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Sairam V. Jabba

Sairam V. Jabba

Research Scientist, Senior
Anesthesiology
sairam.jabba@duke.edu
3 Genome Court #6200 MSRB3, Durham, NC 27710

Selected Publications

Modeling functional responses to pollutant exposure using modular hydrogel supported vascularized alveolosphere-on-a-chip.

Journal Article Biomater Sci · October 21, 2025 Alveolar type 2 (AT2) cells play a pivotal role in maintaining lung homeostasis, and the generation of three-dimensional cultures, such as alveolospheres, provides a valuable model for studying lung development, pathologies, and drug responses. Here, we in ... Full text Link to item Cite

Chemosensory tobacco product toxicology part 1: sensory mechanisms.

Journal Article Toxicological sciences : an official journal of the Society of Toxicology · October 2025 Chemosensory systems detect and discriminate a wide variety of molecules to monitor internal and external chemical environments. They initiate olfactory, gustatory, and chemesthetic sensations; influence human brain cognition and emotion; and guide a wide ... Full text Cite

Chemosensory tobacco product toxicology part 2: toxicological testing, assays, and state of the science.

Journal Article Toxicological sciences : an official journal of the Society of Toxicology · October 2025 The toxicologic impacts on the normative function of the chemosensory system and the loss of its contribution to organism protection and homeostasis remain an underrepresented area of interest in the published literature. The impact of chemical constituent ... Full text Cite

Sugars in Tobacco Products: Toxicity Research and Implications for Tobacco Product Regulation.

Journal Article Chemical research in toxicology · May 2025 Sugars are naturally present in tobacco plants and are introduced as additives during the manufacturing of various tobacco- and nicotine-containing products. Product palatability and appeal are the primary reasons for manufacturers' attention to the sugar ... Full text Open Access Cite

Synthetic cooling agent in oral nicotine pouch products marketed as 'Flavour-Ban Approved'.

Journal Article Tob Control · January 2, 2025 BACKGROUND: US sales of oral nicotine pouches (ONPs) have rapidly increased, with cool/mint-flavoured ONPs the most popular flavour category. Restrictions on sales of flavoured tobacco products have either been implemented or proposed by several US states ... Full text Link to item Cite

Evading Menthol Bans through Chemistry: The tobacco industry illustrates why we need to overhaul the way we regulate chemicals.

Journal Article Sci Am · January 1, 2025 Regulating chemicals one-by-one has allowed the tobacco industry to skirt menthol bans by creating new additives with similar effects but unclear safety profiles ... Full text Link to item Cite

Artificial Sweeteners in US-Marketed Oral Nicotine Pouch Products: Correlation with Nicotine Contents and Effects on Product Preference.

Journal Article Nicotine Tob Res · December 5, 2024 INTRODUCTION: Artificial sweeteners, sucralose and acesulfame-k, are listed as ingredients of oral nicotine pouches (ONPs), a product category with rapidly growing market share. The exact quantities of these sweeteners in ONPs remain unknown. Artificial sw ... Full text Link to item Cite

Prioritizing Common Terminology and Measures to Advance Research on Oral Nicotine Product Use.

Journal Article Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · April 2024 Full text Open Access Cite

Marketing of nicotinamide as nicotine replacement in electronic cigarettes and smokeless tobacco.

Journal Article Tob Prev Cessat · 2024 In the United States, the Food and Drug Administration (FDA) requires tobacco product manufacturers to submit Premarket Tobacco Product Applications (PMTA) for new products, granting marketing approval only if deemed appropriate for the protection of publi ... Full text Link to item Cite

Introduction of nicotine analogue-containing oral pouch products in the United States.

Journal Article Tob Prev Cessat · 2024 In 2023, 6-methyl nicotine (6MN), a synthetic nicotine analog, was introduced in US-marketed electronic cigarette products advertised as exempt from regulation. It is unknown whether the use of 6MN has spread to other product categories. Industry reports, ... Full text Link to item Cite

Ice flavours and non-menthol synthetic cooling agents in e-cigarette products: a review.

Journal Article Tob Control · November 2023 E-cigarettes with cooling flavours have diversified in ways that complicate tobacco control with the emergence of: (1) Ice-hybrid flavours (eg, 'Raspberry Ice') that combine cooling and fruity/sweet properties; and (2) Products containing non-menthol synth ... Full text Link to item Cite

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.

Journal Article Br J Pharmacol · October 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions wit ... Full text Link to item Cite

Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment.

Journal Article Nicotine Tob Res · June 15, 2022 INTRODUCTION: Menthol, through its cooling and pleasant sensory effects, facilitates smoking and tobacco product initiation, resulting in the high popularity of mint/menthol-flavored E-cigarettes. More recently, E-cigarette vendors started marketing synthe ... Full text Open Access Link to item Cite

Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway.

