Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Washington University 2008
• 

  Duke Appointment History

  • Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 2015
• Recognition
• 

  In the News

  • OCT 5, 2017

    Two Duke Faculty Win NIH New Innovator Awards
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  Awards & Honors

  • NIH Director's New Innovator Award. NIH. October 2017
  • Pathway to Independence Award (K99/R00). NINDS. April 1, 2014
• Research
• 

  Selected Grants

  • Manipulating TMEM16F lipid scramblase to understand the transbilayer phospholipid transport phenomenon awarded by National Institutes of Health 2017 - 2022
  • Investigate the Molecular Mechanism of TMEM16A Ca2+-activated Chloride Channel Desensitization awarded by  American Heart Association 2019 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Collaborative effort to dissect the pathological roles of the newly discovered TMEM16 proteins in stroke awarded by Burroughs Wellcome Fund 2017 - 2018
  • Elucidating the role of the calcium-activated chloride channels in essential tremor awarded by International Essential Tremor Foundation 2017 - 2018
  • Ca2+ activated TMEM16 channels and their physiological roles in the brain awarded by National Institutes of Health 2015 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zubcevic, L, Le, S, Yang, H, and Lee, S-Y. "Conformational plasticity in the selectivity filter of the TRPV2 ion channel." Nature Structural & Molecular Biology 25, no. 5 (May 2018): 405-415.  Full Text
    • Zhou, Y, Yang, H, Cui, J, and Lingle, CJ. "Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel." The Journal of General Physiology 149, no. 11 (November 6, 2017): 985-1007.  Full Text
    • Zhang, Y, Zhang, Z, Xiao, S, Tien, J, Le, S, Le, T, Jan, LY, and Yang, H. "Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning." Neuron 95, no. 5 (August 2017): 1103-1111.e4.  Full Text
    • Huang, X, He, Y, Dubuc, AM, Hashizume, R, Zhang, W, Reimand, J, Yang, H, Wang, TA, Stehbens, SJ, Younger, S, Barshow, S, Zhu, S, Cooper, MK, Peacock, J, Ramaswamy, V, Garzia, L, Wu, X, Remke, M, Forester, CM, Kim, CC, Weiss, WA, James, CD, Shuman, MA, Bader, GD, Mueller, S, Taylor, MD, Jan, YN, and Jan, LY. "EAG2 potassium channel with evolutionarily conserved function as a brain tumor target." Nature Neuroscience 18, no. 9 (September 2015): 1236-1246.  Full Text
    • Yang, H, Zhang, G, and Cui, J. "BK channels: multiple sensors, one activation gate." Frontiers in Physiology 6 (January 2015): 29-null. (Review)  Full Text
    • Zhang, G, Yang, H, Liang, H, Yang, J, Shi, J, McFarland, K, Chen, Y, and Cui, J. "A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 34, no. 37 (September 2014): 12280-12288.  Full Text
    • Tien, J, Peters, CJ, Wong, XM, Cheng, T, Jan, YN, Jan, LY, and Yang, H. "A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity." Elife 2014, no. 3 (June 30, 2014).  Full Text
    • Tien, J, Peters, CJ, Wong, XM, Cheng, T, Jan, YN, Jan, LY, and Yang, H. "A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity." Elife 3 (June 30, 2014).  Full Text
    • Hong, T, Yang, H, Zhang, S-S, Cho, HC, Kalashnikova, M, Sun, B, Zhang, H, Bhargava, A, Grabe, M, Olgin, J, Gorelik, J, Marbán, E, Jan, LY, and Shaw, RM. "Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia." Nature Medicine 20, no. 6 (June 2014): 624-632.  Full Text
    • Sun, X, Shi, J, Delaloye, K, Yang, X, Yang, H, Zhang, G, and Cui, J. "The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 33, no. 27 (July 2013): 11253-11261.  Full Text
    • Yang, J, Yang, H, Sun, X, Delaloye, K, Yang, X, Moller, A, Shi, J, and Cui, J. "Interaction between residues in the Mg2+-binding site regulates BK channel activation." The Journal of general physiology 141, no. 2 (February 2013): 217-228.  Full Text
    • Huang, F, Zhang, H, Wu, M, Yang, H, Kudo, M, Peters, CJ, Woodruff, PG, Solberg, OD, Donne, ML, Huang, X, Sheppard, D, Fahy, JV, Wolters, PJ, Hogan, BLM, Finkbeiner, WE, Li, M, Jan, Y-N, Jan, LY, and Rock, JR. "Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction." Proceedings of the National Academy of Sciences of the United States of America 109, no. 40 (October 2012): 16354-16359.  Full Text
