Xiaoyin Jiang | Scholars@Duke

Xiaoyin Jiang
Associate Professor of Pathology

I am a pathologist specializing in cytopathology and surgical pathology. I diagnose diseases through integrating clinical history and studying patient samples under the microscope. As a cytopathologist, I perform fine needle aspiration biopsies in our clinic. I serve as Chief of the Head and Neck Service, and Director of the Duke Pathology Communications Group.
My research interests focus on the pathology of the head and neck and endocrine systems, with particular interest in thyroid nodules and neoplasia, and ultrasound-guided FNA. I work with a multidisciplinary team to improve our understanding of disease. I also focus on novel applications of social media for physicians and medical education.

Current Appointments & Affiliations

Associate Professor of Pathology, Pathology, Clinical Science Departments 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017

Contact Information

Box 3712 Med Ctr, Durham, NC 27710
Rm 3417 Duke Hospital South, Durham, NC 27710

Background
Education, Training, & Certifications
- Fellow, Cytopathology, Duke University School of Medicine 2013 - 2014
- Resident, Pathology, Duke University School of Medicine 2009 - 2013
- M.D., Duke University School of Medicine 2009
Previous Appointments & Affiliations
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2018 - 2020
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2014 - 2018
Leadership & Clinical Positions at Duke
- Chief, Head and Neck Pathology Service 2020-present
  Director, Duke Pathology Communications Group, 2020-present
  Associate Director, Duke Biorepository and Precision Pathology Center, 2017-2019
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Validation of Epigenomic Biomarkers for Thyroid Cancer Diagnostics awarded by City of Hope 2021 - 2023
- Rapid 3D whole-slide microscope digitization for thick cytopathology slides awarded by Ramona Optics, Inc. 2020 - 2023
External Relationships
- American Society for Clinical Pathology
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Jiang, Xiaoyin Sara, and Wen-Chi Foo. “Teaching interventional cytopathology.” Semin Diagn Pathol 39, no. 6 (November 2022): 405–9. https://doi.org/10.1053/j.semdp.2022.01.002.
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  - Torous, Vanda F., Leslie G. Dodd, Patrick J. McIntire, and Xiaoyin Sara Jiang. “Crystals and crystalloids in cytopathology: Incidence and importance.” Cancer Cytopathol 130, no. 10 (October 2022): 759–70. https://doi.org/10.1002/cncy.22602.
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  - Vigliar, Elena, Pasquale Pisapia, Filippo Dello Iacovo, Eduardo Alcaraz-Mateos, Greta Alì, Syed Z. Ali, Zubair W. Baloch, et al. “COVID-19 pandemic impact on cytopathology practice in the post-lockdown period: An international, multicenter study.” Cancer Cytopathol 130, no. 5 (May 2022): 344–51. https://doi.org/10.1002/cncy.22547.
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  - Jiang, Xiaoyin Sara, and Emilio Madrigal. “Innovations: Innovating together while social distancing.” Cancer Cytopathol 129, no. 2 (February 2021): 99–101. https://doi.org/10.1002/cncy.22325.
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  - Vigliar, Elena, Rima Cepurnaite, Eduardo Alcaraz-Mateos, Syed Z. Ali, Zubair W. Baloch, Claudio Bellevicine, Massimo Bongiovanni, et al. “Global impact of the COVID-19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries.” Cancer Cytopathol 128, no. 12 (December 2020): 885–94. https://doi.org/10.1002/cncy.22373.
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  - Deeken, Amy H., Sanjay Mukhopadhyay, and Xiaoyin “Sara” Jiang. “Social media in academics and research: 21st-century tools to turbocharge education, collaboration, and dissemination of research findings.” Histopathology 77, no. 5 (November 2020): 688–99. https://doi.org/10.1111/his.14196.
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  - Jug, Rachel, Wen-Chi Foo, Claudia Jones, Sara Ahmadi, and Xiaoyin Sara Jiang. “High-risk and intermediate-high-risk results from the ThyroSeq v2 and v3 thyroid genomic classifier are associated with neoplasia: Independent performance assessment at an academic institution.” Cancer Cytopathol 128, no. 8 (August 2020): 563–69. https://doi.org/10.1002/cncy.22283.
