Scholars@Duke
Laura Eve Schanberg

Laura Eve Schanberg

Professor of Pediatrics
Pediatrics, Rheumatology
Box 3212 Med Ctr, Durham, NC 27710
T0909, Durham, NC 27710

Selected Publications

Long-term safety of canakinumab in patients with systemic juvenile idiopathic arthritis: 5-year results from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry.

Journal Article Pediatr Rheumatol Online J · October 21, 2025 BACKGROUND: Systemic juvenile idiopathic arthritis (SJIA) is a severe form of juvenile idiopathic arthritis characterized by fever, rash, chronic arthritis, and systemic inflammation. The introduction of biologics has improved the treatment options for SJI ... Full text Link to item Cite

Three-Year Outcomes and Latent Class Trajectory Analysis of the Childhood Arthritis and Rheumatology Research Alliance Polyarticular JIA Consensus Treatment Plans Study.

Journal Article Arthritis Rheumatol · October 2025 OBJECTIVE: To assess the impact of differences in the timing of initial biologic disease-modifying antirheumatic drug (bDMARD) therapy using the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Start Time Optimization of biologics in Polyarti ... Full text Link to item Cite

Disease activity trajectories in paediatric lupus and associations with socioeconomic factors and patient-reported pain.

Journal Article Lupus Sci Med · August 14, 2025 OBJECTIVE: Using data from participants with paediatric SLE (pSLE) in the Childhood Arthritis and Rheumatology Research Alliance Registry, we aimed to: (1) describe 2-year disease activity trajectories, measured by the SLE Disease Activity Index 2000 (SLED ... Full text Link to item Cite

Racial Disparities and Achievement of the Low Lupus Disease Activity State: A CARRA Registry Study.

Journal Article Arthritis Care Res (Hoboken) · January 2025 OBJECTIVE: Differential disease control may contribute to racial disparities in outcomes of childhood-onset systemic lupus erythematosus (cSLE). We evaluated associations of race and individual- or neighborhood-level social determinants of health (SDoH) wi ... Full text Link to item Cite

Effect of an Electronic Pill Bottle on Hydroxychloroquine Adherence in Pediatric Lupus: Results of a Novel Direct-to-Family Pilot Trial.

Journal Article ACR Open Rheumatol · January 2025 OBJECTIVE: The objective of this study was to evaluate the preliminary effectiveness of an electronic pill bottle with automated reminders on hydroxychloroquine (HCQ) adherence in children with pediatric systemic lupus erythematosus (pSLE). METHODS: This w ... Full text Link to item Cite

Evaluating anchor variables and variation in meaningful score differences for PROMIS® Pediatric measures in children and adolescents living with a rheumatic disease.

Journal Article Qual Life Res · December 2024 PURPOSE: Meaningful score differences (MSDs), as defined by recent FDA guidance, can improve the interpretation of outcome measure scores and score changes. Well-accepted methods for estimating MSDs typically rely on external anchor variables, but the appl ... Full text Link to item Cite

Pain Interference in Juvenile Idiopathic Arthritis.

Journal Article J Rheumatol · November 1, 2024 OBJECTIVE: Despite treatment advances, pain remains a serious problem for many children with juvenile idiopathic arthritis (JIA). To better understand pain in children with JIA and identify potentially modifiable factors, this study evaluated Patient-Repor ... Full text Link to item Cite

Development of CARRA/PReS-endorsed consensus Core and Expanded Datasets in childhood-onset systemic lupus erythematosus for international registry-based research.

Journal Article Ann Rheum Dis · October 8, 2024 OBJECTIVES: Childhood-onset systemic lupus erythematosus (cSLE), representing 15%-20% of individuals with SLE, has been difficult to study globally due to differences between registries. This initiative, supported by Childhood Arthritis Rheumatology Resear ... Full text Link to item Cite

Meeting report: patient and caregiver recommendations for a mobile health application for paediatric systemic lupus erythematosus.

Journal Article Lupus Sci Med · July 31, 2024 Paediatric systemic lupus erythematosus (pSLE) management and research could be enhanced by a mobile health application (app); however, no app designed for pSLE is currently available. A development and design committee comprising of patients, parents/care ... Full text Link to item Cite

Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile-Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature.

Journal Article Arthritis Rheumatol · March 2024 OBJECTIVE: Patients with juvenile-onset systemic lupus erythematosus (JSLE) have increased atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) ... Full text Link to item Cite

Health Equity Implications of Missing Data Among Youths With Childhood-Onset Systemic Lupus Erythematosus: A Proof-of-Concept Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Arthritis Care Res (Hoboken) · November 2023 OBJECTIVE: Health disparities in childhood-onset systemic lupus erythematosus (SLE) disproportionately impact marginalized populations. Socioeconomically patterned missing data can magnify existing health inequities by supporting inferences that may misrep ... Full text Link to item Cite

Therapeutic Development in Polyarticular Course Juvenile Idiopathic Arthritis: Extrapolation, Dose Selection, and Clinical Trial Design.

Journal Article Arthritis Rheumatol · October 2023 OBJECTIVE: Stakeholders met to address persistent challenges facing the development of therapeutics for polyarticular juvenile idiopathic arthritis (pJIA), which result in fewer approved therapies for children with pJIA than adults with rheumatoid arthriti ... Full text Link to item Cite

Insurance Status and Tumor Necrosis Factor Inhibitor Initiation Among Children With Juvenile Idiopathic Arthritis in the CARRA Registry.

Journal Article J Rheumatol · August 2023 OBJECTIVE: Prompt escalation to tumor necrosis factor inhibitors (TNFis) is recommended for children with juvenile idiopathic arthritis (JIA) and ongoing disease activity despite treatment with conventional disease-modifying antirheumatic drugs (cDMARDs). ... Full text Link to item Cite

Childhood-Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short-Term Kidney Status and Variation in Care.

Journal Article Arthritis Care Res (Hoboken) · July 2023 OBJECTIVE: The goal was to characterize short-term kidney status and describe variation in early care utilization in a multicenter cohort of patients with childhood-onset systemic lupus erythematosus (cSLE) and nephritis. METHODS: We analyzed previously co ... Full text Link to item Cite

Disease Recapture Rates After Medication Discontinuation and Flare in Juvenile Idiopathic Arthritis: An Observational Study Within the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Arthritis Care Res (Hoboken) · April 2023 OBJECTIVE: Children with well-controlled juvenile idiopathic arthritis (JIA) frequently experience flares after medication discontinuation, but the outcomes of these flares have not been well described. The objective of this study was to characterize the r ... Full text Link to item Cite

Meeting report: the ALPHA project: a stakeholder meeting on lupus clinical trial outcome measures and the patient perspective.

Journal Article Lupus Sci Med · February 2023 Drug development in lupus has improved over the past 10 years but still lags behind that of other rheumatic disease areas. Assessment of prospective lupus therapies in clinical trials has proved challenging for reasons that are multifactorial including the ... Full text Link to item Cite

Trajectories of disease activity in patients with JIA in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Rheumatology (Oxford) · February 1, 2023 OBJECTIVE: To describe 2-year trajectories of the clinical Juvenile Arthritis Disease Activity Score, 10 joints (cJADAS10) and associated baseline characteristics in patients with JIA. METHODS: JIA patients in the Childhood Arthritis and Rheumatology Resea ... Full text Link to item Cite

Construct validity of Patient-Reported Outcomes Measurement Information System Paediatric measures in juvenile idiopathic arthritis and systemic lupus erythematosus: cross-sectional evaluation.

