Wendell Franklyn Rosse

Journal Article Blood · August 5, 2010 During the past decade a large body of experimental and clinical studies has focused on the hypothesis that nitric oxide (NO) depletion by plasma hemoglobin in the microcirculation plays a central role in the pathogenesis of many manifestations of sickle c ... Full text Link to item Cite

Clinical manifestations of paroxysmal nocturnal hemoglobinuria: present state and future problems.

Journal Article Int J Hematol · February 2003 The clinical pathology of paroxysmal nocturnal hemoglobinuria (PNH) involves 3 complications: hemolytic anemia, thrombosis, and hematopoietic deficiency. The first 2 are clearly the result of the cellular defect in PNH, the lack of proteins anchored to the ... Full text Link to item Cite

Clinical management of adult ITP prior to splenectomy: a perspective.

Journal Article Blood Rev · March 2002 A philosophy of management of adult immune thrombocytopenic purpura (ITP) prior to splenectomy is presented. The initial action is to determine whether the condition is hyperacute, acute, or chronic. In symptomatic cases, initial remission usually requires ... Full text Link to item Cite

New insights into paroxysmal nocturnal hemoglobinuria.

Journal Article Curr Opin Hematol · March 2001 The characteristic, defining defect in paroxysmal nocturnal hemoglobinuria is the somatic mutation of the PIG-A gene (essential to the biosynthesis of the glycosylphosphatidylinositol moiety that affixes a number of proteins to the cellular surface) in hem ... Full text Link to item Cite