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  - Lepe, Marcos, Pembe Oltulu, Mariana Canepa, Roseann I. Wu, Amy Deeken, Deepu Alex, Carme Dinares, et al. “#EBUSTwitter: Novel Use of Social Media for Conception, Coordination, and Completion of an International, Multicenter Pathology Study.” Arch Pathol Lab Med 144, no. 7 (July 1, 2020): 878–82. https://doi.org/10.5858/arpa.2019-0297-OA.
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  - Parajuli, Shobha, Rachel Jug, Sara Ahmadi, and Xiaoyin Sara Jiang. “Hurthle cell predominance impacts results of Afirma gene expression classifier and ThyroSeq molecular panel performance in indeterminate thyroid nodules.” Diagn Cytopathol 47, no. 11 (November 2019): 1177–83. https://doi.org/10.1002/dc.24290.
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  - Ahmadi, Sara, Rebecca Herbst, Taofik Oyekunle, Xiaoyin “Sara” Jiang, Kyle Strickland, Sanziana Roman, and Julie A. Sosa. “USING THE ATA AND ACR TI-RADS SONOGRAPHIC CLASSIFICATIONS AS ADJUNCTIVE PREDICTORS OF MALIGNANCY FOR INDETERMINATE THYROID NODULES.” Endocr Pract 25, no. 9 (September 2019): 908–17. https://doi.org/10.4158/EP-2018-0559.
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  - Jiang, Xiaoyin Sara, and Emilio Madrigal. “Innovations: Brave new worlds.” Cancer Cytopathol 127, no. 8 (August 2019): 491–92. https://doi.org/10.1002/cncy.22141.
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  - Jug, Rachel, Shobha Parajuli, Sara Ahmadi, and Xiaoyin Sara Jiang. “Negative Results on Thyroid Molecular Testing Decrease Rates of Surgery for Indeterminate Thyroid Nodules.” Endocr Pathol 30, no. 2 (June 2019): 134–37. https://doi.org/10.1007/s12022-019-9571-x.
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  - Jug, Rachel, Trisha Miller Shattuck, and Xiaoyin Sara Jiang. “Enigma portal case: Phaeohyphomycosis by fine needle aspiration.” Cytopathology 30, no. 3 (May 2019): 330–31. https://doi.org/10.1111/cyt.12671.
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  - Alcaraz-Mateos, Eduardo, Xiaoyin Sara Jiang, Ahmed Abdelraheem Reda Mohammed, Iva Turic, Laura Hernández-Sabater, Fuensanta Caballero-Alemán, Manuel José Párraga-Ramírez, and Enrique Poblet. “A novel simulator model and standardized assessment tools for fine needle aspiration cytology training.” Diagn Cytopathol 47, no. 4 (April 2019): 297–301. https://doi.org/10.1002/dc.24105.
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  - Jug, Rachel, Xiaoyin Sara Jiang, and Sarah M. Bean. “Giving and Receiving Effective Feedback: A Review Article and How-To Guide.” Arch Pathol Lab Med 143, no. 2 (February 2019): 244–50. https://doi.org/10.5858/arpa.2018-0058-RA.
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  - Jug, Rachel C., Michael B. Datto, and Xiaoyin Sara Jiang. “Molecular testing for indeterminate thyroid nodules: Performance of the Afirma gene expression classifier and ThyroSeq panel.” Cancer Cytopathol 126, no. 7 (July 2018): 471–80. https://doi.org/10.1002/cncy.21993.
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  - Range, Danielle E., and Xiaoyin S. Jiang. “An update on noninvasive follicular thyroid neoplasm with papillary-like nuclear features.” Curr Opin Oncol 30, no. 1 (January 2018): 1–7. https://doi.org/10.1097/CCO.0000000000000416.
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  - Fuller, Maren Y., Jerad M. Gardner, and Xiaoyin Sara Jiang. “Social cytopathology: Building a stronger cytopathology community through social media.” Cancer Cytopathol 125, no. 12 (December 2017): 891–95. https://doi.org/10.1002/cncy.21940.
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  - Jiang, Xiaoyin Sara, Emilio Madrigal, and Sinchita Roy-Chowdhuri. “A Twitter primer: Dos and don'ts for cytopathologists.” Diagn Cytopathol 45, no. 7 (July 2017): 577–79. https://doi.org/10.1002/dc.23722.
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  - Madrigal, Emilio, Xiaoyin Sara Jiang, and Sinchita Roy-Chowdhuri. “The professional Twitter account: creation, proper maintenance, and continuous successful operation.” Diagn Cytopathol 45, no. 7 (July 2017): 621–28. https://doi.org/10.1002/dc.23710.
