Huanghe Yang | Scholars@Duke

Huanghe Yang
Assistant Professor of Biochemistry

Current Appointments & Affiliations

Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 2015
Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2017
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2019

Contact Information

151 Nanaline H Duke, Box 3711, DUMC, Durham, NC 27710
Box 3711,DUMC, Durham, NC 27710
huanghe.yang@duke.edu (919) 684-1406

Background
Education, Training, & Certifications
- Ph.D., Washington University in St. Louis 2008
Duke Appointment History
- Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 2015
Recognition
In the News
- OCT 5, 2017
  
  Two Duke Faculty Win NIH New Innovator Awards
Awards & Honors
- NIH Director's New Innovator Award. NIH. October 2017
- Pathway to Independence Award (K99/R00). NINDS. April 1, 2014
Research
Selected Grants
- Manipulating TMEM16F lipid scramblase to understand the transbilayer phospholipid transport phenomenon awarded by National Institutes of Health 2017 - 2022
- Investigate the Molecular Mechanism of TMEM16A Ca2+-activated Chloride Channel Desensitization awarded by American Heart Association 2019 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Collaborative effort to dissect the pathological roles of the newly discovered TMEM16 proteins in stroke awarded by Burroughs Wellcome Fund 2017 - 2018
- Elucidating the role of the calcium-activated chloride channels in essential tremor awarded by International Essential Tremor Foundation 2017 - 2018
- Ca2+ activated TMEM16 channels and their physiological roles in the brain awarded by National Institutes of Health 2015 - 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Le, Trieu, Zhiguang Jia, Son C. Le, Yang Zhang, Jianhan Chen, and Huanghe Yang. “An inner activation gate controls TMEM16F phospholipid scrambling..” Nat Commun 10, no. 1 (April 23, 2019). https://doi.org/10.1038/s41467-019-09778-7.
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  - Le, Trieu, Son C. Le, and Huanghe Yang. “Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids..” The Journal of Biological Chemistry 294, no. 12 (March 2019): 4529–37. https://doi.org/10.1074/jbc.ac118.006530.
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  - Yin, Ying, Son C. Le, Allen L. Hsu, Mario J. Borgnia, Huanghe Yang, and Seok-Yong Lee. “Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel..” Science (New York, N.Y.) 363, no. 6430 (March 2019). https://doi.org/10.1126/science.aav9334.
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  - Zhang, Yang, and Huanghe Yang. “A simple and robust fluorescent labeling method to quantify trophoblast fusion..” Placenta 77 (February 2019): 16–18. https://doi.org/10.1016/j.placenta.2019.01.016.
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  - Zubcevic, Lejla, Son Le, Huanghe Yang, and Seok-Yong Lee. “Conformational plasticity in the selectivity filter of the TRPV2 ion channel..” Nat Struct Mol Biol 25, no. 5 (May 2018): 405–15. https://doi.org/10.1038/s41594-018-0059-z.
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  - Zhou, Yu, Huanghe Yang, Jianmin Cui, and Christopher J. Lingle. “Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel..” The Journal of General Physiology 149, no. 11 (November 2017): 985–1007. https://doi.org/10.1085/jgp.201711845.
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  - Zhang, Yang, Zhushan Zhang, Shaohua Xiao, Jason Tien, Son Le, Trieu Le, Lily Y. Jan, and Huanghe Yang. “Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning..” Neuron 95, no. 5 (August 2017): 1103-1111.e4. https://doi.org/10.1016/j.neuron.2017.08.010.
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  - Huang, Xi, Ye He, Adrian M. Dubuc, Rintaro Hashizume, Wei Zhang, Jüri Reimand, Huanghe Yang, et al. “EAG2 potassium channel with evolutionarily conserved function as a brain tumor target..” Nature Neuroscience 18, no. 9 (September 2015): 1236–46. https://doi.org/10.1038/nn.4088.
