Sairam V. Jabba
Research Scientist
Current Appointments & Affiliations
- Research Scientist, Anesthesiology, Clinical Science Departments
Contact Information
- 3 Genome Court #6200 MSRB3, Durham, NC 27710
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sairam.jabba@duke.edu
+1 919 684 1319
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Sairam Jabba Linkedin
- Recognition
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Awards & Honors
- SOT Science Communication Training Award. Society of Toxicology. June 2021
- Best Abstract Award (Epidemiology and Environment Assembly). European Respiratory Society. . September 2020
- Abstract Scholarship (Assembly on Environmental, Occupational and Population Health). American Thoracic Society. May 2020
- Best Abstract Award from Risk Assessment Specialty Section. Society of Toxicology. March 2020
- Duke Postdoctoral Professional Development Award. Duke University. 2018
- Duke Science Policy Summer Institute fellowship. Duke University. 2018
- Duke University Emerging Leaders Institute . Duke University. 2017
- Duke SciComm Fellowship. Duke University. 2016
- Duke Neurogenetics Travel Award. Duke University Neurogenetics. 2014
- Academic Achievement Award: Best Outgoing Graduate Student. Creighton University. 2012
- Expertise
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Subject Headings
- Animal models in research
- Behavior, Animal
- Calcium
- Calcium Channels
- Calcium Signaling
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell metabolism
- Cellular signal transduction
- Communication in science
- Electronic Nicotine Delivery Systems
- Electronic cigarettes
- Electrophysiology
- Flavor
- Ganglia, Sensory
- Inflammation
- Inhalation Exposure
- Ion Channels
- Membrane potentials (Electrophysiology)
- Menthol
- Mitochondria
- Monoterpenes
- Natural products
- Nerve Growth Factors
- Neurogenic Inflammation
- Neuropharmacology
- Neurotoxicology
- Nicotine
- Nicotine addiction
- Non-Nutritive Sweeteners
- Patch-clamp techniques (Electrophysiology)
- Pulmonary toxicology
- Receptor, trkA
- Receptor, trkB
- Receptors, N-Methyl-D-Aspartate
- Science Policy
- Second messengers (Biochemistry)
- Sensory neurons
- Signal Transduction
- Smoking
- Sodium
- Sodium Channels
- Somatosensory neurons
- Src family kinases
- Sweeteners
- TRP channels
- TRPA1 Cation Channel
- TRPM Cation Channels
- TRPV Cation Channels
- Terpenes
- Thermoreceptors
- Tobacco Products
- Tobacco Regulatory Science
- Tobacco control
- Tobacco, Smokeless
- Toxicology--Animal models
- Trpm8
- Vaping
- Voltage-Gated Sodium Channels
- Voltage-clamp techniques (Electrophysiology)
- Research
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Selected Grants
- Advanced TRPA1 Inhibitor for the Treatment of Chlorine Inhalation Injury awarded by National Institutes of Health 2019 - 2022
- Anesthetic and synthetic cooling flavors in E-cigarettes: Chemistry, respiratory effects and behavioral pharmacology awarded by National Institutes of Health 2018 - 2022
- YALE SUBAWARD - Project 1: Effects of Flavors on Nicotine Choice and Central Reward Me awarded by Yale University 2013 - 2021
- Cellular Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes awarded by Yale University 2019 - 2020
- YALE SUBAWARD - Project 1: Effects of Flavors on Nicotine Choice and Central Reward Me awarded by Yale University 2014 - 2018
- Mechanisms of Itch in Poison Ivy-Induced Allergic Contact Dermatitis awarded by National Institutes of Health 2016 - 2018
- Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity awarded by National Institutes of Health 2014 - 2018
- CARRYOVER Request - Irritant Flavor Products in Heated E-Cigarette Liquids and Vapors awarded by Yale University 2015 - 2017
- Irritant Flavor Products in Heated E-Cigarette Liquids and Vapors awarded by Yale University 2015 - 2016
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Fellowships, Supported Research, & Other Grants
- Cellular Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes awarded by US FDA & Yale TCORS 2019 - 2020
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Ye, L., Bae, M., Cassilly, C. D., Jabba, S. V., Thorpe, D. W., Martin, A. M., … Rawls, J. F. (2021). Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host Microbe, 29(2), 179-196.e9. https://doi.org/10.1016/j.chom.2020.11.011Full Text Link to Item
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Jabba, S. V., Diaz, A. N., Erythropel, H. C., Zimmerman, J. B., & Jordt, S.-E. (2020). Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells. Nicotine Tob Res, 22(Suppl 1), S25–S34. https://doi.org/10.1093/ntr/ntaa185Full Text Link to Item
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Jabba, S. V., & Jordt, S.-E. (2020). Turbocharged Juul device challenges European tobacco regulators. Eur Respir J, 56(2). https://doi.org/10.1183/13993003.02430-2020Full Text Link to Item