Journal Article BMJ Open · January 27, 2023 OBJECTIVES: Evaluate construct validity of Patient-Reported Outcomes Measurement Information System (PROMIS) Paediatric measures of symptoms and functioning against measures of disease activity among youth with juvenile idiopathic arthritis (JIA) or system ... Full text Link to item Cite

Extrapolation of Adult Efficacy Data to Pediatric Systemic Lupus Erythematosus: Evaluating Similarities in Exposure-Response.

Journal Article J Clin Pharmacol · January 2023 To streamline drug development, the United States Food and Drug Administration (FDA) can consider the extrapolation of adult efficacy data to children when the disease and drug effects are sufficiently similar. This study explored whether the relationship ... Full text Link to item Cite

Patient-Reported Outcomes Among Transition-Age Young Adults With Juvenile Idiopathic Arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article J Rheumatol · January 2023 OBJECTIVE: To evaluate patient-reported care utilization and outcomes among young adults with juvenile idiopathic arthritis (JIA), including factors associated with complete transfer to adult rheumatology. METHODS: We included young adults with JIA enrolle ... Full text Link to item Cite

Race, ethnicity and patient-reported outcomes in childhood-onset systemic lupus erythematosus.

Journal Article Clin Exp Rheumatol · January 2023 OBJECTIVES: This study assesses the association of race/ethnicity with the Patient-Reported Outcomes Measurement Information System (PROMIS®) in childhood-onset systemic lupus erythematosus (cSLE) patients from the Childhood Arthritis and Rheumatology Rese ... Full text Link to item Cite

First-line options for systemic juvenile idiopathic arthritis treatment: an observational study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans.

Journal Article Pediatr Rheumatol Online J · December 8, 2022 BACKGROUND: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare treatment initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First-line options for sJIA treatment (F ... Full text Link to item Cite

Intraarticular steroids as DMARD-sparing agents for juvenile idiopathic arthritis flares: Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Pediatr Rheumatol Online J · November 25, 2022 BACKGROUND: Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience a flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment with disease modifying anti-rheumatic drugs (DMAR ... Full text Link to item Cite

Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial.

Journal Article Lupus Sci Med · November 2022 OBJECTIVE: Determine the pharmacokinetics (PK) and exposure-response of hydroxychloroquine (HCQ) and desethylhydroxychloroquine (DHCQ) in paediatric SLE (pSLE). METHODS: We conducted an exploratory phase 2, direct-to-family trial. Children enrolled in the ... Full text Link to item Cite

Pediatric rheumatologists' perspectives on diagnosis, treatment, and outcomes of Sjögren disease in children and adolescents.

Journal Article Pediatr Rheumatol Online J · September 5, 2022 BACKGROUND: Sjögren disease in children and adolescents (pedSD) presents differently than adult disease. Diagnosis and classification are controversial, optimal treatment is unknown and outcomes are poorly understood. Here, we describe the current perspect ... Full text Link to item Cite

Urinary HER2, TWEAK and VCAM-1 levels are associated with new-onset proteinuria in paediatric lupus nephritis.

Journal Article Lupus Sci Med · August 2022 OBJECTIVE: Lupus nephritis is a key driver of morbidity and mortality in SLE. Detecting active nephritis on a background of pre-existing renal damage is difficult, leading to potential undertreatment and accumulating injury. An unmet need is a biomarker th ... Full text Link to item Cite

Baseline characteristics of children with juvenile dermatomyositis enrolled in the first year of the new Childhood Arthritis and Rheumatology Research Alliance registry.

Journal Article Pediatr Rheumatol Online J · July 19, 2022 BACKGROUND: To report baseline characteristics, patient reported outcomes and treatment of children with Juvenile Dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. METHODS: Children newly diagnosed with J ... Full text Link to item Cite

Self-Reported Health Outcomes of Children and Youth with 10 Chronic Diseases.

Journal Article J Pediatr · July 2022 OBJECTIVES: To identify pediatric patient-reported outcomes (PROs) that are associated with chronic conditions and to evaluate the effects of chronic disease activity on PROs. STUDY DESIGN: Participants (8-24 years old) and their parents were enrolled into ... Full text Link to item Cite

Feasibility and Efficacy of Online Strategies to Recruit Parents of Children With Rheumatic Diseases for Research.

Journal Article ACR Open Rheumatol · May 2022 OBJECTIVE: We aimed to determine the feasibility and efficacy of online strategies to recruit parents of children with pediatric rheumatic diseases (PRDs) for research and to evaluate the degree to which known features of various rheumatic disease groups w ... Full text Link to item Cite

Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis.

Journal Article Pediatr Rheumatol Online J · March 7, 2022 BACKGROUND: Social determinants of health (SDH) greatly influence outcomes during the first year of treatment in rheumatoid arthritis, a disease similar to polyarticular juvenile idiopathic arthritis (pJIA). We investigated the correlation of community pov ... Full text Link to item Cite

Cardiovascular Health in Pediatric Rheumatologic Diseases.

Journal Article Rheum Dis Clin North Am · February 2022 Cardiovascular disease risk is evident during childhood for patients with juvenile systemic lupus erythematosus, juvenile dermatomyositis, and juvenile idiopathic arthritis. The American Heart Association defines cardiovascular health as a positive health ... Full text Link to item Cite

Pediatric Rheumatology Comes of Age: Part II.

Journal Article Rheum Dis Clin North Am · February 2022 Full text Link to item Cite

Down Syndrome-Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes.

Conference Arthritis Care Res (Hoboken) · December 2021 OBJECTIVE: Down syndrome-associated arthritis (DA) is underrecognized, and current therapies used for juvenile idiopathic arthritis (JIA) appear to be poorly tolerated and less effective in patients with DA. The objective of this study was to characterize ... Full text Link to item Cite

Pediatric Rheumatology Comes of Age: Part I.

Journal Article Rheum Dis Clin North Am · November 2021 Full text Link to item Cite

CARRA: The Childhood Arthritis and Rheumatology Research Alliance.

Journal Article Rheum Dis Clin North Am · November 2021 The Childhood Arthritis & Rheumatology Research Alliance (CARRA) launched in 2000 as a small network of pediatric rheumatologists and investigators dedicated to promoting collaborative research to improve the care and outcomes of childhood-onset rheumatic ... Full text Link to item Cite

Improved Disease Course Associated With Early Initiation of Biologics in Polyarticular Juvenile Idiopathic Arthritis: Trajectory Analysis of a Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans Study.

Journal Article Arthritis Rheumatol · October 2021 OBJECTIVE: To investigate the effects of early introduction of biologic disease-modifying antirheumatic drugs (bDMARDs) on the disease course in untreated polyarticular juvenile idiopathic arthritis (JIA). METHODS: We analyzed data on patients with polyart ... Full text Link to item Cite

Optimizing the Start Time of Biologics in Polyarticular Juvenile Idiopathic Arthritis: A Comparative Effectiveness Study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans.

Journal Article Arthritis Rheumatol · October 2021 OBJECTIVE: The optimal time to start biologics in polyarticular juvenile idiopathic arthritis (JIA) remains uncertain. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed 3 consensus treatment plans (CTPs) for untreated polyarticul ... Full text Link to item Cite

Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Pediatr Rheumatol Online J · August 21, 2021 BACKGROUND: We aimed to characterize etanercept (ETN) use in juvenile idiopathic arthritis (JIA) patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. METHODS: The CARRA Registry is a convenience cohort of patien ... Full text Link to item Cite

Community poverty level influences time to first pediatric rheumatology appointment in Polyarticular Juvenile Idiopathic Arthritis.

