Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Nephrology, Medicine, Duke University 2003 - 2005
  • Medical Resident, Medicine, Duke University 2000 - 2003
  • M.D., Free University of Berlin (Germany) 1995
• 

  Previous Appointments & Affiliations

  • Associate Professor of Medicine, Medicine, Nephrology, Medicine 2017 - 2020
  • Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2016 - 2017
  • Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2008 - 2016
  • Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2005 - 2008
• Research
• 

  Selected Grants

  • Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2023
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Esagian, Stepan Michran, Dimitrios Spinos, Anastasia Vasilopoulou, Nikolaos Syrigos, Muath Bishawi, Ruediger Wilhelm Lehrich, John Paul Middleton, Paul Vincent Suhocki, Theodore Nick Pappas, and Konstantinos P. Economopoulos. “Influence of peritoneal dialysis catheter type on complications and long-term outcomes: an updated systematic review and meta-analysis.” J Nephrol 34, no. 6 (December 2021): 1973–87. https://doi.org/10.1007/s40620-021-01016-y.
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    • Esagian, Stepan M., Georgios A. Sideris, Muath Bishawi, Ioannis A. Ziogas, Ruediger W. Lehrich, John P. Middleton, Paul V. Suhocki, Theodore N. Pappas, and Konstantinos P. Economopoulos. “Surgical versus percutaneous catheter placement for peritoneal dialysis: an updated systematic review and meta-analysis.” J Nephrol 34, no. 5 (October 2021): 1681–96. https://doi.org/10.1007/s40620-020-00896-w.
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    • Seay, N Winn, Ruediger W. Lehrich, and Arthur Greenberg. “Diagnosis and Management of Disorders of Body Tonicity-Hyponatremia and Hypernatremia: Core Curriculum 2020.” Am J Kidney Dis 75, no. 2 (February 2020): 272–86. https://doi.org/10.1053/j.ajkd.2019.07.014.
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    • Mohottige, Dinushika, Ruediger Wilhelm Lehrich, and Arthur Greenberg. “Hypovolemic Hyponatremia.” Front Horm Res 52 (2019): 93–103. https://doi.org/10.1159/000493240.
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    • Roberts, John K., Saumil M. Chudgar, Deborah Engle, Elizabeth K. McClain, Emma Jakoi, Michael Berkoben, and Ruediger W. Lehrich. “Digital chalk-talk videos improve knowledge and satisfaction in renal physiology.” Adv Physiol Educ 42, no. 1 (March 1, 2018): 146–51. https://doi.org/10.1152/advan.00131.2017.
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    • Roberts, John K., Matthew A. Sparks, and Ruediger W. Lehrich. “Medical student attitudes toward kidney physiology and nephrology: a qualitative study.” Ren Fail 38, no. 10 (November 2016): 1683–93. https://doi.org/10.1080/0886022X.2016.1230459.
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    • Roberts, John K., Charles W. Hargett, Alisa Nagler, Emma Jakoi, and Ruediger W. Lehrich. “Exploring student preferences with a Q-sort: the development of an individualized renal physiology curriculum.” Adv Physiol Educ 39, no. 3 (September 2015): 149–57. https://doi.org/10.1152/advan.00028.2015.
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    • Middleton, John P., and Ruediger W. Lehrich. “Prescriptions for dietary sodium in patients with chronic kidney disease: how will this shake out?” Kidney Int 86, no. 3 (September 2014): 457–59. https://doi.org/10.1038/ki.2014.124.
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    • Lehrich, Ruediger W., David I. Ortiz-Melo, Mehul B. Patel, and Arthur Greenberg. “Role of vaptans in the management of hyponatremia.” Am J Kidney Dis 62, no. 2 (August 2013): 364–76. https://doi.org/10.1053/j.ajkd.2013.01.034.
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    • Malone, Andrew F., Matthew A. Sparks, David N. Howell, John Paul Middleton, Stephen R. Smith, and Ruediger W. Lehrich. “IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia.” J Nephrol 26, no. 6 (2013): 1195–98. https://doi.org/10.5301/jn.5000298.
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    • Lehrich, Ruediger W., and Arthur Greenberg. “Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients.” J Intensive Care Med 27, no. 4 (2012): 207–18. https://doi.org/10.1177/0885066610397016.
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    • Stegbauer, Johannes, Susan B. Gurley, Matthew A. Sparks, Magdalena Woznowski, Donald E. Kohan, Ming Yan, Ruediger W. Lehrich, and Thomas M. Coffman. “AT1 receptors in the collecting duct directly modulate the concentration of urine.” J Am Soc Nephrol 22, no. 12 (December 2011): 2237–46. https://doi.org/10.1681/ASN.2010101095.
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    • Pun, Patrick H., Ruediger W. Lehrich, Emily F. Honeycutt, Charles A. Herzog, and John P. Middleton. “Modifiable risk factors associated with sudden cardiac arrest within hemodialysis clinics.” Kidney Int 79, no. 2 (January 2011): 218–27. https://doi.org/10.1038/ki.2010.315.