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Jabba, S. V., & Jordt, S.-E. (2020). Estimating Fluid Consumption Volumes in Electronic Cigarette Use-Reply. Jama Intern Med, 180(3), 468–469. https://doi.org/10.1001/jamainternmed.2019.6630Full Text Link to Item
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Jabba, S. V., & Jordt, S.-E. (2019). Risk Analysis for the Carcinogen Pulegone in Mint- and Menthol-Flavored e-Cigarettes and Smokeless Tobacco Products. Jama Intern Med, 179(12), 1721–1723. https://doi.org/10.1001/jamainternmed.2019.3649Full Text Link to Item
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Erythropel, H. C., Jabba, S. V., DeWinter, T. M., Mendizabal, M., Anastas, P. T., Jordt, S. E., & Zimmerman, J. B. (2019). Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. Nicotine Tob Res, 21(9), 1248–1258. https://doi.org/10.1093/ntr/nty192Full Text Link to Item
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Jordt, S.-E., & Jabba, S. (2019). Tobacco industry's investment in sweetness comes full circle. Bmj, 365, l2338. https://doi.org/10.1136/bmj.l2338Full Text Link to Item
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Jordt, S. E., & Jabba, S. (2019). Sweeteners are added to modify consumer behaviour. Bmj, 364, l366. https://doi.org/10.1136/bmj.l366Full Text Link to Item
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Caceres, A. I., Liu, B., Jabba, S. V., Achanta, S., Morris, J. B., & Jordt, S.-E. (2017). Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. Br J Pharmacol, 174(9), 867–879. https://doi.org/10.1111/bph.13760Full Text Link to Item
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Fan, L., Balakrishna, S., Jabba, S. V., Bonner, P. E., Taylor, S. R., Picciotto, M. R., & Jordt, S.-E. (2016). Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. Tob Control, 25(Suppl 2), ii50–ii54. https://doi.org/10.1136/tobaccocontrol-2016-053209Full Text Link to Item
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Fan, L., Balakrishna, S., Jabba, S. V., Bonner, P. E., Taylor, S. R., Picciotto, M. R., & Jordt, S. E. (2016). Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism (Accepted). Tobacco Control. https://doi.org/10.1136/annrheumdis-2016-053209Full Text
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Jabba, S., Goyal, R., Sosa-Pagán, J. O., Moldenhauer, H., Wu, J., Kalmeta, B., … Grandl, J. (2014). Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. Neuron, 82(5), 1017–1031. https://doi.org/10.1016/j.neuron.2014.04.016Full Text Link to Item
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Li, H., Bowling, J. J., Fronczek, F. R., Hong, J., Jabba, S. V., Murray, T. F., … Jung, J. H. (2013). Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx. Biochimica Et Biophysica Acta, 1830(3), 2591–2599. https://doi.org/10.1016/j.bbagen.2012.11.015Full Text
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Nunnery, J. K., Engene, N., Byrum, T., Cao, Z., Jabba, S. V., Pereira, A. R., … Gerwick, W. H. (2012). Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. The Journal of Organic Chemistry, 77(9), 4198–4208. https://doi.org/10.1021/jo300160eFull Text
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Jabba, S. V., Prakash, A., Dravid, S. M., Gerwick, W. H., & Murray, T. F. (2010). Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. The Journal of Pharmacology and Experimental Therapeutics, 332(3), 698–709. https://doi.org/10.1124/jpet.109.161802Full Text
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George, J., Dravid, S. M., Prakash, A., Xie, J., Peterson, J., Jabba, S. V., … Murray, T. F. (2009). Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 29(10), 3288–3301. https://doi.org/10.1523/jneurosci.6104-08.2009Full Text
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Jabba, S. V., Oelke, A., Singh, R., Maganti, R. J., Fleming, S., Wall, S. M., … Wangemann, P. (2006). Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model. Bmc Medicine, 4, 37. https://doi.org/10.1186/1741-7015-4-37Full Text
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Singh, R., Maganti, R. J., Jabba, S. V., Wang, M., Deng, G., Heath, J. D., … Wangemann, P. (2005). Microarray-based comparison of three amplification methods for nanogram amounts of total RNA. American Journal of Physiology. Cell Physiology, 288(5), C1179–C1189. https://doi.org/10.1152/ajpcell.00258.2004Full Text
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Wangemann, P., Itza, E. M., Albrecht, B., Wu, T., Jabba, S. V., Maganti, R. J., … Marcus, D. C. (2004). Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model. Bmc Medicine, 2, 30. https://doi.org/10.1186/1741-7015-2-30Full Text
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Jabba, S. V., Erythropel, H. C., Torres, D. G., Delgado, L. A., Anastas, P. T., Zimmerman, J. B., & Jordt, S.-E. (n.d.). Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Disposable E-cigarettes: Chemical Analysis and Risk Assessment. https://doi.org/10.1101/2021.06.09.446946Full Text
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