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IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia.

Publication ,  Journal Article
Malone, AF; Sparks, MA; Howell, DN; Middleton, JP; Smith, SR; Lehrich, RW
Published in: J Nephrol
2013

BACKGROUND: Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG4-related systemic diseases can affect many organ systems including the kidney and typically respond to corticosteroid treatment. CASE: We present a case of IgG4-related TIN in a patient with concomitant chronic lymphocytic leukemia. To our knowledge, IgG4-related TIN has not been associated with any hematological disorder such as chronic lymphocytic leukemia.
 CONCLUSION: We propose that all kidney biopsies with significant plasma cell infiltrate should be stained for IgG4 as response to treatment is common.

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Published In

J Nephrol

DOI

EISSN

1724-6059

Publication Date

2013

Volume

26

Issue

6

Start / End Page

1195 / 1198

Location

Italy

Related Subject Headings

  • Urology & Nephrology
  • Nephritis, Interstitial
  • Male
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Kidney
  • Immunoglobulin G
  • Humans
  • Biopsy
  • Aged
  • 42 Health sciences
 

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Malone, A. F., Sparks, M. A., Howell, D. N., Middleton, J. P., Smith, S. R., & Lehrich, R. W. (2013). IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia. J Nephrol, 26(6), 1195–1198. https://doi.org/10.5301/jn.5000298
Malone, Andrew F., Matthew A. Sparks, David N. Howell, John Paul Middleton, Stephen R. Smith, and Ruediger W. Lehrich. “IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia.J Nephrol 26, no. 6 (2013): 1195–98. https://doi.org/10.5301/jn.5000298.
Malone AF, Sparks MA, Howell DN, Middleton JP, Smith SR, Lehrich RW. IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia. J Nephrol. 2013;26(6):1195–8.
Malone, Andrew F., et al. “IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia.J Nephrol, vol. 26, no. 6, 2013, pp. 1195–98. Pubmed, doi:10.5301/jn.5000298.
Malone AF, Sparks MA, Howell DN, Middleton JP, Smith SR, Lehrich RW. IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia. J Nephrol. 2013;26(6):1195–1198.
Journal cover image

Published In

J Nephrol

DOI

EISSN

1724-6059

Publication Date

2013

Volume

26

Issue

6

Start / End Page

1195 / 1198

Location

Italy

Related Subject Headings

  • Urology & Nephrology
  • Nephritis, Interstitial
  • Male
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Kidney
  • Immunoglobulin G
  • Humans
  • Biopsy
  • Aged
  • 42 Health sciences