Research Interests
- 1988 – 1997 Investigated the molecular biology of T-cell differentiation. Dr. Russel Kaufman and Dr. Barton Haynes, Department of Medicine, Duke University Medical Center, Durham, North Carolina
- 1994 – 2000 Investigated pain coping mechanisms and family environment in juvenile fibromyalgia patients and the efficacy of cognitive behavioral therapy in this group. Dr. Francis Keefe, Department of Psychiatry, Duke University Medical Center, Durham, North Carolina.
- 1995 – Present Currently investigating the pain experience of children with rheumatic disease
- 1996 – Present Currently investigating the relationship of daily stress, mood, and emotion regulation to pain and other disease symptoms, disease activity and functional status in children with juvenile arthritis
- 2000 – Present Currently investigating the impact of parental beliefs and experiences on child health status in children with chronic rheumatic disease
- 2002 – 2014 Currently investigating the effect of statins on the prevention of premature cardiovascular disease in children with SLE
- 2009 – Present Pediatric rheumatology registry and safety surveillance
- 2012 – Present Comparative effectiveness of biologic agents for treatment of JIA
Selected Grants
Trial of Sequential Medications AfteR TNF failure in JIA (SMART-JIA)
ResearchPrincipal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2024 - 2031SMART-JIA Drug Donation - AbbVie
ResearchPrincipal Investigator · Awarded by AbbVie Inc. · 2025 - 2030SMART-JIA Drug Donation - Pfizer Inc.
ResearchPrincipal Investigator · Awarded by Pfizer, Inc. · 2025 - 2030SMART-JIA Drug Donation - Amgen, Inc
ResearchPrincipal Investigator · Awarded by Amgen, Inc. · 2025 - 20302/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Direct-to-family pharmacokinetics intervention for hydroxychloroquine non-adherence in adolescents with systemic lupus erythematosus
ResearchMentor · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2024 - 2029Learning to Predict Disease Trajectories
ResearchCo Investigator · Awarded by Boston Children's Hospital · 2025 - 2027DCRI CARRA Registry
ResearchPrincipal Investigator · Awarded by Childhood Arthritis & Rheumatology Research Alliance · 2015 - 2027Congruence Between Child Self-Reported and Caregiver-Proxy Health-Related Quality of Life in Children with JIA and SLE
ResearchCollaborating Investigator · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2026 - 2026Improving Pediatric Lupus Care and Outcomes through the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Lupus Registry
ResearchPrincipal Investigator · Awarded by University of Utah · 2022 - 2026Trial of Sequential Medications AfteR TNFi failure in Juvenile Idiopathic Arthritis (SMART-JIA)
ResearchPrincipal Investigator · Awarded by Pfizer, Inc. · 2025 - 2026Duke Center for Advancement of Child Health (CAtCH).
Inst. Training Prgm or CMEMentor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021 - 2026Improving Outcomes in Limited Juvenile Idiopathic Arthritis
ResearchPrincipal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2018 - 2026A Randomized, Open Label, Multi-Center, Phase 3 Efficacy Study of Sub-Q Abatacept in Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)
Clinical TrialPrincipal Investigator · Awarded by Bristol-Myers Squibb Company · 2019 - 2025Patient-Centered Stress Reduction & Cardiovascular Health Promotion Intervention: Engaging Patients with Lupus & Dermatomyositis
ResearchMentor · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2025 - 2025Optimal Dosing for Biologic Agents in Obese Patients with Rheumatoid and Juvenile Arthritis
ResearchMentor · Awarded by National Institutes of Health · 2020 - 2025PRECISE Study (Precision Biologics in Rheumatology)
ResearchMentor · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2021 - 2025COVID seroconversion in abatacept and control children in LIMIT-JIA
ResearchPrincipal Investigator · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2021 - 2025Learning to Predict Disease Trajectories
ResearchCo Investigator · Awarded by Harvard Pilgrim Health Care, Inc. · 2023 - 2025Duke CTSA (TL1) Year 5
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024Sample collection to predict response to abatacept in Limit-JIA
ResearchPrincipal Investigator · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2021 - 2024CARRA
ResearchPrincipal Investigator · Awarded by Childhood Arthritis & Rheumatology Research Alliance · 2015 - 2024Optimizing Hydroxychloroquine to Reduce Disease Activity in Pediatric Lupus
