURES

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 1993 Link to item Cite

ECT-induced status.

Journal Article Neurology · April 1993 Full text Link to item Cite

Spontaneous temporal encephalocele. Case report.

Journal Article J Neurosurg · March 1993 The authors report a 36-year-old woman with a 23-year history of simple and complex partial seizures who was treated surgically for an anteroinferior temporal encephalocele, with resolution of the seizure disorder. This patient's presentation, findings, an ... Full text Link to item Cite

False lateralization of scalp EEG seizure onset

Journal Article Journal of Epilepsy · January 1, 1993 We report a patient with lateralized right-sided ictal scalp EEG activity contralateral to left mesial temporal seizure onset as documented by depth electrodes. Subsequent left temporal lobectomy revealed mesial temporal sclerosis and resulted in a marked ... Full text Cite

ECT-induced status [3]

Journal Article Neurology · 1993 Cite

Accuracy and interobserver reliability of scalp ictal EEG.

Journal Article Neurology · December 1992 We studied the accuracy and reliability of scalp ictal EEG in 137 complex partial seizures (119 temporal and 18 extratemporal) in 35 patients in whom we knew the correct site of seizure origin because all patients had been seizure-free for more than 2 year ... Full text Link to item Cite

Periodic limb movement variability in older DIMS patients across consecutive nights of home monitoring.

Journal Article Sleep · April 1992 Older difficulty initiating and/or maintaining sleep (DIMS) patients who met criteria for periodic limb movement disorder (PLMD) were monitored for three consecutive nights in their homes using ambulatory polysomnography (PSG). Correlational analyses of th ... Link to item Cite

Preferred instruments, inc.

Journal Article Journal of Clinical Neurophysiology · January 1, 1992 Cite

The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group.

Journal Article Arch Ophthalmol · December 1991 The baseline characteristics of 448 eligible patients entered into the Optic Neuritis Treatment Trial are described in an effort to summarize the clinical profile of acute optic neuritis. A total of 77.2% of the patients were women. Mean age was 31.8 years ... Full text Link to item Cite

Therapy of seizures associated with stroke.

Journal Article Clin Neuropharmacol · February 1991 Full text Link to item Cite

Temporal lobectomy and independent bitemporal interictal activity: what degree of lateralization is sufficient?

Journal Article Epilepsia · 1991 We attempted to determine whether the degree of lateralization of independent bitemporal interictal spikes and sharp waves (ISSW) is correlated with good results after temporal lobectomy. Three observers independently counted ISSW in the scalp EEGs of 59 c ... Full text Link to item Cite

Scalp EEG differs in temporal and extratemporal complex partial seizures

Journal Article Journal of Epilepsy · January 1, 1991 We compared scalp ictal EEG in complex partial seizures originating in extratemporal regions with seizures originating in the temporal lobe. All patients were seizure-free for 2 or more years after appropriate cortical resection confirming focus of seizure ... Full text Cite

Value of intraoperative brainstem auditory evoked potential monitoring in reducing the auditory morbidity associated with microvascular decompression of cranial nerves.

Journal Article Skull Base Surg · 1991 The present study was performed to determine whether the intraoperative monitoring of brainstem auditory evoked potentials (BAEPs) during microvascular decompression operations is effective in preventing profound hearing loss or deafness in the ipsilateral ... Full text Link to item Cite

MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings.

Journal Article AJR Am J Roentgenol · September 1990 Thirty-nine consecutive patients with medically intractable complex partial seizures were studied with electroencephalography and MR imaging to localize an epileptogenic focus for temporal lobectomy. The patients were divided into three groups on the basis ... Full text Link to item Cite

Anterior temporal lobectomy for complex partial seizures: evaluation, results, and long-term follow-up in 100 cases.

Journal Article Neurology · March 1990 We report evaluation and results in 100 patients who had undergone anterior temporal lobectomy for intractable complex partial seizures. Average follow-up was 9.0 years (range, 2 to 21 years). In the 2nd postoperative year, 63% were seizure free, 16% were ... Full text Link to item Cite

Reply: Speech automatisms

Journal Article Neurology · January 1, 1990 Cite

MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings.