Journal Article Pediatr Rheumatol Online J · August 14, 2021 BACKGROUND: The impact of social determinants of health on children with polyarticular juvenile idiopathic arthritis (pJIA) is poorly understood. Prompt initiation of treatment for pJIA is important to prevent disease morbidity; however, a potential barrie ... Full text Link to item Cite

Biologic Switching Among Nonsystemic Juvenile Idiopathic Arthritis Patients: A Cohort Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article J Rheumatol · August 2021 OBJECTIVE: Biologic medications have significantly improved disease control and outcomes of patients with juvenile idiopathic arthritis (JIA). Current treatment recommendations suggest escalating therapy, including changing biologics if needed, when inacti ... Full text Link to item Cite

Juvenile Spondyloarthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: High Biologic Use, Low Prevalence of HLA-B27, and Equal Sex Representation in Sacroiliitis.

Journal Article Arthritis Care Res (Hoboken) · July 2021 OBJECTIVE: To describe characteristics of children with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (PsA) who were enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry. METHODS: All children with E ... Full text Link to item Cite

Delivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial.

Journal Article Lupus Sci Med · May 2021 INTRODUCTION: Direct-to-family clinical trials efficiently provide data while reducing the participation burden for children and their families. Although these trials can offer significant advantages over traditional clinical trials, the process of designi ... Full text Link to item Cite

The ALPHA Project: Establishing consensus and prioritisation of global community recommendations to address major challenges in lupus diagnosis, care, treatment and research.

Journal Article Lupus Sci Med · February 2021 The Addressing Lupus Pillars for Health Advancement (ALPHA) Project is a global consensus effort to identify, prioritise and address top barriers in lupus impacting diagnosis, care, treatment and research. To conduct this process, the ALPHA Project convene ... Full text Link to item Cite

Systemic lupus erythematosus in children

Chapter · January 1, 2021 An estimated 15%-20% of all systemic lupus erythematosus (SLE) is diagnosed during childhood (childhood-onset systemic lupus erythematosus [cSLE]). This chapter focuses on the unique features of cSLE, including clinical presentation and manifestations, tre ... Full text Cite

New Medications Are Needed for Children With Juvenile Idiopathic Arthritis.

Journal Article Arthritis & rheumatology (Hoboken, N.J.) · November 2020 ObjectiveTo document the need for additional Food and Drug Administration (FDA)-approved medications for the treatment of juvenile idiopathic arthritis (JIA).MethodsThe electronic medical records of JIA patients treated at Cincinnati Chil ... Full text Cite

Dr. Balevic, et al reply.

Journal Article J Rheumatol · October 1, 2020 Full text Link to item Cite

Identifying clinically meaningful severity categories for PROMIS pediatric measures of anxiety, mobility, fatigue, and depressive symptoms in juvenile idiopathic arthritis and childhood-onset systemic lupus erythematosus.

Journal Article Qual Life Res · September 2020 PURPOSE: A key limitation to widespread adoption of patient-reported outcome (PRO) measures is the lack of interpretability of scores. We aim to identify clinical severity thresholds to distinguish categories of no problems, mild, moderate, and severe alon ... Full text Link to item Cite

Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.

Journal Article J Rheumatol · May 11, 2020 OBJECTIVE: To characterize hydroxychloroquine (HCQ) exposure in patients with rheumatic disease receiving longterm HCQ compared to target concentrations with reported antiviral activity against the coronavirus disease 2019 caused by SARS-CoV-2 (COVID-19). ... Full text Link to item Cite

Toward Accelerated Authorization and Access to New Medicines for Juvenile Idiopathic Arthritis.

Journal Article Arthritis Rheumatol · December 2019 A meeting was organized to bring together multiple stakeholders involved in the testing and authorization of new medications for juvenile idiopathic arthritis (JIA) to discuss current issues surrounding clinical trials and access to new medications for chi ... Full text Link to item Cite

Patient perspectives on the linkage of health data for research: Insights from an online patient community questionnaire.

Journal Article Int J Med Inform · July 2019 OBJECTIVE: To examine the patient perspective on the risks and benefits of linking existing data sources for research. MATERIALS AND METHODS: Between December 2015 and February 2016, we fielded a questionnaire in PatientsLikeMe, an online patient community ... Full text Link to item Cite

The Association of Black Cardiologists (ABC) Cardiovascular Implementation Study (CVIS): A Research Registry Integrating Social Determinants to Support Care for Underserved Patients.

Journal Article Int J Environ Res Public Health · May 10, 2019 African Americans, other minorities and underserved populations are consistently under- represented in clinical trials. Such underrepresentation results in a gap in the evidence base, and health disparities. The ABC Cardiovascular Implementation Study (CVI ... Full text Link to item Cite

Multisite Randomized Clinical Trial Evaluating an Online Self-Management Program for Adolescents With Juvenile Idiopathic Arthritis.

Journal Article J Pediatr Psychol · April 1, 2019 OBJECTIVE: To determine the efficacy in improving pain and health-related quality of life (HRQOL) of an online self-management program for adolescents with juvenile idiopathic arthritis (JIA). METHODS: Youth ages 12-18 years with JIA were recruited from 10 ... Full text Link to item Cite

Pharmacokinetics of Hydroxychloroquine in Pregnancies with Rheumatic Diseases.

Journal Article Clin Pharmacokinet · April 2019 BACKGROUND: Hydroxychloroquine is an oral drug prescribed to pregnant women with rheumatic disease to reduce disease activity and prevent flares. Physiologic changes during pregnancy may substantially alter drug pharmacokinetics. However, the effect of pre ... Full text Link to item Cite

Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes.

Journal Article J Rheumatol · January 2019 OBJECTIVE: Pregnancies in women with active rheumatic disease often result in poor neonatal outcomes. Hydroxychloroquine (HCQ) reduces disease activity and flares; however, pregnancy causes significant physiologic changes that may alter HCQ levels and lead ... Full text Link to item Cite

Global consensus building and prioritisation of fundamental lupus challenges: the ALPHA project.

Journal Article Lupus Sci Med · 2019 OBJECTIVE: Lupus is a complex, heterogeneous autoimmune disease that has yet to see significant progress towards more timely diagnosis, improved treatment options for short-term and long-term outcomes, and appropriate access to care. The Addressing Lupus P ... Full text Link to item Cite

Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE).

Journal Article Lupus Sci Med · 2019 OBJECTIVE: Systemic lupus erythematosus (SLE) features high frequency of cardiovascular disease (CVD) and fluctuating complement levels. The clinical trial Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) aimed to evaluate whether atorva ... Full text Link to item Cite

Pilot study comparing the childhood arthritis and rheumatology research alliance consensus treatment plans for induction therapy of juvenile proliferative lupus nephritis.

Journal Article Pediatr Rheumatol Online J · October 22, 2018 BACKGROUND: To reduce treatment variability and facilitate comparative effectiveness studies, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) published consensus treatment plans (CTPs) including one for juvenile proliferative lupus nephr ... Full text Link to item Cite

Using social media to promote medication adherence.

Journal Article Nat Rev Rheumatol · August 2018 Full text Link to item Cite

Bayesian comparative effectiveness study of four consensus treatment plans for initial management of systemic juvenile idiopathic arthritis: FiRst-Line Options for Systemic juvenile idiopathic arthritis Treatment (FROST).