Journal Article Journal of natural products · March 2022 Voltage-gated sodium channel (VGSC) activators promote neurite outgrowth by augmenting intracellular Na+ concentration ([Na+]i) and upregulating N-methyl-d-aspartate receptor (NMDAR) function. NMDAR activation stimulates ca ... Full text Cite

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.

Journal Article Cell Host Microbe · February 10, 2021 The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous system, but whether they also relay signals from intestinal microbes remains un ... Full text Link to item Cite

Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment

Journal Article · 2021 Background Menthol, through its cooling and pleasant sensory effects, facilitates smoking and tobacco product initiation, resulting in the high popularity of mint/menthol-flavored E-cigarettes. More recently, E-cigarette vendors started marketing ... Full text Cite

Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells.

Journal Article Nicotine Tob Res · December 15, 2020 INTRODUCTION: Flavor aldehydes in e-cigarettes, including vanillin, ethyl vanillin (vanilla), and benzaldehyde (berry/fruit), rapidly undergo chemical reactions with the e-liquid solvents, propylene glycol, and vegetable glycerol (PG/VG), to form chemical ... Full text Link to item Cite

Risk Analysis for the Carcinogen Pulegone in Mint- and Menthol-Flavored e-Cigarettes and Smokeless Tobacco Products.

Journal Article JAMA Intern Med · December 1, 2019 This analysis assesses the levels of the carcinogen pulegone in top-marketed brands of e-cigarettes and smokeless tobacco products. ... Full text Link to item Cite

Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids.

Journal Article Nicotine Tob Res · August 19, 2019 INTRODUCTION: "Vaping" electronic cigarettes (e-cigarettes) is increasingly popular with youth, driven by the wide range of available flavors, often created using flavor aldehydes. The objective of this study was to examine whether flavor aldehydes remain ... Full text Link to item Cite

Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.

Journal Article Br J Pharmacol · May 2017 BACKGROUND AND PURPOSE: Eucalyptol (1,8-cineol), the major ingredient in the essential oil of eucalyptus leaves and other medicinal plants, has long been known for its anti-inflammatory properties. Eucalyptol interacts with the TRP cation channels among ot ... Full text Link to item Cite

Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism.

Journal Article Tob Control · November 2016 BACKGROUND: Nicotine is a major oral irritant in smokeless tobacco products and has an aversive taste. Mentholated smokeless tobacco products are highly popular, suggesting that menthol increases their palatability and may facilitate initiation of product ... Full text Link to item Cite

Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism

Journal Article Tobacco Control · October 19, 2016 © 2016 by the BMJ Publishing Group Ltd. Background Nicotine is a major oral irritant in smokeless tobacco products and has an aversive taste. Mentholated smokeless tobacco products are highly popular, suggesting that menthol increases their palatability an ... Full text Cite

Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six.

Journal Article Neuron · June 4, 2014 Several transient receptor potential (TRP) ion channels are activated with high sensitivity by either cold or hot temperatures. However, structures and mechanism that determine temperature directionality (cold versus heat) are not established. Here we scre ... Full text Link to item Cite

Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx.

Journal Article Biochimica et biophysica acta · March 2013 BackgroundHerein we report the discovery of a cystine-crosslinked peptide from Porifera along with high-quality spatial details accompanied by the description of its unique effect on neuronal calcium influx.MethodsAsteropsin A (ASPA) was ... Full text Cite

Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.

Journal Article The Journal of organic chemistry · May 2012 Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthi ... Full text Cite

Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.

Journal Article The Journal of pharmacology and experimental therapeutics · March 2010 Antillatoxin (ATX) is a structurally novel lipopeptide that activates voltage-gated sodium channels (VGSC) leading to sodium influx in cerebellar granule neurons and cerebrocortical neurons 8 to 9 days in vitro (Li et al., 2001; Cao et al., 2008). However, ... Full text Cite

Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons.

Journal Article The Journal of neuroscience : the official journal of the Society for Neuroscience · March 2009 A range of extrinsic signals, including afferent activity, affect neuronal growth and plasticity. Neuronal activity regulates intracellular Ca(2+), and activity-dependent calcium signaling has been shown to regulate dendritic growth and branching (Konur an ... Full text Cite

Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model.

Journal Article BMC medicine · December 2006 BackgroundPendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pendrin expression and deaf ... Full text Cite

Microarray-based comparison of three amplification methods for nanogram amounts of total RNA.

Journal Article American journal of physiology. Cell physiology · May 2005 Gene expression profiling using microarrays requires microgram amounts of RNA, which limits its direct application for the study of nanogram RNA samples obtained using microdissection, laser capture microscopy, or needle biopsy. A novel system based on Rib ... Full text Cite

Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model.

Journal Article BMC medicine · August 2004 BackgroundPendred syndrome, a common autosomal-recessive disorder characterized by congenital deafness and goiter, is caused by mutations of SLC26A4, which codes for pendrin. We investigated the relationship between pendrin and deafness using mice ... Full text Cite