Scholars@Duke
Wendell Franklyn Rosse

Wendell Franklyn Rosse

Florence McAlister Distinguished Professor Emeritus of Medicine, in the School of Medicine
Medicine, Hematology
rosse001@mc.duke.edu
Box 3939 Med Ctr, Durham, NC 27710
2212 Elba St, Durham, NC 27705

Overview

My work has been focused on the hemolytic anemias and other hematocytopenias with particular emphasis on diseases due to immunological reactions (paroxysmal nocturnal hemoglobinuria, autoimmune hemolytic anemia, autoimmune thrombocytopenia, etc) and those due to abnormalities of hemoglobin (sickle cell disease, in particular).
Key Words: paroxysmal nocturnal hemoglobinuria, sickle cell disease, complement

Current Appointments & Affiliations

Florence McAlister Distinguished Professor Emeritus of Medicine, in the School of Medicine · 1999 - Present Medicine, Hematology, Medicine
Professor Emeritus of Medicine · 1999 - Present Medicine, Hematology, Medicine

Recent Publications

Pulmonary hypertension and nitric oxide depletion in sickle cell disease.

Journal Article Blood · August 5, 2010 During the past decade a large body of experimental and clinical studies has focused on the hypothesis that nitric oxide (NO) depletion by plasma hemoglobin in the microcirculation plays a central role in the pathogenesis of many manifestations of sickle c ... Full text Link to item Cite

Clinical manifestations of paroxysmal nocturnal hemoglobinuria: present state and future problems.

Journal Article Int J Hematol · February 2003 The clinical pathology of paroxysmal nocturnal hemoglobinuria (PNH) involves 3 complications: hemolytic anemia, thrombosis, and hematopoietic deficiency. The first 2 are clearly the result of the cellular defect in PNH, the lack of proteins anchored to the ... Full text Link to item Cite

Clinical management of adult ITP prior to splenectomy: a perspective.

Journal Article Blood Rev · March 2002 A philosophy of management of adult immune thrombocytopenic purpura (ITP) prior to splenectomy is presented. The initial action is to determine whether the condition is hyperacute, acute, or chronic. In symptomatic cases, initial remission usually requires ... Full text Link to item Cite
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Recent Grants

Duke/Unc Comprehensive Sickle Cell Center

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1977 - 2000

Comprhensive Sickle Cell Center

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1977 - 1998

Duke-Unc Comprehensive Sickle Cell Center

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1977 - 1998

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Education, Training & Certifications

The University of Chicago · 1958 M.D.