Huanghe Yang | Scholars@Duke

Huanghe Yang
Assistant Professor of Biochemistry

Current Appointments & Affiliations

Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 2015
Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2017
Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2019

Contact Information

213 Nanaline H Duke, Box 3711, DUMC, Durham, NC 27710
Box 3711,DUMC, Durham, NC 27710
huanghe.yang@duke.edu (919) 684-1406
Lab Link

Background
Education, Training, & Certifications
- Ph.D., Washington University in St. Louis 2008
Recognition
In the News
- OCT 5, 2017
  
  Two Duke Faculty Win NIH New Innovator Awards
Awards & Honors
- NIH Director's New Innovator Award. NIH. October 2017
- Pathway to Independence Award (K99/R00). NINDS. April 1, 2014
Expertise
Subject Headings
- Muser Mentor
Research
Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health 1975 - 2026
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Optogenetic stimulation of TMEM16F to control phospholipid flip-flop awarded by National Institutes of Health 2022 - 2024
- Molecular Underpinning and Functions of Endothelial Shear-induced Chloride Conductance awarded by American Heart Association 2022 - 2023
- BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer 2021 - 2023
- Manipulating TMEM16F lipid scramblase to understand transbilayer phospholipid transport phenomenon awarded by National Institutes of Health 2017 - 2022
- Targeting BK calcium-activated potassium channels in absence epilepsy awarded by American Epilepsy Society 2020 - 2021
- Investigate the expression and activation mechanism of TMEM16F phospholipid scramblase in endothelial cells. awarded by American Heart Association 2020
- Investigate the Molecular Mechanism of TMEM16A Ca2+-activated Chloride Channel Desensitization awarded by American Heart Association 2019 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- BW Collaborative Research Travel Grant: Collaborative effort to dissect the pathological roles of the newly discovered TMEM16 proteins in stroke awarded by Burroughs Wellcome Fund 2017 - 2018
- Elucidating the role of the calcium-activated chloride channels in essential tremor 2017 - 2018
- Ca2+ activated TMEM16 channels and their physiological roles in the brain awarded by National Institutes of Health 2015 - 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Zhang, Yang, Pengfei Liang, Liheng Yang, Ke Zoe Shan, Liping Feng, Yong Chen, Wolfgang Liedtke, Carolyn B. Coyne, and Huanghe Yang. “Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.” Elife 11 (June 7, 2022). https://doi.org/10.7554/eLife.78840.
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  - Dong, Ping, Yang Zhang, Arsen S. Hunanyan, Mohamad A. Mikati, Jianmin Cui, and Huanghe Yang. “Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia.” Proc Natl Acad Sci U S A 119, no. 12 (March 22, 2022): e2200140119. https://doi.org/10.1073/pnas.2200140119.
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  - Chen, Yong, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology 161, no. 1 (July 2021): 301-317.e16. https://doi.org/10.1053/j.gastro.2021.03.049.
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  - Liang, Pengfei, and Huanghe Yang. “Molecular underpinning of intracellular pH regulation on TMEM16F.” J Gen Physiol 153, no. 2 (February 1, 2021). https://doi.org/10.1085/jgp.202012704.
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  - Le, Son C., Pengfei Liang, Augustus J. Lowry, and Huanghe Yang. “Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases.” Front Physiol 12 (2021): 787773. https://doi.org/10.3389/fphys.2021.787773.
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  - Le, Son C., and Huanghe Yang. “Structure-Function of TMEM16 Ion Channels and Lipid Scramblases.” Adv Exp Med Biol 1349 (2021): 87–109. https://doi.org/10.1007/978-981-16-4254-8_6.
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  - Le, Son C., and Huanghe Yang. “An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation.” Cell Rep 33, no. 13 (December 29, 2020): 108570. https://doi.org/10.1016/j.celrep.2020.108570.
