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Scott Joseph Antonia

Professor of Medicine
Medicine, Medical Oncology

Selected Grants


Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2029

Role of mregDC-PCSK9-mediated Inhibition of DC Antigen Cross-Presentation in Tumor Immunotherapy Resistance

ResearchCollaborator · Awarded by V Foundation for Cancer Research · 2024 - 2027

Novel roles of PCSK9 in regulating the tumor immune microenvironment during radiotherapy

ResearchCo-Principal Investigator · Awarded by National Cancer Institute · 2022 - 2027

Duke ACS Institutional Research Grant

ResearchSignificant Contributor · Awarded by American Cancer Society, Inc. · 2024 - 2026

Duke Center for Advancement of Child Health (CAtCH).

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Epigenetic Engineering of Tumor-Infiltrating Lymphocytes

ResearchCo Investigator · Awarded by Yosemite · 2025 - 2025

Phase Ib Study of MEM-288 Oncolytic Virus in Combination with Nivolumab in Non-Small Cell Lung Cancer (NSCLC)

ResearchMentor · Awarded by Bristol-Myers Squibb Foundation · 2023 - 2025

Clinical Biomarker Study of the Tumor NLRP3 Inflammasome and its Role in Anti-PD-1 Immunotherapy Resistance

ResearchCollaborator · Awarded by Conquer Cancer Foundation · 2021 - 2024

Nektar PROPEL

Clinical TrialPrincipal Investigator · Awarded by Nektar Therapeutics · 2020 - 2024

Discovering Novel Tumor-Reactive Antibodies in Pembrolizumab-Treated NSCLC

ResearchMentor · Awarded by Lung Cancer Initiative of North Carolina · 2023 - 2023

Eco-Evolutionary dynamics of NSCLC to immunotherapy: Response and Resistance

ResearchPrincipal Investigator · Awarded by H. Lee Moffitt Cancer Center & Research Institute · 2019 - 2023

Use of an oncolytic adenovirus to promote anti-tumor T-cell responses in ovarian cancer

ResearchMentor · Awarded by Foundation for Women's Cancer · 2022 - 2023

T32 UNC - Duke Immunotherapy Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by University of North Carolina - Chapel Hill · 2021 - 2022

Identifying Epigenetic Biomarkers that Predict Response to Immunotherapy in Lung Cancer Patients

ResearchMentor · Awarded by Lung Cancer Initiative of North Carolina · 2020 - 2022

Anonymous Donation

ResearchPrincipal Investigator · Awarded by Anonymous Trust · 2020 - 2022

Targeting Immunosuppressive Cancer Associated Fibroblasts and Immune Checkpoints in NSCLC

ResearchPrincipal Investigator · Awarded by H. Lee Moffitt Cancer Center & Research Institute · 2019 - 2022

Tumor Infiltrating lymphocyte adoptive T cell therapy for NSCLC

ResearchPrincipal Investigator · Awarded by H. Lee Moffitt Cancer Center & Research Institute · 2019 - 2021

CA191146: Long-acting PEG-like conjugates of an immune checkpoint inhibitor and a selective cytokine for combination immunotherapy

ResearchCo-Mentor · Awarded by United States Army Medical Research Acquisition Activity · 2020 - 2021

External Relationships


  • Achilles Therapeutics
  • Cellepus Therapeutics
  • Guardian Bio
  • Immutep
  • Leap Therapeutics
  • Memgen
  • RAPT Biotherapeutics
  • Shoreline
  • Tubulis
  • Xilis, Inc

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.