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Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients.

Publication ,  Journal Article
Lee, N; Tien, RD; Lewis, DV; Friedman, AH; Felsberg, GJ; Crain, B; Hulette, C; Osumi, AK; Smith, JS; VanLandingham, KE
Published in: Epilepsia
September 1995

To assess the value of magnetic resonance imaging (MRI)-measured hippocampal volume in the detection of hippocampal sclerosis, we studied 28 patients undergoing anterior temporal lobectomy for medically intractable mesial temporal lobe epilepsy. Hippocampal volumetry and visual analysis of T2 signal change were performed using fast spin-echo T2-weighed MRI. Quantitative neuronal density measurements were performed in the resected hippocampal specimens. There was a significant correlation between MRI-measured absolute hippocampal volume (AHV) and neuronal density in CA1, CA2, and CA3 subfields (p < 0.0001, p < 0.01, and p < 0.05, respectively). Differential hippocampal volume (side-to-side volume difference) failed to detect bilateral atrophy in three patients, but the bilateral hippocampal atrophy was recognized by considering AHV in these patients. This study suggests that MRI-measured AHV can be of value in elevating patients with mesial temporal lobe epilepsy, especially when there is no side-to-side difference in hippocampal volumetry.

Duke Scholars

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

September 1995

Volume

36

Issue

9

Start / End Page

899 / 904

Location

United States

Related Subject Headings

  • Temporal Lobe
  • Sclerosis
  • Neurons
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Female
 

Citation

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Chicago
ICMJE
MLA
NLM
Lee, N., Tien, R. D., Lewis, D. V., Friedman, A. H., Felsberg, G. J., Crain, B., … VanLandingham, K. E. (1995). Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients. Epilepsia, 36(9), 899–904. https://doi.org/10.1111/j.1528-1157.1995.tb01633.x
Lee, N., R. D. Tien, D. V. Lewis, A. H. Friedman, G. J. Felsberg, B. Crain, C. Hulette, A. K. Osumi, J. S. Smith, and K. E. VanLandingham. “Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients.Epilepsia 36, no. 9 (September 1995): 899–904. https://doi.org/10.1111/j.1528-1157.1995.tb01633.x.
Lee N, Tien RD, Lewis DV, Friedman AH, Felsberg GJ, Crain B, et al. Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients. Epilepsia. 1995 Sep;36(9):899–904.
Lee, N., et al. “Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients.Epilepsia, vol. 36, no. 9, Sept. 1995, pp. 899–904. Pubmed, doi:10.1111/j.1528-1157.1995.tb01633.x.
Lee N, Tien RD, Lewis DV, Friedman AH, Felsberg GJ, Crain B, Hulette C, Osumi AK, Smith JS, VanLandingham KE. Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients. Epilepsia. 1995 Sep;36(9):899–904.
Journal cover image

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

September 1995

Volume

36

Issue

9

Start / End Page

899 / 904

Location

United States

Related Subject Headings

  • Temporal Lobe
  • Sclerosis
  • Neurons
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Female