Platelet and red cell responses to three North American pit vipers.
Publication
, Journal Article
Francis, S; Khandelwal, S; Straight, R; Welton, L; Liang, P; Yang, H; Gerardo, CJ; Arepally, G
Published in: Toxicon
August 28, 2024
We investigated the hemotoxic effects of three North American pit vipers in healthy human donor blood. Using experiments focusing on platelet and red blood cell activity, we found differential effects of these venoms on these cellular components. Platelet aggregation was most induced by C. adamanteus. Platelet activation was highest with C. atrox. Red blood cells had calcium expression and erythrocyte formation most induced by C. adamanteus and A. piscivorus. These results demonstrate the complex interplay of individual cellular effects with clinical presentations seen in envenomings from these species.
Duke Scholars
Published In
Toxicon
DOI
EISSN
1879-3150
Publication Date
August 28, 2024
Volume
247
Start / End Page
107798
Location
England
Related Subject Headings
- Toxicology
- Platelet Aggregation
- Platelet Activation
- Humans
- Erythrocytes
- Crotalinae
- Crotalid Venoms
- Calcium
- Blood Platelets
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Francis, S., Khandelwal, S., Straight, R., Welton, L., Liang, P., Yang, H., … Arepally, G. (2024). Platelet and red cell responses to three North American pit vipers. Toxicon, 247, 107798. https://doi.org/10.1016/j.toxicon.2024.107798
Francis, Samuel, Sanjay Khandelwal, Richard Straight, Luke Welton, Pengfei Liang, Huanghe Yang, Charles J. Gerardo, and Gowthami Arepally. “Platelet and red cell responses to three North American pit vipers.” Toxicon 247 (August 28, 2024): 107798. https://doi.org/10.1016/j.toxicon.2024.107798.
Francis S, Khandelwal S, Straight R, Welton L, Liang P, Yang H, et al. Platelet and red cell responses to three North American pit vipers. Toxicon. 2024 Aug 28;247:107798.
Francis, Samuel, et al. “Platelet and red cell responses to three North American pit vipers.” Toxicon, vol. 247, Aug. 2024, p. 107798. Pubmed, doi:10.1016/j.toxicon.2024.107798.
Francis S, Khandelwal S, Straight R, Welton L, Liang P, Yang H, Gerardo CJ, Arepally G. Platelet and red cell responses to three North American pit vipers. Toxicon. 2024 Aug 28;247:107798.
Published In
Toxicon
DOI
EISSN
1879-3150
Publication Date
August 28, 2024
Volume
247
Start / End Page
107798
Location
England
Related Subject Headings
- Toxicology
- Platelet Aggregation
- Platelet Activation
- Humans
- Erythrocytes
- Crotalinae
- Crotalid Venoms
- Calcium
- Blood Platelets
- Animals