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  - Liao, Chengheng, Yang Zhang, Cheng Fan, Laura E. Herring, Juan Liu, Jason W. Locasale, Mamoru Takada, et al. “Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.” Cancer Discov 10, no. 11 (November 2020): 1706–21. https://doi.org/10.1158/2159-8290.CD-20-0288.
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  - Zhang, Guohui, Rebecca A. Gibson, Marie McDonald, Pengfei Liang, Po Wei Kang, Jingyi Shi, Huanghe Yang, Jianmin Cui, and Mohamad A. Mikati. “A Gain-of-Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy.” Mov Disord 35, no. 10 (October 2020): 1868–73. https://doi.org/10.1002/mds.28138.
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  - Le, Trieu, Son C. Le, Yang Zhang, Pengfei Liang, and Huanghe Yang. “Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F.” J Biol Chem 295, no. 35 (August 28, 2020): 12537–44. https://doi.org/10.1074/jbc.AC120.014872.
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  - Zhang, Yang, Trieu Le, Ryan Grabau, Zahra Mohseni, Hoejeong Kim, David R. Natale, Liping Feng, Hua Pan, and Huanghe Yang. “TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development.” Sci Adv 6, no. 19 (May 2020): eaba0310. https://doi.org/10.1126/sciadv.aba0310.
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  - Le, Son C., Zhiguang Jia, Jianhan Chen, and Huanghe Yang. “Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A.” Nat Commun 10, no. 1 (August 21, 2019): 3769. https://doi.org/10.1038/s41467-019-11784-8.
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  - Zhang, Yang, Trieu Le, Ryan Grabau, Zahra Mohseni, Hoejeong Kim, David R. Natale, Liping Feng, Hua Pan, and Huanghe Yang. “TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development,” July 24, 2019. https://doi.org/10.1101/711473.
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  - Zhang, Yang, and Huanghe Yang. “Corrigendum to "A simple and robust fluorescent labeling method to quantify trophoblast fusion" [Placenta 77 (2019) 16-18].” Placenta 82 (July 2019): 57. https://doi.org/10.1016/j.placenta.2019.05.011.
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  - Le, Trieu, Zhiguang Jia, Son C. Le, Yang Zhang, Jianhan Chen, and Huanghe Yang. “An inner activation gate controls TMEM16F phospholipid scrambling.” Nat Commun 10, no. 1 (April 23, 2019): 1846. https://doi.org/10.1038/s41467-019-09778-7.
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  - Le, Trieu, Son C. Le, and Huanghe Yang. “Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids.” J Biol Chem 294, no. 12 (March 22, 2019): 4529–37. https://doi.org/10.1074/jbc.AC118.006530.
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  - Yin, Ying, Son C. Le, Allen L. Hsu, Mario J. Borgnia, Huanghe Yang, and Seok-Yong Lee. “Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.” Science 363, no. 6430 (March 1, 2019). https://doi.org/10.1126/science.aav9334.
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  - Zhang, Yang, and Huanghe Yang. “A simple and robust fluorescent labeling method to quantify trophoblast fusion.” Placenta 77 (February 2019): 16–18. https://doi.org/10.1016/j.placenta.2019.01.016.
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  - Le, Son C., Zhiguang Jia, Jianhan Chen, and Huanghe Yang. “A Phosphoinositide Binding Module Controls TMEM16A Desensitization,” November 20, 2018.
    Open Access Copy
  - Zubcevic, Lejla, Son Le, Huanghe Yang, and Seok-Yong Lee. “Conformational plasticity in the selectivity filter of the TRPV2 ion channel.” Nat Struct Mol Biol 25, no. 5 (May 2018): 405–15. https://doi.org/10.1038/s41594-018-0059-z.
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  - Zhou, Yu, Huanghe Yang, Jianmin Cui, and Christopher J. Lingle. “Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel.” J Gen Physiol 149, no. 11 (November 6, 2017): 985–1007. https://doi.org/10.1085/jgp.201711845.
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  - Zhang, Yang, Zhushan Zhang, Shaohua Xiao, Jason Tien, Son Le, Trieu Le, Lily Y. Jan, and Huanghe Yang. “Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.” Neuron 95, no. 5 (August 30, 2017): 1103-1111.e4. https://doi.org/10.1016/j.neuron.2017.08.010.