Journal Article Clin Trials · June 2018 BACKGROUND: Systemic juvenile idiopathic arthritis is a rare febrile arthritis of childhood characterized by a potentially severe course, including prolonged glucocorticoid exposure, growth failure, destructive arthritis, and life-threatening macrophage ac ... Full text Link to item Cite

The Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans: Toward Comparative Effectiveness in the Pediatric Rheumatic Diseases.

Journal Article Arthritis Rheumatol · May 2018 The pediatric rheumatic diseases are a heterogeneous group of rare diseases, posing a number of challenges for the use of traditional clinical and translational research methods. Innovative comparative effectiveness approaches are needed to efficiently stu ... Full text Link to item Cite

Analysis of relationships between 25-hydroxyvitamin D, parathyroid hormone and cathelicidin with inflammation and cardiovascular risk in subjects with paediatric systemic lupus erythematosus: an Atherosclerosis Prevention in Paediatric Lupus Erythematosus (APPLE) study.

Journal Article Lupus Sci Med · 2018 OBJECTIVES: Previous studies demonstrated associations between reduced serum 25-hydroxyvitamin D (25OHD), inflammation and disease activity in paediatric systemic lupus erythematosus (pSLE). The goal of this study was to assess parathyroid hormone (PTH) in ... Full text Link to item Cite

Transition and transfer of the patient with paediatric-onset lupus: a practical approach for paediatric and adult rheumatology practices.

Journal Article Lupus Sci Med · 2018 The prevalence of paediatric-onset SLE (pSLE) is estimated at 1million people worldwide and accounts for a significant proportion of SLE morbidity, mortality and cost. Patients with pSLE are especially vulnerable during and immediately following transfer f ... Full text Link to item Cite

Clinical Trial Design in Juvenile Idiopathic Arthritis.

Journal Article Paediatr Drugs · October 2017 Randomized clinical trials provide the gold standard evidence base to guide clinical practice. Despite major advances in trial design, pediatric clinical trials are still difficult to perform and pose unique challenges, including the need to consider the i ... Full text Link to item Cite

Malignancy in Pediatric-onset Systemic Lupus Erythematosus.

Journal Article J Rheumatol · October 2017 OBJECTIVE: To determine cancer incidence in a large pediatric-onset systemic lupus erythematosus (SLE) population. METHODS: Data were examined from 12 pediatric SLE registries in North America. Patients were linked to their regional cancer registries to de ... Full text Link to item Cite

Transancestral mapping and genetic load in systemic lupus erythematosus.

Journal Article Nat Commun · July 17, 2017 Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispa ... Full text Link to item Cite

Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus.

Journal Article Lupus · May 2017 Objective Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's ... Full text Link to item Cite

A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities.

Journal Article Pediatr Rheumatol Online J · April 19, 2017 BACKGROUND: To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration. METHODS: We surveyed investigators from N ... Full text Link to item Cite

The new Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry: design, rationale, and characteristics of patients enrolled in the first 12 months.

Journal Article Pediatr Rheumatol Online J · April 17, 2017 BACKGROUND: Herein we describe the history, design, and rationale of the new Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and present the characteristics of patients with juvenile idiopathic arthritis (JIA) enrolled in the first ... Full text Link to item Cite

Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans.

Journal Article Pediatr Rheumatol Online J · April 11, 2017 OBJECTIVES: To assess the feasibility of studying the comparative effectiveness of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) for systemic Juvenile Idiopathic Arthritis (JIA) using an observational r ... Full text Link to item Cite

Use of Smartphones to Prospectively Evaluate Predictors and Outcomes of Caregiver Responses to Pain in Youth with Chronic Disease.

Journal Article Pain · April 2017 This study examined outcomes and predictors of different types of responses to child pain used by caregivers of youth with chronic disease. Sixty-six children and adolescents (ages 7-18) with juvenile idiopathic arthritis answered questions about pain, pai ... Full text Link to item Cite

Missed opportunities for timely diagnosis of pediatric lupus in South Africa: a qualitative study.

Journal Article Pediatr Rheumatol Online J · February 23, 2017 BACKGROUND: Systemic Lupus Erythematosus (SLE) is a serious multisystem autoimmune disease, which is more aggressive in children and people of African descent. In South Africa, pediatric SLE (pSLE) patients are at high risk for severe disease. Similar to p ... Full text Link to item Cite

Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa.

Journal Article Lupus · February 2017 Background Systemic lupus erythematosus (SLE) is a life-threatening multisystem autoimmune disease that is more severe in patients of African ancestry and children, yet pediatric SLE on the African continent has been understudied. This study describes a co ... Full text Link to item Cite

Parent and Child Report of Pain and Fatigue in JIA: Does Disagreement between Parent and Child Predict Functional Outcomes?

Journal Article Children (Basel) · January 30, 2017 While previous research in juvenile idiopathic arthritis (JIA) has identified discrepancy between parent and child perception of disease-related symptoms such as pain, the significance and impact of this disagreement has not been characterized. We examined ... Full text Link to item Cite

Validation of Patient-Reported Outcomes Measurement Information System Short Forms for Use in Childhood-Onset Systemic Lupus Erythematosus.

Journal Article Arthritis Care Res (Hoboken) · January 2017 OBJECTIVE: To validate the pediatric Patient-Reported Outcomes Measurement Information System short forms (PROMIS-SFs) in childhood-onset systemic lupus erythematosus (SLE) in a clinical setting. METHODS: At 3 study visits, childhood-onset SLE patients com ... Full text Link to item Cite

Use of Smartphones to Prospectively Evaluate Predictors and Outcomes of Caregiver Responses to Pain in Youth with Chronic Disease.

Journal Article Pain · December 15, 2016 This study examined outcomes and predictors of different types of responses to child pain used by caregivers of youth with chronic disease. Sixty-six children and adolescents (ages 7-18) with juvenile idiopathic arthritis answered questions about pain, pai ... Full text Link to item Cite

Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study.

Journal Article Arthritis Rheumatol · October 2016 OBJECTIVE: To uniquely classify children with microscopic polyangiitis (MPA), to describe their demographic characteristics, presenting clinical features, and initial treatments in comparison to patients with granulomatosis with polyangiitis (Wegener's) (G ... Full text Link to item Cite

The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013.

Journal Article J Rheumatol · September 2016 OBJECTIVE: We aimed to identify the (1) demographic/clinical characteristics, (2) medication usage trends, (3) variables associated with worse disease activity, and (4) characteristics of patients with persistent chronic arthritis in the Childhood Arthriti ... Full text Link to item Cite

Safety and efficacy of pregabalin in adolescents with fibromyalgia: a randomized, double-blind, placebo-controlled trial and a 6-month open-label extension study.

Journal Article Pediatr Rheumatol Online J · July 30, 2016 BACKGROUND: Fibromyalgia (FM) is a common pain condition characterized by widespread musculoskeletal pain and tenderness. Pregabalin is an approved treatment for adults in the United States, but there are no approved treatments for adolescents with FM. MET ... Full text Link to item Cite

Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting : Toronto, Canada. 14-17 April 2016.