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  - Harrison, Grant, Julie Ann Sosa, and Xiaoyin Jiang. “Evaluation of the Afirma Gene Expression Classifier in Repeat Indeterminate Thyroid Nodules.” Arch Pathol Lab Med 141, no. 7 (July 2017): 985–89. https://doi.org/10.5858/arpa.2016-0328-OA.
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  - Jiang, Xiaoyin Sara, Grant P. Harrison, and Michael B. Datto. “Reply to Young Investigator Challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features.” Cancer Cytopathol 125, no. 4 (April 2017): 293–94. https://doi.org/10.1002/cncy.21829.
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  - Cohen, David, Timothy Craig Allen, Serdar Balci, Philip T. Cagle, Julie Teruya-Feldstein, Samson W. Fine, Dibson D. Gondim, et al. “#InSituPathologists: how the #USCAP2015 meeting went viral on Twitter and founded the social media movement for the United States and Canadian Academy of Pathology.” Mod Pathol 30, no. 2 (February 2017): 160–68. https://doi.org/10.1038/modpathol.2016.223.
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  - Jiang, Xiaoyin Sara, and David Howell. “CV Polymerase: A Publication Primer for Young Pathology Faculty Members.” Arch Pathol Lab Med 141, no. 2 (February 2017): 189–90. https://doi.org/10.5858/arpa.2016-0304-ED.
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  - Tang, Sherry, Andrew Buck, Claudia Jones, and Xiaoyin Sara Jiang. “The utility of thyroglobulin washout studies in predicting cervical lymph node metastases: One academic medical center's experience.” Diagn Cytopathol 44, no. 12 (December 2016): 964–68. https://doi.org/10.1002/dc.23554.
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  - Jiang, Xiaoyin Sara, Grant P. Harrison, and Michael B. Datto. “Young Investigator Challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features.” Cancer Cytopathol 124, no. 12 (December 2016): 893–900. https://doi.org/10.1002/cncy.21802.
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  - Soo, Joanne, George Kokosis, Michael Ogilvie, Xiaoyin Sara Jiang, David B. Powers, Daniel J. Rocke, and Detlev Erdmann. “A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible.” Plast Reconstr Surg Glob Open 4, no. 12 (December 2016): e1070. https://doi.org/10.1097/GOX.0000000000001070.
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  - Ahmadi, Sara, Michael Stang, Xiaoyin Sara Jiang, and Julie Ann Sosa. “Hürthle cell carcinoma: current perspectives.” Onco Targets Ther 9 (2016): 6873–84. https://doi.org/10.2147/OTT.S119980.
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  - Michelotti, Gregory, Xiaoyin Jiang, Julie Ann Sosa, Anna Mae Diehl, and Brittany Bohinc Henderson. “LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.” Oncotarget 6, no. 33 (October 27, 2015): 34549–60. https://doi.org/10.18632/oncotarget.5330.
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  - St Romain, Paul, Svetang Desai, Sarah Bean, Xiaoyin Jiang, and Rebecca A. Burbridge. “Extramedullary plasmacytoma of the gallbladder diagnosed by endoscopic ultrasound fine needle aspiration (EUS-FNA).” J Gastrointest Oncol 6, no. 2 (April 2015): E7–9. https://doi.org/10.3978/j.issn.2078-6891.2014.092.
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  - Dodd, Leslie G., Xiaoyin Sara Jiang, Kathleen Rao, and Marilyn M. Bui. “Pleomorphic liposarcoma: a cytologic study of five cases.” Diagn Cytopathol 43, no. 2 (February 2015): 138–43. https://doi.org/10.1002/dc.23148.
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  - Jiang, Xiaoyin, H Bryan Anderson, Cynthia D. Guy, Paul J. Mosca, Richard F. Riedel, and Diana M. Cardona. “Rhabdomyosarcomatous Transformation of a Gastrointestinal Stromal Tumor following Treatment with Imatinib.” Case Rep Oncol Med 2015 (2015): 317493. https://doi.org/10.1155/2015/317493.
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  - Jiang, Xiaoyin Sara, Liron Pantanowitz, Marilyn M. Bui, Robert Esther, Debra Budwit, and Leslie G. Dodd. “Clear cell chondrosarcoma: Cytologic findings in six cases.” Diagn Cytopathol 42, no. 9 (September 2014): 784–91. https://doi.org/10.1002/dc.23043.