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  - Huang, Xi, Ye He, Adrian M. Dubuc, Rintaro Hashizume, Wei Zhang, Jüri Reimand, Huanghe Yang, et al. “EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.” Nat Neurosci 18, no. 9 (September 2015): 1236–46. https://doi.org/10.1038/nn.4088.
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  - Yang, Huanghe, Guohui Zhang, and Jianmin Cui. “BK channels: multiple sensors, one activation gate.” Front Physiol 6 (2015): 29. https://doi.org/10.3389/fphys.2015.00029.
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  - Zhang, Guohui, Huanghe Yang, Hongwu Liang, Junqiu Yang, Jingyi Shi, Kelli McFarland, Yihan Chen, and Jianmin Cui. “A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.” J Neurosci 34, no. 37 (September 10, 2014): 12280–88. https://doi.org/10.1523/JNEUROSCI.1174-14.2014.
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  - Tien, J., C. J. Peters, X. M. Wong, T. Cheng, Y. N. Jan, L. Y. Jan, and H. Yang. “A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.” Elife 2014, no. 3 (June 30, 2014). https://doi.org/10.7554/eLife.02772.001.
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  - Tien, Jason, Christian J. Peters, Xiu Ming Wong, Tong Cheng, Yuh Nung Jan, Lily Yeh Jan, and Huanghe Yang. “A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.” Elife 3 (June 30, 2014). https://doi.org/10.7554/eLife.02772.
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  - Hong, TingTing, Huanghe Yang, Shan-Shan Zhang, Hee Cheol Cho, Mariya Kalashnikova, Baiming Sun, Hao Zhang, et al. “Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.” Nat Med 20, no. 6 (June 2014): 624–32. https://doi.org/10.1038/nm.3543.
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  - Sun, Xiaohui, Jingyi Shi, Kelli Delaloye, Xiao Yang, Huanghe Yang, Guohui Zhang, and Jianmin Cui. “The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating.” J Neurosci 33, no. 27 (July 3, 2013): 11253–61. https://doi.org/10.1523/JNEUROSCI.0620-13.2013.
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  - Yang, Junqiu, Huanghe Yang, Xiaohui Sun, Kelli Delaloye, Xiao Yang, Alyssa Moller, Jingyi Shi, and Jianmin Cui. “Interaction between residues in the Mg2+-binding site regulates BK channel activation.” J Gen Physiol 141, no. 2 (February 2013): 217–28. https://doi.org/10.1085/jgp.201210794.
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  - Huang, Fen, Hongkang Zhang, Meng Wu, Huanghe Yang, Makoto Kudo, Christian J. Peters, Prescott G. Woodruff, et al. “Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.” Proc Natl Acad Sci U S A 109, no. 40 (October 2, 2012): 16354–59. https://doi.org/10.1073/pnas.1214596109.
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  - Yang, Huanghe, Andrew Kim, Tovo David, Daniel Palmer, Taihao Jin, Jason Tien, Fen Huang, et al. “TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.” Cell 151, no. 1 (September 28, 2012): 111–22. https://doi.org/10.1016/j.cell.2012.07.036.
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  - Berg, Jim, Huanghe Yang, and Lily Yeh Jan. “Ca2+-activated Cl- channels at a glance.” J Cell Sci 125, no. Pt 6 (March 15, 2012): 1367–71. https://doi.org/10.1242/jcs.093260.
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  - Yang, Junqiu, Gayathri Krishnamoorthy, Akansha Saxena, Guohui Zhang, Jingyi Shi, Huanghe Yang, Kelli Delaloye, David Sept, and Jianmin Cui. “An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.” Neuron 66, no. 6 (June 24, 2010): 871–83. https://doi.org/10.1016/j.neuron.2010.05.009.
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  - Cui, J., H. Yang, and U. S. Lee. “Molecular mechanisms of BK channel activation.” Cell Mol Life Sci 66, no. 5 (March 2009): 852–75. https://doi.org/10.1007/s00018-008-8609-x.
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  - Yang, Huanghe, Jingyi Shi, Guohui Zhang, Junqiu Yang, Kelli Delaloye, and Jianmin Cui. “Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains.” Nat Struct Mol Biol 15, no. 11 (November 2008): 1152–59. https://doi.org/10.1038/nsmb.1507.
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  - Yang, Huanghe, Guohui Zhang, Jingyi Shi, Urvi S. Lee, Kelli Delaloye, and Jianmin Cui. “Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels.” Biophys J 94, no. 12 (June 2008): 4678–87. https://doi.org/10.1529/biophysj.107.121590.
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  - Yang, Huanghe, Lei Hu, Jingyi Shi, Kelli Delaloye, Frank T. Horrigan, and Jianmin Cui. “Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels.” Proc Natl Acad Sci U S A 104, no. 46 (November 13, 2007): 18270–75. https://doi.org/10.1073/pnas.0705873104.
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  - Yang, Huanghe, Lei Hu, Jingyi Shi, and Jianmin Cui. “Tuning magnesium sensitivity of BK channels by mutations.” Biophys J 91, no. 8 (October 15, 2006): 2892–2900. https://doi.org/10.1529/biophysj.106.090159.
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  - Hu, Lei, Huanghe Yang, Jingyi Shi, and Jianmin Cui. “Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels.” J Gen Physiol 127, no. 1 (January 2006): 35–49. https://doi.org/10.1085/jgp.200509317.
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  - Du, Wei, Jocelyn F. Bautista, Huanghe Yang, Ana Diez-Sampedro, Sun-Ah You, Lejin Wang, Prakash Kotagal, et al. “Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder.” Nat Genet 37, no. 7 (July 2005): 733–38. https://doi.org/10.1038/ng1585.
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  - Tang, J. W., H. H. Yang, L. L. Ren, A. Q. Wang, L. Ma, T. Zhang, and L. W. Lin. “The Decomposition of NO in Microwave Discharge.” Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities 23, no. 4 (April 1, 2002): 635.
  - Tang, J., T. Zhang, D. Liang, H. Yang, N. Li, and L. Lin. “Direct decomposition of NO by microwave heating over Fe/NaZSM-5.” Applied Catalysis B: Environmental 36, no. 1 (February 8, 2002): 1–7. https://doi.org/10.1016/S0926-3373(01)00268-5.
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  - Tang, J. W., H. H. Yang, L. L. Ren, A. Q. Wang, L. Ma, T. Zhang, and L. W. Lin. “The decomposition of NO in microwave discharge.” Chemical Journal of Chinese Universities Chinese 23, no. 4 (2002): 632–35.
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  - Yang, H., T. Zhang, H. Tian, J. Tang, D. Xu, W. Yang, and L. Lin. “Effect of Sr substitution on catalytic activity of La1-xSrxMnO3 (0≤x≤0.8) perovskite-type oxides for catalytic decomposition of hydrogen peroxide.” Reaction Kinetics and Catalysis Letters 73, no. 2 (December 1, 2001): 311–16. https://doi.org/10.1023/A:1014115508872.
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  - Yang, H., T. Zhang, H. Tian, X. U. Dezhu, T. Junwang, and L. Liwu. “Decomposition of high concentration hydrogen peroxide over alumina-supported La0.6Sr0.4MnO3 perovskite catalyst.” Chinese Journal of Catalysis 22, no. 3 (December 1, 2001): 225–26.
  - Tang, J., T. Zhang, A. Wang, L. Ren, H. Yang, L. Ma, and L. Lin. “Removal of NO by microwave discharge with the addition of CH4.” Chemistry Letters, no. 2 (January 1, 2001): 140–41. https://doi.org/10.1246/cl.2001.140.
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  - Tian, H., T. Zhang, H. Yang, X. Sun, D. Liang, and L. Lin. “Manganese-lead mixed oxide catalysts for decomposition of hydrogen peroxide.” Chinese Journal of Catalysis 21, no. 6 (November 1, 2000): 602.
- Book Sections
  - Yang, H., and L. Y. Jan. “TMEM16 Membrane Proteins in Health and Disease.” In Ion Channels in Health and Disease, 165–97, 2016. https://doi.org/10.1016/B978-0-12-802002-9.00007-8.
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  - Yang, H., and J. Cui. “BK channels.” In Handbook of Ion Channels, 227–39, 2015. https://doi.org/10.1201/b18027-25.
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- Conference Papers
  - Yang, H., T. Zhang, H. Tian, J. Tang, D. Xu, L. Ren, J. Zhao, and L. Lin. “Perovskite Type Oxides: A Novel Type of Catalysts Suitable for Hydrogen Peroxide Decomposition.” In European Space Agency, (Special Publication) Esa Sp, 197–200, 2001.
- Preprints
  - Yang, Liheng, Pengfei Liang, Huanghe Yang, and Carolyn B. Coyne. “Trophoblast organoids with physiological polarity model placental structure and function.,” January 12, 2023. https://doi.org/10.1101/2023.01.12.523752.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

In the News

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Preprints

Recent Courses