ResearchCo-Mentor · Awarded by Thrasher Research Fund · 2021 - 2023A Randomized, Open Label, Multi-Center Phas 3 Efficacy Study of Sub-Q Abatacept in Preventing Extension of Oligoarticular JIA (Limit-JIA)
Clinical TrialPrincipal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2019 - 2023Improving Pediatric Lupus Care and Outcomes through the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Lupus Registry
ResearchPrincipal Investigator · Awarded by University of Utah · 2021 - 2022Expanding HL7 FHIR to support post-marketing research and surveillance within multi-source, chronic disease registries
ResearchPrincipal Investigator · Awarded by Boston Children's Hospital · 2018 - 2021Disease Recapture After Drug Discontinuation and Flare in JIA
ResearchPrincipal Investigator · Awarded by Seattle Children's Hospital · 2019 - 2021Enabling Real-time, Personalized Engagement in Research: an App-based Approach
ResearchPrincipal Investigator · Awarded by Boston Children's Hospital · 2019 - 2021PARTNERS Extension
ResearchPrincipal Investigator · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2019 - 2020HCQ Pharmacokinetics in Pediatric Lupus
ResearchMentor · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2019 - 2020Comparative Effectiveness of CARRA Treatment Strategies for Polyarticular Juvenile Idiopathic Arthritis
ResearchPrincipal Investigator · Awarded by Hackensack University Medical Center · 2015 - 2019Urinary HER2 as a biomarker for lupus nephritis
ResearchPrincipal Investigator · Awarded by Children's Hospital of Philadelphia · 2014 - 2019CARRA Accelerating Toward an Evidence Based in Pediatric Rheumatology
ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2018 - 2019Duke Research Training Program for Pediatricians
Inst. Training Prgm or CMETraining Faculty · Awarded by National Institutes of Health · 2002 - 2018Comparison of Methotrexate and Biologics in JIA (COMPARE-JIA)
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018Training Program in Inflammatory and Immunological Diseases
Inst. Training Prgm or CMECo-Director · Awarded by National Institutes of Health · 1980 - 2017Enhancing CARRA Research: Integration and Dissemination of Clinical Data
Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2016Pediatric Rheumatology Research Annual Scientific Meeting
ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2016WebSMART Trial-Year 4
ResearchPrincipal Investigator · Awarded by The Children's Mercy Hospital · 2011 - 2016PULSE: Pediatric Update on Lupus in South Africa: Epidemiology & Management
ResearchMentor · Awarded by Lupus Foundation of America · 2014 - 2015PARTNERS
ResearchPrincipal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2014 - 2015CARRA Planning Grant-Subcontract to UAB
ResearchPrincipal Investigator · Awarded by University of Alabama at Birmingham · 2014 - 2015Standardizing and Optimizing Childhood Lupus Nephritis Treatment through CARRA
Clinical TrialPrincipal Investigator · Awarded by University of California - San Francisco · 2013 - 2015Risk stratification using genetic and microbial determinants in childhood onset RA
Clinical TrialPrincipal Investigator · Awarded by Emory University · 2013 - 2015CARRA_Cooperative Agreement for Clinical Research in Children with Rheumatic Disaeses
ResearchPrincipal Investigator · Awarded by Arthritis Foundation · 2013 - 2014CARRA: Accelerating Toward an Evidence Based Culture in Pediatric Rheumatology
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2013Electronic Diary Assessment of Pain in Juvenile Arthritis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2012Prevention of Cardiovascular Complications of Pediatric SLE
Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2011Nitric Oxide Metabolism in Statin-treated Pediatric SLE
ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2011Stress, Mood & Disease Activity In Juvenile Rheumatoid Art
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2000Regulation Of The T Cell Specific Gene Cd7
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1998Regulation Of The T-Cell Specific Gene Cd7
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1997Regulation Of The T Cell-Specific Gene Cd7
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1992 - 1997External Relationships
- AbbVie, Inc.
- Amgen, Inc.
- Bristol-Myers Squibb
- Childhood Arthritis and Rheumatology Research Alliance
- Fresenius-Kabi
- Pfizer Inc.
- Sanofi US Services Inc
- UCB
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.