Journal Article Pediatr Rheumatol Online J · July 12, 2016 P1 Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis Lampros Fotis, Nur Shaikh, Kevin Baszis, Anthony French, Phillip Tarr P2 Oral health and anti-citrullinated peptide antibodies (ACPA) in juvenile idiopathic arthriti ... Full text Open Access Link to item Cite

Prospective Mediation Models of Sleep, Pain, and Daily Function in Children With Arthritis Using Ecological Momentary Assessment.

Journal Article Clin J Pain · June 2016 OBJECTIVES: Sleep is an emerging area of concern in children with juvenile idiopathic arthritis (JIA). Research shows the presence of poor sleep quality and related adverse outcomes in pediatric pain populations, including JIA, but few studies have examine ... Full text Link to item Cite

Identifying Targets for Improving Mental Healthcare of Adolescents with Systemic Lupus Erythematosus: Perspectives from Pediatric Rheumatology Clinicians in the United States and Canada.

Journal Article J Rheumatol · June 2016 OBJECTIVE: To identify targets for improving mental healthcare of adolescents with systemic lupus erythematosus (SLE) by assessing current practices and perceived barriers for mental health intervention by pediatric rheumatology clinicians. METHODS: Member ... Full text Link to item Cite

Malignancy incidence in 5294 patients with juvenile arthritis.

Journal Article RMD Open · 2016 OBJECTIVE: To determine cancer incidence in a large clinical juvenile-onset arthritis population. METHODS: We combined data from 6 existing North American juvenile-onset arthritis cohorts. Patients with juvenile-onset arthritis were linked to regional canc ... Full text Link to item Cite

HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

Journal Article Proceedings of the National Academy of Sciences · December 29, 2015 SignificanceTo determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, ... Full text Cite

Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature.

Journal Article Pediatr Rheumatol Online J · April 23, 2015 Featured Publication UNLABELLED: Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to ... Full text Open Access Link to item Cite

Extension study of participants from the trial of early aggressive therapy in juvenile idiopathic arthritis.

Journal Article J Rheumatol · December 2014 OBJECTIVE: To follow children with juvenile idiopathic arthritis (JIA) who had completed at least 6 months of the TRial of Early Aggressive Therapy (TREAT) clinical study for an additional 2 years, describing safety of early aggressive treatment, disease a ... Full text Link to item Cite

Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis.

Conference Arthritis Rheumatol · September 2014 OBJECTIVE: To assess the efficacy and safety of rilonacept, an interleukin-1 inhibitor, in a randomized, double-blind, placebo-controlled trial. METHODS: An initial 4-week double-blind placebo phase was incorporated into a 24-week randomized multicenter de ... Full text Link to item Cite

Vitamin D deficiency is common and associated with increased C-reactive protein in children and young adults with lupus: An Atherosclerosis Prevention in Pediatric Lupus Erythematosus substudy

Conference Lupus Science and Medicine · June 1, 2014 Objective: Epidemiological associations suggest vitamin D may play a role in inflammation and atherosclerosis. Using frozen serum and data from the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, we assessed associations between ... Full text Cite

Clinically inactive disease in a cohort of children with new-onset polyarticular juvenile idiopathic arthritis treated with early aggressive therapy: time to achievement, total duration, and predictors.

Journal Article J Rheumatol · June 2014 OBJECTIVE: To determine the elapsed time while receiving aggressive therapy to the first observation of clinically inactive disease (CID), total duration of CID and potential predictors of this response in a cohort of children with recent onset of polyarti ... Full text Link to item Cite

Persistent pain in chronically ill children without detectable disease activity.

Journal Article Pain Manag · May 2014 Children with organic diseases may experience persistent pain in the presence of controlled disease, as evidenced by little or no measurable disease activity or inflammation. Historically, dualistic definitions of pain have informed standard diagnostic app ... Full text Link to item Cite

A32: Low Vitamin D Status is Associated with Avascular Necrosis: An Atherosclerosis Prevention in Pediatric Lupus Erythematosus Substudy.

Journal Article Arthritis Rheumatol · March 2014 Avascular necrosis (AVN) can result in significant morbidity. Previous studies suggest that AVN is associated with systemic lupus erythematosus (SLE) and corticosteroid treatment. Hypovitaminosis D has been postulated to play a role in bisphosphonate-assoc ... Full text Link to item Cite

A167: variations in patterns of care across pediatric rheumatic diseases in the childhood arthritis & rheumatology alliance network registry.

Journal Article Arthritis Rheumatol · March 2014 In 2009, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) established a longitudinal multi-center, multiple disease U.S. national registry (CARRA Registry) for pediatric rheumatology with the intent of providing a new framework to drive o ... Full text Link to item Cite

A31: Vitamin D Status is a Determinant of the Effect of Atorvastatin on Carotid Intima Medial Thickening Progression Rate in Children with Lupus: An Atherosclerosis Prevention in Pediatric Lupus Erythematosus Substudy.

Journal Article Arthritis Rheumatol · March 2014 Epidemiologic associations suggest that vitamin D status may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements, and other existing data from the Atherosclerosis Preventio ... Full text Link to item Cite

A134: Validation of Patient Reported Outomes Measurement Information System Modules for use in Childhood-;onset Lupus.

Journal Article Arthritis Rheumatol · March 2014 Childhood-onset lupus (cSLE) is a chronic autoimmune disease and its effect on health-related quality of life (HRQoL) has not been systematically established. The Patient Reported Outcomes Measurement Information System (PROMISâ„¢, http://nihpromis.org) is a ... Full text Link to item Cite

Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein.

Journal Article Ann Rheum Dis · March 2014 OBJECTIVE: Participants in the Atherosclerosis Prevention in Paediatric Lupus Erythematosus (APPLE) trial were randomised to placebo or atorvastatin for 36 months. The primary endpoint, reduced carotid intima medial thickness (CIMT) progression, was not me ... Full text Link to item Cite

Self-reported pain and disease symptoms persist in juvenile idiopathic arthritis despite treatment advances: an electronic diary study.

Journal Article Arthritis Rheumatol · February 2014 OBJECTIVE: To use electronic diaries (e-diaries) to determine whether pain, stiffness, and fatigue continue to be common, disabling symptoms in children with juvenile idiopathic arthritis (JIA) despite the use of aggressive treatments in contemporary medic ... Full text Link to item Cite

Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus: an Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy.

Journal Article Lupus Sci Med · 2014 OBJECTIVE: Epidemiological associations suggest that vitamin D status may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements and other existing data from the Atheroscleros ... Full text Link to item Cite

Vitamin D deficiency is common and associated with increased C-reactive protein in children and young adults with lupus: an Atherosclerosis Prevention in Pediatric Lupus Erythematosus substudy.

Journal Article Lupus Sci Med · 2014 OBJECTIVE: Epidemiological associations suggest vitamin D may play a role in inflammation and atherosclerosis. Using frozen serum and data from the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, we assessed associations between ... Full text Link to item Cite

Using registries to identify adverse events in rheumatic diseases.

Journal Article Pediatrics · November 2013 The proven effectiveness of biologics and other immunomodulatory products in inflammatory rheumatic diseases has resulted in their widespread use as well as reports of potential short- and long-term complications such as infection and malignancy. These com ... Full text Link to item Cite

Annexin A5 anticoagulant activity in children with systemic lupus erythematosus and the association with antibodies to domain I of β2-glycoprotein I.

Journal Article Lupus · June 2013 Children with systemic lupus erythematosus (SLE) have a high prevalence of antiphospholipid (aPL) antibodies and are at increased risk for aPL-related thrombosis. We investigated the association between annexin A5 anticoagulant activity and antibodies to t ... Full text Link to item Cite

A systematic review of sleep in pediatric pain populations.