    • Yang, H, Kim, A, David, T, Palmer, D, Jin, T, Tien, J, Huang, F, Cheng, T, Coughlin, SR, Jan, YN, and Jan, LY. "TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation." Cell 151, no. 1 (September 2012): 111-122.  Full Text
    • Berg, J, Yang, H, and Jan, LY. "Ca2+-activated Cl- channels at a glance." Journal of cell science 125, no. Pt 6 (March 2012): 1367-1371. (Review)  Full Text
    • Yang, J, Krishnamoorthy, G, Saxena, A, Zhang, G, Shi, J, Yang, H, Delaloye, K, Sept, D, and Cui, J. "An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing." Neuron 66, no. 6 (June 2010): 871-883.  Full Text
    • Cui, J, Yang, H, and Lee, US. "Molecular mechanisms of BK channel activation." Cellular and Molecular Life Sciences : Cmls 66, no. 5 (March 2009): 852-875. (Review)  Full Text
    • Yang, H, Shi, J, Zhang, G, Yang, J, Delaloye, K, and Cui, J. "Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains." Nature structural & molecular biology 15, no. 11 (November 2008): 1152-1159.  Full Text
    • Yang, H, Zhang, G, Shi, J, Lee, US, Delaloye, K, and Cui, J. "Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels." Biophysical journal 94, no. 12 (June 2008): 4678-4687.  Full Text
    • Yang, H, Hu, L, Shi, J, Delaloye, K, Horrigan, FT, and Cui, J. "Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels." Proceedings of the National Academy of Sciences of the United States of America 104, no. 46 (November 5, 2007): 18270-18275.  Full Text
    • Yang, H, Hu, L, Shi, J, and Cui, J. "Tuning magnesium sensitivity of BK channels by mutations." Biophysical journal 91, no. 8 (October 2006): 2892-2900.  Full Text
    • Hu, L, Yang, H, Shi, J, and Cui, J. "Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels." The Journal of general physiology 127, no. 1 (January 2006): 35-49.  Full Text
    • Du, W, Bautista, JF, Yang, H, Diez-Sampedro, A, You, S-A, Wang, L, Kotagal, P, Lüders, HO, Shi, J, Cui, J, Richerson, GB, and Wang, QK. "Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder." Nature Genetics 37, no. 7 (July 2005): 733-738.  Full Text
    • Tang, JW, Yang, HH, Ren, LL, Wang, AQ, Ma, L, Zhang, T, and Lin, LW. "The Decomposition of NO in Microwave Discharge." Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities 23, no. 4 (April 1, 2002): 635-null.
    • Tang, J, Zhang, T, Liang, D, Yang, H, Li, N, and Lin, L. "Direct decomposition of NO by microwave heating over Fe/NaZSM-5." Applied Catalysis B: Environmental 36, no. 1 (February 8, 2002): 1-7. (Review)  Full Text
    • Yang, H, Zhang, T, Tian, H, Dezhu, XU, Junwang, T, and Liwu, L. "Decomposition of high concentration hydrogen peroxide over alumina-supported La0.6Sr0.4MnO3 perovskite catalyst." Chinese Journal of Catalysis 22, no. 3 (December 1, 2001): 225-226.
    • Yang, H, Zhang, T, Tian, H, Tang, J, Xu, D, Yang, W, and Lin, L. "Effect of Sr substitution on catalytic activity of La1-xSrxMnO3 (0≤x≤0.8) perovskite-type oxides for catalytic decomposition of hydrogen peroxide." Reaction Kinetics and Catalysis Letters 73, no. 2 (December 1, 2001): 311-316.  Full Text
    • Tang, J, Zhang, T, Wang, A, Ren, L, Yang, H, Ma, L, and Lin, L. "Removal of NO by microwave discharge with the addition of CH4." Chemistry Letters , no. 2 (January 1, 2001): 140-141.  Full Text
    • Tian, H, Zhang, T, Yang, H, Sun, X, Liang, D, and Lin, L. "Manganese-lead mixed oxide catalysts for decomposition of hydrogen peroxide." Chinese Journal of Catalysis 21, no. 6 (November 1, 2000): 602-null.

  • Book Sections

    • Yang, H, and Jan, LY. "TMEM16 Membrane Proteins in Health and Disease." In Ion Channels in Health and Disease, 165-197. July 29, 2016.  Full Text

  • Conference Papers

    • Yang, H, Zhang, T, Tian, H, Tang, J, Xu, D, Ren, L, Zhao, J, and Lin, L. "Perovskite Type Oxides: A Novel Type of Catalysts Suitable for Hydrogen Peroxide Decomposition." December 1, 2001.
• Teaching & Mentoring
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  Recent Courses

  • BIOCHEM 393: Research Independent Study 2019
  • BIOCHEM 593: Research Independent Study 2019
  • NEUROBIO 793: Research in Neurobiology 2019

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