Overview
This is my fifteenth year on the faculty at DUMC. During these years, there was an initial focus of research work on the pharmacokinetics and pharmacodynamics of anesthetic agents in children and now includes the sedation of mentally challenged children as well as pediatric regional anesthesia.
Industry funding is presently being provided for several multicenter studies and Duke has been an active participant. I am the PI for Duke on the investigation of the pk and pd of rocuronium in children that will be completed by mid-2007. Prior years I have been a PI or coPI for investigations in children at Duke for fentanyl, remifentanil, rapacuronium, rocuronium, and ondansetron.
In addition to the research that involves anesthetic agents, I remain very active in research regarding the sedation of children who are mentally challenged. By teaming up with members in the psychiatry department at UNC, I have been able to be a coinvestigator in 2 studies that are funded by NIMH involving imaging procedures under sedation in children who are autistic or developmentally delayed. My presence for the MRI studies in these children is in its seventh year.
Although the above projects offer funding for the department, my main interest continues to be in the area of pediatric regional anesthesia. Duke anesthesiologists have become well-known for their work in regional anesthesia, and this is true in the pediatric arena as well. Trials are ongoing and have resulted in many abstracts, papers, and lectures.
Industry funding is presently being provided for several multicenter studies and Duke has been an active participant. I am the PI for Duke on the investigation of the pk and pd of rocuronium in children that will be completed by mid-2007. Prior years I have been a PI or coPI for investigations in children at Duke for fentanyl, remifentanil, rapacuronium, rocuronium, and ondansetron.
In addition to the research that involves anesthetic agents, I remain very active in research regarding the sedation of children who are mentally challenged. By teaming up with members in the psychiatry department at UNC, I have been able to be a coinvestigator in 2 studies that are funded by NIMH involving imaging procedures under sedation in children who are autistic or developmentally delayed. My presence for the MRI studies in these children is in its seventh year.
Although the above projects offer funding for the department, my main interest continues to be in the area of pediatric regional anesthesia. Duke anesthesiologists have become well-known for their work in regional anesthesia, and this is true in the pediatric arena as well. Trials are ongoing and have resulted in many abstracts, papers, and lectures.
Current Appointments & Affiliations
Professor Emeritus of Anesthesiology
·
2024 - Present
Anesthesiology, Pediatrics,
Anesthesiology
Professor in Pediatrics
·
2020 - Present
Pediatrics,
Clinical Science Departments
Recent Publications
Postanesthesia Care Unit Management
Chapter · January 1, 2020 In infants, perioperative anesthetic morbidity is higher than in other age groups, which underscores the importance of the dedicated pediatric postanesthesia care unit (PACU). The pediatric PACU environment requires careful planning and ongoing maintenance ... Full text CiteRe: The Association between Caudal Anesthesia and Increased Risk of Postoperative Surgical Complications in Boys Undergoing Hypospadias Repair.
Journal Article J Urol · April 2019 Full text Link to item CiteAnalysis of the impact of race on blood transfusion in pediatric scoliosis surgery.
Journal Article Paediatr Anaesth · April 2018 INTRODUCTION: Surgical correction of pediatric scoliosis is associated with significant blood loss. Minimizing estimated blood loss and blood transfusion is beneficial as transfusions have been associated with increased morbidity, including risk of surgica ... Full text Link to item CiteRecent Grants
West-Ward Pharma Peds Oral Morphine Sulfate
Clinical TrialPrincipal Investigator · Awarded by West-Ward Pharmaceuticals · 2018 - 2020ENDO EN3319-304 Oxymorphone for Postop Pain
Clinical TrialPrincipal Investigator · Awarded by Endo Pharmaceuticals · 2016 - 2020MNK15000300-Phase 4 Xartemis XR in Postsurgical Adolescents with Moderate to Severe Acute Pain
Clinical TrialPrincipal Investigator · Awarded by Mallinckrodt Pharmaceuticals · 2015 - 2018View All Grants