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  - Yang, Huanghe, Guohui Zhang, and Jianmin Cui. “BK channels: multiple sensors, one activation gate..” Frontiers in Physiology 6 (January 2015). https://doi.org/10.3389/fphys.2015.00029.
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  - Zhang, Guohui, Huanghe Yang, Hongwu Liang, Junqiu Yang, Jingyi Shi, Kelli McFarland, Yihan Chen, and Jianmin Cui. “A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 34, no. 37 (September 2014): 12280–88. https://doi.org/10.1523/JNEUROSCI.1174-14.2014.
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  - Tien, J., C. J. Peters, X. M. Wong, T. Cheng, Y. N. Jan, L. Y. Jan, and H. Yang. “A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.” Elife 2014, no. 3 (June 30, 2014). https://doi.org/10.7554/eLife.02772.001.
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  - Tien, Jason, Christian J. Peters, Xiu Ming Wong, Tong Cheng, Yuh Nung Jan, Lily Yeh Jan, and Huanghe Yang. “A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity..” Elife 3 (June 30, 2014). https://doi.org/10.7554/eLife.02772.
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  - Hong, TingTing, Huanghe Yang, Shan-Shan Zhang, Hee Cheol Cho, Mariya Kalashnikova, Baiming Sun, Hao Zhang, et al. “Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia..” Nature Medicine 20, no. 6 (June 2014): 624–32. https://doi.org/10.1038/nm.3543.
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  - Sun, Xiaohui, Jingyi Shi, Kelli Delaloye, Xiao Yang, Huanghe Yang, Guohui Zhang, and Jianmin Cui. “The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 33, no. 27 (July 2013): 11253–61. https://doi.org/10.1523/JNEUROSCI.0620-13.2013.
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  - Yang, Junqiu, Huanghe Yang, Xiaohui Sun, Kelli Delaloye, Xiao Yang, Alyssa Moller, Jingyi Shi, and Jianmin Cui. “Interaction between residues in the Mg2+-binding site regulates BK channel activation..” The Journal of General Physiology 141, no. 2 (February 2013): 217–28. https://doi.org/10.1085/jgp.201210794.
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  - Huang, Fen, Hongkang Zhang, Meng Wu, Huanghe Yang, Makoto Kudo, Christian J. Peters, Prescott G. Woodruff, et al. “Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction..” Proc Natl Acad Sci U S A 109, no. 40 (October 2, 2012): 16354–59. https://doi.org/10.1073/pnas.1214596109.
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  - Yang, Huanghe, Andrew Kim, Tovo David, Daniel Palmer, Taihao Jin, Jason Tien, Fen Huang, et al. “TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation..” Cell 151, no. 1 (September 2012): 111–22. https://doi.org/10.1016/j.cell.2012.07.036.
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  - Berg, Jim, Huanghe Yang, and Lily Yeh Jan. “Ca2+-activated Cl- channels at a glance..” Journal of Cell Science 125, no. Pt 6 (March 2012): 1367–71. https://doi.org/10.1242/jcs.093260.
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  - Yang, Junqiu, Gayathri Krishnamoorthy, Akansha Saxena, Guohui Zhang, Jingyi Shi, Huanghe Yang, Kelli Delaloye, David Sept, and Jianmin Cui. “An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing..” Neuron 66, no. 6 (June 2010): 871–83. https://doi.org/10.1016/j.neuron.2010.05.009.
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  - Cui, J., H. Yang, and U. S. Lee. “Molecular mechanisms of BK channel activation..” Cellular and Molecular Life Sciences : Cmls 66, no. 5 (March 2009): 852–75. https://doi.org/10.1007/s00018-008-8609-x.
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  - Yang, Huanghe, Jingyi Shi, Guohui Zhang, Junqiu Yang, Kelli Delaloye, and Jianmin Cui. “Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains..” Nature Structural & Molecular Biology 15, no. 11 (November 2008): 1152–59. https://doi.org/10.1038/nsmb.1507.