Journal Article AJNR Am J Neuroradiol · 1990 Thirty-nine consecutive patients with medically intractable complex partial seizures were studied with electroencephalography and MR imaging to localize an epileptogenic focus for temporal lobectomy. The patients were divided into three groups on the basis ... Link to item Cite

Nothing new about insomnia (I: Reply)

Journal Article Sleep · January 1, 1990 Full text Cite

Neologistic speech automatisms during complex partial seizures.

Journal Article Neurology · January 1990 There are no documented cases of seizures causing reiterative neologistic speech automatisms. We report an 18-year-old right-handed woman with stereotypic ictal speech automatisms characterized by phonemic jargon and reiterative neologisms. Video-EEG durin ... Full text Link to item Cite

Speech automatisms (I: Reply)

Journal Article Neurology · January 1, 1990 Full text Cite

Polysomnographic assessment of DIMS: empirical evaluation of its diagnostic value.

Journal Article Sleep · August 1989 This investigation examined the diagnostic value of polysomnography (PSG) for evaluating disorders of initiating and maintaining sleep (DIMS). The sample consisted of 100 outpatients who presented to the Duke Sleep Disorders Center with a complaint of chro ... Link to item Cite

Efficacy of MR vs CT in epilepsy.

Journal Article AJR Am J Roentgenol · February 1989 We studied 59 seizure patients with CT, MR, and EEG to determine the efficacy of each in the detection of an epileptogenic focus. EEG was most sensitive (67%), MR was next (53%), and CT was least sensitive (42%). MR detected an abnormality in five patients ... Full text Link to item Cite

Intraoperative brainstem auditory evoked potentials: significant decrease in postoperative morbidity.

Journal Article Neurology · February 1989 Evoked potentials are commonly used for intraoperative monitoring of neural tissue under surgical threat despite the lack of unequivocal evidence demonstrating its effectiveness in preventing neural injury. This study retrospectively compares the auditory ... Full text Link to item Cite

Utility of FDG-PET in the evaluation of seizures and primary brain tumors

Journal Article Journal of Nuclear Medicine · January 1, 1989 Cite

Intraoperative monitoring of auditory and brain-stem function.

Journal Article Neurol Clin · November 1988 Extensive clinical experience has demonstrated that intraoperative brain stem auditory evoked potentials (BAEPs) are a reliable method of monitoring auditory and brain stem function during posterior fossa surgery. An intraoperative BAEP change identifies p ... Link to item Cite

Efficacy of MR vs CT in epilepsy

Journal Article American Journal of Neuroradiology · January 1, 1988 We studied 59 seizure patients with CT, MR, and EEG to determine the efficacy of each in the detection of an epileptogenic focus. EEG was most sensitive (67%), MR was next (53%), and CT was least sensitive (42%). MR detected an abnormality in five patients ... Cite

USEFULNESS OF INTRAOPERATIVE BRAIN-STEM AUDITORY EVOKED-POTENTIALS

Conference ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY · August 1, 1986 Link to item Cite

BRAIN-STEM AUDITORY EVOKED-POTENTIALS IN CHILDREN WITH MYELOMENINGOCELE AND ARNOLD-CHIARI MALFORMATION

Conference ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY · August 1, 1986 Link to item Cite

Abnormal sensory evoked potentials in amyotrophic lateral sclerosis.

Journal Article Neurology · June 1986 We have reviewed sensory evoked potential (EP) findings in 17 patients with amyotrophic lateral sclerosis (ALS). Somatosensory EPs were abnormal in 7 of 16 patients after lower-extremity stimulation and in 2 of 16 patients after upper-extremity stimulation ... Full text Link to item Cite

Limitations of brain stem auditory evoked potentials for intraoperative monitoring during a posterior fossa operation: case report and technical note.

Journal Article Neurosurgery · June 1985 We have encountered an example of the insensitivity of brain stem auditory evoked potentials (BAEPs) for monitoring the brain stem during a posterior fossa operation. The addition of somatosensory evoked potential recording to conventional BAEP protocols i ... Full text Link to item Cite

A review of electroencephalographic features of normal sleep.

Journal Article J Clin Neurophysiol · July 1984 The electrographic features of sleep have been studied intensively using both routine electroencephalography and polysomnography. The two sections of this paper describe and illustrate the major characteristics of sleep physiology and associated clinical e ... Full text Link to item Cite