Journal Article J Dev Behav Pediatr · February 2013 OBJECTIVE: The primary aim of this systematic review was to examine the evidence for a pain-sleep relationship in children with persistent pain by reviewing studies using single and mixed pediatric persistent pain samples. METHODS: Electronic searches of M ... Full text Link to item Cite

Cancer risk in childhood-onset systemic lupus.

Journal Article Arthritis Res Ther · 2013 INTRODUCTION: The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE). METHODS: We ascertained cancers within SLE registries at 10 pediatric centers. Subjects were linked to cancer registries for the obser ... Full text Link to item Cite

An i2b2-based, generalizable, open source, self-scaling chronic disease registry.

Journal Article J Am Med Inform Assoc · January 1, 2013 OBJECTIVE: Registries are a well-established mechanism for obtaining high quality, disease-specific data, but are often highly project-specific in their design, implementation, and policies for data use. In contrast to the conventional model of centralized ... Full text Link to item Cite

Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article J Rheumatol · December 2012 OBJECTIVE: To assess the relative effect of clinical factors and medications on pain intensity, physical function, and health status in juvenile idiopathic arthritis (JIA). METHODS: We conducted a retrospective cross-sectional study of data from children w ... Full text Link to item Cite

The health education for lupus study: a randomized controlled cognitive-behavioral intervention targeting psychosocial adjustment and quality of life in adolescent females with systemic lupus erythematosus.

Journal Article Am J Med Sci · October 2012 INTRODUCTION: To examine in a randomize controlled feasibility clinical trial the efficacy of a cognitive-behavioral intervention designed to manage pain, enhance disease adjustment and adaptation and improve quality of life among female adolescents with s ... Full text Link to item Cite

Validation of Promis Modules for Use in Childhood-Onset Lupus.

Conference ARTHRITIS AND RHEUMATISM · October 1, 2012 Link to item Cite

Algorithm development for corticosteroid management in systemic juvenile idiopathic arthritis trial using consensus methodology.

Journal Article Pediatr Rheumatol Online J · August 29, 2012 BACKGROUND: The management of background corticosteroid therapy in rheumatology clinical trials poses a major challenge. We describe the consensus methodology used to design an algorithm to standardize changes in corticosteroid dosing during the Randomized ... Full text Link to item Cite

Reply

Journal Article Arthritis and Rheumatism · August 1, 2012 Full text Cite

Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis.

Journal Article Arthritis Rheum · June 2012 Featured Publication OBJECTIVE: To determine whether aggressive treatment initiated early in the course of rheumatoid factor (RF)-positive or RF-negative polyarticular juvenile idiopathic arthritis (JIA) can induce clinical inactive disease within 6 months. METHODS: Between Ma ... Full text Link to item Cite

Parent perceptions of child vulnerability are associated with functioning and health care use in children with chronic pain.

Journal Article J Pain Symptom Manage · May 2012 CONTEXT: The extent to which parent variables are associated with the level of disability experienced by children with persistent pain has been an area of increasing research. OBJECTIVES: To evaluate the extent to which parent perceptions of their child's ... Full text Link to item Cite

Inactive disease and remission in childhood-onset systemic lupus erythematosus.

Journal Article Arthritis Care Res (Hoboken) · May 2012 OBJECTIVE: To define inactive disease (ID) and clinical remission (CR) and to delineate variables that can be used to measure ID/CR in childhood-onset systemic lupus erythematosus (cSLE). METHODS: Delphi questionnaires were sent to an international group o ... Full text Link to item Cite

Developing a standardized approach to the assessment of pain in children and youth presenting to pediatric rheumatology providers: a Delphi survey and consensus conference process followed by feasibility testing.

Journal Article Pediatr Rheumatol Online J · April 10, 2012 BACKGROUND: Pain in children with rheumatic conditions such as arthritis is common. However, there is currently no standardized method for the assessment of this pain in children presenting to pediatric rheumatologists. A more consistent and comprehensive ... Full text Link to item Cite

Daily sleep quality and mood as predictors of pain in children with juvenile polyarticular arthritis.

Journal Article Health Psychol · March 2012 Featured Publication OBJECTIVE: Children with arthritis experience frequent pain, but the predictors of daily pain variations are largely unidentified. The goal of this study was to examine sleep quality as a predictor of pain in children with arthritis and to determine whethe ... Full text Link to item Cite

Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus.

Journal Article Arthritis Care Res (Hoboken) · March 2012 Featured Publication OBJECTIVE: To formulate consensus treatment plans (CTPs) for induction therapy of newly diagnosed proliferative lupus nephritis (LN) in juvenile systemic lupus erythematosus (SLE). METHODS: A structured consensus formation process was employed by the membe ... Full text Link to item Cite

Pediatric analgesic clinical trial designs, measures, and extrapolation: report of an FDA scientific workshop.

Journal Article Pediatrics · February 2012 Analgesic trials pose unique scientific, ethical, and practical challenges in pediatrics. Participants in a scientific workshop sponsored by the US Food and Drug Administration developed consensus on aspects of pediatric analgesic clinical trial design. Th ... Full text Link to item Cite

Emotion regulation predicts pain and functioning in children with juvenile idiopathic arthritis: an electronic diary study.

Journal Article J Pediatr Psychol · 2012 Featured Publication OBJECTIVES: This study utilized e-diaries to evaluate whether components of emotion regulation predict daily pain and function in children with juvenile idiopathic arthritis (JIA). METHODS: 43 children ages 8-17 years and their caregivers provided baseline ... Full text Link to item Cite

Use of atorvastatin in systemic lupus erythematosus in children and adolescents.

Journal Article Arthritis Rheum · January 2012 Featured Publication OBJECTIVE: Statins reduce atherosclerosis and cardiovascular morbidity in the general population, but their efficacy and safety in children and adolescents with systemic lupus erythematosus (SLE) are unknown. This study was undertaken to determine the 3-ye ... Full text Link to item Cite

Malignancy and JIA: Updated Results

Conference ARTHRITIS AND RHEUMATISM · October 1, 2011 Link to item Cite

Cancer Risk In Pediatric Systemic Lupus: Updated Analyses

Conference ARTHRITIS AND RHEUMATISM · October 1, 2011 Link to item Cite

Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus.

Journal Article Arthritis Care Res (Hoboken) · September 2011 OBJECTIVE: To develop widely acceptable preliminary criteria of global flare for childhood-onset systemic lupus erythematosus (cSLE). METHODS: Pediatric rheumatologists (n = 138) rated a total of 358 unique patient profiles with information about the cSLE ... Full text Link to item Cite

Functional limitation in JIA: A matter of pain or disease severity?

Journal Article CLINICAL AND EXPERIMENTAL RHEUMATOLOGY · March 1, 2011 Link to item Cite

Parental perceptions of child vulnerability and parent stress as predictors of pain and adjustment in children with chronic arthritis

Journal Article Children S Health Care · January 1, 2011 Parental predictors of child psychological adjustment and pain were investigated in 51 children with arthritis. Children rated depressive symptoms, anxiety, and pain. Disease severity was determined by a physician provided active joint count, as well as a ... Full text Cite

Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort.

Journal Article Lupus · October 2010 As part of the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Trial, a prospective multicenter cohort of 221 children and adolescents with systemic lupus erythematosus (SLE) (mean age 15.7 years, 83% female) underwent baseline measurem ... Full text Link to item Cite

A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus.

