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Huanghe Yang

Associate Professor of Biochemistry
Biochemistry
Box 3711,DUMC, Durham, NC 27710
213 Nanaline H Duke, Box 3711, DUMC, Durham, NC 27710

Current Appointments & Affiliations


Associate Professor of Biochemistry · 2023 - Present Biochemistry, Basic Science Departments
Assistant Professor of Cell Biology · 2022 - Present Cell Biology, Basic Science Departments
Associate Professor in Medicine · 2024 - Present Medicine, Hematology, Medicine
Associate Professor in Neurobiology · 2024 - Present Neurobiology, Basic Science Departments
Faculty Network Member of the Duke Institute for Brain Sciences · 2019 - Present Duke Institute for Brain Sciences, University Institutes and Centers

In the News


Published October 5, 2017
Two Duke Faculty Win NIH New Innovator Awards

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Recent Publications


Structural and functional basis of mechanosensitive TMEM63 channelopathies.

Journal Article Neuron · June 2, 2025 TMEM63A, -B, and -C constitute a mammalian family of mechanosensitive ion channels that are mutated in neurodevelopmental disorders. The molecular mechanisms underlying TMEM63 activation by force and the impact of disease-associated mutations have not been ... Full text Link to item Cite

Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications.

Journal Article bioRxiv · May 31, 2025 A deeper understanding of sickle cell disease (SCD) pathophysiology is critical for identifying novel therapeutic targets. A hallmark of SCD is abnormal phosphatidylserine (PS) exposure on sickle red blood cells (RBCs), which contributes to anemia, thrombo ... Full text Link to item Cite

PIEZO1 Drives Trophoblast Fusion and Placental Development.

Journal Article bioRxiv · March 26, 2025 PIEZO1, a mechanosensor1,2 in endothelial cells, plays a critical role in fetal vascular development during embryogenesis3,4. However, its expression and function in placental trophoblasts remain unexplored. Here, we demonstrate that PIEZO1 is expressed in ... Full text Link to item Cite
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Recent Grants


LpxH Inhibitors as Novel Therapeutics Against Multidrug-resistant Enterobacterales

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2030

Neurobiology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029

Advancing mechanistic understanding of membrane ion and lipid transport

ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2024 - 2029

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Education, Training & Certifications


Washington University in St. Louis · 2008 Ph.D.

External Links


Lab Link