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  - Yang, Huanghe, Guohui Zhang, Jingyi Shi, Urvi S. Lee, Kelli Delaloye, and Jianmin Cui. “Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels..” Biophysical Journal 94, no. 12 (June 2008): 4678–87. https://doi.org/10.1529/biophysj.107.121590.
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  - Yang, Huanghe, Lei Hu, Jingyi Shi, Kelli Delaloye, Frank T. Horrigan, and Jianmin Cui. “Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels..” Proceedings of the National Academy of Sciences of the United States of America 104, no. 46 (November 5, 2007): 18270–75. https://doi.org/10.1073/pnas.0705873104.
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  - Yang, Huanghe, Lei Hu, Jingyi Shi, and Jianmin Cui. “Tuning magnesium sensitivity of BK channels by mutations..” Biophysical Journal 91, no. 8 (October 2006): 2892–2900. https://doi.org/10.1529/biophysj.106.090159.
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  - Hu, Lei, Huanghe Yang, Jingyi Shi, and Jianmin Cui. “Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels..” The Journal of General Physiology 127, no. 1 (January 2006): 35–49. https://doi.org/10.1085/jgp.200509317.
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  - Du, Wei, Jocelyn F. Bautista, Huanghe Yang, Ana Diez-Sampedro, Sun-Ah You, Lejin Wang, Prakash Kotagal, et al. “Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder..” Nature Genetics 37, no. 7 (July 2005): 733–38. https://doi.org/10.1038/ng1585.
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  - Tang, J. W., H. H. Yang, L. L. Ren, A. Q. Wang, L. Ma, T. Zhang, and L. W. Lin. “The Decomposition of NO in Microwave Discharge.” Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities 23, no. 4 (April 1, 2002).
  - Tang, J., T. Zhang, D. Liang, H. Yang, N. Li, and L. Lin. “Direct decomposition of NO by microwave heating over Fe/NaZSM-5.” Applied Catalysis B: Environmental 36, no. 1 (February 8, 2002): 1–7. https://doi.org/10.1016/S0926-3373(01)00268-5.
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  - Yang, H., T. Zhang, H. Tian, J. Tang, D. Xu, W. Yang, and L. Lin. “Effect of Sr substitution on catalytic activity of La1-xSrxMnO3 (0≤x≤0.8) perovskite-type oxides for catalytic decomposition of hydrogen peroxide.” Reaction Kinetics and Catalysis Letters 73, no. 2 (December 1, 2001): 311–16. https://doi.org/10.1023/A:1014115508872.
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  - Yang, H., T. Zhang, H. Tian, X. U. Dezhu, T. Junwang, and L. Liwu. “Decomposition of high concentration hydrogen peroxide over alumina-supported La0.6Sr0.4MnO3 perovskite catalyst.” Chinese Journal of Catalysis 22, no. 3 (December 1, 2001): 225–26.
  - Tang, J., T. Zhang, A. Wang, L. Ren, H. Yang, L. Ma, and L. Lin. “Removal of NO by microwave discharge with the addition of CH 4.” Chemistry Letters, no. 2 (January 1, 2001): 140–41. https://doi.org/10.1246/cl.2001.140.
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  - Tian, H., T. Zhang, H. Yang, X. Sun, D. Liang, and L. Lin. “Manganese-lead mixed oxide catalysts for decomposition of hydrogen peroxide.” Chinese Journal of Catalysis 21, no. 6 (November 1, 2000).
- Book Sections
  - Yang, H., and L. Y. Jan. “TMEM16 Membrane Proteins in Health and Disease.” In Ion Channels in Health and Disease, 165–97, 2016. https://doi.org/10.1016/B978-0-12-802002-9.00007-8.
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- Conference Papers
  - Yang, H., T. Zhang, H. Tian, J. Tang, D. Xu, L. Ren, J. Zhao, and L. Lin. “Perovskite Type Oxides: A Novel Type of Catalysts Suitable for Hydrogen Peroxide Decomposition.” In European Space Agency, (Special Publication) Esa Sp, 197–200, 2001.
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses