Scholars@Duke
Ryan Everett Fecteau

Ryan Everett Fecteau

Assistant Professor of Radiation Oncology
Radiation Oncology

Selected Publications

Updated 5-year results for short course abiraterone acetate and LHRH agonist for unfavorable intermediate and favorable high-risk prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · June 2025 Combined androgen deprivation therapy (ADT) and radiotherapy (RT) improves outcomes for intermediate and high-risk prostate cancer. Treatment intensification with abiraterone acetate/prednisone (AAP) provides additional benefit for high-risk disease. We pr ... Full text Link to item Cite

Gastrointestinal Malignancies

Chapter · January 1, 2022 While there is much interest in how dietary and nutritional factors contribute to gastrointestinal cancer risk, definitive data is still lacking due to limitations in study design and research funding. Despite these shortcomings, favorable and unfavorable ... Full text Cite

Quantifying the impact of SpaceOAR hydrogel on inter-fractional rectal and bladder dose during 0.35 T MR-guided prostate adaptive radiotherapy.

Journal Article J Appl Clin Med Phys · September 2021 PURPOSE: To investigate the impact of rectal spacing on inter-fractional rectal and bladder dose and the need for adaptive planning in prostate cancer patients undergoing SBRT with a 0.35 T MRI-Linac. MATERIALS AND METHODS: We evaluated and compared SBRT p ... Full text Link to item Cite

Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia.

Journal Article JAMA Oncol · October 1, 2016 IMPORTANCE: Esophageal adenocarcinoma and its precursor lesion Barrett esophagus have seen a dramatic increase in incidence over the past 4 decades yet marked genetic heterogeneity of this disease has precluded advances in understanding its pathogenesis an ... Full text Link to item Cite

Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.

Journal Article Sci Rep · March 23, 2016 The molecular basis of aberrant protein glycosylation, a pathological alteration widespread in colorectal cancers (CRC), and the mechanisms by which it contributes to tumor progression remain largely unknown. We performed targeted re-sequencing of 430 glyc ... Full text Link to item Cite

Abstract 3830: Employing reduced representation bisulfite sequencing for biomarker discovery in colorectal cancer

Conference Cancer Research · August 1, 2015 AbstractUsing reduced representation bisulfite sequencing (RRBS), we have identified 3 candidate loci with aberrant methylation in colon cancer that in combination have 92% sensitivity for CRC tumor detectio ... Full text Cite

GNAS mutations identify a set of right-sided, RAS mutant, villous colon cancers.

Journal Article PLoS One · 2014 The purpose of this study is to determine the genetic frequency of GNAS activating mutations in colorectal cancer and the corresponding pathology of GNAS mutant tumors. Oncogenic mutations in GNAS have been described in a number of neoplasms including thos ... Full text Link to item Cite

CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes.

Journal Article Mol Cell Biol · January 2011 Tumor necrosis factor alpha (TNF-α) is a critical mediator of inflammation, and its production is tightly regulated, with control points operating at nearly every step of its biosynthesis. We sought to identify uncharacterized TNF-α 3' untranslated region ... Full text Link to item Cite

Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element.

Journal Article J Biol Chem · February 8, 2008 Tumor necrosis factor-alpha (TNF-alpha) production is regulated by transcriptional and posttranscriptional mechanisms. Lipopolysaccharide activates the NFkappaB pathway increasing TNF-alpha transcription. Lipopolysaccharide also activates the mitogen-activ ... Full text Link to item Cite