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Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy.

Publication ,  Journal Article
Radtke, RA; Hanson, MW; Hoffman, JM; Crain, BJ; Walczak, TS; Lewis, DV; Beam, C; Coleman, RE; Friedman, AH
Published in: Neurology
June 1993

To investigate the relationship of temporal lobe hypometabolism demonstrated on PET to surgical outcome and underlying pathology, we reviewed 30 consecutive epilepsy patients who underwent interictal PET studies with 18F fluorodeoxyglucose before temporal lobectomy. Two interpreters blindly reviewed the PET studies and graded them for degree, extent, and location of temporal lobe hypometabolism. Pathologic analysis of en bloc resected tissue showed mesial temporal sclerosis (n = 22), astrocytoma (n = 2), and no pathologic diagnosis (n = 6). Outcome (24 to 40 months' follow-up) was rated as seizure-free (21 patients), significantly improved (five patients), and not significantly improved (four patients). Both the degree and extent of the temporal lobe hypometabolism demonstrated on PET were strongly associated with subsequent seizure control. Pathologic findings, however, did not correlate with degree of PET hypometabolism or subsequent outcome. These data demonstrate that in patients judged to have temporal lobe epilepsy, the presence of temporal lobe hypometabolism is associated with a positive outcome after ipsilateral temporal lobectomy.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

June 1993

Volume

43

Issue

6

Start / End Page

1088 / 1092

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, Emission-Computed
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Follow-Up Studies
  • Fluorodeoxyglucose F18
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Radtke, R. A., Hanson, M. W., Hoffman, J. M., Crain, B. J., Walczak, T. S., Lewis, D. V., … Friedman, A. H. (1993). Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy. Neurology, 43(6), 1088–1092. https://doi.org/10.1212/wnl.43.6.1088
Radtke, R. A., M. W. Hanson, J. M. Hoffman, B. J. Crain, T. S. Walczak, D. V. Lewis, C. Beam, R. E. Coleman, and A. H. Friedman. “Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy.Neurology 43, no. 6 (June 1993): 1088–92. https://doi.org/10.1212/wnl.43.6.1088.
Radtke RA, Hanson MW, Hoffman JM, Crain BJ, Walczak TS, Lewis DV, et al. Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy. Neurology. 1993 Jun;43(6):1088–92.
Radtke, R. A., et al. “Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy.Neurology, vol. 43, no. 6, June 1993, pp. 1088–92. Pubmed, doi:10.1212/wnl.43.6.1088.
Radtke RA, Hanson MW, Hoffman JM, Crain BJ, Walczak TS, Lewis DV, Beam C, Coleman RE, Friedman AH. Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy. Neurology. 1993 Jun;43(6):1088–1092.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

June 1993

Volume

43

Issue

6

Start / End Page

1088 / 1092

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, Emission-Computed
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Follow-Up Studies
  • Fluorodeoxyglucose F18