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  - Nussbaum, Daniel P., Syamal D. Bhattacharya, Xiaoyin Jiang, Diana M. Cardona, John H. Strickler, and Dan G. Blazer. “Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication.” Arch Pathol Lab Med 138, no. 3 (March 2014): 428–31. https://doi.org/10.5858/arpa.2012-0523-CR.
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  - Jiang, Xiaoyin, David A. Reardon, Annick Desjardins, James J. Vredenburgh, Jennifer A. Quinn, Alan D. Austin, James E. Herndon, Roger E. McLendon, and Henry S. Friedman. “O6-methylguanine-DNA methyltransferase (MGMT) immunohistochemistry as a predictor of resistance to temozolomide in primary CNS lymphoma.” J Neurooncol 114, no. 1 (August 2013): 135–40. https://doi.org/10.1007/s11060-013-1162-y.
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  - Jiang, Xiaoyin Sara, Dava S. West, and Anand S. Lagoo. “Lymph node infarction: role of underlying malignancy, tumour proliferation fraction and vascular compromise--a study of 35 cases and a comprehensive review of the literature.” Histopathology 62, no. 2 (January 2013): 315–25. https://doi.org/10.1111/j.1365-2559.2012.04361.x.
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  - DeRienzo, Christopher M., Karen Frush, Michael E. Barfield, Priya R. Gopwani, Brian C. Griffith, Xiaoyin Jiang, Ankit I. Mehta, et al. “Handoffs in the era of duty hours reform: a focused review and strategy to address changes in the Accreditation Council for Graduate Medical Education Common Program Requirements.” Acad Med 87, no. 4 (April 2012): 403–10. https://doi.org/10.1097/ACM.0b013e318248e5c2.
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  - Quinn, Jennifer A., Sara Xiaoyin Jiang, David A. Reardon, Annick Desjardins, James J. Vredenburgh, Allan H. Friedman, John H. Sampson, Roger E. McLendon, James E. Herndon, and Henry S. Friedman. “Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy.” J Neurooncol 95, no. 3 (December 2009): 393–400. https://doi.org/10.1007/s11060-009-9937-x.
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  - Quinn, Jennifer A., Sara Xiaoyin Jiang, David A. Reardon, Annick Desjardins, James J. Vredenburgh, Sridharan Gururangan, John H. Sampson, Roger E. McLendon, James E. Herndon, and Henry S. Friedman. “Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.” Cancer 115, no. 13 (July 1, 2009): 2964–70. https://doi.org/10.1002/cncr.24336.
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  - Quinn, Jennifer A., Sara Xiaoyin Jiang, David A. Reardon, Annick Desjardins, James J. Vredenburgh, Jeremy N. Rich, Sridharan Gururangan, et al. “Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.” J Clin Oncol 27, no. 8 (March 10, 2009): 1262–67. https://doi.org/10.1200/JCO.2008.18.8417.
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  - Quinn, Jennifer A., Sara Xiaoyin Jiang, James Carter, David A. Reardon, Annick Desjardins, James J. Vredenburgh, Jeremy N. Rich, et al. “Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.” Clin Cancer Res 15, no. 3 (February 1, 2009): 1064–68. https://doi.org/10.1158/1078-0432.CCR-08-2130.
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  - Quinn, J. A., X. S. Jiang, J. N. Rich, A. Desjardins, J. J. Vredenburgh, D. A. Reardon, S. Gururangan, et al. “Phase I trial of temozolomide plus O⁶-benzylguanine on three different 5-day temozolomide regimens for patients with progressive glioblastoma multiforme.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 2084–2084. https://doi.org/10.1200/jco.2008.26.15_suppl.2084.
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- Book Sections
  - Jiang, X. S., S. Maygarden, and L. G. Dodd. “Pathologic diagnosis of thyroid cancer.” In Management of Differentiated Thyroid Cancer, 37–63, 2017. https://doi.org/10.1007/978-3-319-54493-9_4.
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- Conference Papers
  - Teoh, Deanna, William J. Lowery, Xiaoyin Jiang, Jessie Ehrisman, Paige Halvorson, Gloria Broadwater, Rex Bentley, et al. “Vaginal cuff thermal injury by mode of colpotomy at total laparoscopic hysterectomy: a randomized clinical trial.” In J Minim Invasive Gynecol, 22:227–33, 2015. https://doi.org/10.1016/j.jmig.2014.10.002.
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Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Awards & Honors

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers