Scholars@Duke
Ruediger Wilhelm Lehrich

Ruediger Wilhelm Lehrich

Professor of Medicine
Medicine, Nephrology
ruediger.lehrich@duke.edu
Duke Box 2747, Durham, NC 27710
2424 Erwin Road, Durham, NC 27705

Selected Publications

Influence of peritoneal dialysis catheter type on complications and long-term outcomes: an updated systematic review and meta-analysis.

Journal Article J Nephrol · December 2021 BACKGROUND: There is currently no consensus regarding the optimal type of peritoneal dialysis catheter (PDC). We compared the outcomes of PDCs according to the number of cuffs, intercuff and intraperitoneal segment shape, and presence of a weighted tip. ME ... Full text Link to item Cite

Surgical versus percutaneous catheter placement for peritoneal dialysis: an updated systematic review and meta-analysis.

Journal Article J Nephrol · October 2021 BACKGROUND: No consensus currently exists regarding the optimal approach for peritoneal dialysis catheter placement. We aimed to compare the outcomes of percutaneous and surgical peritoneal dialysis catheter placement. METHODS: A systematic review of the l ... Full text Link to item Cite

Diagnosis and Management of Disorders of Body Tonicity-Hyponatremia and Hypernatremia: Core Curriculum 2020.

Journal Article Am J Kidney Dis · February 2020 Overall body fluid concentration is regulated within a narrow range by the concerted action of the hypothalamic-pituitary axis to influence water intake through thirst and water excretion via the effect of vasopressin, or antidiuretic hormone, on renal col ... Full text Link to item Cite

Hypovolemic Hyponatremia.

Journal Article Front Horm Res · 2019 The etiology of hyponatremia is often multifactorial. The most common causes include hypovolemia from gastrointestinal (GI) or other fluid losses, thiazide diuretics, and SIAD [1]. In this chapter, we will discuss hypovolemic ... Full text Link to item Cite

Digital chalk-talk videos improve knowledge and satisfaction in renal physiology.

Journal Article Adv Physiol Educ · March 1, 2018 The authors began a curriculum reform project to improve the experience in a Renal Physiology course for first-year medical students. Taking into account both the variety of learning preferences among students and the benefits of student autonomy, the auth ... Full text Open Access Link to item Cite

Medical student attitudes toward kidney physiology and nephrology: a qualitative study.

Journal Article Ren Fail · November 2016 Interest in nephrology among trainees is waning in the USA. Early perceptions and attitudes to subject matter can be linked to the quality of pre-clinical curricula. We wanted to explore these attitudes in the setting of modern curriculum redesign. We util ... Full text Open Access Link to item Cite

Exploring student preferences with a Q-sort: the development of an individualized renal physiology curriculum.

Journal Article Adv Physiol Educ · September 2015 Medical education reform is underway, but the optimal course for change has yet to be seen. While planning for the redesign of a renal physiology course at the Duke School of Medicine, the authors used a Q-sort survey to assess students' attitudes and lear ... Full text Link to item Cite

NephSAP: End-Stage Renal Disease and Dialysis

Other NephSAP · November 1, 2014 Featured Publication Cite

Prescriptions for dietary sodium in patients with chronic kidney disease: how will this shake out?

Journal Article Kidney Int · September 2014 Patients with chronic kidney disease (CKD) are at risk of exhibiting expanded extracellular volume, and low-sodium diets are often prescribed to limit clinical complications from this condition. Fan et al. performed a post hoc study from the database of th ... Full text Link to item Cite

Role of vaptans in the management of hyponatremia.

Journal Article Am J Kidney Dis · August 2013 Hyponatremia, the most commonly encountered electrolyte abnormality, affects as many as 30% of hospitalized patients. It is a powerful predictor of poor outcomes, especially in patients with congestive heart failure or cirrhosis. The failure to excrete ele ... Full text Link to item Cite

IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia.

Journal Article J Nephrol · 2013 BACKGROUND: Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG4-related systemic diseases can ... Full text Link to item Cite

Vasopressin receptor antagonists

Chapter · January 1, 2013 Arginine vasopressin is the hormone principally responsible for the genesis of most hyponatremic disorders. The persistent inappropriate or maladaptive secretion of this hormone, also known as antidiuretic hormone, prevents excretion of electrolyte-free wa ... Full text Cite

Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients.

Journal Article J Intensive Care Med · 2012 Hyponatremia in critically ill patients is a common and challenging problem. Increased levels of arginine vasopressin almost always contribute to the etiology. Inhibition of the vasopressin receptor with a vasopressin receptor antagonist (vaptan) is a nove ... Full text Link to item Cite

AT1 receptors in the collecting duct directly modulate the concentration of urine.

Journal Article J Am Soc Nephrol · December 2011 Mice lacking AT(1) angiotensin receptors have an impaired capacity to concentrate the urine, but the underlying mechanism is unknown. To determine whether direct actions of AT(1) receptors in epithelial cells of the collecting duct regulate water reabsorpt ... Full text Link to item Cite

Modifiable risk factors associated with sudden cardiac arrest within hemodialysis clinics.

Journal Article Kidney Int · January 2011 Sudden cardiac arrest is the most common cause of death among patients with end-stage kidney disease (ESKD) maintained on hemodialysis. Here we sought to identify dialysis-related factors associated with this increased risk in a case-control study encompas ... Full text Link to item Cite

When is it appropriate to use vasopressin receptor antagonists?

Journal Article J Am Soc Nephrol · June 2008 Hyponatremia is a common and challenging disorder. The mainstays of treatment until recently were water restriction and hypertonic saline. The first nonpeptide vasopressin receptor antagonist (VRA) is now approved by the US Food and Drug Administration for ... Full text Link to item Cite

A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease.

Journal Article Am J Kidney Dis · December 2007 BACKGROUND: Preclinical data suggest that cyclooxygenase 2 inhibitors decrease proteinuria and preserve glomerular structure in animal models of diabetic nephropathy. The objective of this study is to compare the efficacy and safety of celecoxib with place ... Full text Link to item Cite

Predictors of survival after cardiac arrest in outpatient hemodialysis clinics.

Journal Article Clin J Am Soc Nephrol · May 2007 Cardiac arrest (CA) is the most common cause of death in hemodialysis patients, and factors that improve survival after arrest are unknown. This study sought to identify modifiable factors that are associated with survival after CA in hemodialysis clinics. ... Full text Link to item Cite

Automated external defibrillators and survival from cardiac arrest in the outpatient hemodialysis clinic.

Journal Article J Am Soc Nephrol · January 2007 Automated external defibrillators (AED) have been recommended for use in outpatient dialysis clinics to improve outcomes from cardiac arrest, the most common cause of death in patients with ESRD. The effectiveness of this policy is unknown. The study cohor ... Full text Link to item Cite

Intravenous immunoglobulin and plasmapheresis in acute humoral rejection: experience in renal allograft transplantation.

Journal Article Hum Immunol · April 2005 Acute humoral rejection (AHR) in kidney transplantation is associated with higher rates of allograft loss when compared with acute cellular rejection (ACR). Treatment with intravenous immunoglobulin (IVIG) combined with plasmapheresis (PP) has been used re ... Full text Link to item Cite

The anion gap: A simple, helpful tool in the differential diagnosis of metabolic acidosis

Journal Article Intensivmedizin und Notfallmedizin · May 1, 1999 Metabolic acidosis is a primary disturbance in acid-base physiology characterized by either a gain of H+ or a loss of HCO-3. The distinction is not trivial, since a gain in H+ is an emergency which may be life threatening. The anion gap, Na+-(Cl+HCO-3), is ... Full text Cite

Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium.

Journal Article J Clin Invest · February 15, 1998 Defective trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common cause of cystic fibrosis. In chloride-secreting epithelia, it is well established that CFTR localizes to intracellular organelles and to apical membr ... Full text Link to item Cite

Tyrosine phosphorylation is a novel pathway for regulation of chloride secretion in shark rectal gland.

Journal Article Am J Physiol · October 1995 We used the specific tyrosine kinase inhibitor genistein to define the involvement of tyrosine phosphorylation in the regulation of chloride transport in the rectal gland of the dogfish shark, a model for chloride secretion via a cystic fibrosis transmembr ... Full text Link to item Cite

TYROSINE PHOSPHORYLATION IS A NOVEL PATHWAY FOR REGULATION OF CHLORIDE SECRETION IN SHARK RECTAL GLAND

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY · October 1, 1995 Link to item Cite

Protein kinase C zeta is associated with the mitotic apparatus in primary cell cultures of the shark rectal gland.

Journal Article J Biol Chem · December 23, 1994 Protein kinase C zeta (PKC zeta) is an atypical PKC isoform that has recently been implicated in cell division and cell growth. However, there has been no morphologic evidence for the involvement of PKC zeta in mitogenic signal transduction. Here we use im ... Link to item Cite