Journal Article Arthritis Care Res (Hoboken) · July 2010 Featured Publication OBJECTIVE: To develop and propose a standardized battery of neuropsychological tests for the assessment of cognitive functioning of children and adolescents with pediatric systemic lupus erythematosus (SLE). METHODS: A committee of health care professional ... Full text Link to item Cite

Toward the development of criteria for global flares in juvenile systemic lupus erythematosus.

Journal Article Arthritis Care Res (Hoboken) · June 2010 Featured Publication OBJECTIVE: To develop a definition of global flare in juvenile systemic lupus erythematosus (SLE) and derive candidate criteria for measuring juvenile SLE flares. METHODS: Pediatric rheumatologists answered 2 Delphi questionnaires to achieve consensus on a ... Full text Link to item Cite

Parent pain responses as predictors of daily activities and mood in children with juvenile idiopathic arthritis: the utility of electronic diaries.

Journal Article J Pain Symptom Manage · March 2010 Featured Publication The present study used electronic diaries to examine how parent responses to their child's pain predict daily adjustment of children with juvenile idiopathic arthritis (JIA). Nine school-aged children with JIA along with one of their parents completed thri ... Full text Link to item Cite

Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood.

Journal Article Arthritis Rheum · November 2009 OBJECTIVE: To compare the criteria for Wegener's granulomatosis (WG) of the American College of Rheumatology (ACR) with those of the European League Against Rheumatism/Pediatric Rheumatology European Society (EULAR/PRES) in a cohort of children with WG and ... Full text Link to item Cite

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.

Journal Article Arthritis Rheum · May 2009 Featured Publication OBJECTIVE: To evaluate risk factors for subclinical atherosclerosis in a population of patients with pediatric systemic lupus erythematosus (SLE). METHODS: In a prospective multicenter study, a cohort of 221 patients underwent baseline measurements of caro ... Full text Link to item Cite

Neurocognitive impairment in children and adolescents with systemic lupus erythematosus.

Journal Article Nat Clin Pract Rheumatol · February 2009 Featured Publication Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, in which neuropsychiatric manifestations are a common cause of significant morbidity. The American College of Rheumatology has identified 19 distinct neuropsychiatric syndromes associa ... Full text Link to item Cite

Evaluating and managing pediatric musculoskeletal pain in primary care

Journal Article · December 1, 2008 Musculoskeletal pain is common in pedi-atric populations, reported in up to half of children from community samples, and is a frequent presenting complaint in pediatric primary care. Evaluating pedi-atric musculoskeletal pain is complicated by the extensiv ... Full text Cite

Therapy Insight: cardiovascular disease in pediatric systemic lupus erythematosus.

Journal Article Nat Clin Pract Rheumatol · May 2008 Featured Publication In 15-20% of cases, systemic lupus erythematosus (SLE) presents before the age of 18 years, and such early-onset SLE seems to be particularly severe. SLE is an independent risk factor for premature atherosclerosis and death in young, premenopausal women wi ... Full text Link to item Cite

Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus.

Journal Article Pediatr Rheumatol Online J · April 1, 2008 BACKGROUND: North American pediatric rheumatologists have created an investigator-initiated research network (the Childhood Arthritis and Rheumatology Research Alliance - CARRA) to facilitate multi-centre studies. One of the first projects undertaken by th ... Full text Link to item Cite

Infliximab to treat chronic noninfectious uveitis in children: retrospective case series with long-term follow-up.

Journal Article Am J Ophthalmol · December 2007 PURPOSE: To assess a response to infliximab therapy in childhood uveitis. DESIGN: Retrospective case series. METHODS: We reviewed the course of 16 children with noninfectious uveitis treated with infliximab at an academic medical center. Outcome measures i ... Full text Link to item Cite

Assessment and management of pain syndromes and arthritis pain in children and adolescents.

Journal Article Rheum Dis Clin North Am · August 2007 Featured Publication Chronic musculoskeletal pain, whether it is idiopathic or disease-related, is common in childhood. Pediatric rheumatologists and other pediatric health care providers must understand the epidemiology of musculoskeletal pain as part of childhood, diagnose p ... Full text Link to item Cite

Management of dyslipidemia in children and adolescents with systemic lupus erythematosus.

Journal Article Lupus · 2007 Featured Publication Systemic lupus erythematosus (SLE) is an independent risk factor for atherosclerosis, placing children and adolescents with SLE at great risk for developing cardiovascular sequelae, including myocardial infarction, in adulthood. Dyslipidemia and other trad ... Full text Link to item Cite

Latest developments in the assessment and management of chronic musculoskeletal pain syndromes in children.

Journal Article Curr Opin Rheumatol · September 2006 PURPOSE OF REVIEW: As many as 25% of new patients in pediatric rheumatology clinics present with idiopathic chronic pain and recent data suggest the prevalence of these conditions is increasing. Knowledge of the latest developments in assessment and treatm ... Full text Link to item Cite

Treatment of pain in juvenile idiopathic arthritis: a survey of pediatric rheumatologists.

Journal Article Arthritis Rheum · February 15, 2006 Featured Publication OBJECTIVE: To assess the opinions and current practice of pediatric rheumatologists regarding treatment of chronic pain in children with juvenile idiopathic arthritis (JIA). METHODS: Standardized questionnaires were distributed to pediatric rheumatologists ... Full text Link to item Cite

The management of pediatric systemic lupus erythematosus.

Journal Article Nat Clin Pract Rheumatol · December 2005 Featured Publication Most children and adolescents with systemic lupus erythematosus (SLE) now survive into adulthood, leading the pediatric rheumatology community to focus on preventing long-term complications of SLE, including atherosclerosis, obesity, and osteoporosis, and ... Full text Link to item Cite

Pain, stiffness, and fatigue in juvenile polyarticular arthritis: contemporaneous stressful events and mood as predictors.

Journal Article Arthritis Rheum · April 2005 Featured Publication OBJECTIVE: To analyze patterns of stress, mood, disease symptoms, and activity reduction in children with polyarticular arthritis, using a prospective daily diary method. METHODS: For a 2-month period, 51 children with polyarticular arthritis (mean age 12. ... Full text Link to item Cite

Pediatric pain syndromes and management of pain in children and adolescents with rheumatic disease.

Journal Article Pediatr Clin North Am · April 2005 This article introduces important issues related to pain in children with musculoskeletal pain syndromes and rheumatic disease, using juvenile primary fibromyalgia syndrome (JPFS) and juvenile idiopathic arthritis (JIA) as models. A brief summary of the pr ... Full text Link to item Cite

Parry-Romberg syndrome with fatal brain stem involvement.

Journal Article J Pediatr · March 2005 We report the case of a 4 year-old boy with Parry-Romberg syndrome who had intractable seizures, progressive cerebral hemisphere atrophy, and fatal brain stem involvement. ... Full text Link to item Cite

Long-term open-label preliminary study of the safety and efficacy of leflunomide in patients with polyarticular-course juvenile rheumatoid arthritis.

Journal Article Arthritis Rheum · February 2005 OBJECTIVE: To obtain preliminary data regarding the efficacy and long-term safety of leflunomide in patients with refractory polyarticular-course juvenile rheumatoid arthritis (JRA). METHODS: Twenty-seven patients were entered into the initial 26-week open ... Full text Link to item Cite

Dyslipoproteinemia and premature atherosclerosis in pediatric systemic lupus erythematosus.