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    • Greenberg, Arthur, and Ruediger W. Lehrich. “Treatment of chronic hyponatremia: now we know how, but do we know when or if?” J Am Soc Nephrol 21, no. 4 (April 2010): 552–55. https://doi.org/10.1681/ASN.2010020157.
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    • Lehrich, Ruediger W., and Arthur Greenberg. “When is it appropriate to use vasopressin receptor antagonists?” J Am Soc Nephrol 19, no. 6 (June 2008): 1054–58. https://doi.org/10.1681/ASN.2008010089.
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    • Sinsakul, Marvin, Mohammed Sika, Roger Rodby, John Middleton, Yu Shyr, Heidi Chen, Ernest Han, et al. “A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease.” Am J Kidney Dis 50, no. 6 (December 2007): 946–51. https://doi.org/10.1053/j.ajkd.2007.09.005.
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    • Pun, Patrick H., Ruediger W. Lehrich, Stephen R. Smith, and John P. Middleton. “Predictors of survival after cardiac arrest in outpatient hemodialysis clinics.” Clin J Am Soc Nephrol 2, no. 3 (May 2007): 491–500. https://doi.org/10.2215/CJN.02360706.
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    • Lehrich, Ruediger W., Patrick H. Pun, Nadine D. Tanenbaum, Stephen R. Smith, and John P. Middleton. “Automated external defibrillators and survival from cardiac arrest in the outpatient hemodialysis clinic.” J Am Soc Nephrol 18, no. 1 (January 2007): 312–20. https://doi.org/10.1681/ASN.2006040392.
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    • Lehrich, Ruediger W., Paulo N. Rocha, Nancy Reinsmoen, Arthur Greenberg, David W. Butterly, David N. Howell, and Stephen R. Smith. “Intravenous immunoglobulin and plasmapheresis in acute humoral rejection: experience in renal allograft transplantation.” Hum Immunol 66, no. 4 (April 2005): 350–58. https://doi.org/10.1016/j.humimm.2005.01.028.
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    • Lehrich, R. W., S. Moll, and F. C. Luft. “The anion gap: A simple, helpful tool in the differential diagnosis of metabolic acidosis.” Intensivmedizin Und Notfallmedizin 36, no. 4 (May 1, 1999): 355–60. https://doi.org/10.1007/s003900050251.
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    • Lehrich, R. W., S. Moll, and F. C. Luft. “Evaluating a critically ill patient with metabolic acidosis: the ifosfamide paradigm.” Nephrol Dial Transplant 14, no. 1 (January 1999): 226–30. https://doi.org/10.1093/ndt/14.1.226.
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    • Lehrich, R. W., S. G. Aller, P. Webster, C. R. Marino, and J. N. Forrest. “Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium.” J Clin Invest 101, no. 4 (February 15, 1998): 737–45. https://doi.org/10.1172/JCI803.
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    • LEHRICH, R. W., and J. N. FORREST. “TYROSINE PHOSPHORYLATION IS A NOVEL PATHWAY FOR REGULATION OF CHLORIDE SECRETION IN SHARK RECTAL GLAND.” American Journal of Physiology Renal Fluid and Electrolyte Physiology 269, no. 4 (October 1, 1995): F594–600.
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    • Lehrich, R. W., and J. N. Forrest. “Tyrosine phosphorylation is a novel pathway for regulation of chloride secretion in shark rectal gland.” Am J Physiol 269, no. 4 Pt 2 (October 1995): F594–600. https://doi.org/10.1152/ajprenal.1995.269.4.F594.
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    • Lehrich, R. W., and J. N. Forrest. “Protein kinase C zeta is associated with the mitotic apparatus in primary cell cultures of the shark rectal gland.” J Biol Chem 269, no. 51 (December 23, 1994): 32446–50.
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  • Book Sections

    • Patel, M. B., R. W. Lehrich, and A. Greenberg. “Vasopressin receptor antagonists.” In Hyponatremia: Evaluation and Treatment, 193–220, 2013. https://doi.org/10.1007/978-1-4614-6645-1_11.
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    • Duronville, J. V. “Home Dialysis (Accepted).” In Nephrology Secrets, n.d.

  • Other Articles

    • MIddleton, J. P., and R. W. Lehrich. “NephSAP: End-Stage Renal Disease and Dialysis.” Nephsap. ASN, November 1, 2014.

  • Conference Papers

    • Pun, P. H., R. W. Lehrich, S. R. Smith, and J. P. Middleton. “Predictors of survival following sudden cardiac arrest in outpatient hemodialysis clinics.” In Journal of Investigative Medicine, 54:S298–S298. B C DECKER INC, 2006.
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• Teaching & Mentoring
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  Recent Courses

  • MEDICINE 424C: Fluids and Electrolytes 2021

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