Sanjay Khandelwal
Assistant Professor in Medicine
Current Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Hematology, Medicine 2021
Contact Information
- Room 371, Alex H Sands Building, Research Drive, Durham, NC 27710
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sanjay.khandelwal@duke.edu
(919) 668-1550
- Background
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Education, Training, & Certifications
- Ph.D., Jawaharlal Nehru University (India) 2007
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Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Hematology, Medicine 2019 - 2020
- Expertise
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Subject Headings
- Research
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Selected Grants
- Complement and Thrombosis in HIT awarded by National Institutes of Health 2020 - 2024
- An examination of coagulation and inflammatory response of healthy donor whole blood to three North American snake venoms 2021 - 2022
- Complement and CR2/CD21 in the Immune Pathogenesis of HIT(R01) awarded by National Institutes of Health 2018 - 2022
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Khandelwal, Sanjay, Ayiesha Barnes, Lubica Rauova, Amrita Sarkar, Ann H. Rux, Serge V. Yarovoi, S Sergei Zaitsev, et al. “Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes.” Blood 138, no. 21 (November 25, 2021): 2106–16. https://doi.org/10.1182/blood.2020009487.Full Text Link to Item
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Schmitz, Robin, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, et al. “C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.” Nat Commun 12, no. 1 (September 15, 2021): 5456. https://doi.org/10.1038/s41467-021-25745-7.Full Text Link to Item
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Duarte, Madelaine, Maragatha Kuchibhatla, Sanjay Khandelwal, Gowthami M. Arepally, and Grace M. Lee. “Heterogeneity in neutrophil responses to immune complexes.” Blood Adv 3, no. 19 (October 8, 2019): 2778–89. https://doi.org/10.1182/bloodadvances.2019000235.Full Text Link to Item
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Khandelwal, Sanjay, Joann Ravi, Lubica Rauova, Alexandra Johnson, Grace M. Lee, Jennifer B. Gilner, Sreenivasulu Gunti, et al. “Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.” Blood 132, no. 23 (December 6, 2018): 2431–40. https://doi.org/10.1182/blood-2018-03-834598.Full Text Link to Item
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Khandelwal, Sanjay, Alexandra M. Johnson, Jian Liu, David Keire, Cynthia Sommers, Joann Ravi, Grace M. Lee, John D. Lambris, Edimara S. Reis, and Gowthami M. Arepally. “Novel Immunoassay for Complement Activation by PF4/Heparin Complexes.” Thromb Haemost 118, no. 8 (August 2018): 1484–87. https://doi.org/10.1055/s-0038-1660858.Full Text Link to Item
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Lee, Grace M., Manali Joglekar, Maragatha Kuchibhatla, Sanjay Khandelwal, Rui Qi, Lubica Rauova, and Gowthami M. Arepally. “Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies.” Blood Adv 1, no. 11 (April 25, 2017): 644–51. https://doi.org/10.1182/bloodadvances.2017004408.Full Text Link to Item
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Cines, Douglas B., Serge V. Yarovoi, Sergei V. Zaitsev, Tatiana Lebedeva, Lubica Rauova, Mortimer Poncz, Gowthami M. Arepally, et al. “Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.” Blood Adv 1, no. 1 (November 29, 2016): 62–74. https://doi.org/10.1182/bloodadvances.2016000877.Full Text Link to Item
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Khandelwal, Sanjay, and Gowthami M. Arepally. “Immune pathogenesis of heparin-induced thrombocytopenia.” Thromb Haemost 116, no. 5 (October 28, 2016): 792–98. https://doi.org/10.1160/TH16-01-0074.Full Text Link to Item
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Khandelwal, Sanjay, Grace M. Lee, C Garren Hester, Mortimer Poncz, Steven E. McKenzie, Bruce S. Sachais, Lubica Rauova, et al. “The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).” Blood 128, no. 14 (October 6, 2016): 1789–99. https://doi.org/10.1182/blood-2016-04-709634.Full Text Link to Item
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Joglekar, M., S. Khandelwal, D. B. Cines, M. Poncz, L. Rauova, and G. M. Arepally. “Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages.” J Thromb Haemost 13, no. 8 (August 2015): 1416–27. https://doi.org/10.1111/jth.13003.Full Text Link to Item
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Banerjee, Rajdeep, Sanjay Khandelwal, Yukiko Kozakai, Bikash Sahu, and Sanjai Kumar. “CD47 regulates the phagocytic clearance and replication of the Plasmodium yoelii malaria parasite.” Proc Natl Acad Sci U S A 112, no. 10 (March 10, 2015): 3062–67. https://doi.org/10.1073/pnas.1418144112.Full Text Link to Item
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Bosch, Berta, Adam C. Berger, Sanjay Khandelwal, Erica L. Heipertz, Brian Scharf, Laura Santambrogio, and Paul A. Roche. “Disruption of Multivesicular Body Vesicles Does Not Affect Major Histocompatibility Complex (MHC) Class II-Peptide Complex Formation and Antigen Presentation by Dendritic Cells*.” Journal of Biological Chemistry 288, no. 34 (August 2013): 24286–92. https://doi.org/10.1074/jbc.m113.461996.Full Text
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Saxena, Rajiv K., Nitin Bhardwaj, Sumedha Sachar, Niti Puri, and Sanjay Khandelwal. “A Double in vivo Biotinylation Technique for Objective Assessment of Aging and Clearance of Mouse Erythrocytes in Blood Circulation.” Transfusion Medicine and Hemotherapy 39, no. 5 (2012): 335–41. https://doi.org/10.1159/000342524.Full Text
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Khandelwal, Sanjay, and Paul A. Roche. “Distinct MHC Class II Molecules Are Associated on the Dendritic Cell Surface in Cholesterol-dependent Membrane Microdomains.” Journal of Biological Chemistry 285, no. 46 (November 2010): 35303–10. https://doi.org/10.1074/jbc.m110.147793.Full Text
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Khandelwal, Sanjay, and Rajiv K. Saxena. “A role of phosphatidylserine externalization in clearance of erythrocytes exposed to stress but not in eliminating aging populations of erythrocyte in mice.” Experimental Gerontology 43, no. 8 (August 2008): 764–70. https://doi.org/10.1016/j.exger.2008.05.002.Full Text
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Khandelwal, Sanjay, and Rajiv K. Saxena. “Erratum to: Age-dependent increase in green autofluorescence of blood erythrocytes.” Journal of Biosciences 32, no. S3 (December 2007): 1345–1345. https://doi.org/10.1007/s12038-007-0144-7.Full Text
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Khandelwal, Sanjay, Nico van Rooijen, and Rajiv K. Saxena. “Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation.” Transfusion 47, no. 9 (September 2007): 1725–32. https://doi.org/10.1111/j.1537-2995.2007.01348.x.Full Text
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Khandelwal, Sanjay, and Rajiv K. Saxena. “Assessment of survival of aging erythrocyte in circulation and attendant changes in size and CD147 expression by a novel two step biotinylation method.” Experimental Gerontology 41, no. 9 (September 2006): 855–61. https://doi.org/10.1016/j.exger.2006.06.045.Full Text
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