Journal Article Curr Rheumatol Rep · December 2004 Featured Publication While modern treatments for systemic lupus erythematosus (SLE) have resulted in greatly improved long term outcome in children and adults, complications of atherosclerosis have become a major cause of morbidity and mortality. Although children and adolesce ... Full text Link to item Cite

Peer rejection, social behavior, and psychological adjustment in children with juvenile rheumatic disease.

Journal Article J Pediatr Psychol · 2004 Featured Publication OBJECTIVE: To examine the associations among disease status, social competence, and depressive symptoms in children with juvenile rheumatic disease (JRD) and to test the hypothesis that individual differences in children's social competence account for a s ... Full text Link to item Cite

Widespread pain in children: when is it pathologic?

Journal Article Arthritis Rheum · September 2003 Featured Publication Full text Link to item Cite

Infliximab to treat pediatric chronic inflammatory uveitis.

Conference ARTHRITIS AND RHEUMATISM · September 1, 2003 Link to item Cite

Daily pain and symptoms in children with polyarticular arthritis.

Journal Article Arthritis Rheum · May 2003 Featured Publication OBJECTIVE: To analyze patterns of daily pain, stiffness, and fatigue related to juvenile arthritis; to examine the relationships of demographics, disease severity, and psychological adjustment to daily disease symptoms; and to examine daily disease symptom ... Full text Link to item Cite

Pain in children with arthritis: a review of the current literature.

Journal Article Arthritis Rheum · April 15, 2003 Featured Publication Full text Link to item Cite

Brief report: Parental perceptions of child vulnerability in children with chronic illness.

Journal Article J Pediatr Psychol · 2003 Featured Publication OBJECTIVE: To determine the extent to which parental perceptions of child vulnerability predict school and social adjustment in children with chronic illness. METHODS: Sixty-nine child-parent dyads were recruited from pediatric rheumatology and pulmonary c ... Full text Link to item Cite

Thank you reviewers!

Journal Article Journal of Musculoskeletal Pain · December 1, 2001 Full text Cite

Family pain history predicts child health status in children with chronic rheumatic disease.

Journal Article Pediatrics · September 2001 Featured Publication OBJECTIVES: To examine the relationships of parental and family pain history on the pain experience of children with chronic rheumatic disease. The aims of the study were as follows: 1) to describe the pain history of parents and families of children with ... Full text Link to item Cite

Juvenile idiopathic arthritis.

Journal Article Curr Opin Rheumatol · September 2001 A significant amount of work has been performed over the past 2 years further defining the pathophysiology of juvenile idiopathic arthritis (JIA). The development of the biologic agent etanercept represents successful translational research. This genetical ... Full text Link to item Cite

Girls with polyarticular arthritis report more disease symptoms than boys.

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 2001 Link to item Cite

Juvenile primary fibromyalgia syndrome.

Journal Article Curr Rheumatol Rep · April 2001 Juvenile primary fibromyalgia syndrome (JPFS) is a common musculoskeletal pain syndrome of unknown etiology characterized by widespread persistent pain, sleep disturbance, fatigue, and the presence of multiple discrete tender points on physical examination ... Full text Link to item Cite

Effects of inherited thrombophilic mutations in an adolescent with antiphospholipid syndrome and systemic lupus erythematosus.

Journal Article J Rheumatol · February 2001 Thrombophilia can result from either inherited or acquired conditions. We describe a teenager who developed extensive thrombosis requiring aggressive and prolonged anticoagulation. Laboratory evaluation revealed an acquired lupus anticoagulant, consistent ... Link to item Cite

The relationship of daily mood and stressful events to symptoms in juvenile rheumatic disease.

Journal Article Arthritis Care Res · February 2000 Featured Publication OBJECTIVES: The purpose of this study was 3-fold: 1) to assess the feasibility of a daily diary for use with children with juvenile rheumatic disease (JRD), 2) to describe daily variation in mood, stressful events, and symptoms in children with JRD, and 3) ... Full text Link to item Cite

Reply.

Other J Infect Dis · February 2000 Full text Link to item Cite

Prevention of leg length discrepancy in young children with pauciarticular juvenile rheumatoid arthritis by treatment with intraarticular steroids.

Journal Article Arthritis Rheum · November 1999 OBJECTIVE: To determine if intraarticular (i.a.) injection of triamcinolone hexacetonide (steroids) used early in the course of pauciarticular juvenile rheumatoid arthritis (pauci JRA) is associated with less leg length discrepancy (LLD) or thigh circumfer ... Full text Link to item Cite

Renal outcome in childhood systemic lupus erythematosus.

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 1999 Link to item Cite

Causes of pain in children with arthritis.

Journal Article Rheum Dis Clin North Am · February 1999 Pain in children with juvenile rheumatoid arthritis (JRA) is often not fully recognized and is therefore incompletely treated. The use of pain assessment instruments developed specifically for children may enhance recognition by health care providers. Rece ... Full text Link to item Cite

Social context of pain in children with Juvenile Primary Fibromyalgia Syndrome: parental pain history and family environment.

Journal Article Clin J Pain · June 1998 Featured Publication OBJECTIVE: The purpose of this study was to describe parental pain history and the family environment as it relates to the functional status of children with Juvenile Primary Fibromyalgia Syndrome (JPFS). DESIGN AND OUTCOME MEASURES: Twenty-nine parents of ... Full text Link to item Cite

Pain coping and the pain experience in children with juvenile chronic arthritis.

Journal Article Pain · November 1997 Featured Publication This study examined the pain experience and pain coping of children with juvenile chronic arthritis (JCA). The purpose of the study was to describe present pain and the pain coping strategies utilized by children with juvenile chronic arthritis and examine ... Full text Link to item Cite

Pain coping and the pain experience in children with juvenile chronic arthritis.

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 1997 Link to item Cite

Seldom recognized cutaneous manifestations of juvenile dermatomyositis (JDMS).

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 1996 Link to item Cite

Pain coping strategies in children with juvenile primary fibromyalgia syndrome: correlation with pain, physical function, and psychological distress.

Journal Article Arthritis Care Res · April 1996 Featured Publication OBJECTIVES: The purpose of this study was twofold: 1) to describe the coping strategies used by children with juvenile primary fibromyalgia syndrome (JPFS), and 2) to examine how pain coping relates to measures of pain, disability/function, psychological d ... Full text Link to item Cite

The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters.

Journal Article Immunogenetics · 1996 Human CD7 (hCD7) is a 40 000 Mr member of the immunoglobulin gene superfamily that is expressed early in natural killer (NK) and T-lymphocyte development. CD7 is involved in lymphocyte activation, as ligation of CD7 activates NK and TCRgammadelta T lymphoc ... Link to item Cite

Characterization of human CD7 transgenic mice.

Journal Article J Immunol · September 1, 1995 CD7 is a 40-kDa transmembrane glycoprotein member of the lg gene superfamily expressed on most peripheral blood T lymphocytes and NK cells. CD7 is also expressed on myeloid, NK, B, and T cell precursors during adult hematopoiesis. Because Thy-1 is absent i ... Link to item Cite

Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.

Journal Article Proc Natl Acad Sci U S A · January 15, 1991 The human CD7 molecule is a 40-kDa member of the immunoglobulin gene superfamily that is expressed on T-lymphoid and myeloid precursors in fetal liver and bone marrow. CD7 is also expressed on T lymphocytes in multiple stages of T-cell development, includi ... Full text Link to item Cite